Cannabis och hjrnansbelningssystem-med fokus p den vxande hjrnan

Maria.Ellgren@gmail.comMaria Ellgren PhD Kristiansand 2 Februari 2010

UpplggKort introduktion till hjrnanBelningssystemetCannabis pverkan p hjrnan och belningssystemetCannabis som gatewaydrog

Signalsubstanser utsndras och binder till specifika receptorer (mottagarmolekyler) p nsta nervcell.

Signalsubstanser, ex.Glutamat allmn accelerator, gaspedalGABA (gamma-aminobutyric acid) allmn bromseffektDopamin rrelser, belningNoradrenalin stressrespons, flyktSerotoninknsloregulator (aggressivitet, depression)

UpplggKort introduktion till hjrnanBelningssystemetCannabis pverkan p hjrnan och belningssystemetCannabis som gatewaydrog

Av en slump upptcktes att om ett specifikt hjrnomrde stimuleras ger det en knsla av vlbefinnande.

Elektricitet aktiverar nervceller s att de brjar signalera.

Hjrnans belningssystem-mesokortikolimbiska dopaminsystemet

Hjrnans belningssystemAktiveras av

mat- och vattenintag, sex och fysisk aktivitet

beroendeframkallande droger Knsla av vlbefinnande

kad dopamin-aktivitet i nucleus accumbensinjektion

Diagr5

95.8636177553100

104.186953837595

99.949428407299

99.6211455789125

102.773459003150

100.7356085397145

103.761039846140

106.2043563683135

111.197329379130

115.3029637607110

112.7535116103107

114.4273648501105

koksalt

cannabis

Tid (min)

Dopamin (% av basnivn)

Blad1

-40100

-2095

099

20125

40150

60145

80140

100135

120130

140110

160107

180105

Blad1

95.863617755396.48268534230

104.186953837598.53909356570

99.9494284072104.9782210920

99.6211455789442.3679274690

102.773459003881.62052163040

100.7356085397633.8414503060

103.761039846480.11612088820

106.2043563683381.36435486760

111.197329379310.30028587410

115.3029637607282.71086794630

112.7535116103246.8457475220

114.4273648501225.59397413720

koksalt

amfetamin

cannabis

Tid (min)

Dopamin (% av basnivn)

Blad2

Blad3

Beroendeframkallande drogerkar dopaminaktiviteten i belningssystemet

Sjlvadministreras av djur

Dopaminaktivitet ndvndig

Stress kar intag

Inte bara dopaminKroppsegna opioider, endorfinereufori

Glutamatdrogsug

GABA

Serotonin

UpplggKort introduktion till hjrnanBelningssystemetCannabis pverkan p hjrnan och belningssystemetCannabis som gatewaydrog

Cannabis Sativa (hemp)haschoch marijuana

Cannabinoider-9-tetrahydrocannabinol (THC) Kroppsegna cannabinoidert.ex. anandamid och 2-AG

THC / kroppsegna cannabinoiderbinder till cannabisreceptorerCB1 - finns till stort antal i hjrnanCB2-ffa i immunsystemetinhibitoriska receptorer som leder till att nervcellens aktivitet dmpas

Frekomsten av cannabisreceptorer i hjrnan

Hjrnfunktionerrrelsekoordinationsynsensorikminne BelningmotivationOmdmeViljangest

VTANAcdopaminneuronGABAinterneuroncannabis och belningssystemetCB1

Hjrnans belningssystem-mesokortikolimbiska dopaminsystemet

VTANAcdopaminneuronGABAinterneuronXTHCcannabis och belningssystemetCB1

cannabis kar ven fristtningen av opioider i belningssystemet

UpplggKort introduktion till hjrnanBelningssystemetCannabis pverkan p hjrnan och belningssystemetCannabis som gatewaydrog

Kraftig utveckling av hjrnan sker under fosterstadiet och fortstter under tonrenCannabis r den mest anvnda drogen i vrt samhlle, speciellt bland ungaVad r konsekvenserna av cannabisbruk i unga r?

