1. 1. , XIV - (18-19 2013 .) 2013 Copyright & A K-C
2. 2. 2 61.001.06+616-084 5 437 - : . . ., . . ; . . ., . . ; ..., . . ; . . ., . . ; . . ., . . 437 , : XIV - (18-19 2013 .). - : , 2013. - . , , , , . , , , . , . 61.001.06+616-084 5 , 2013 , 2013 Copyright & A K-C
3. 3. 3 PACIFIC STATE MEDICAL UNIVERSITY ACTUAL PROBLEMS OF EXPERIMENTAL, PREVENTIVE AND CLINICAL MEDICINE PROCEEDINGS OF THE XIV INTERNATIONAL PACIFIC SCIENTIFIC CONFERENCE OF STUDENTS AND YOUNG SCIENTISTS (APRIL, 18-19, 2013) Medicina DV Vladivostok 2013 Copyright & A K-C
4. 4. 4 I. - - .., .. , .. : ..., .. CLINICAL AND EPIDEMIOLOGICAL ASPECTS OF HERPES ZOSTER VIRUS INFECTION Belomestnov I.V., Lee A.K. At present, the most important problem of socially significant infections are herpes infections, and especially in our country. Given their prevalence in the population (according to different sources, from 60 to 90%), a variety of clinical forms, a tendency to chronic and recurrent course, the emergence of new resistant mutant viruses, despite the wide range of drugs, and is not a high level of quality of life patients, this actual problem is difficult to overestimate. . , 3 , Varicella Zoster, , , , , . - - , 2 . 2012 . 74 15 45 , 23 . . 198 70,2%, 29,8%. 60 , 57%, 15 . 134 (67,7%) , 64 (32,3%) . , , , , . : 141 (71,3%) , 39 (19,7%) - , . - ( 4% ), ( 5% ). - . 14 (7%) Copyright & A K-C
5. 5. 5 , . 4 (2%) . , - , 60 , . .., .. , . . ..., .. VALUE NONINVASIVE TECHNIQUE FOR DIAGNOSING SKIN IN PRACTICE DOCTOR DERMATOVENEROLOGY Dvoryaninova I.E., Taran M.G. The tumor of the skin is actual problem for men. Recently the increase of the rate of melanosarcomal nevi cases is registered, which is connected with unfavorable ecologic influence and other factors. The patients with nevi, papillomas, angiomas etc have been diagnosed and operated. Dermatoskopya & ultrasonograpya is a contemporale metod for diagnostic tumor of the skin. () . 100% , . . 10% 80%. , . . . . . , , , , . . . . . . Copyright & A K-C
6. 6. 6 , , . , , . .. , . . : ..., .. OPHTHALMOLOGIC COMPLICATIONS WITH HERPES ZOSTER Borovskaya O.A. The actual problem is that the herpes infection is the most common viral infection of humans. Herpes Zoster in most cases is shown at the female population. From 2009 to 2012 the tendency of growth of cases of incidence of a herpetic infection is observed. , . 90% , 60% ( ). , 250-300 . : - . : , 2. 110 . : 2009 122 , 2010 140; 2011 165; 2012 198. 2009 23 (19%) ; 2010 38 (27%); 2011 21 (13%); 2012 28 (14%). , , , , , . , , . , . : , (67%). 2009 2012 Herpes Zoster, Copyright & A K-C
7. 7. 7 . Herpes Zoster , , (, , , , , ). , , . . . , . . . : ..., . . PLACE OF PRURIGO SIMPLEX IN THE MORBIDITY STRUCTURE OF ATOPIC DERMATITIS Vandysheva M. A. Prurigo is the heterogeneous disease that is characterized by erithematous urticarial papules that are intensely pruritic in symmetrical distribution, especially on the extensor surfaces of the extremities, has the most persistent current and resistance to conducted therapy. Prurigo simplex is one of clinical forms of atopic dermatitis. . - . (IgE) - (). (1998) L20 () ( ) L20.0 . ( ) , IgE . . - 1242 . IgE Micro Reader 4 (Hyperion, ). . . 1242 (46,5% 53,5% ). 189 (43,4% 56,6% ), 48,33 ( 18 82 ). (23,2%) (24,3%) 51 60 . IgE, 189 , 2 . 1- (113 Copyright & A K-C
8. 8. 8 ) IgE 100 /, 59 (65%) 54 (35%). 2- (34 ) IgE 100 /, 23 (70,6%) 53 (29,4%). . , 15,2%. IgE- 59,8%, IgE- 40,2%. . , HANTAAN .. , . . : ..., .. CLINICAL FEATURES OF HEMORRHAGIC FEVER WITH RENAL SYNDROME ASSOCIATED WITH SEROTYPE HANTAAN Verkhoturova V.I. The analysis of case records of 65 patients with hemorrhagic fever with renal syndrome, taking place in infection hospitals of Primorsky region is done. It is shown that hemorrhagic fever with renal syndrome associated with serotype Hantaan is characterized by moderate intoxication and acute renal failure and a sufficient frequency of liver insufficienty and hemorrhagic syndrome. - - . 3 : Hantaan, Amur Seoul. 65 , Hantaan, 2005-2012 . 6 - , . (, , , , - ). 16,133,6*109 /. , , , , . , . 17,7% , . 37,9% , - 13,9%. 57,5% 18,332,29 / 271,8332,25 / . 87,2% 1,440,72 /. , , . 69,5% : Copyright & A K-C
