RIKEN 2016-026（2016年4月発行）

2016

組 織 図○ 理研 理事長 ○ 理研 脳科学総合研究センター（BSI） ○ BSI セ ン タ ー 長 利根川 進 ○ アドバイザリー・カウンシル ○ 特別顧問 伊藤 正男 ○ BSI 副センター長 岡本 仁 甘利 俊一 宮脇 敦史 加藤 忠史 ○ サイエンスコーディネーター　　津本 忠治 合田 裕紀子 ○ 研究業務担当コーディネーター Charles Yokoyama 大河内 眞 ○ 39 研究チーム○ 脳科学研究推進室 ○ 5 連携センター ○ BTCC : 理研 BSI -トヨタ連携センター ○ BTaC : 理研 BSI - タケダ連携センター ○ BOCC : 理研 BSI - オリンパス連携センター ○ BKCC : 理研 BSI - 花王連携センター ○ 理研 - MIT 神経回路遺伝学研究センター ○ RRC : 研究基盤センター ○ NIJC : 神経情報基盤センター ○ 情報センター

○ Brain/MINDS 中核拠点 : 脳機能ネットワークの包括的解明プロジェクト

2016年4月１日現在

理化学研究所脳科学総合研究センター〒351-0198 埼玉県和光市広沢２番１号和光市駅から理研和光キャンパスまで徒歩15分

アクセスhttp://www.brain.riken.jp/jp/access

BSIウェブサイト

www.brain.riken.jpBSI 創立 20 周年 特設サイトwww.riken-bsi20.jp

脳科学とは自分自身を知ることである人生をかけるに値する科学があなたを求めている。共に挑戦しよう。

脳は、宇宙と並ぶ人類最大のミステリー。考えるだけでわくわくしませんか。

私がセンター長を務める理化学研究所 脳科学総合研究センター（BSI）は、この脳の神秘を解き明かすべく、未開の地を進んでいます。BSIでは、世界各国から集まったさまざまな分野の研究者が、脳を分子レベルから神経回路、さらには人間の社会的な関係性といった多様な切り口で基礎と応用の両面から研究しています。

BSIはその名高い歴史のなかで、ほかに例のない多くの重要な発見をしてきました。そして、世界でも有数の脳科学の研究拠点として高い評価を得ています。

脳科学の可能性への期待がますます高まる現代社会において、研究に欠かせない最先端技術を生み出し、それを駆使して脳の神経回路が働くメカニズムを解明し、さらにさまざまな精神疾患の根本的な原因を発見するべく努力を続けるBSIの果たす役割は一段と大きくなっています。

また、産業界との連携を通じて、BSIは基礎研究の成果を社会に還元し、生活の質の向上につなげることにも貢献しています。さらには、次世代の脳科学研究を担う人材の育成にも力を入れ、さまざまなプログラムを提供しています。

脳科学とは、人間の活動すべてを研究対象とする唯一の科学です。BSIは「人間とは何か」という問いへの明確な答えを求め、理想とする科学と社会の未来像に向けて飛躍します。

脳とこころの神秘の解明を目指して脳を理解したい人間の「こころ」を理解するためには脳の分子レベルからの解明が不可欠である。全ての動物が持つ意思決定、記憶、情動といった基本的な脳機能に加えて、人間は創造力や言語、イマジネーションなどのより高次な知能や脳機能を獲得してきた。我々は、これらの機能を多角的アプローチで探求し、複雑で謎に満ちた人間の脳機能の解明を目指している。「脳を理解する」、これは人類史上最大のチャレンジだろう。脳科学はこれまでに、アルツハイマー病や自閉症、統合失調症やうつ病などの疾患が、脳の機能不全によることを明らかにしてきた。しかし、脳内のどのような不具合が症状につながるのかをつきとめるには、まず健全な脳の発達の仕組みを理解しなければならない。

すべては基礎研究から基礎研究は「なぜなのか」「どうしてなのか」というシンプルな疑問をもとに、根源的な謎の解明を目指す。そこで得られた知識はやがて我々の生活になくてはならないテクノロジーや医療技術、治療薬となって還元される。現在、一般的に用いられている感染症治療薬や慢性的疾患への治療薬、診断に使用されるMRI装置などは生物学的、物理学的現象を追求する基礎研究における発見が、数十年の時を経て形となったものだ。基礎研究という地道ではあるが自由な研究は、時に偶然を味方につけ思いもよらぬ発見を導く。そう、基礎研究は、後世へと続くイノベーションの源泉なのだ。

