Metolar-XR (Metoprolol Capsules)
Metoprolol Capsules
Clearsky Pharmacy
Metolar-XR (Metoprolol Capsules) is used for the treatment of
hypertension (blood pressure), long-term treatment of angina
pectoris, treatment of stable, symptomatic heart failure of
ischemic, hypertensive or cardiomyopathic origin as well as for
migraine prophylaxis.
Metolar-XR Capsules
Clearsky Pharmacy
Metolar-XR Capsules are manufactured by Cipla limited,
India.(Website: www.cipla.com)
Metoprolol Succinate Capsules Brand Names
Clearsky Pharmacy
Metoprolol Succinate capsules and tablets are available as
Lopressor, Toprol XL, Metolar-XR, Betaloc, Betaone-XL, Embeta,
Lopresor, Metocard-XL, Metolar, Metscore XL, Prolomet-XL, Met-XL,
Sitelol XR, Starpress XL, and Topol-XL .
Active Ingredient
Clearsky Pharmacy
The active ingredient contained in Metolar-XR capsules is
Metoprolol Succinate. Each extended-release Metolar XR capsule
contains Metoprolol Succinate equivalent to 25 mg, 50 mg or 100 mg
of Metoprolol Tartrate.
Chemical Structure
Clearsky Pharmacy
The structure of Metoprolol Succinate is given below:
Uses of Metolar-XR Capsules
Clearsky Pharmacy
Metolar-XR Capsules manufactured by Cipla limited India, is a
beta-blocker used to treat chest pain (angina), heart failure, high
blood pressure, Maintenance treatment after myocardial infarction,
Hyperthyroidism , Paediatric hypertension and migraine
prophylaxis.
Metolar-XR Dosage
Clearsky Pharmacy
Hypertension: The usual starting adult dosage is 25 mg to 100 mg
daily in a single dose. The dosage may be increased at weekly (or
longer) intervals until optimum blood pressure reduction is
achieved.
Angina Pectoris: The dosage must be individualized. The usual
starting adult dosage is 100 mg daily, given in a single dose.
Gradually the dosage has to be increased at weekly intervals until
optimum clinical response has been obtained or there is a
pronounced slowing of the heart rate.
The dosage of Metolar-XR Capsules (Metoprolol Succinate) is
given below:
Metoprolol Succinate Dosage
Clearsky Pharmacy
Heart Failure: The dosage must be individualized and closely
monitored during up-titration. Before initiation of Metolar XR,
stabilize the dose of other heart failure medication therapy. The
recommended adult starting dose is 25 mg once daily for two weeks
in patients with NYHA class II heart failure and 12.5 mg once daily
in patients with more severe heart failure. Double the dose very
two weeks to the highest dosage level tolerated by the patient or
up to 200 mg of Metolar XR.
Migraine Prophylaxis: The dosage is 100 mg to 200 mg once daily
in the morning.
The dosage of Metolar-XR capsules (Metoprolol Succinate) is
given below:
Storage Instructions
Clearsky Pharmacy
Metolar-XR (Metoprolol Capsules) have to be stored at controlled
room temperature i.e. at 25C (77F) with excursions permitted
between 15 to 30C (59 to 86F). Keep this as well as all other
medicines away from children and pets.
Metolar-XR Capsules
Clearsky Pharmacy
Contraindications
Metolar-XR Capsules is contraindicated in patients with a
hypersensitivity to Metoprolol Succinate or any other component of
this medication.This medicine is also contraindicated in cases of
Severe bradycardia, Second- or third-degree heart block,
Cardiogenic shock, Decompensated cardiac failure, Sick sinus
syndrome (unless a permanent pacemaker is in place), Bronchial
asthma or other obstructive lung disorders and Severe peripheral
arterial circulatory disorder.
Warnings
Clearsky Pharmacy
Heart Failure: Beta blockers, like Metolar-XR, can cause
depression of myocardial contractility and can precipitate heart
failure and cardiogenic shock. Do not abruptly stop Metoprolol
capsules therapy in patients with coronary artery disease. Severe
exacerbation of angina, myocardial infarction, and ventricular
arrhythmias have been observed in patients with coronary artery
disease following the abrupt discontinuation of therapy with
beta-blockers Use of Metoprolol During Major Surgery: Chronically
administered beta-blocking therapy should not be routinely
withdrawn before major surgery; however, the impaired ability of
the heart to respond to reflex adrenergic stimuli may augment the
risks of general anesthesia and surgical procedures.
