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7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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ENDOCRINE GLANDSKBK
BLOK 10 / 2011
MARISI H. SIREGAR, DR., PHK (K)
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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ENDOCRINE GLANDS
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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ENDOCRINE GLANDS
ORGAN YANG DIPELAJARI GLD.THYROID
GLD.ADRENAL ( SUPRARENAL ORGAN)
GLD.HYPOPHISIS
PANCREAS ( ISLETS of LANGERHANS)
GLD.PARATHYROID
GLD.PINEAL
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THYROID GLAND
Lo!"#$% &"'.*"+ - $&""- "+
M*3+"$ 2 o&3# $-3&3+'!"+ o- $#4-3#+$"+' 4"5-" 4*"4 $&""- 5"4$"'o 5$5o$.
M$!o#!o*$!% T-o$ fo$! $"*$#$ *$4 #"*$#
!3&$#,3!3"+ %0,2 60,7 ,$#$ % !oo$( #3"+#$'"4$+)M"#" "+"!6"+"!, "+f""4 %
*!&"+'"+ +o" #""f *3#"4
*!&"+'"+ #$#4 3#!3o#!4"D"#", "+f""4 %
4"&o$# &&"'"$ 8"$+'"+ "+ o'"+
4-o'3"#$
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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HISTO9ISIOLOGI
Hoo+ 34""%T-o$+ ( 44"$oo4-o+$+ (T:) "+
T$$oo4-o+$+ (T;).
T#$*"+ "" 5oo$ "+' 3*"!"+'5o*o4$+ ( 4-o'o&3$+ BM% <00.000
o.4)
M4"&o$# 3!"+% Io$+ ( Io$+ =4-o#$+ $o$+"4 4-o'o&3$+)
93+'#$ $!o+4o o- % TSH ( -*o*-#$#)
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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C$+$5" "**$5"4$o+ HYPERTHYROIDISM
S$*( +o+ 4o$5) 'o$4 % P&#""+ !.4-o$$#&"&!"+ &3!"+ *o## ""+' "4"3 +o*"#"
G">?# $#"# ( H*4-o$$#) % P&#""+4-o$ ( goiter ) "!$&"4 *o3!#$ -oo+ 4-o$+
&&$-"+. HYPOTHYROIDISMM" % #!#$ TSH +33+ ("#"),+'"+
'8"" "-,3"- +'"+43!,"!4$f$4"# +4""&"4,8"$+'"+ #3&534"+ "+ !3$4 +&".
C4$+$# % #!#$ TSH +33+ ( "+"!6"+"!)+'"+ '8"" *43&3-"+ 43"+'
"&"4,#*$"4o $#4##,+4" 4""4$o+.
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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GRA@E?S DISEASE
HYPERTHYROIDISM,B"#o?# $#"#ETIOLOGY % BELUM DIKETAHUI
KELENJARTHYROIDMEMBESAR(DI99USEGOITER )
,OPHTHALMOPATHY,DERMATOPATHY.EPITEL 9OLIKEL TINGGI DAN LAPISAN DINDING
MENEBAL
KELUHAN % LEMAS,BERAT BADAN TURUN TETAPI
NA9SU MAKAN TINGGI,BANYAK
KERINGAT,TREMOR,EOPHTHALMUS.
TERAPI% RADIOACTI@E IODINE DAN SUBTOTAL
THROIDECTOMY
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ADRENAL GLANDS
Lo!"#$ % !343& "4"# !3" '$+8"B+43! % *$*$-,4$"+'3", 4&" 1 5
T$$ "$ 2 &"'$"+ % Co4 "+ M3"
O'"+ $"*$#$ o- !"*#3" 8"$+'"+ *+"&3+'*""4.