BSIが目指すもの未だ治療法の確立していない難病への新しいアプローチを探し、またその研究が人類の財産となる科学的発見へとつながることを信じ、我々は日夜研究を続ける。いくつもの階層にまたがる複雑な脳機能の解明のために、細胞一つひとつの活動や特質を識別し、ニューロン同士が情報伝達を行う仕組みを理解し、記憶や意思決定から行動へと至る神経回路システムを探求する。そして、階層的機能を超えた時に、こころや意識がどのように生まれるのかを解明したい。そのために革新的な技術を開発し、数理的に脳の機能を表現する新たな理論の創出に挑戦し、大規模な生物学的データセットを効率的に分析する方法の開発を続けている。それぞれの努力が、さまざまな脳疾患における発症機構の解明につながり、予防・診断・治療を可能にし、現代社会の抱える難題の解決へつながるという信念のもとに。

積み上げられてきた知識の上に、好奇心と創造力を総動員させ、脳の神秘の解明を目指す我々の挑戦は、スタート地点では思いもよらないような遥かに遠くて高いゴールへとつながる可能性を無限に秘めている。人類の「なぜ、どうして」に応える喜びを誇りに、BSIは挑戦を続けよう。

ContentsGroup 1 革新的な技術と理論を開発する ……4

Group 2 基本的構成要素からの脳の構築 ……6

Group 3 神経回路の機能解明からこころを知る …8

Group 4 豊かなこころの動きを理解する … 10

Group 5 脳の病に挑む ………………………… 12

Group 6 研究基盤センター ………………… 14

産業界との連携 ……………………… 14

BSIプログラム ここで一流になる ……………… 15

組織図 …………………………………………… 17

Director 脳科学総合研究センター長

利根川 進

32

optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural infor-mation process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhyth-mic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress opto-genetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic os-cillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics compu-tation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process deci-sion making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memo-ry circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation plasticity mathematics jellyfish theoretical neuroscience cutting edge neural circuits physics computational neuroscience perception microcircuits neural information process decision making social behavior imaging fluorescent proteins learning analysis computers technology brain waves information science neuroinformatics database rhythmic oscillation memory circuit mechanism adaptive behavior GFP geometry Hebb’s rule modeling simulation prediction progress network optical clearing brain clearing progress optogenetics computation

brain clearing

optogenetics

imaging

memoryprediction progressplasticity mathematics jellyfish theoretical neuroscience

database rhythmic oscillation

cutting edge

networkcircuit mechanism adaptive behavior GFP geometry Hebb’s rule

computers technology brain waves

learning modeling simulation progress

physics

neural circuits computational neuroscience perception microcircuits

computation

analysis information science neuroinformaticsanalysis information science neuroinformatics

circuit mechanism adaptive behavior GFP geometry Hebb’s rule

optogenetics

network database rhythmic oscillation memoryplasticity mathematics jellyfish theoretical neuroscience prediction progress

computers technology brain waves

computation

imagingphysics

cutting edge

learning modeling simulationneural information processneural information process

progressneural circuits computational neuroscience perception microcircuits

brain clearing

深井 朋樹

脳の情報処理の原理を探る

甘利 俊一数理的理論とそれに基づく手法で脳を理解し

数理脳科学の確立をめざす

宮脇 敦史脳内のさまざまな生命現象の

時間・空間的変化を可視化する

革新的な技術の開発と理論の確立は、脳科学における未知の現象の発見や新たな概念の創出を導きます。

宮脇研究チームは、新規蛍光タンパク質の開発や脳組織の透明化技術など、これからの脳科学の進歩に不可欠な最先端テクノロジーを創造しています。甘利・深井・豊泉の各研究チームは、脳の情報処理やシナプス可塑性の動的変化、記憶や感情の神経回路メカニズムなどを数理的に表す、新たな理論の確立へ向けて挑戦を続けています。Cichocki研究チームと山口率いるNIJC

（神経情報基盤センター）は、脳科学分野における大規模な生物学的データセットの効率的な分析方法の開発や、その統合に役立つアルゴリズムの考案を進め、研究者がそれらを自由に利用できるような支援体制を確立しています。

