7

(cholinesterase,ChE) ( AChE)ChE

ChEChEAchChEAch

, , , ,

(neostigmine)

AChE.

1.2.

[]

1.2.3.

AchEAchMNN2Ach

1.2., 3.4.

MN, ,

(6~8h)

1.,,2.

AchEAchAchM

1.AchE5~15min 2.

(edrophonium choride)

2mg30~45 8mg ()

() ambenonium chloride AchE

(galanthamine) ()

(demecarium bromide) AchE15~60min24h19

DDVPSarin, Tabun

ChEChEAch,,.

aging:

AchE,,AchE,Ach,.

MNN+

M,,,,,,

N,,,

AChE

.

: + : ,

1. 2. NS2% NaHCO33.

1. ,,2. ,3.

cholinesterase reactivatorsPAM PAM-Cl

PAM

(Oxime), , :ChEPAM

ChE,

N>>>>M > , >>>

1., , , 2.

M N.

+ +..

1.,,2.,,im