9. 9. 9 -111,7319,86 /; - 94,2620,02 /. , . Hantaan- 57,2 % 122,8321,71*109 /. , , , . , Hantaan- . . . , . . : ..., . . THE ANALYSIS OF SYPHILIS MORBILITY IN PRIMORYE Vlasova Y .S. The analysis of syphilis morbility in Prymorye in 2009-2012. Situation of syphilis sickness rate today and in last millennium are characterized by difficult social economic and demographic chanches in our country. The syphilis morbility stays in line of the most important problem of native health service. . . : - . : 3 , 2009 2012. , , , . , 905 , : - 356 (35.9%), - 283 (31.2%), - 162 (17.9%), - 104 (11.4%). 2010 236 (26%), 2011 314 (34.6%), 2012 355 (39,4%). 45 (12,6%), 80 (22,4%), 84 (23,5%), 135 (37,9%), 12 (3,6%). 170(60%). : 18(11%), . 25(15,4), . 38(23,4%), Copyright & A K-C
10. 10. 10 81(50%). 80% 13 18 . 95 (96%). , . - . 13 . , - . , ( ). . . , . . . : ..., . . CLINICAL FEATURES SYPHILIS IN PATIENTS WITH HEPATITIS C Gabrusenko A. L. Analyzed the clinical features of syphilis in combination with hepatitis C. Co-infection with syphilis and hepatitis C is characterized by the presence of several syphilides simultaneously lengthening the permit syphilides against the therapy. : . . : . : 12 . 2009 2012 . 53 %, 46. 7 %. : 25 %, : 75 %. 50 . : , 15 18 . . , , 85 % . , 12-15 10- 13 . Copyright & A K-C
11. 11. 11 : , . , . -9 .., .. , . . : ..., .. THE ROLE OF SERUM MMP-9 LEVEL IN DIAGNOSIS OF LIVER FIBROSIS AT THE STATE OF CHRONIC VIRAL HEPATATIS C I.S. Gorelova S.V. Knysh. One of the important factor in chronic inflammatory process is an activity of MMP-9. The strong negative correlation between MMP-9 concentration and fibrosis degree has been examined. Thereby the role of MMP-9 in diagnostic of liver fibrosis at the state of chronic viral hepatitis C has been confirmed. () . , () . , -9 (-9). : -9 . : - 41 (21 20 ) . . . -9 (R&D Diagnostics Inc., USA) 1 /. 14 . Statistica 6,0 Windows. : (F0, n = 12), (F1-2, n = 14) (F3-4, n = 15) . -9 . , -9 F0 16950011200 /, F1-2 - 11070030500 / F3-4 - 5085011400 /, (p0,05) 48 . . 12 () , Copyright & A K-C
12. 17. 17 48 () . .., .., .. , . . : ..., .. STUDY OF SOME OF THE PARAMETERS OF THE CYTOKINE STATUS IN PATIENTS ENTEROVIRAL INFECTION Mirgorodskaya N.V., Vlasenko A.U.,Voronuk A.S. In the scientific aspects the infection became widespread teaching of CYTOKINE- important regulators of the immune response of the cell type. The aim of the work was to determine the cytokine status of the blood serum of patients with different clinical variants of EVIE. The obtained correlation of the studied indicators can be considered diagnostically significant reaction of the body to EVIE. () . , . . ( TNF- ) ( 1 - TGF-1) (N=40). TNF- TGF-1 - (. ). 10 , . : () 25% - 75%. 52,5%, 47,5%. 23 . 2 5 (12-14 ). TGF-1 3,7 (44,72 12,04 /), 2,3 (27,75 12,04 /), (0,1). TNF- TGF-1 . Copyright & A K-C
13. 18. 18 , TGF-1 , TGF-1 , , TNF- . - ..1 , ..2 , ..3 , ..1 , ..1 , ..1 1 , . . . . 2 , . . 3 , . . . : ..., .., ..., .., ..., ... .. COMET ASSAY IN THE CLINIC OF INFECTIOUS DISEASES Mikhailov A.O., Slobodscova V.V., Kukla S.P., AnglichanovaK.Yi., Chernov P.N., Startsev M.G. It was found that two thirds of patients were with lymphocyte DNA damage. Genetic damage index was 2.7, dominated comet class C3. % DNA in the tail ranged from 5% to 57%. The above changes were correlated with the severity of liver fibrosis and observed mainly in patients with liver cirrhosis (F4). - ( -). (.., 2008), , (BertolasoL., 2008), (Zhanataev ., 2008), ( .., 2008). , , . , . 18 , 2 IV 2012 . 24 62 , 43 . 11 , 7. 2 27 , F0 F4 METAVIR. 10 . . -. 100 . (Cavas, 2008). Comet Score. Copyright & A K-C
