37
1 (1) 3 e-QTL (2)

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ê/ijÛRHori et al., Cell, 2008; Amano et al., J. Cell Biol., 2009[UâÑ� ¡��HÀSAê/q����Ç,À��Ë��þ¦À��ê³RNishino et al., EMBO J. 32: 424-436, 2013øHori et al., J. Cell Biol. 200: 45-60, 2013[ÌN[íã�KÉUO��2mûm*mí>m�ÀA./U ¡� DNAD¥���ª�DLqyz��ÀW�/.�Ì &I���0Õ�ULqË�W¥DEQÀá/.�Ì$[�9HP�Q��lmy�34� Dø�

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Ë�í�Û\ªPø�Àg�ê³RFujisawa & Eguchi, Journal of Multivariate Analysis, 2008[Ì9[�.ÜL�~Àj-¢ç��D���¢ç��D�XPê�_â����;ÛÕÄUÎAZ'Û��U

%\�ÕôÐ���ø�À"¾ê³RNinomiya & Fujisawa, Biometrics, 2007[Ì@[q�yzDo� �� Dyz�<./U��yzJ'¬�I�ÀZ¶.�.�Pø�Õ��D¢ç �c pmÀ�É�ø�À"¾ê³Rº�0äQTLyzD��)]k���D¢ç �cç421��D��`H, óôGHuÊt, 2008; Kuriki, Harushima, Fujisawa & Kurata, Annals of the Institute of Statistical Mathematics, 2014[ÌN[¨©Ï¾¦-yz�Lqê/U<ÉDºãmD$�ø�ÀGÚ���ê/=��. QÀá�í��EÄê³ (Fujisawa, H., Horiuchi, Y., Harushima, Y., Takada, T., Eguchi, S., Mochizuki, T., Sakaguchi, T., Shiroishi, T. and Kurata, N., BMC Bioinformatics, 2009)Ì°[.�-ÃD77� QTL yz�<./U��L�À��êU�v D]���-./yzÀ�ï³RDou, Kuriki, Maeno, Takada & Shiroishi, Biometrical Journal, 2014[Ìß[�ê.yièɺ��=� PmDV��Àg�ê³Ì7Ù����ã/ijyièɺ��=�PmDV���^êô�îÕ�P.ÌPmV�Û�î�P�VèÀc�ê/UóD5l D^ÕEêP��ø�À~uê³RFujisawa, H. and Sakaguchi, T., TEST, 2012[Ì�[[/7P�§ÀY�Ë�³�DQk��¬�m�(�¬lDø�À"¾êU�v (��wæ5]���êAê³RDou, Kuriki, Lin & Richards, Computational Statistics & Data Analysis, 2014[ÌíãÑDEQDñ´U$[U@[�-./�U&I���9�ôLqê/U� 1Ç�������123456ä�_¢Ú yzçÀ^_�Ë�EQU6[�-./�� 1ÇÃÑD$5^D���ÕÐ�Ì &I���9�-./�U&I���0��Ú�� 1Ç�������123456ä�_¢Ú yzç�ao�EQÀ�A�êUâÑ�� IIÇD���<./ôUW¥D=ñP¿"ÛWdU�³PEQÛáÑã/.�Ì $[�v �<./�U� I ÇD����DabcdJ¨©�yz�KÉ/U ¡�æû¢§

RTakada et al., Genome Res.,2013[����� 2013.6.7� gÖY+îZ][âÑ��UíD¢§Àà�(ã³������DyzROka et al., PLos Genetics, 2014[�W¿ÛÐï³ÌʳU¥¦§ÀjAê³��yz��RDou X et al., Biom. J.2014[À&I��� 2�DqrÕ±ê³Ì����Dabcd�Lê/�UMamm. genome 2012; Exp. anim.2012�)ÀÀ±ê/.�Ì�m52 CT¿�DH�yzÕ�U��D�����=�EQRRoy S et al. Med. Image Comput. Comput-Assist. Interv. 2013[J¨©yzRTamura et al. Hum. Mol. Genet.,2013[�-./ô�AÀ±ê³Ì¦È�UíãÊÕ�áÑã³������]��<=> ¡�æû¢§PÞUGØÙ]