革新的な技術と理論を開発する

脳の機能を視覚化したい脳の働きを数学的に理解できるかビッグデータの解析には何が必要か

自己再生海馬ニューロン系のパターン分離能力

甘利 俊一

変分ベイズ法による多電極同時記録データからのスパイク列の分離

深井 朋樹

ScaleA2試薬により透明化したマウス胎仔（右）

宮脇 敦史

豊泉 太郎経験に応じて神経回路が学習するしくみを

理論的に解明する

Andrzej Cichocki脳信号や脳画像のリアルタイム解析処理や

コンピュータツールを開発する

山口 陽子脳研究の国際的協力基盤「ニューロインフォマティクス

国際統合機構（INCF）」の日本拠点経験による脳回路の変化を新モデルで予測Neuron, 豊泉www.riken.jp/pr/press/2014/20141023_1 www.riken.jp/pr/press/2013/20130408_1

動物の体作りに重要なレチノイン酸の可視化に成功Nature, 宮脇

アルツハイマー病の組織病変をズームインNature Neuroscience, 宮脇www.riken.jp/pr/press/2015/20150915_1

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evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocam-pus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebel-lum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippo-campus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cer-ebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues cerebellum evolution thalamus memory connectivity molecular mechanisms cortex information processing circuit genetics neural circuit synapse gene/genetics plasticity neural networks hippocampus glia molecular mechanism learning system neuroscience model organism cortical hippocampal network olfactory behavior axon neuronal circuit regeneration dendrite stem cell axon guidance microtubule kinesin motility tubulin olfaction barrel cortex synaptic plasticity neuroligin neurotransmitter embryo activity mutants genome cell biology guidance cues

barrel cortexneuroligin

genomeneural circuitmicrotubule kinesin motility tubulin olfaction

cell biology guidance cues

synaptic plasticity

activityevolution thalamus memory connectivity molecular mechanisms cortexevolution thalamus memory connectivity molecular mechanisms cortex

information processing circuit genetics

regeneration dendrite stem cell axon guidance

glia

molecular mechanism learning system neuroscience model organism

gene/genetics

cortical hippocampal network

neural networks hippocampus

activity cell biology guidance cues genomemicrotubule kinesin motility tubulin olfaction neural circuit

information processing circuit genetics

gliagene/geneticsbarrel cortexneuroliginsynaptic plasticity

cortical hippocampal network

neural networks hippocampusregeneration dendrite stem cell axon guidance

molecular mechanism learning system neuroscience model organism

多様な分子群によるシグナル伝達・特異的なシナプス結合の形成・ニューロンやグリア細胞の相互作用、これらの神経回路素子を基盤として脳は階層的に構築され、機能し、可塑的に変化しています。

上口・武藤の両研究チームは、神経突起における細胞内シグナル伝達や物質輸送機構の分子レベルでの解明を目指しています。合田・林・Launeyの各研究チームは、ニューロン同士が情報伝達を行う重要な場所であるシナプスの構造・機能・可塑性の分子メカニズムの解明に挑んでいます。下郡・細谷・Mooreの各研究チームは、複雑であるが精緻な神経回路網の形成・機能を司る分子群の同定を行っています。平林研究チームは、脳の機能と再生における脂質代謝の役割を探索しています。御子柴・平瀬の両研究チームは、ニューロンおよびグリア細胞におけるカルシウムイオンの多様な役割を研究しています。

Thomas Launey記憶の基となるシナプスタンパク質を

同定しその働きを明らかにする

Adrian Moore神経細胞が脳部位によって特異的な形態と

回路を形成する仕組みを解明する

平瀬 肇脳の情報処理におけるグリアの

役割を明らかにする

林 康紀

学習と記憶の分子基盤を明らかにする

下郡 智美感覚情報を大脳皮質へ中継する視床の神経回路形成メカニズムを解明する

細谷 俊彦局所的な神経回路の機能解析を通して

脳の理解に貢献する

基本的構成要素からの脳の構築

ニューロンを形作るものとは脳内のネットワークが機能するしくみとはどのようにしてニューロンは繋がっていくのか

御子柴 克彦細胞内カルシウムの動態と脳機能の関係を

分子レベルで解明する

平林 義雄神経細胞とグリアの相互作用をはじめとする

脳機能における糖や脂質の役割を明らかにする

合田 裕紀子神経ネットワークの基礎となるシナプスの

形成メカニズムを解明する

武藤 悦子神経軸索内物質輸送の

原動力となるメカニズムを解明する

上口 裕之神経回路の構築と再生の仕組みを

分子のレベルで解き明かす

マウスバレル野での２重 in situ 染色による領域特異性

下郡 智美

神経回路の構築に中心的な役割を担う成長円錐

上口 裕之

錐体細胞の形態とシナプス（緑と赤の接点）

合田 裕紀子

ラットのアストロサイトの形態（緑：形態マーカー , 赤：アストロサイトマーカー）

平瀬 肇, 三嶋 恒子

生後６日目のマウスの視覚野の前頭断切片。核（ピンク）と Subcerebral projection neurons （緑）が小さな円柱状の集合体を形成する

細谷 俊彦

GFP-アクチンを発現する海馬CA1錐体細胞

岡本 賢一, 林 康紀

神経回路構築を制御する脂質を発見Science, 上口 , 平林www.riken.jp/pr/press/2015/20150828_2 www.riken.jp/pr/press/2013/20131101_1 www.sciencedirect.com/science/article/pii/S0896627314010782

