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Tyrosine: an amino acid found in proteins such as
meat, nuts, and eggs also Dairy products such
as cheese
the body can synthesize tyrosine from
phenylalanine
MAO
MAO
(COMT)
Guanithidine--
Bretylium --
--SNRIs(duloxetine), Imipramine,
Na+
Na/cl
transporte
Mg++ / ATP
Transporter
reserpine --
Adrenergic Rs:
-two family depending on response to the
adrenergic agonist
(nor epinephrine,epinephrine ,isoproterenol)
1) α - adrenoceptor
Show weak response to synthetic agonist
isoproterenol
epinephrine ≥ nor epineph >> isoproterenol
depending on affinities to agonist
& blocker:
α1:A-D
α1A in urinary tract, α1B in BV
specific agonist: phenylephrine
specific antagonist: prazosin
mech: G-pr Ip3 & DAG
Ca++
located on sm , vascular sm , eye ,
pilomotor sm , prostatic capsule
the effect of α-1 R:
- vasoconstriction (especially skin & viscera but slight in cerebral & coronary arterioles)
peri resis & BP
- veins constriction
-increase closure of bladder sphincter
- mydriasis ( due to contraction of radial muscle of iris)
Alpha receptors
:Adrenergic receptors
Alpha 1 receptors are present in
the radial muscles of the iris
- sweat gland secretion (note)
-pilomotor: piloerection
-male : ejaculation & contraction of
prostatic capsule
-uterus (pregnancy): contraction
- intestinal sm : relaxation
α 2: A-C
specific agonist: clonidine
specific antagonist: yohimbine
mech: G-pr inhibit cAMP
synthesis , K , Ca
located on presynaptic N , β-cell
& sm of veins , git & lipocyte
& in CNS adrenaline release
and hypotension.
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