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âöUz�ü��AîZâã³ÌDuoMouse�¨©�Dv4I&m6ÃÑn%�Õ¨"êUóDEQ�1¯ %%� âãU��Pâã³Ì>Y 2013-2014ÏW�DEQ�ê/U�v ��yzD¨©�a`��RTakahashi et al., Behav Genet.,2006, Mamm. Genome,2008, Behav. Genet.,2009, Umemori et al. BMC Genetics, 2009[DEQÀ¾¥ê³Ì

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9[m��<./�U¦�r ¡�¢§<=>¾¦-��� SNEP D"¾RFujisawa et al., BMC Bioinfo.,2009[J�%÷i�ÏDÜ�!AyzRMizuta et al., PNAS 2010[U��m�¢�¦�D¦�W�L»�� m�Ý!gÀÍ�RHuang, Kurata, Wang, Wei,et al., Nature,2012[ê³EQÀuêUíãÑDEQÀâÑ�à�i¶³�U¢�¦�D��m�ÀA.³ GWASRgenome-wide association study[yzD³�D����À�.UGWAS yzD����À&I'��0���ÕW�³ÌʳUm�¨©Ï¾¦«¬�æ6��5yzD³�U¦�rDG�¾¦]��Dyz<=> e-QTLA(¸!EÀ�ï³Ì @[$Ilnwæ�¬�<./�UTô�AB�­®Í��� Gal4 À¾¦Ë�6l� 34­æ5

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�.¢�DEQÀá/ijRAsakawa et al., Dev Dynamics, 2012; Hirata et al., J Biol Chem, 2012; Pujiol-Marti et al., J Neurosci, 2012; Nakayama et al., Dev Growth Diff, 2012; Fukui et al., FEBS let, 2012; Yano et al., Development, 2012; Shimizu et al., Dev Biol, 2012; Umeda et al., Neurosci Res, 2013; Wada et al., PNAS, 2013; Kishimoto et al., Nature Neurosci, 2013; Asakawa et al., Frontiers in Neural Circuits, 2013; Muto et al., Frontiers in Neural Circuits, 2013; Banjoet al. Nature Comm, 2013; Wada et al. Curr Biol, 2013; Satou et al. Development 2013; Kwon et al. Development 2013; Nakayama et al. Mech Dev 2013; Sittaramane et al. Dev Biol, 2013[Ì N[2002ÏÃÑ 2009ÏÊÕ� RNAi��,¦� 13,000¦�À!uêUTõGHóô Ü�ÄÅ��

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4.� Fukagawa, T., Earnshaw, WC. Neocentromeres.. Curr. Biol. 24:R946-947, 2014. 5.� Kagawa, N., Hori, T., Hoki, Y., Hosoya, O., Tsutsui, K., Saga, Y., Sado, T,, Fukagawa, T. The

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A., Kimura, H., Earnshaw, WC., Fukagawa, T. Histone H4 Lys 20 monomethylation of the CENP-A nucleosome is essential for kinetochore assembly. Dev. Cell 29: 740-749, 2014.

8.� Ito, T., Tarutani, Y., To, TK., Kassam, M., Duvernois-Berthet, E., Cortijo, S., Takashima, K., Saze, H., Toyoda, A., Fujiyama, A., Colot,V., Kakutani, T. Genome-wide negative feedback drives transgenerational DNA methylation dynamics in Arabidopsis. PLOS Genetics, in press.

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8.� Arakawa, T., Tanave, A., Ikeuchi, S., Takahashi, A., Kakihara, S., Kimura, S., Sugimoto, H., Asada, N., Shiroishi, T., Tomihara, K., Tsuchiya, T., Koide, T. A male-specific QTL for social interaction behavior in mice mapped with automated pattern detection by a hidden Markov model incorporated into newly developed freeware. Journal of Neuroscience Methods 234: 127-134, 2014.

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