樹状突起の形態形成を決める分子メカニズムの一端を解明Science, 下郡

Stoichiometry and phosphoisotypes of hippocampal AMPA-type glutamate receptor phosphorylationNeuron, 林

76

stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spa-tial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates ag-gression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plas-ticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optoge-netic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymme-try cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fi-beroptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory pro-cessing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit ge-netics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippo-campal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sen-sory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse in-habitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggres-sion sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall con-text laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex deci-sion making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch mo-tor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons ver-tebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram en-coding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visu-al cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear ex-perience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal cir-cuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning cir-cuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression senso-ry information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse in-habitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggres-sion sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall con-text laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex deci-sion making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch mo-tor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons ver-tebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram en-coding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visu-al cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear ex-perience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior brain oscillation visual cortex decision making circuit genetics GABAergic neurons vertebrates aggression sensory information fear experience sensory nervous system hippocampal circuit fiberoptic imaging optogenetic mouse inhabitation inhibitory neurons engram encoding recall context laser light false memory emotional switch motor control stimuli fruit fly two-photon imaging visual cortex emotion memory habenula left-right asymmetry cognition neural plasticity learning sensory processing perception attention anxiety spatial learning circuit genetics Zebrafish dendritic activity neural circuit imaging behavior

Zebrafishexperience

stimulitwo-photon imagingvisual cortex emotion memory habenula

cognition neural plasticity

false memory

behaviorfiberoptic imaging optogenetic mouse inhabitation inhibitory neurons

fruit fly left-right asymmetry learning

attention anxiety spatial learning aggression

engram

circuit genetics dendritic activity neural circuit imaging brain oscillationcircuit genetics dendritic activity neural circuit imaging brain oscillation

sensory information fear

encoding recall context laser light

sensory processing perception

stimulitwo-photon imaging

behavior cognition neural plasticityfiberoptic imaging optogenetic mouse inhabitation inhibitory neurons

visual cortex emotion memory habenula

fruit fly left-right asymmetry learning

Zebrafish sensory information fear engramexperiencefalse memory

encoding recall context laser light

sensory processing perceptionaggressionattention anxiety spatial learningexperienceexperience

最先端の神経回路遺伝学は、記憶・情動・意思決定・行動発現など、脳機能の根源的メカニズムの解明を可能とします。

利根川研究チームは、神経回路遺伝学の先駆的存在であり、記憶の形成・維持・想起・動的変化を司る脳の仕組みの解明を目指しています。糸原・McHugh・藤澤の各研究チームは、記憶・意思決定から行動へと至る神経回路の機能を探求しています。岡本・Johansenの両研究チームは、快・不快という情動が記憶・意思決定に与える影響とその制御機構を研究しています。Benucci・村山・風間・吉原の各研究チームは視覚、嗅覚、触覚などの感覚入力が行動出力を誘起する神経回路メカニズムを明らかにしようとしています。

