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LIPID
ANABOLISM
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fig 21-1
acetyl-CoA carboxylase
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fig 21-1
acetyl-CoA carboxylase
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fig 21-1
acetyl-CoA carboxylase
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fig 21-2
condensation
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fig 21-2
reduction
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dehydration
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reduction
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synthesis of fatty acids
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acyl carrier protein
(ACP) in E. co li
a lot like
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13/71fig 16-3 coenzyme A
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malonyl-CoA-ACP transferase(MT)
fig 21-6 (4th)
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-ketoacyl-ACPsynthase (KS)
fig 21-6
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-ketoacyl-ACPreductase (KR)
fig 21-6
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-hydroxyacyl-ACPdehydratase (HD)
fig 21-6
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enoyl-ACPreductase (ER)
fig 21-6
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acetylCoA-ACPtransacetylase (AT)
fig 21-6
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fig 21-7
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fig 21-7
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fig 21-7
fatty acidsynthasesvariationsof the FAScomplex
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fig 21-10
citrate as a source of building blocks
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fig 21-10
citrate lyase as an anabolic carbon source
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fig 21-10
and a minor NADPH source
majority supplied bypentose phosphate p.way
Allosteric regulation of fatty acid synthesis
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fig 21-11
Allosteric regulation of fatty acid synthesis
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fig 21-11
Phosphorylation of fatty acid synthesis
active un-phosphorylated ACC
makes cytosolic filaments
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fig 21-12
now what?
elongation
desaturation
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fig 21-14.
providedby plants:polyunsat.fatty acids
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fig 21-15.
cyclooxygenasea key reactionof inflammation inmammals
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fig 21-15.
aspirin: a cycloxygenase inhibitor
willowbark
i CO i i i S
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box 21-2
a family of COX inhibitors: NSAIDs
f il f COX i hibi NSAID
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box 21-2
a family of COX inhibitors: NSAIDs
T COX i
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box 21-2
Two COX isozymes
COX1gastricfunctions
COX2inflammationpain fever
COX2 ifi i hibit
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box 21-2
COX2-specific inhibitors
COX2 specific inhibitors
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COX2-specific inhibitors
COX2 specific inhibitors
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COX2-specific inhibitors
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lipid menagerie
phospholipid
triglyceride
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phospholipids or glycerophospholipids
phophatidylcholine phophatidylserine
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fig 21-17.
mobilizingglycerol
adding
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fig 21-17.
addingacylgroups
phosphatidic acida phospholipid
more
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fig 21-18.
morephospholipidsor glycerides
anatomy of a phospholipid
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fig 21-23.
anatomy of a phospholipid
another
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trinucleotide-based carrier:CTP
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The isoprene unit:
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The isoprene unit:a branched lipid structure
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fig 21-32
four stages
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fig 21-33
four stagesofcholesterolsynthesis
four stages
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fig 21-33
four stagesofcholesterolsynthesis
four stages
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fig 21-33
four stagesofcholesterolsynthesis
stage 1
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fig 21-34.
stage 1mevalonateproduction
stage 1
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fig 21-34.
stage 1mevalonateproduction
stage 1
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fig 21-34.
mevalonateproduction
stage 1
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fig 21-34.
stage 1mevalonateproduction
synthesis
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fig 21-34.
synthesisofmevalonate
first steps
of ketonebodyformation
stage 2: conversion to
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fig 21-35
stage 2: conversion toactive isoprenes
condensation of isoprenes
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fig 21-36.
head tail
further condensation of isoprenes
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fig 21-36.
and even more condensation of isoprenes
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fig 21-36
from squalene to cholesterol
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fig 21-37.
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fig 21-38.
LDL:
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fig 21-39.
theinfamouslipoprotein
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fi 21-39
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fig 21-40
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fig 21-40
regulation
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fig 21-44
of cholesterolmetabolism
both uptakeand synthesisare involved
As does nature, so does pharma...
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box 21-3
sterols
l !
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fig 21-45
galore!
isoprenoids
l !!
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galore!!
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