ハイブリッドシミュレーション ～数理腫瘍学の基本ツール

2015. 12. 24

鈴木 貴

V. Quaranta (Vanderbilt Univ.)

Mathematical

Modeling

Integrative Mathematical Oncology

Systems Biology

Hybrid Simulation with Fluctuations

M. Chaplain (Andrews Univ.)

Applications

Cell BiIology Bio-Informatics

Bio-Statistics

C. Lopez et. al.

A. Anderson et. al.

Data Science

Blind micro

Blind macro

Malignancy control

Drug resistance

Morbid prediction

Therapy strategy

Drug design

basement membrane

blood vessel

EC endothelial cell

avascular tumor

VEGF vascular endothelial growth factor

receptor

haptotaxis

chemotaxis ECM Extra cell matrix (fibronectin)

1. Angiogenesis Levine-Sleeman 1997

tumor-induced angiogenesis

p: particle density v: chemical concentration

c.f. barrier model

hybrid simulation between individual – continuous objects