Biochemistry Aipg (2)

8/13/2019 Biochemistry Aipg (2)

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BIOCHEMISTRY(AIPG)

1. Acetyl CoA coverts to all except-A. GlucoseB. Fatty acidsC. CholesterolD. Ketone bodies

2. Vitamin which deficiency leads to pyurvate andlactic acid is

A. ThiamineB. RiboflavinC. NiacinD. Pyridoxine

3. All are genetic amino acid deficiency diseasesexcept:

A.

PhenylketonuriaB. HomocystinuriaC. GalactosemiaD. Alkaptonuria

4. What is the most sensitive indicator of cellularenergy?

A. ATPB. ADPC. PhosphocreatineD. AMP

5. Which of the following is not present in basallamina

A. RhodopsinB. EntactinC. LamininD. Integrin6. Sphingomyelinse deficiency is seen inA. Niemann pick diseaseB. Garber diseaseC. Tay sachs diseaseD. Krabbes disease7. Decreased BMR is seen inA. ObesityB. HyperthyroidismC. FeedingD. Exercise8. Somatomedin mediateA. Chondritin sulfate depositionB. LipolysisC. GluconeogenesisD. Decreased rate of glucose uptake by cells

9. Gout is disorder ofA. Purine metabolismB. Pyrimidine metabolismC. Ketone metabolismD. Protein metabolis10. Most LIPOGENIC carbohydrateA. FructoseB. GlucoseC. RiboseD. Sucrose11. Denaturation of DNAA. Fragmentation of DNA moleculesB. Reversible separation of DNAC. Irreversible separation of DNAD. Coagulation of DNA12. Cereals are deficient inA. Vitamin CB. Vitamin B ComplexC. IronD. Calcium13. ATP are store house of?A. EnergyB. PhosphateC. ProteinD. Glucose14. During phagocytes respiratory burst involves

activation of

A. OxidasesB. HydrolaseC. PeroxidaseD. All15. FSH, LH, TSH acts throughA. Cyclic AMPB. Cyclic GMPC. BothD. None16. The Highest percentages of polyunsaturated fatty

acids are present in?

A. Ground nut oilB. Palm oilC. MargarineD. Soya bean oil17. ___ is not a transcription factorsA. InsulinB. EstrogenC. Vitamin D


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D. Glucocoticoid18. Ist clinical sign of vitamin A deficiency isA. Night blindnessB. Bitots spotsC. XerostomiaD. Conjunctival dryness

19. The reducing equivalent for fatty acid synthesis isderived from

A. GlycolysisB. Krebs cycleC. Urea cycleD. Pentose phosphate pathway20. Compared to cows milk, mothers milk has

abundance of

A.

LactoseB. FatC. ProteinD. All21. Steroid hormone receptors have attachment site

for all EXCEPT

A. Steroid hormoneB. Transcription repressorsC. Hormone responsive elementD. Transcription activators22. Insulin causes lipogenesis by all EXCEPT?A. Increasing acetyl CoA carboxylase activityB. Increase the transport of glucose into the cellC. Inhibit pyruvate dehydrogenaseD. Decrease intracellular cAMP level23. True about G protein coupled receptors isA. G protein bind to hormones on the cell surfaceB. All the three subunits alpha, beta & Gamma should

bind to each other for G protein to act

C. G proteins acts as inhibitory and excitatory becauseof difference in alpha sub unit

D. G protein bound to GTP in resting stage24. Thiamine deficiency causes decreased energy

production because

A. It is required for the process of transaminationB. It is co factor in exudative reductionC. It is co - enzyme for transketolase in pentose

phosphate pathway

D. It is co enzyme for pyruvate dehydrogenase

25. All are true about glutathione EXCEPT

A. It is a tripeptideB. It converts Hb to met HbC. It conjugates xenobioticsD. It scavenges free radicals and superoxide ions26. In molecular cloning Blue White screening is

used for

A. To screen for recombinant vectorsB. To detect gene mutationC. To identify desired chromosomal DNA insert in

plasmid vectors

D. To detect host DNA in Situ27. Amino acid which is used in transportation of

ammonia and helps in urea synthesis is

A. ArginineB. GlutamateC. AspirtateD.

Glycin

28. Which of the following enzyme is stable at acidicpH?

A. PepsinB. TrypsinC. ChemotrypsimD. Carboxypeptidase29. Type of collage found in hyaline cartilage isA. Type IB. Type IIC. Type IIID. Type IV30. Protein purification and separation can be done

by all EXCEPT

A. CentrifugationB. ElectrophoresisC. DensitometryD. Chromatography31. All of the following processes are involved in the

detection of mRNA expression EXCEPT

A. Northern blotB. RT PCRC. MicroarrayD. RNA sequencing32. All of the following are the components of

basement membrane EXCEPT

A. RhodopsinB. LamininC. EntactinD. Dystroglycan


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33. Which of the following is the most active form ofcalcium in the circulation?