Risker med cannabisexponering under fosterstadiet-Kliniska studierFrsmrade kognitiva funktioner, t.ex. koncentrationssvrigheter, hos barn(Fried and Watkinson 1990, Fried and Smith 2001)

Foster som utsatts fr cannabis visar frndringar i hjrnomrden viktiga fr knsloreglering, t.ex. dopaminreceptor- och enkefalin-niver.(Wang et al 2003, Wang et al 2006 )

kad risk fr kognitiva strningar(Eherenreich et al 1999, Pope et al 2003)Risker med cannabisexponering under tonren-Kliniska studierkad risk fr utveckling av schizofreni, samt vrre frlopp(Arseneault et al 2002, Ferguson et al 2003, van Os et al 2002, Green et al 2004, Veen et al 2004)kad risk fr beroendeutveckling av andra droger(Yamaguchi and Kandel 1984, Ferguson and Horwood 2000, Lynskey et al 2003, Agrawal et al 2004)

De flesta som brjar anvnda cannabis r i tidiga tonren medan medelldern fr att brja anvnda amfetamin och heroin r runt 2020(NHSDA 2001)

Stds av flertalet epidemiologiska studier(t.ex.Yamaguchi and Kandel 1984, Ferguson and Horwood 2000, Lynskey et al 2003)OrsakerSamma underliggande faktorer? (t.ex. genetisk srbarhet, social status, drogtillgnglighet)Neurobiologiska frndringar?

Cannabis gateway-hypothesen- Cannabisanvndning i unga r kar risken fr att falla in ett missbruk av andra droger senare i livet

Orsakar cannabisbruk under perioder av aktiv hjrnutveckling frndringar i hjrnan s att den blir mer mottaglig fr beroendeframkallande effekter av andra droger?

Anvnde en rttmodell fr att titta nrmre p hur cannabisexponering under tonrsperioden pverkar hjrnans belningssystem och om det frndrar knsligheten fr heroinberoendeFrgestllning

cannabis och opiater

Opiater(heroin, morfin, endorfiner)Aktiverar opiatreceptorer i hjrnan (My, Delta och Kappa) inhibitoriska receptorer som minskar nervcellens aktivitet

knsla av eufori

Kroppsegna opioiderendorfinerenkefalin, beta-endorfin, dynorfin

Har en viktig funktion i regleringen av sinnesstmning(frndringar vid bl.a. depression och drogberoende)

Ex.Mss som saknar cannabisreceptorer sjlvadministrerar inte morfin, men dremot nikotin och kokain

Rttor och apor slutar att sjlvadministrera heroin om cannabisreceptorerna blockeras och vice versaStarka kopplingar funna i experimentella djurstudiercannabis och opiater

Cannabisexp.Cannabis under tonrsperioden-studiedesignNeurobiologiska studierHeroin sjlvadministreringPND 284957102THC (0 or 1.5 mg/kg) one injection every third dayCPP

Drog-sjlvadministrering

Rttor exponerade fr cannabis under tonrsperioden valde att ta mer heroin*** = p

conditioned place preference (CPP)koksaltmorfin (4 mg/kg)

Rttor som ftt cannabis under tonren var knsligare fr morfinets belnande effekter** = p

Neurobiologiska studierCannabisexponering under tonren pverkar kroppens endorfinsystem i hjrnomrden som reglerar motivation och vlbefinnande

Kroniska effekter!

Sammanfattning -Cannabisexponering under tonrsperioden Humanstudier kad risk fr kognitiva frsmringar, schizofreni och annat drogberoende (gateway-effekt)

Rttstudier, bl.a.kat heroinintag och endorfinrelaterade frndringar i belningssystemet hos vuxna rttor stder gateway hypotesen(Ellgren et al Neuropsychopharmacology 2006)

Cannabisexponering under fosterstadiet-studiedesignTHC (0 eller 0.15 mg/kg i.v.) till de drktiga honorna

Drog-sjlvadministrering

Vuxna rttor som ftt cannabis under fosterstadiet tog mer heroin vid lga doserDe r ocks snabbare p att ta frsta dosen * = p

De var ocks knsligare fr mild stresspverkanoch kade d sitt heroinintag* = p

Vuxna rttor som exponerats fr cannabis som foster skte mer efter heroin nr det inte lngre var tillgngligt* = p

Neurobiologiska studierCPCannabisexponering under fosterstadiet frndrar endorfinsystemet i hjrnomrden som reglerar motivation, vlbefinnande och stress.

Kroniska effekter!

HumanstudierFrndringar i belningssystemet hos foster och kognitiva frsmringar hos barn

Rttstudier, bl.a.Opioidrelaterade frndringar i belningssystemet hos vuxna rttor som ocks visar ett kat heroinintag, ffa under inverkan av stress(Spano et al Biological Psychiatry 2006)Sammanfattning -Cannabisexponering under fosterstadiet

Sammanfattning -Cannabis generelltI hjrnan finns det specifika cannabisreceptorer och kroppseget cannabis (anandamid och 2-AG)

Cannabis, liksom alla beroendeframkallande droger, kar dopaminaktiviteten i belningssystemet och ger drmed upphov till ett rus.

