(lipids)

TG

::CnH2nO2CnH2n-2O2CnH2n-4O2C20:5 (EPA)C22:6 (DHA) C20:4 C18:2

Fats - SolidSaturated fatty acids have crystallization stabilized by hydrophobic interactions.

Oils - LiquidMixtures of saturated and unsaturated fatty acids. The cis-double bonds of the unsaturated fatty acids introduce bends in the hydrocarbon tail and inhibit close packing.

:phosphatidyl cholinePCphosphatidyl serinePSphosphatidyl ethanolamine PEphosphatidyl inositolPIDPGsphingomyelinSMsphingoine

HDL-LDL-VLDLCM

CM VLDL CM

LDL LDL HDL HDLSFAHDL

1 1 2 10 20% 2 5% 3 3

1 1 kg of fat weight corresponds to the total energy expenditure of 4.6 days, or to 17 h of intense aerobic exercise like running (600 kcal/h).In a fasted day, it would result in the mobilization of 160 g of FA per day (calculated as palmitate) of which about one-third would be oxidized and the rest would be reesterified into TG

2 3. 4 5 6 7.

1 2 3 4 5 6

190% 2D 3 4

+-

CoANADHFADH2Cnn/21n/2CoAn/2NADHn/2FADH2CoATCANADHFADH2ATP18CATP

CoATCAD--CoA

GluCoACoACoA- 3 +

phospholipaseA(A1A2)BCD

-CoAL--3--CoA-CoA

0.3 0.8 1

12cholic acidNADPHO2--3D

1 142 812 6 3

SFA) LDL

(MUFA) (PUFA) n-3-3 n-6-6

-EPADHAn-3TG VLDLTGHDLC

EPA DHA-

n-6:LDL HDLn-6PUFA

LDLHDL

essential fatty acidEFA

-

(n-3n-6)

1 2 3

4 5

6X7DHA

ADEKADADE

EE

0.3%3.2%1%4%

80%B1B2E9294%

85%47.8%97%E100g10mg

ADEK

-EA

ADEK

ED

AD -

90%

EPADHA

5044502184001351250

mg/100g-1

Lecithin

SFAMUFAPUFA 2050UFASFA1PUFAPUFA

30SFAMUFAPUFA10 111

20002030EFAEFA1-2%300mg/ SFAMUFAPUFA101010

n-6n-3 PUFA1994FAOn-6n-35~101WHOFAO PUFA n-6n-3461

1 45~50% 0~6800ml27.7g1MJ239.0kcal47%45~50635~40%

2 198330%10%100mg/l000kcal198825~30%

3 AI25%~30

4 RDA30%~35%101025~30% 5 15~25300 mg/d

6 45~59BMI > 2516.6%26.2%6016.9%22.4%11.917%20%~3010%300mg/d

OlestraJojobaOilSorbestrinTATCAEPGDDMOlestraFDA

7

(TC)2.96.0mmol/L(TG)0.221.20mmol/L(CE)7075%(HDL-C)0.801.68 mmol/L0.901.98mmol/L(LDL-C)1.684.53mmol/L

1

2LDLMUFAEPADHA

2

VE!

4An-3PUFA)

8

1

2. .

PUFAC=CC=CC-HpHPUFADNAC(HC-H-CH2-L-LOO-LOO-

C-C.

20271016

0721940.62.118.1109.891.573.42.51.50

(1)l00(2)400 (3)8001200()

(1) (2) (3) (4) (5)

POV1kg(AV)1gKOH(IV)100g(SV)1gKOH

*