A. Ionized calciumB. Complexed with phosphateC. Complexed with oxalatesD. Bound to albumin34. A small Ca2+ binding protein that modifies the

activity of many enzymes and other proteins in

response of changes of Ca2+ concentration is

known as

A. CyclineB. CalmodulinC. CollagenD. Kinesin35. Which of the following has low glycemic index?A. Whole wheat breadB.

Brown rice

C. Ice creamD. Potato36. Keton bodies are utilized by all EXCEPTA. RBCB. BrainC. HeartD. Muscles37. Which of the following is a good sources of

saturated fatty acids

A. Palm oilB. Sunflower oilC. Ground nut oilD. Olive oil38. All are good sources of n e poly unsaturated

fatty acids EXCEPT

A. Groundnut oilB. Mustard oilC. Corn oilD. Fish oil39. Which of the following maskes hydrophobic to

hydrophilic?

A. MethylationB. AcetylationC. GlucuronidationD. Hydroxylation40. The conversion of ethanol to aldehyde is

mediated byA. Alcohol dehydrogenaseB. Aldehyde dehydrogenaseC. Xenthine oxidaseD. Catalase

41. Which of the following participates intransamination reaction?

A. Thiamine pyrophosphateB. Pyridoxal phosphateC. CyanocobalamineD. Niacin42. Regarding pentose phosphate pathway all of the

following are true EXCEPT

A. Occurs in the cytosolB. No ATP is produced in the cycleC. It is active in adipose tissue, liver, and gonadsD. The oxidative phase generates NADPH and the

nonoxidative phase generates pyruvate

43. All of the following are precursor of adrenalineEXCEPT

A.

NoradrenalinB. PhenylalanineC. IsoprenalineD. Dopamine44. Intrinsic factorA. Is a polysaccharideB. Is a glycoproteinC. Helps in foliate absorptionD. Helps in blood coagulation45. Which of the following is true about vitamin K ?A. Vitamin K1 is synthesized in intestine by microbial

flora

B. Vitamin K2exists in plantsC. Vitamin K is fat soluble and require bile for its

absorption

D. Vitamin K absorbs because it is water soluble46. The most abundant protein present in body isA. GlobulinB. AlbuminC. CollagenD. Hemoglobin47. All of the following types of collagen EXCEPT

one are present in cartilage

A. 2B. 4C. 6D. 9

48. All of the following are sarcolemmal proteinsEXCEPT

A. SyntrophinB. DystrophinC. Dystrobrevin


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D. Dysmorphin49. High content of cholesterol is present inA. Coconut oilB. Egg yolkC. Hydrogenated fatD. Ghee (unsaturated)50. Fatty acids help in synthesis of all EXCEPTA. GlucoseB. CholesterolC. Ketone bodiesD. Fat51. Increase in pyruvate and lactate is seen in which

of the following deficiency?

A. ThiamineB. PyridoxineC.

Niacin

D. Vitamin C52. Exrahepatic cholestasis is associated withA. Increased bilirubin in urineB. Increased urobilirubin in urineC. Increased bilirubin and increased urobilirubbin in

serum

D. Increased bilirubin in serum53. Dark color urine and clay stool is seen inA. Obstructive jaundiceB. Hemolytic jaundiceC. Hepatocellular jaundiceD. Severe dehydration54. Which of the following is correct method for

estimation of true serum creatinine?

A. Jaffe reactionB. Kinetic jaffe reactionC. Enzyme immunoassayD. Plasma gel filtration55. For glucose estimation in blood the mode of

transport from a primary health care center to

laboratory is done by addition of

A. Potassium oxalate + NaFB. Potassium oxalate + citrateC. EDTAD. Sodium citrate56. In all of the following RNA participates directly

EXCEPTA. Post translational modificationB. Post transcriptional modificationC. DNA replicationD. Splicing

57. All of the following procedure can be used todetect the chromosomal mutation EXCEPT

A. Single stranded length polymorphismB. Agarose gel electrophoresisC. Protein gradient electrophoresisD. SPulse field gel electrophoresis58. Vitamin B12 acts a coenzymes to which one of the

following enzymes?Isocitrate dehydrogenase

A. Isocitrate dehydrogenaseB. Homocysteine methyl transferaseC. Glycogen synthaseD. G-6-P dehydrogenase59. The ligand receptor complex dissociates in the

endosome because;