Cannabis sjlvadministreras av frsksdjur

Publikationer:Ellgren M., Spano M.S., Hurd Y.L. Adolescent cannabis exposure alters opiate intake and opioid limbic neuronal populations in adult rats. Neuropsychopharmacology 2007 Mar;32(3):607-15

Spano M.S., Ellgren M., Wang X., Hurd Y.L. Prenatal cannabis exposure increases heroin seeking with allostatic changes in limbic enkephalin systems in adulthood. Biological Psychiatry 2007 Feb 15;61(4):554-63

Professor Yasmin Hurd, Psychiatry and Pharmacology & Systems Therapeutics, Mount Sinai School of Medicine, New York, U.S.A.yasmin.hurd@mssm.edu

Studierna finansierades med anslag frn National Institute of Drug Abuse (NIDA), NIH, U.S.A.

Rttor exponerade fr cannabis under tonrsperioden visar ett kat uttryck av enkefalin mRNA i Nucleus Accumbens* = p

Hjrnans belningssystem-mesokortikolimbiska dopaminsystemet

Rttor exponerade fr cannabis under tonrsperioden visar en kad myOpioid-receptorfunktion i VTA* = p

VTANAcdopaminneuronGABAinterneuronXmorfinheroin och belningssystemetMOR

Cannabis under fosterstadiet kar uttrycket av enkefalin mRNA i nucleus accumbens och amygdala

******* = p

The latency to the first lever press at the initiation of a session was shorter in cannabis exposed off-springs.* = p

Paper II -Results Proenkephalin mRNA expressionExpression of pro-enkephalin mRNA was increased in the nucleus accumbens shell in adult rats exposed to cannabis during adolescence, even after 45 days of heroin self-administration.** = p

Paper II -Results OR functionDAMGO-stimulated [35S]GTPS was increased in the substantia nigra and the ventral tegmental area in adult rats exposed to cannabis during adolescence* = p)333.7263.0681.3507.4243.8282.2301.7119.794.8427.0333.7472.1375.6292.0107.2427.0301.9443.8350.2244.885.1367.1187.388.6234.7152.6117.8246.1

spec2302.1341.8307.2228.8233.6330.1319.4123.992.2422.9

stim1865.31011.6817.41023.41236.41274.8787.0685.5224.0222.51352.0882.0916.6747.2983.61172.21222.9672.0658.8212.9202.11330.5899.3865.41197.5665.4207.51330.5867.5837.11172.1618.2185.31270.7

stim2898.6821.7676.9943.81108.11171.0557.0632.1201.7181.81309.0

NS38.125.437.219.521.529.343.451.024.419.959.831.728.325.447.222.259.8

9veh-herspec1371.5374.2493.2305.9204.9240.190.5426.3407.6353.8519.2984.5350.3449.3217.8269.078.6445.5380.7751.8399.8243.478.6445.5326.3713.1348.2191.263.4404.4199.927.8184.2223.3129.8224.5

spec2443.7333.4545.2443.9394.8449.3230.7297.966.8464.7

stim11080.71135.91026.9924.21017.61122.0643.1670.0165.9142.31366.21047.41018.5975.3924.2960.31122.0643.1697.4179.5142.41353.61033.0949.71041.2670.3160.91353.6978.5911.0989.6618.0145.71312.6

stim21014.1901.1923.8903.1724.9193.1142.61341.0

NS59.449.531.546.055.248.049.654.911.419.041.154.438.751.652.215.241.1

11veh-herspec1274.0351.8322.8385.6266.3312.1307.1274.2140.8178.0415.7294.4363.1319.2374.2253.4296.4307.1274.2140.8178.0399.4328.8346.7274.9290.6159.4399.4297.0318.4249.5243.4137.3339.6165.7145.8184.678.647.0192.1

spec2314.9374.5315.6362.9240.5280.6383.2

stim1820.9810.8735.3461.9502.0214.1233.91051.9820.9810.8735.3481.9224.01051.9789.2782.5709.9434.7201.8992.1