Thomas McHugh分子遺伝学や神経化学、in vivo 電気生理学により

記憶を形成し修飾する神経回路を解明する

糸原 重美注意に関連する行動を司る神経回路と

分子機構を遺伝学的手法で明らかにする

神経回路の機能解明からこころを知る

感情とは何か記憶はどうやって形成されるのかどのように五感が生み出されるのか

マウスの鼻から脳へと至る一次嗅覚神経回路の遺伝学的蛍光可視化

吉原 良浩

ゼブラフィッシュの二次嗅覚神経回路

吉原 良浩

ショウジョウバエ−次嗅覚中枢の投射細胞

風間 北斗

危険を予測するゼブラフィッシュの手綱核−縫線核回路（緑）

岡本 仁

トランスジェニックマウス視覚野のGCaMP6f 画像（脳組織はScale法により透明化）

A. Benucci

新たに発見された海馬の記憶神経回路（緑：歯状回, 赤：苔状繊維, オレンジ：CA2）

利根川 進, 小原 圭吾

風間 北斗感覚情報が脳内でどのように表現・処理され

知覚が生じるかを理解する

Joshua Johansen嫌な経験がどのように神経回路を変化させて

情動の記憶が形成されるかを知る

村山 正宜動物行動と神経活動との因果関係を単一神経細胞および神経ネットワークレベルで明らかにする

岡本 仁情動による行動プログラムの制御機構および

脳の神経新生と左右差の解明

Andrea Benucci

脳の知覚認識の神経機構を解明する

藤澤 茂義意思決定や短期記憶などの認知機能を神経ネットワークレベルで解明する

利根川 進

学習と記憶を司る脳のメカニズムを解読する

吉原 良浩匂いに基づく行動の基盤となる嗅覚神経系の分子・細胞・神経回路メカニズムを解明する

“感じる脳”のメカニズムを解明Neuron, 村山

www.riken.jp/pr/press/2015/20150522_1 www.riken.jp/pr/press/2014/20141121_2

危険に対して冷静かつ適切に対処できるようになるための神経回路を発見Neuron, 岡本

98

アルツハイマー病で記憶は失われていない可能性Nature, 利根川www.riken.jp/pr/press/2016/20160317_1

symbols high-order representation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmo-set human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reali-ty strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attachment parent-infant relationship visual recog-nition goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activi-ty inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain ma-chine interface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strate-gy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity infe-rior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relation-ships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine inter-face fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object rec-ognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelli-gence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-di-rected behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order repre-sentation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recogni-tion social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attach-ment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence in-fant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behav-ior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation lan-guage prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neuro-physiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social be-haviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attachment parent-in-fant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence infant develop-mental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object im-ages macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchroni-zation motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language proso-dy phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intel-ligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution sym-bols high-order representation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque mon-key object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coher-ence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology ma-ternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses de-cision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attachment parent-infant relationship visual recogni-tion goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence rela-tionships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-or-der representation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine in-terface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelli-gence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-di-rected behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order repre-sentation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recogni-tion social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attach-ment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence in-fant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behav-ior higher brain functions brain machine interface fMRI neurophysiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social behaviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation lan-guage prosody phonology maternal behavior attachment parent-infant relationship visual recognition goal-directed behavior higher brain functions brain machine interface fMRI neuro-physiological analyses Marmoset human intelligence infant developmental psychology neural activity inferior temporal cortex object images macaque monkey object recognition social be-haviors neural circuit analyses decision making intuition prefrontal cortex adaptive Intelligence relationships communication synchronization motion coherence visual cortex metacognition categorization substitute reality strategy game-playing shogi tool use evolution symbols high-order representation language prosody phonology maternal behavior attachment parent-in-

symbols

social behaviors neural circuit analyses

evolution

game-playingevolution

intuition prefrontal cortex adaptive Intelligence

categorization

visual cortex metacognition

intuition

Marmoset

object images

evolution

game-playingevolution

symbolsfMRI shogi tool usefMRI shogi tool useintuition prefrontal cortex adaptive Intelligence

prosody phonology maternal behavior attachment parent-infant relationshipvisual cortex metacognition

object images

strategystrategyprosody phonology maternal behavior attachment parent-infant relationship

social behaviors neural circuit analyses

high-order representation languagehigh-order representation languagehuman intelligence infant developmental psychology neural activity

Marmoset

intuition

human intelligence infant developmental psychology neural activity

categorization

goal-directed behavior higher brain functionsgoal-directed behavior higher brain functions

substitute reality communicationsubstitute reality communication

人の知性を特徴づける言語・社会的適応・高度な認知機能の解明は、脳研究における究極のフロンティアです。

田中啓治研究チームは、直観や目的をもった行動、視覚認識など、高次認知機能の神経基盤を理解するための研究を行っています。入來研究チームは動物が道具を利用する行動を通して、また、谷藤研究チームは高次脳領域における視覚の表現メカニズムに焦点を置いて、霊長類のもつ複雑な認知能力の発現機構を探求しています。社会的認知に関しては、藤井研究チームが他者や環境に対しての認知・適応行動の基になる脳機能の解明を進め、馬塚研究チームは乳幼児の言語獲得のしくみの研究を行っています。黒田研究チームでは、親子関係を中心とした社会行動の脳内機構の解明を目指しています。中原研究チームはこころや知能を創造する神経回路基盤の数理的解明を目指して研究を進めています。