A. Of its large sizeB.

The vesicle looses its clathrin coat

C. Of the acidic pH of the vesicleD. Of the basic pH of the vesicle60. The human plasma lipoprotein containing the

highest percentage of triacylglycerol by weight is

A. VLDLB. ChylomicronsC. HdlD. Ldl61. The sigma (s) subunit of prokaryotic RNA

polymerase

A. Binds the antibiotic rifampicinB. Is inhibited by a=amanitinC. Specifically recognizes the promoter siteD. Is part of the core enzyme62. An affected male infant born to normal parent

could be an example of all of the following except;

A. mRNAB. tRNAC. rRNAD. snRNA63. proteins are linear polymers of amino acids, they

fold into compact structures. Sometimes these

folded structure associate to form homo-or hetero-

dimers. Which one of the following refers to this

associated from?

A. Denatured stateB. Molecular aggregationC. PrecipitationD. Quaternary structures


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64. The structural proteins are involed in maintainingthe shape of cell or in the formation of matrices in

the body. The shape of these point is

A. GlobularB. FibrousC. Stretch of beadsD. Planar65. Iron is present in all of the following except;A. MyoglobinB. CytochromeC. CatalaseD. Pyruvate kinase66. During phagocytosis, the metabolic process called

respiratory burst involves the activation of;

A. OxidaseB. HydrolaseC.

Peroxidase

D. Dehydrogenase67. The cell component that is genetically continuous

from one cell generation to the next is

A. Nuclear membraneB. Golgi complexC. Central BodiesD. Chromatin68. Golgi bodies are responsible for:A. Synthesis of plypeptidesB. Formation of glycoproteins onlyC. Modification and sorting of glycoproteinsD. Lipid and steroid synthesis69. Enzymes that move a molecular group from one

molecule to another are known as:

A. LigasesB. OxidoreductasesC. TranserasesD. Dipeptidases70. The amino acid residue having an imino side

chain is:

A. LysineB. HistidineC. TyrosineD. Proline71. Vitamin AA. Is water solubleB. Deficiency causes impaired visionC. Maintains normal plasma of clotting factorsD. Is required for formation of clotting factors

72. Differential expression of same gene dependingon parent of origin is referred to as:

A. Genomic imprintingB. MosaicismC. AnticipationD. Non penetrance73. Fluoride used in collection of blood samples for

glucose elimation, inhibits the enzyme

A. GlucokinaseB. HexokinaseC. EnolaseD. Glucose 6 phosphtase74. Shine Dalgarno sequence in bacterial mRNA is

near:

A. AUG codonB. UAA codonC.

AUG codon

D. UGA codon75. A segment of Eukaryotic gene that is not

represented in the mature mRNA is known as:

A. IntronB. ExonC. PlasmidD. TATA Box76. An enzyme that makes a double stranded DNA

copy form a single stranded RNA template

molecule is known as:

A. DNA polymeraseB. RNA polymeraseC. Reverse transcriptaseD. Phosphokinase77. The transmemebrane region of protein is likely to

have:

A. A stretch of hydrophilic amino acidsB. A stretch of hydrophobic amino acidsC. A disulphide loopD. Alternating hydrophilic and hydrophobic amino

acids

78. Which of the following group of proteins assist inthe folding of other proteins:

A. ProteasesB. ProteosomesC. TemplatesD. Chaperones79. Which of the following is membrane bound

enzyme that catalyses the formation of cyclic AMP

from ATP:

A. Tyrosine kinase


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B. PolymeraseC. ATP synthaseD. Adenylate cyclase80. To which of the following family of chemical

mediators of inflammation, the lipoxins belong:

A. Kinin systemB. CytokinesC. ChemokinesD. Arachidonic acid metabolites81. The most abundant glycoproteins present in the

basement membrane is

A. LamininB. FibronectinC. Collagen type 4D. Heparin sulphate

82.

A person on fat free carbohydrate rich dietcontinues to grow obese, which of the following

lipoproteins is likely to be elevated in his blood?

A. ChylomicronsB. VLDLC. LDLD. HDL83. Which of the following elements is known to

influence the bodys ability to handle oxidative

stress:

A. CalciumB. IronC. PotassiumD. Selenium84. The most common condition of inherited

blindness due to mitochondrial chromosomal

anomaly is:

A. Retinopathy of prematurityB. Lebers hereditary optic neuropathyC. Retinitis pigmentosaD. Retinal detachment85. Enzymes concerned with the citric acid cycle are

found in the:

A. NucleusB. RibosomesC. MitochondriaD. Non particulate cytoplasm86. Which cell organelle contains DNAA. MitochondrionB. Golgi bodyC. Endoplasmic reticulumD. Centriole