14. 19. 19 , 2/3 . 2,7, 3. 5% 57%. (F4). - . . , .. . : ... .. , ... . . CLINICAL-EPIDEMIOLOGICAL FEATURES OF CONGENITAL SYPHILIS IN THE PRIMORYE TERRITORY Mikhalik I.A. The author presents the results of a survey of 42 children placed in childrens hospital of the city of Vladivostok with suspected congenital syphilis for 2010-2012. The diagnosis of congenital syphilis was confirmed in 10(23,8%) children and 32(76,2%) children had preventive treatment of congenital syphilis. - , . : , , , , , ( ), , , . 1 . 1 2010 31 2012 . 42 , 2010 2012 . : 2010 -23(55%) , 2011- 5 (12%), 2012- 14 (33%). : 10(23,8%) , 32 (76,2%) . 3 : 3 - 3 (7%) , 4 33 (78,5%), 1 2 - 6 (14,5%). -25 (59%), -17 (41%). 30 (71%) . , . Copyright & A K-C
15. 20. 20 . . . . , .. . : ..., . . PSORIASIS CLINICAL FEATURES AMONG ADVANCED AGE PERSONS Myagkaya O. S. Big number of people with psoriasis, atypical psoriasis forms and complications is fixed during the last years. Clinical features of psoriasis among advanced age persons such as plaque forms, widespread character, generalize itch are revealed. The therapy approach has to be complex and involve other section physicians. : , , , . : . : 87 60 , . : 2009 2012 . : 20-49 . : , 60 , 3.5 , 49 . 60 , . . 60 ( , , , ) 78%, 20-49 12% . 60 - - , , . : 60 , , . Copyright & A K-C
16. 21. 21 60 . .., .., .., . , . . . : . . ., .. FEATURES OF THE IMMUNE STATUS OF PATIENRS WITH MONO AND CO HERPESVIRUS INFECTION Ovakimyan K.M. Tyan K.V. Saybel A.V. Fatkiev R.Z. The immune status of patients with mono and co herpesvirus infection is different. Arise in the level of CD 20+ cells were revealed in patients with mono herpesvirus infection. There is a decrease in the expression of receptor positive (CD 25+) activation in co-herpesvirus. () - , , . - -, , -, , -. : . : 91 . . (Ig M,G,A) . - St.aureus, 100 , - St. ureus, 1 . : , CD3+ CD4+ (CD25+) (CD95+) . CD25+ , . CD20+ ; (CD25+) . Ig A , . Copyright & A K-C
17. 22. 22 .. , .. . . : ..., .. HISTORY OF THE DEVELOPMENT OF THE INFECTIOUS SERVICE IN PRIMORSKY REGION Pilipenko I.S., Popova E.V. The First infectious department in Vladivostok became to function in 1872 at military hospital, in 1898 infectious department at Vladivostok town hospital was opened. In 1934 infectious hospital 1 was opened. At the following years infectious permanent establishments, cabinets of the infectious diseases were opened. By 2013 in Primorsky Region there are 1121 infectious beds, 85 consulting rooms, 115 specialists on infectious diseases. 22 1872 , 120 . .. . . 1893 . 18 1898 . . .. 1903 . 25 . 70 . , , , , , , , . . 1934 . 1 . . . . , 7 200 : 81 , 55 , 25, 25 14 . 1940 . .. , 1970 . 2012 . . , . 1961. . 2013 1121 32 , 1 . 85 . 115 -, 42,6% , 14,8% - , 7,8 % - . Copyright & A K-C
18. 23. 23 - .. , .. : ..., .. CLINIC OF CHRONIC VIRAL HEPATITIS-MIXED ETIOLOGY Putilova E.A. A comprehensive clinical and laboratory study of 120 patients (64 women and 56 men) took place, of them - 60 people with the mixed hepatitis B + C, B + D, B + D + C. Anamnestic data analysis showed the absence of acute hepatitis in the majority of patients. The most characteristic feature was the undulating course of the disease, when during acute identify new or previously amplified symptoms. In patients with chronic viral hepatitis, despite the paucity of symptoms, quite pronounced polymorphism symptoms were revealed. - 120 (64 56 ). 30 . HCV- , 30 . HBV- 60 . -: +, +D, B+D+C. (78,46,3%). , . - : (94,61,5%); (93,81,8%) (55,49,1%). - , -. (rS=0,8) (rS=0,5) , (rS=0,5), (rS=0,7). (2 =0,7; =1 .; p