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真核细胞 DNA 复制中的酶和蛋白质
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真核细胞 DNA 复制中的酶和蛋白质. 第九小组 刘少英、马丹炜、罗孟军、王萍 主讲：刘少英. 细胞周期. DNA 复制有关酶. DNA 聚合酶. DNA 引发酶（ PRIMASE ）. 是 DNA 合成中合成 RNA 引物的酶，引发酶行使 2 个功能：首先在起点处起始先导链的合成。其二在延伸中帮助岗奇片段的反复起始。. DNA 解旋酶. DNA 拓扑异构酶. 单链结合蛋白（ SSB ）. 核酸酶（ nucleases ）. - PowerPoint PPT Presentation
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DNA
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DNA
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DNA
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DNAPRIMASEDNARNA2
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DNA
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DNA
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SSB
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nucleasesDNase RNase3-5RNaseH5-3
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DNADNADNA53ATPDNADNA4DNAI
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MCM2-7MCM2-7DNAORCCDc6Cdt1DNA
G1-SCDc45CDc7Cdk2MCMORCXENOPUSDNADNA80bpORCMCM11DNAMCMMCMCDc45DNAMCMDNA
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CDc7Cdk2 CDc45DNAMCM2-7
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DNA
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G1
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DNA
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ORCMCM82-bpDNA
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MCMDNAORCDNA
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MCM
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DNACDC45DNA
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MCMCDC7
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CDC45D
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DNA
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MCM82bpDNAORC80bpDNAG1MCMDNADNA82bpMCMORCMCMORCDNAMCMDNACDC6CDT1
ORCCDC6CDT1DNAMCMMCMORCDNAORCMCM
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MCMCDC7MCM4CDC7DCDC45MCM1MCMCDC45DNACDC45MCMMCM106MCMMCMG1GI/S
G1SG2GIG0RDNA
DNADNADNADNADNA RNARF-CDNAPCNADNA 5DNADNA
NDADNADNADNAATPDNA5-33-5RFDNADNAI /II /DNAPol:,ssRP-A1CDC CDK MCM
DNADNAORCORCDNAMMCM2-7SSSFP2
CDc7SCDKDNAORCMCM1DNAMCMORC22-63kbDNAPCR202DNAMCMORC24GEMININMCM3MCMCDT15NPECDc456P27KIPCDc45CDK2c45CDK2ORCMCMDNA#A&B251
bpPCRbead beads25115412094670 bpDNADNAbead2%ABCDNA
beads1-56-10Geminin D67 bpDNAMCM94bpMCMOCR=11
D82bpMCMA0.3-6kbORC10-15kbORCMCM3DNAGemininMCMDNAORCDNADNAB6kbDNAMCM3ORC220-401.CMCM2-7MCM31kbPCR100bpDNAORC21kb
100bpMCM3100bpMCM7MCM4MCM3MCM2-7DNAD1kbMCM3ORC2111MCM3DNA90bp
ORCORCMCM2-7DNAORCMCM6kbORCMCM100bpMCM1M
KCL1kb100bpDNAMCMDNAORC0.6M
KCLDNADNAORCMCMCCDC-45DNACDK-2ORC2DNAMCMCDC45MCMCDC45DNAMCM3ORC2CDC45CDC45ORC2MCM3ABCDC45DNADNACDC45CDC45CMCMDNAMCM50%DNAMCM6%NPEDNAMCMMCM4CDK2MCM4NPECDC76MCM3ORC22016MCM4NPE42CDC7MCM2-7DNAMCMCDC7MCN2-7CDC45MCMCDC45MCMCDC45MCMCDC45MCMCDC45CDC45CDK2MCM2-7CDC7MCM
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