Warnings
Clearsky Pharmacy
Bradycardia: Bradycardia, including sinus pause, heart block,
and cardiac arrest have occurred with the use of Metoprolol
Capsules. Diabetes and Hypoglycemia: Beta blockers such as
Metolar-XR Capsules may mask tachycardia occurring with
hypoglycemia, but other manifestations such as dizziness and
sweating may not be significantly affected.Pheochromocytoma: If
Metolar-XR Capsules are used in the setting of pheochromocytoma, it
should be given in combination with an alpha blocker, and only
after the alpha blocker has been initiated.Thyrotoxicosis:
Lopressor may mask certain clinical signs (e.g., tachycardia) of
hyperthyroidism. Avoid abrupt ithdrawal of beta blockade, which
might precipitate a thyroid storm.
Warnings
Clearsky Pharmacy
Risk of Anaphylactic Reactions: While taking beta blockers,
patients with a history of severe anaphylactic reaction to a
variety of allergens may be more reactive to repeated challenge,
either accidental, diagnostic, or therapeutic.
Catecholamine-depleting drugs: Catecholamine-depleting drugs (e.g.,
reserpine) may have an additive effect when given along with
beta-blocking agents or monoamine oxidase (MAO) inhibitors. Observe
patients treated with Metolar-XR plus a catecholamine depletor for
evidence of hypotension or marked bradycardia, which may produce
vertigo, syncope, or postural hypotension.
Warnings
Clearsky Pharmacy
Digitalis glycosides and beta blockers: Both digitalis
glycosides and beta blockers like Metolar-XR slow atrioventricular
conduction and decrease heart rate. Concomitant use can increase
the risk of bradycardia. Monitor patients heart rate and PR
interval.Calcium channel blockers:Concomitant administration of a
beta-adrenergic antagonist with a calcium channel blocker may
produce an additive reduction in myocardial contractility because
of negative chronotropic and inotropic effects. General
Anesthetics:Some inhalation anesthetics may enhance the
cardiodepressant effect of beta blockers.
Metoprolol Capsules Side Effects
Clearsky Pharmacy
Metolar-XR (Metoprolol Capsules) side effects can include
tiredness and dizziness, Mental confusion, short-term memory loss,
Headache, somnolence, nightmares, and insomnia , Worsening angina
or myocardial infarction, Shortness of breath, bradycardia,
Worsening heart failure, Worsening AV block, Wheezing
(bronchospasm) and dyspnea, Diarrhea, Nausea, dry mouth, gastric
pain, constipation, flatulence, digestive tract disorders,
heartburn, Pruritus or rash, Peyronies disease, Musculoskeletal
pain, blurred vision, decreased libido, and tinnitus
Metoprolol Capsules Overdose
Clearsky Pharmacy
Signs and symptoms of overdosage of Metolar XR (Metoprolol
Capsules) are severe bradycardia, hypotension and cardiogenic
shock. Other symptoms can also include AV block, heart failure,
bronchospasm, hypoxia, impairment of consciousness/coma, nausea and
vomiting.
Metoprolol Capsules Overdose
Clearsky Pharmacy
Consider treating the patient with intensive care. Patients with
myocardial infarction or heart failure may be prone to significant
hemodynamic instability.
Beta-blocker overdose can result in significant resistance to
resuscitation with adrenergic agents, including beta-agonists. On
the basis of the pharmacologic actions of Metoprolol capsules
employ the following measures.
There is very limited experience with the use of hemodialysis to
remove metoprolol, however metoprolol is not highly protein
bound.
Metoprolol Capsules Overdose
Clearsky Pharmacy
Bradycardia: Administer IV Atropine; repeat to effect. If the
response is inadequate, consider intravenous isoproterenol or other
positive chronotropic agents. Evaluate the need for transvenous
pacemaker insertion. Hypotension: Treat underlying bradycardia.
Consider intravenous vasopressor infusion, such as dopamine or
norepinephrine.
Bronchospasm: Administer a beta2-agonist, including albuterol
inhalation, or an oral theophylline derivative. Cardiac Failure:
Administer diuretics or digoxin for congestive heart failure. For
cardiogenic shock, consider IV dobutamine, isoproterenol or
glucagon.
Metoprolol During Pregnancy
Clearsky Pharmacy
Metoprolol (Metolar-XR Capsules) has been classified by the US
FDA as Pregnancy Category C. Controlled studies with animals have
revealed no evidence of impaired fertility or teratogenicity. There
are no adequate and well-controlled studies conducted in pregnant
women. Since animal reproduction studies are not always predictive
of human response, this drug should be used during pregnancy only
if clearly needed.
Metolar-XR Capsules
For more details on Metolar-XR Capsules click here
Clearsky Pharmacy
Metolar-XR (Metoprolol Succinate Capsules) by Cipla Limited,
India .