ADRENAL CORTEX 4$$ "$ "*$#"+%
o+" Go3o#"
o+" 9"#5$53"4"
o+" R4$53"$#
ADRENAL MEDULLA 4$$ "$ S 5-o"ff$+
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CORTE ADRENAL
o+" Glomerulosa % o+" 44"! !"4*3!""+ !"*#3,#6# *$4$" &&+43!
!o3+".S!#$ % "o#4o+
o+" Fasciculata % o+" 44"! $4+'"-
($+4$"4),# &&+43! *o$-"
&&+43! !o3 "+8"+'.S!#$ % Co4$#o
o+" Reticularis % o+" 44"! $ &"'$"+ ""
!"4 "3",# 5o3+" &+43! 8""#"$+' &"+"#4oo#$#.
S!#$%D-o*$"+o#4o+
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MEDULLA ADRENAL
T$$ "$ #6# &#" &!o*o!
!"4 +'"+ !"*$ "+ >+3".
( C-o"ff$+ C#)
S$+' $#&34 #&"'"$ o$f$!"#$
'"+'$o+ #$*-"44$5
. S!#$ % C"45-o"$+( No*$+*-$+ "+ E*$+*-$+ )
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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H$#4of$#$oo'$
o+".Go3o# % M$+"o5o4$5o$(Ao#4o+). M+'o+4o >o3 5"$"+ 43&3-"3$ "&#o&#$ N"4$3 '$+8".
o+".9"#5$53"4" % G35o5o4$5o$( 5o4$#o).93+'#$ % +33+!"+ #$+4#"*o4$+,+$+'!"4!"+ '35o+o'+#$#.
o+".R4$53"$# % A+o'+
( -$o*$"+o#4o+),*o4+#$ #!# -oo+!5$ $&"+$+' 4#4o#4o+.
Co4 "+" $!o+4o o- ACTH
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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H$#4of$#$oo'$
M3" "+" %
S!#$ C"45-o"$+ (E*$+*-$+
"+ No*$+*-$+)
R#*o+# 4-""* "#" 4"!34 "+ #4##
#-' -"4 "4 +$+'!"4,'35o# 4$+''$
D$!o+4o o- *3#"4 -*o4-""3#"3$ +>3# #*"+5-+$53# ( >$#5")
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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C$+$5" "**$5"4$o+
ADDISON?S DISEASE (-*of3+'#$ !o4!# "+") A!$&"4 $+f!#$ 5-o+$5,*o## "34o$3+'+"#$ !."+""+o5o4$5" $+#3ff$#$+#$ #!#$ -oo+ $+"3"4.G8"" %-*o4+#$,f"4$3,"!+##,*$'+4"#$ "&+o" !3$4.
CUSHING SYNDROM (-*f3+'#$ !o4!# "+")
A!$&"4 43o *"# $#4"$# -*-o*-$#$# #!#$ ACTH&&$-"+.G8""%-*4+#$o+,o&#$4"#,o#4o*oo#$#,-$#34$#,4&+43! '"$# !3+'3"+ *"" !3$4"&o+
4"*$ &$"#"+" $"!3!"+ !#$#$ 43o -*of$#$# "4"343o "+"
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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H*o*-#$# '"+( P$43$4")
Lo!"#$ $&""- o4"!,$""- #" 43#$5"P"+8"+' 1 5,4&" 0,F 5,&"4 0,F '"M+'-"#$!"+ -oo+ *43&3-"+,*o3!#$
"+ 4"&o$#T&"'$ "4"# %
1. A+o-*o*-# ( "+4$o o&)
2. N3o-*o*-# ( *o#4$o o&) A+o-*o*-# 4% P"# $#4"$#,*"#
$+4$" "+ *"# 43&"$#N3o-*-o*-# *"#+>o#" (*o#4$o
o&)
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ADENOHYPOPHYSE
P"# $#4"$# 4"*"4 # chromofils "+chromophob
S Chromofils 4 %
1.# Acidophils #!#$%Go4--oo+(GH),Po"54$+ ( PRL)
2. # asophils #!#$ %
A+o5o4$5o4o*$+,TSH,9SH,LH S chromophob #4$+' #54o 5#,4$"!