87. The code world of which proteins is also aninitiation code for proteins:

A. LeucineB. IsoleucineC. MethionineD. Lysine88. The main enzyme responsible for activation of

Xenobiotics is:

A. Cytochrome P 450B. Glutathione S- transferaseC. NADPH cytochrome P 450D. Glucuronyl transferase89. In oxidative phosphorylation, the ATP production

and respiratory chain are linked by:

A. Chemical methodsB. Physical methodsC.

Chemiosmotic methods

D. Confirmational changes90. Substrate level phosphorylation is seen in the

conversion of:

A. Acetoaccatate to alpha ketoglutarateB. Succinyl CoA to succinateC. Fumarate to malateD. Succinate to funarate91. The nitrogen of the body is supplied by:A. Triacyl glycerolB. ProteinsC. GlucoseD. Lipids92. Collagen is rich in:A. Glutamate and glycineB. Alanine and glycineC. Proline and glycineD. Glutamate and proline

SL

NOANS

REFERENCE

1. A

2. A

3. C

4 C

5 ARef: James 3/e p. 294

6 A Ref: Satyanarayan 3/E, 307

7 ARef: Ganong 22/e p. 462

8 ARef: Ganong 22/e p. 382


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9 ARef: Harrison 17/e p. 2444

10 ARef: Harper 22/e p 193

11 BRef: Aynes 2/e p. 427

12 ARef: Lippincott 2/e 15

13 A

Harper 22/e 337

14 A

15 AHarper 22/e 427

16 DPark 19/e 481

17 A

18 DDavidson 19/e 318

19 DHarper 22/e 202

20 A

Park 19/e 500(vasu 6thed pg no

365 ))

21 BRef: Harper 26/e, p. 458

22 C

23 CRef: Harper 26/e, p. 458

24 DRef: Harper 26/e, p. 488

25 BRef: Harper 26/e, p. 629

26 C

27 B

Ref: Lippincotts 2/e, p. 286, 240-

241

28 ARef: Harper27 / e p. 485

29 BRef: Harper 27/E p. 561, 546

30 CRef: Harper 27/E p. 21-24

31 D Ref: Harper 27/E p. 409-410

32 ARef: Harper 27/E p. 550-571

33 ARef: Guyton 8/e p. 870-81

34 BRef: Harper 27/E p. 482

35 CRef: Harper 27/E p. 482

36 ARef: Harper 27/E p. 191-192

37 A Ref: lippincotts 2/e, p 314


39 DRef: Harper 27/E p. 633-637

40 ARef: Harper 27/E p. 225, 95,96


42 DRef: Harper 27/E p. 177, 180

43 CRef: Harper 27/E p. 276, 455

44 BRef: Harper 27/E p 499-500

45 CRef: Harper 27/E p 495


47 BRef: Harper 27/E p 561

48 DRef: Harper 27/E p 575

49 B

Ref: Harper 27/E p. 230

50 ARef: Harper 27/E p. 134

51 ARef: Harper 27/E p. 496-497

52 ARef: Harper 27/E p 290-292

53 ARef: Harper 27/E p 292

54 C




58 B

Ref: Chetterjea Shindre, 6/E, P.

181

59 C

Ref: Chetterjea Shindre, 6/E, P.

19

60 CRef: Lippioncott, 3/E, P. 225, 230

61 C

62 BRef: Harper, 26/E, P. 356

63 DRef: Harper, 26/E, P. 34

64 ARef: Harper, 26/E, P. 38

65 DRef: Harpers, 25/E, P. 360

66 ARef: Robbins, 7/E, P. 60

67 D

68 C

Ref: Garlands Publishing

Company, 1/E, P. 355 361


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69 CRef: Mathews, 3/E, P. 392

70 DRef: Harpers, 25/E, P. 29

71 B

Ref: Biochemistry by Devlin ,

5/E, P. 1140, 1141

72 ARef: Robbins, 7/E, P. 186

73 CRef: Harper, 26/E, P. 137

74 A

Ref: Lippincotts Biochemistry,

2/E, P. 395

75 ARef: Harper, 26/E, P. 253

76 CRef: Harper, 25/E, P. 407


78 D

Ref: Harper, 26/E, P. 507

79 DRef: Ganong, 19/E, P. 41

80 D

81 ARef: Tencates 5/e p. 366, 368


83 DHarrison 15/e 469

84 B

Harrison 15/e 1711, 405

85 CRef: Harper 25/e p. 230

86 ARef: Harper 26/e p.322, 323

87 CRef: Lehninger 2/e p. 898

88 ARef: Harper 25/e 780

89 CRef: Lippincott 2/e p 70

90 B Ref: Harper 25/e 192, 185

91 B

92 CRef: Harper 25/e 696, 697

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Biochemistry Aipg (2)