藤井 直敬他者や環境に適応する能力の基盤となる

脳機能を明らかにする

馬塚 れい子乳幼児が言語を獲得する過程を

韻律に注目して理解する

谷藤 学物体像が脳内でどのように表現され

認識されるのかを理解する

入來 篤史ヒトの知性を特徴づける象徴概念の発達と進化の神経生物学的メカニズムを解明する

田中 啓治視覚認識や目的をもった行動などの高次機能の

基盤となる脳内メカニズムを明らかにする

豊かなこころの動きを理解する

直観とは何か人はどのように言語を獲得するのか人をつなぎ社会をつくる脳の高次機能とは

中原 裕之意思決定と社会行動の

脳情報処理メカニズムを探求する

黒田 公美ほ乳類の子育て行動や親子の愛着の基盤となる

脳内メカニズムを解明する

乳幼児の言語理解を調べる行動実験

馬塚 れい子

直観的思考中のプロ棋士の脳活動

田中 啓治, 程 康

下側頭葉の視覚連合野における視覚物体に対する応答のグループ分け

谷藤 学

他者のこころを読む時の脳活動

中原 裕之

現実と仮想の区別がない体験を生成するSRシステム

藤井 直敬

直観的な戦略決定を行う脳のメカニズムを解明Nature Neuroscience, 田中 , Chengwww.riken.jp/pr/press/2015/20150421_1 www.riken.jp/pr/press/2015/20150930_1

マウスの「父性の目覚め」に重要な脳部位を発見The EMBO Journal, 黒田

君は君、我は我なり、他人の価値観を学ぶ脳機能の解明Neuron, 中原www.riken.jp/pr/press/2012/20120621

1110

Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadi-an rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biolo-gy proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression dis-ease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse trans-poson biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome ab-normal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling pro-tein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids caus-al genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank thera-pies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calci-um signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epi-genetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural degeneration recov-ery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuro-pathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion am-yloids brain bank therapies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural de-generation recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amy-loid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alz-heimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syn-drome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadi-an rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biolo-gy proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression dis-ease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse trans-poson biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome ab-normal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling pro-tein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids caus-al genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank thera-pies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calci-um signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epi-genetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural degeneration recov-ery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuro-pathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion am-yloids brain bank therapies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural de-generation recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amy-loid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alz-heimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syn-drome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadi-an rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biolo-gy proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression dis-ease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse trans-poson biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome ab-normal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling pro-tein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids caus-al genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank thera-pies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calci-um signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epi-genetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural degeneration recov-ery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuro-pathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion am-yloids brain bank therapies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural de-generation recovery prevention gene therapy depression disease models Alzheimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syndrome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amy-loid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug development neural degeneration recovery prevention gene therapy depression disease models Alz-heimer’s disease aging proteolysis IP3 calcium signaling protein misfolding amyloid mental disorders schizophrenia autism genetics lipids causal genes mutations epilepsy Down syn-drome bipolar disorder mitochondria epigenetics treatment diagnostic methods circadian rhythm amyloid-β peptide neuropathophysiology next gen AD mouse transposon biomarkers Proteolytic reactions glial cells Huntington disease neurobiology genetics structural biology proteomics adaptation prion amyloids brain bank therapies genome abnormal behavior drug

causal genesepilepsy

recoveryautism geneticsmitochondria epigenetics circadian rhythm

treatment diagnostic methods

amyloid-β

amyloidAlzheimer’s disease aging proteolysis IP3 calcium signaling

protein misfolding mental disorders schizophrenia

Huntington disease genetics structural biology proteomics adaptationbrain bank

glial cells

peptide neuropathophysiology next gen AD mouse

neurobiology

lipids mutations Down syndrome bipolar disorder

abnormal behavior drug developmen

recoveryamyloid treatment diagnostic methodsAlzheimer’s disease aging proteolysis IP3 calcium signaling

mitochondria epigenetics circadian rhythm autism genetics

protein misfolding mental disorders schizophrenia

causal genes neurobiology glial cells

amyloid-β epilepsylipids mutations Down syndrome bipolar disorder

abnormal behavior drug developmenbrain bankpeptide neuropathophysiology next gen AD mouse