&'"+3"
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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A+o-*-o*-#
P"# $+4$"
S!#$ MSH
( M"+o54
S4$3"4$+'Hoo+)
P"# 43&"$#T"*"4 # &&+43!
!3&$# "+ !o3+"
+"-,4$"!
&'"+3,54o*"#
+'"+3+'
'$!o'+.
Hoo+% 4$"! ""
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N3o-*-o*-#
M+5"!3* &"'$"+ $"+ $++5-*o4-""3#,$+f3+$&33 "+ *"#+>o#".
B"+"! 4"*"4 "o+ ta! berm"eli# "+' &""+ #+" 4*4 *"" +353##3*"o*4$5 "+ +353# *"">+4$53".
T"*"4 # *$43$#$4M+'-"#$!"+ -oo+ O$"toci# "+
%asopressi# ' AD()
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CLINICAL APPLICATION
G$'"+4$#% S!#$ GH &&$-"+ #&3 *$*-#$#
+343* *"" "#" *43&3-"+.
A5o'"$ % "!$&"4 43o *"# $#4"$#,48"$ *""
o"+' "#" #-$+''" *o3!#$ GH &&$-"+.
C3#-$+' $#"#( -*#!#$ ACTH)H**o"54$+$" ( HPL)
D$"&4# I+#$*$3#% "&+o"$4"# #!#$ >"#o*##$+
'8""% #$+' "#" -"3# "+ $+3 &"+"!( polidipsi ) #-$+''" #$+' !+5$+' 'poliuri ) !"+"
!4$"!"*3"+ '$+8" +'!o+#+4"#$!"+ 3$+.
T"*$ +'"+ $+8!#$ "4"3 o" >"#o*##$+
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PANCREAS
O'"+ P"+5"# % $ '"+# (e$ocri#e "+ e#docri#e).
O'"+ &&+43! *$*$- ( *"+6&"!"+') +**"" $+$+' *o#4$o o+''" "&o+ #"*$+'
"+43 '"#4.P"+8"+' % 125 1F 5E$ocri#e %
T$*#$+,5-o4$*#$+,5"&o**4$"#,""#,"#4"#,$&o+35"# "+ 5"&o"#.
E#docri#e %I+#3$+,G35"'o+,So"4o#4"4$+,P"+5"4$5 *o$**4$
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I#4# of L"+'-"+#
B"'$"+ e#do!ri# "$ o'"+ *"+5"#T$$ "$ &$&36$&3 # &!o*o!
"+' $"*$#$ #"&34 4$!3.T"*"4 : 8+$# *$4$" # "$43%
S "f" ( A65#) % G35"'o+
S &4" ( B65#) % I+#3$+
D65# % So"4o#4"4$+
965# % P"+5"4$5 *o$**4$
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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C$+$5" "**$5"4$o+
DIABETES MELLITUS( DM)
A!$&"4 4"&o$# I+#3$+ 4'"+''3
D3" 4* %
1. T* I ( IDDM)83>+$ $"&4# I+#3$+6
*++4 $"&4# $43#,48"$ * 331F 4-+,"34o$3+ "!$&"4+" # 3#"!$+#3$+ (6)*++4 $+#3$+ $+854$o+
2. T* II ( NIDDM) "43 o+#4 No+6$+#3$+*++4 $"&4# $43#.T8"$ * 33 :04-+ "4"3 &$-, o/! o&#$4"#,$+#3$+ $*o3!#$44"*$ $+"3"4
A534 *"+5"4$4$#
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PARATHYROID GLANDS
KELENJAR BERBENTUK O@OID KECILMENEMPEL PADA BAGIAN POSTERIORGLD.THYROID.