stim2820.9679.3810.8569.1735.3579.6461.9502.0214.1233.91051.9

NS38.125.437.219.521.529.343.451.024.419.959.831.728.325.447.222.259.8

14veh-herspec1324.3368.2292.5373.9382.4347.3300.2283.3161.7158.0557.4316.6357.1288.9374.1347.6346.7315.0324.5161.7160.9562.5336.8331.5347.2319.7161.3562.5293.3280.7311.4291.5143.2545.7176.9178.3282.594.5118.2153.3

spec2308.9345.9285.3374.3312.8346.2329.8365.7163.7567.7

stim1856.1952.3817.5920.41248.61147.3559.7705.31481.1792.3919.1809.9854.21264.31189.0584.3606.0353.0308.01399.4855.7832.11226.6595.1330.51399.4812.1781.31190.8566.9312.41382.5

stim2728.4885.9802.2788.01280.01230.7608.9506.6353.0308.01317.7

NS34.053.234.167.418.553.123.832.710.026.216.843.650.835.828.318.116.8

16veh-herspec1358.2357.5504.3465.9346.9270.5290.9127.5141.7491.7345.2361.4494.9447.1348.2338.8270.5285.1120.3118.4470.8353.3471.0343.5277.8119.4470.8303.9436.5317.1221.689.8420.7185.8104.0198.2117.2126.0163.9

spec2332.2365.4485.5428.2349.5338.8279.3113.195.2449.8

stim1934.61096.8850.11048.5990.4502.8190.51108.8870.6965.7872.3977.8955.2988.9545.0530.3197.2267.81160.4918.1925.1972.0537.6232.51160.4868.7890.6945.7481.4203.01110.4

stim2806.5834.6894.6907.1920.0988.9545.0557.8203.9267.81212.1

NS26.472.424.844.19.143.749.163.326.932.150.149.434.526.456.229.550.1

5THC-herspec1303.7352.3387.4479.2382.2467.5328.4120.8107.2547.8315.1384.2411.9481.9420.1460.6280.1263.2139.3114.5500.6349.6446.9440.3271.6126.9500.6310.1428.9426.2223.5110.0491.3145.676.6103.5202.4213.3144.4

spec2326.5416.0436.5484.5458.0453.7231.8263.2157.8121.7453.4

stim1774.9833.5800.9782.8825.6668.5791.8810.7768.3782.8937.9824.5724.2339.3383.61210.2801.2775.5881.2724.2361.51210.2761.7757.6867.0676.1344.61200.9

stim2808.7787.8735.6937.9823.4779.8339.3383.61210.2

NS42.636.522.113.916.911.540.655.629.54.39.339.518.014.248.116.99.3

7THC-herspec1264.3293.3352.5240.0298.6324.6325.585.9108.6546.7275.9346.5352.5273.2298.6306.5324.797.1114.3513.9275.9349.5285.9315.6105.7513.9250.8312.2270.7288.193.9484.1308.0184.6287.6116.8107.6162.6

spec2287.5399.6306.4288.4323.8108.2120.0481.2

stim11097.4999.2940.01143.9657.0647.0152.7260.81301.01097.4999.2878.3973.31086.21043.0657.0647.0152.7260.81301.01048.3925.81064.6652.0206.71301.01023.2888.61049.5624.5195.01271.2

stim2816.7973.31028.51043.0

NS33.017.233.640.913.317.016.538.610.912.629.925.137.215.227.511.829.9

10THC-herspec1258.8259.7318.0353.9186.4181.9333.0317.2104.1100.5482.7258.8255.6318.0357.0184.3181.9333.0320.5100.7108.6474.5257.2337.5183.1326.8104.6474.5219.9323.9177.1279.392.7412.8173.4124.0388.8109.368.7148.0

spec2251.5360.1182.2323.897.2116.7466.2

stim1739.1928.6869.0656.0608.2199.7136.91085.3638.3739.1874.2869.0656.0608.2199.7136.91085.3638.3739.1871.6632.1168.31085.3601.0725.5865.6584.6156.41023.6

stim2638.3819.9

NS30.044.715.112.211.30.847.048.09.214.761.737.313.66.047.512.061.7

15THC-herspec1301.3374.6411.6321.1310.1327.2133.4464.9301.2376.5392.8316.5310.1205.3300.9133.9491.0301.2384.7313.3253.1133.9491.0246.4361.0282.5204.1103.6447.6265.6204.4227.2215.549.1194.2