Huntington disease genetics structural biology proteomics adaptation

さまざまな脳疾患の発症機序の解明と、それを予防・診断・治療の向上へ還元させ社会へ貢献することが、脳研究の最終目標です。

西道研究チームでは、患者の病態を再現する次世代型アルツハイマー病モデルマウスの作製に成功し、脳のタンパク質代謝系に着目してアルツハイマー型認知症の発症機序の解明、予防・治療の可能性に挑んでいます。田中元雅研究チームは、プリオン病などにおけるタンパク質の異常凝集の解析を通して、神経変性の病態解明に挑戦しています。加藤研究チームは躁うつ病について、吉川研究チームは統合失調症について、内匠研究チームは自閉症について、山川研究チームはてんかんについて、それぞれ遺伝学的基盤・分子的病態発症機序の解明、人間の病態を再現したモデルマウスの作製を行っており、近い将来における予防・診断・治療への応用を目指しています。

内匠 透自閉症を中心とした精神疾患の

遺伝学的・生物学的基盤を理解する

吉川 武男統合失調症や自閉症の遺伝学的・

生物学基盤を解明し早期診断法を開発する

加藤 忠史双極性障害の神経生物学的基盤の研究から

新しい診断法・治療法につなげる

山川 和弘てんかんやダウン症の発症機構を

遺伝学的手法を用いて明らかにする

田中 元雅神経変性疾患におけるタンパク質の

異常凝集に注目しその病態を解明する

西道 隆臣アルツハイマー病の発症に関わる神経老化の機構を明らかにする

脳の病に挑む

疾患の分子的・遺伝的背景を探る脳の疾患はなぜひき起こされるのか疾患の早期診断や予防のためのツールを開発したい

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アルツハイマー病患者の脳内に見られる二大病理：老人斑（緑）と神経原線維変化（赤）

西道 隆臣, 斉藤 貴志

新型アルツハイマー病モデルマウスでは激しいアミロイド病理（緑の斑点）を呈する

西道 隆臣, 斉藤 貴志

自閉症に関連する脂肪酸トランスポーター遺伝子の変異

吉川 武男

統合失調症における第８番染色体（短腕）の遺伝子解析

吉川 武男

９ヵ月齢４ヵ月齢 ２ヵ月齢

次世代型アルツハイマー病モデルマウスの開発に成功Nature Neuroscience, 西道www.riken.jp/pr/press/2014/20140414_1 www.riken.jp/pr/press/2012/20120420 www.riken.jp/pr/press/2015/20151020_1

プリオンタンパク質の凝集が出芽酵母の生存に有利に働くことを発見Science, 田中

自発的なうつ状態を繰り返す初めてのモデルマウスMolecular Psychiatry, 加藤

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BSI プログラム ここで一流になるBSIの大きな特徴のひとつは、それぞれの研究室が情報を交換し、互いに刺激を与え合うことができる“学際的な場”であるということ。そして、末来を担う若い世代には、世界規模で日進月歩する最先端の脳科学研究に大いに触れてもらいたいと考えています。彼らが世界トップクラスの研究環境のなかで切磋琢磨しながら専門性を深め、研究者として自立し、重要な成果をあげることをBSIは期待しています。

学生・若手研究者のためのキャリアプログラムBSIでは、国内外問わず、大学院生ならびにポスドク研究者に対し各種キャリアプログラムを提供しています。詳細や応募方法につきましては、理研またはBSIウェブサイトを参照ください。

サマープログラム　　対象：ポスドク・博士課程・修士課程・学部在籍者BSIの研究室に所属して２か月間の研究プロジェクトを行うインターンシップコースと、国内外から招聘された講師陣による英語での１週間のレクチャーコースがあります。多数の応募者の中から厳しい選考を経て選ばれた約50名（約85％が海外の学生）は、同世代の学生たちと共に刺激を受け合い、親交を深めながら、脳科学について深く学ぶ夏をBSIで過ごします。プログラム参加者の滞在費等の一部をBSIが援助します。

対象：博士課程在籍者国際連携大学院協定を結んでいる海外の大学・研究機関から、外国籍を有する大学院博士（後期）課程の学生を受け入れ、BSIの研究者と学生の所属する大学等の研究者が共同で学位取得のための研究指導を行う制度。３年を上限に、滞在費や宿泊費等の支給・補助を受けることができます。2010年からは短期間の受け入れプログラムも始まりました。

国際プログラム・アソシエイト（IPA）制度

対象：博士課程在籍者柔軟な発想と強い意欲をもつ大学院博士（後期）課程の学生を受け入れ、BSIの知識・経験豊富な研究者とともに研究する機会を設けることで、次代を担う研究者を育成する制度。連携大学院および研究協力等の協定を締結している大学院在籍者から選抜され、最長３年間の契約期間のなかで博士号の取得を目指します。