TERDAPAT : BADAN KELENJAR UKURAN
PANJANG F MM,DIAMETER : MM TEBAL 2 MMDAN BERAT 20 6F0 MGSEKRESI PARATHYROID HORMON YANG
BEKERJA DALAM TULANG,USUS DAN GINJALYANG MENJAGA KONSENTRASI CALSIUM
DALAM DARAH DAN CAIRANEKSTRASELULER.CALSIUM JUGA BERPERANPADA KONTRAKSI OTOT,SEKRESIKELENJAR,KOAGULASI DARAH DAN AKTI9ASIBERBAGAI ENYM.
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PARATHYROID GLANDS
MIKROSKOPIK % DILAPISI CAPSULA9IBROSA TIPIS.9OLIKEL LEBIH KECILDARI THYROID BERISI COLOID.
PERTUMBUHAN KELENJAR DARILAHIR SAMPAI MAKSIMUM UMUR 20THN.
TERDIRI DARI % CHIE9 CELLS ( HSL%PARATHYROIS HORMON) DANOYPHIL CELLS ( NO SECRETORY )
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CLINICAL APPLICATION
HYPERPARATHYROIDISM HORMON PARATHYROID BERLEBIH AKAN
MELEPASKAN CALSIUM DARI TULANG SHG TULANGMENJADI LEMBUT,PADA SARA9 AKAN BERAKIBATRE9LEKS OTOT SKELET MELEMAH DAN DALAM
DARAH AKAN BERAKIBAT GARAM CALSIUMMENUMPUK SEHINGGA DAPAT TERJADI BATUGINJAL.
HYPOPARATHYROIDISM
DAPAT DIAKIBATKAN OLEH TRAUMA ATAU PADAAKTU DILAKUKAN THYROIDECTOMY,INI AKANBERAKIBAT SARA9 MUDAH TERANGSANG,MUSCLESPASM ( TETANY) DAN KEJANG.
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PINEAL GLAND
EPIPHYSIS CEREBRI ORGAN BERUKURAN PANJANG %F6 DAN
LEBAR% ;6F TERLETAK PADA ATAPDIENCEPHALON DI GRS TENGAH OTAK.
TERDAPAT SEL PINEALOCYT YANG MENSEKRESIMELATONIN DAN SEL ASTROGLIAL.
MENGATUR 9UNGSI GONAD PADA MANUSIA TERDAPAT BADAN KHAS
ETRACELLULAR YG DISEBUT CORPORA
ARENACEA ( RAI* +A*D) MATRIKSNYA BERISICALSIUM 9OS9AT DAN CALSIUM CARBONAT BERSI9AT RADIOOPAUE RADIOLOGI UNTUKDETEKSI LOKALISASI TUMOR OTAK.
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T-o$ '"+
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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T-o$ '"+
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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9o$! 4-o$
SEL 9OLLIKEL
COLLOID
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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T-o$
A# fo$!
B 5oo$
C #*""fo$!3"
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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A # *""fo$!3
B # fo$! 4-o$
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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I#4# of L"+'-"+#
PULAU LANGERHANS
KELENJAR EKSOKRIN
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A+" '"+#
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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Co4 "+"
KAPSULA 9IBROSA
CORTE
MEDULLA
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Co4 "+"
ONA GLOMERULOSA
ONA 9ASCICULATA
ONA RETICULARIS
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H*o*-#$# '"+
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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H*o*-#$#/P$43$4" '"+
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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H*o*-#
APARS ANTERIOR/DISTALIS
B *"#$+4$"
CNEUROHIPHO9ISIS/*"#+>o#"
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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HYPOPHISIS PARS ANTERIOR
SEL CHROMO9OB
SEL BASO9IL
SEL ACIDO9IL
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A # 5-oof$
B # 5-oofo&
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S *$43$#$4 / PARS NER@OSA
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P""4-o$ '"+
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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A+" '"+
7/23/2019 Endocrine 011 - Dr. Marisi (t2-d2-w1)
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9o$! "+ Coo$
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