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MYCOTIC INFECTIONSSubmitted by
NILIMA T.S.
NORTH AMERICAN BLASTOMYCOSISCaused by Blastomyces dermatiditis.
CLINICAL FEATURES-Tiny miliary abscess or pustules.-crateriform lesions.-Fever.-weight loss.-productive cough.
NORTH AMERICAN BLASTOMYCOSIS
NORTH AMERICAN BLASTOMYCOSIS-DOUBLY REFRACTILE CAPSULE
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ORAL MANIFESTATIONTiny ulcer.Abscess formation.
HISTOLOGIC FEATURESInflamed connective tissue.Giant cells and macrophages.Round organism with doubly refractile
capsule.Microabscess.
SOUTH AMERICAN BLASTOMYCOSISCaused by Blastomyces brasiliensis.Fungus varies 10um to60um in diameter and
is larger than that of north american blastomycosis.
SOUTH AMERICAN BLASTOMYCOSIS
HISTOPLASMOSISAlso called Darling’s disease.Caused by Histoplasma capsulatum.CLINICAL FEATURESLow grade fever.Splenomegaly.Hepatomegaly.Lymphadenopathy.
HISTOPLASMOSIS
ORAL MANIFESTATIONNodular,ulcerative or vegetative lesions.Ulcerated areas covered by nonspecific gray
membrane.Common on buccal
mucosa,gingiva,tongue,palate or lips.
HISTOLOGIC FEATURESOrganism appear as tiny intracellular
structures measuring a little more than 1um in diameter.
TREATMENT:Amphotericin B
HISTOPLASMOSIS
CANDIDIASISCaused by Candida albicans . CLASSIFICATION:Primary Candidiasis:Acute forms-Psuedomembranous-Erythematous
Chronic forms-Hyperplstic Nodular Plaque-like-Erythematous-PsuedomembranousCandida associated lesions-Denture stomatitis
-Angular cheilitis-Mediam rhomboid glossitisKeratinized primary lesions super infected
with Candida-Leukoplakia-Lichen planus-Lupus erythematosusSECONDARY ORAL CANDIDIASIS
ATROPHIC CANDIDIASIS
ERYTHEMATOUS CANDIDIASIS
HYPERPLASTIC CANDIDIASIS
TREATMENTNystatinClotrimazoleAmphotericin BMiconazole
PHYCOMYCOSISAlso called as Mucormycosis,Zygomycosis.Caused by Mucorales and Entomophthorales.CLINICAL FEATURES2 main types-Superficial -VisceralVisceral-Pulmonary -Gastrointestinal -Rhinocerebral
ZYGOMYCOSIS
HISTOLOGIC FEATURES Organisms appear large,nonseptate hyphae
with branching at obtuse angles.Round or ovoid sporangia.
TREATMENTControl of predisposing factors.Surgical excisionAmphotericin B
ZYGOMYCOSIS
RHINOSPORIDIOSISCaused by Rhinosporidium seeberi.CLINICAL FEATURESMucoid discharge.Soft polypoid growth spreading to pharynx
and larynx.Lesions are vascular.
HISTOLOGIC FEATURESSporangia containing large number of round
or ovoid endospores,each 5-7um in diameter.Focal abscess formation and multinucleated
giant cells.
TREATMENTSurgical removal.
COCCIDIODOMYCOSISCaused by Coccidiodes immitis.
CLINICAL FEATURES2 forms-Primary nondisseminated and
Progressive disseminated.
ORAL MANIFESTATIONProliferative granulomatous and ulcerated lesions.Lytic lesions of jaw.
HISTOLOGIC FEATURES
Foci of coagulation necrosis.Endospores within large spherules.
TREATMENTAmphotericin B
CRYPTOCOCCOSISAlso called as Tolurosis ,European
blastomycosis.Caused by cryptococcus neoformans.CLINICAL FEATURESMultiple brown papules.Occurs in patients with malignant lymphoma.
ORAL MANIFESTATIONSNon specific single or multiple ulcers.
HISTOLOGIC FEATURES
Gram positive, budding,yeast-like cell with thick gelatinous capsule.
Measures 5-20um with a clear halo.
TREATMENTAmphotericin B
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