大学院生リサーチ・アソシエイト（JRA）制度

対象：博士課程・修士課程在籍者理研と協定を結んでいる大学院に所属する博士および修士課程の学生が主な対象者です。BSIのチームリーダーが大学の客員教員となり、学生の研究指導と学位論文審査などに関わります。申請時点で協定を結んでいない大学院に所属している学生も、本制度を利用することが可能な場合があります。

連携大学院制度

対象：ポスドク自然科学の博士号を取得した若手研究者を対象とする制度です。募集分野は、物理学（物理学Ⅰ（素粒子、原子核、宇宙など）、物理学Ⅱ（物性））、化学、生物科学、医科学、工学の科学技術分野で、理研の研究領域に関連性を有するものとします。創造性、独創性に富んだ若手研究者が、自らが設定した研究課題について、自由な発想で主体的に研究できる場を提供し、科学技術のさらなる発展のために将来国際的に活躍できるよう支援します。

基礎科学特別研究員（SPDR）制度Brain/MINDS革新的技術による脳機能ネットワークの全容解明プロジェクト

下田 真吾

知能行動制御連携ユニット

北城 圭一

脳リズム情報処理連携ユニット

熊田 孝恒

認知行動科学連携ユニット

このプロジェクトは、飛躍的な進歩をとげているイメージング技術や発展著しい分子生物学、向上を続ける遺伝子操作技術などにより、脳科学の核心へと迫る研究を行います。また、高次脳機能ならびにアルツハイマー病などの病態像を解析し脳全体の構造と機能の解明を目指します。理研は本プロジェクトの中核拠点としてBSI内に「脳機能ネットワークの包括的解明プロジェクト」を設置し、国内外のさまざまな大学や研究機関等と連携し、研究プロジェクトを推進します。

國吉 康夫

BTCC センター長

産業界との連携 理研 BSI －トヨタ連携センター（BTCC）

理研 BSI －タケダ連携センター（BTaC）

加藤 忠史

BTaC センター長

理研 BSI －オリンパス連携センター（BOCC）

理研 BSI －花王連携センター（BKCC）

宮脇 敦史

BOCC センター長

岡本 仁

BKCC センター長

脳科学塾　　対象：ポスドク・博士課程・修士課程・学部在籍者2010年に始まった選抜少人数制の通年教育プログラム。幅広い脳科学知識の習得のため、BSIのチームリーダーに加え、大学教授や専門研究機関の研究者が講義をするとともに、英語によるプレゼンテーションとディスカッションを重視したトレーニングを、年間30コマ以上行います。一つの学部ではカバーしきれない学際的な脳科学の分野から研究者が集まる、BSIならではのプログラムです。http://brainminds.jp

俣賀 宣子

生体物質分析支援ユニット

高橋 英機

動物資源開発支援ユニット

研究基盤センター（RRC）

板倉 智敏

RRC センター長

程 康 / Kang Cheng機能的磁気共鳴画像

（fMRI）測定支援ユニット

連携研究チーム

岡ノ谷 一夫

認知行動連携研究チーム

BSI セミナーシリーズ（BSS）月に一度開催されるセミナーシリーズでは、脳科学の幅広い分野で活躍する世界トップレベルの研究者が、現在研究を進めているテーマについてプレゼンテーションを行います。BSI内外の研究者が自由に参加でき、そこで得た新しい知識や発想を自分の研究へ活かしています。

BSI ディスカバリーセミナーシリーズ（DSS）2015年から始まった、BSI以外の科学コミュニティーにも開かれたフォーラムです。BSIのチームリーダーが発表した最新研究成果について議論を通じて理解を深め、科学の発展を促す場です。

BSI リトリート年に一度、BSIの研究者たちが研究室から離れた場所に集まり、今まさに取り組んでいる研究について発表し議論するBSIリトリート。研究者間のコミュニケーションを深めることで、共同研究を促進するとともに、新しいアイディアが生まれる場です。

PDFA（ポスドクフェローアソシエーション）BSI発ポスドクのためのポスドクによる自治組織。BSIでの研究生活のさらなる発展や充実のため、ワークショップやセミナーを自主的に開催しています。

科学コミュニティへの貢献

RRCは３ユニットで構成されたBSI全体の研究技術支援組織で、熟練した技術者が高度かつ様々な技術を提供します。また、共用の実験施設・機器を管理し、研究室の利用に供します。

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