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New tools for protein structures http://odonoghuelab.org Seán O’Donoghue B. Sc. (Hons), Ph. D., FRSC and phosphorylation pathways - plus another animation Monday, 31 March 14

New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

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Round out this year's FOAM with VizBi founder and CSIRO Science Leader Sean O'Donoghue as he takes us through his team's latest work, including an animation about pancreatic cancer.

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Page 1: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

New tools for protein structures

http://odonoghuelab.org

Seán O’DonoghueB. Sc. (Hons), Ph. D., FRSC

and phosphorylation pathways

- plus another animation

Monday, 31 March 14

Page 2: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

New tools for protein structures

http://odonoghuelab.org

Seán O’DonoghueB. Sc. (Hons), Ph. D., FRSC

Monday, 31 March 14

Page 3: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

Monday, 31 March 14

Page 4: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

New tools for protein structures

http://odonoghuelab.org

Seán O’Donoghue Julian Heinrich

Monday, 31 March 14

Page 5: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

Monday, 31 March 14

Page 6: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

Monday, 31 March 14

Page 7: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

Visualising Protein Ensembleswith Parallel Coordinates

Monday, 31 March 14

Page 8: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

Visualising Protein Ensembleswith Parallel Coordinates

Monday, 31 March 14

Page 9: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

Observed Disorder vs. Predicted Disorder

retinoic acid receptorobserved predicted

Monday, 31 March 14

Page 10: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

Visually Query and Filter by Principal Components

retinoic acid receptor

Monday, 31 March 14

Page 11: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

Visually Query and Filter by Principal Components

retinoic acid receptorJ. Heinrich, M. Krone, S. O’Donoghue, and D. Weiskopf, “Visualising Intrinsic Disorder and Conformational Variation in Protein Ensembles,” Faraday Discuss., 2014.Monday, 31 March 14

Page 12: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

New tools for phosphorylation pathways

http://odonoghuelab.org

Seán O’DonoghueB. Sc. (Hons), Ph. D., FRSC

Monday, 31 March 14

Page 13: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

Humphrey et al., Cell Metabolism 2013

Monday, 31 March 14

Page 14: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

Minard, 1863

Monday, 31 March 14

Page 15: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

0 sec 15 sec 30 sec 60 sec 2 min

20 min60 min 10 min 5 min

N U C L E U S

T I M E

M E M B R A N E

M E M B R A N E

Monday, 31 March 14

Page 16: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

Monday, 31 March 14

Page 17: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

http://odonoghuelab.org

Seán O’DonoghueB. Sc. (Hons), Ph. D., FRSC

Finally: one more animation

Monday, 31 March 14

Page 18: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

Sandeep  Kaur

Coming  April  10  -­‐  h6p://vizbi.org/plus

The  Hungry  Microbiome Cancer  is  not  one  disease Type  2  diabetes

Monday, 31 March 14

Page 19: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

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Maja  DivjakWalter  and  Eliza  Hall  Ins0tute,  Melbourne

Type  2  diabetes

Monday, 31 March 14

Page 20: New tools for protein structures and phosphorylation pathways - Sean O'Donoghue

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Monday, 31 March 14