spec2301.2378.4374.1311.8205.3274.6134.5517.0

stim1953.4985.91039.2891.6697.0181.9175.51415.7935.2976.21129.11115.71039.2870.9687.2698.4181.9187.71360.4955.71122.4955.1692.8184.81360.4900.91098.7924.2643.8154.51317.1

stim2917.1966.41129.11115.7850.2687.2699.9200.01305.2

NS51.158.631.416.034.627.038.059.930.430.243.354.823.730.849.030.343.3

23vehspec1255.8311.7358.3255.2223.9189.4209.580.4485.2300.0332.0361.9286.3223.9197.4218.8131.397.2498.8300.0347.0255.1208.1114.3498.8300.0347.0255.1208.1114.3450.0152.1113.0324.585.318.3178.8

spec2344.3345.7332.0365.5317.4205.5228.2131.3114.1512.4

stim1693.4675.5937.3352.5377.2127.01329.2760.6752.2743.0735.11082.81082.7394.2377.2135.21303.3756.4739.11082.8385.7135.21303.3756.4739.11082.8385.7135.21254.5

stim2760.6810.9810.6735.11228.41082.7435.9143.41277.3

NS29.235.410.931.16.94.262.760.628.438.548.848.8

25vehspec1

spec2

stim1

stim2

NS47.447.138.549.522.927.541.649.419.919.847.647.344.025.241.634.747.6

27vehspec1254.9296.6275.1212.0282.0133.8512.2273.5343.1275.1241.8282.0140.8469.6273.5343.1275.1261.9140.8469.6245.4323.3259.1215.385.4422.0244.9151.7304.0136.271.8179.8

spec2292.1389.6271.7147.7427.0

stim1920.3821.4837.01087.5954.7513.0497.0189.5196.41207.9900.8848.6856.5810.81136.6989.0570.5539.9189.5214.81228.4874.7833.61062.8555.2202.11228.4846.6813.91046.8508.6146.81180.8

stim2881.3875.7875.9810.81185.61023.3628.0582.8233.11248.9

NS18.237.914.824.69.122.846.669.241.530.647.628.119.716.046.655.347.6

29vehspec1248.9240.277.9305.4226.8213.1214.7184.8228.7236.986.4274.8226.8213.9206.7236.986.4274.8185.4179.8170.2205.769.5253.6374.6339.4419.681.4105.9352.7

spec2226.8213.1214.7184.8228.7233.694.8244.1

stim1885.3760.1721.9821.8783.4369.8153.21145.1959.6883.1811.1837.3925.6915.8404.3160.01169.1921.3824.2920.7404.3160.01169.1880.0790.1884.1373.2143.21147.9

stim21033.9883.1862.1952.61029.31048.2438.9166.91193.1

NS41.341.430.837.338.434.831.216.821.241.334.136.631.216.821.2

33vehspec1232.1230.0186.9188.6207.4244.1186.9185.4207.4244.1186.2162.8203.8150.1358.7218.8548.7

spec2207.4177.3258.1182.3

stim1855.0954.6837.8745.1706.7673.51011.51007.9791.5690.11009.7746.9649.8973.7

stim2820.6745.1706.7673.51011.51061.3

NS45.244.041.239.336.435.844.640.336.1

35vehspec1236.6253.5204.5157.4171.1245.5293.191.6133.7493.6236.6204.5240.3194.2170.6219.8246.6115.5487.8236.6222.4182.4233.2115.5487.8215.8189.0154.7192.977.3446.6339.6343.4592.1143.970.3179.6

spec2237.7240.3231.1170.1194.0200.1116.397.2482.0

stim1876.4913.2862.11116.8504.5577.0143.7231.21342.21024.4914.1880.9862.11080.41116.8506.9514.7145.7193.91289.9969.3871.51098.6510.8169.81289.9948.5838.21071.0470.5131.61248.7

stim21024.4951.9848.61080.4509.4452.4147.7156.51237.5

NS20.421.221.545.216.039.440.358.018.227.141.220.833.327.740.338.141.2

28THCspec1191.5136.5158.1168.4147.2184.3105.0104.7410.7191.5158.1168.4147.2184.3104.7410.7191.5163.3147.2184.3104.7410.7164.6144.3134.2130.077.3358.6297.4303.5400.8308.2145.5278.1

spec2

stim1667.4676.7636.9679.8621.7596.7180.8201.31453.9690.1672.3638.7564.0710.3659.7584.9208.9225.61408.1681.2601.3685.0584.9217.21408.1654.3582.4672.0530.6189.81356.0

stim2690.1677.2600.7491.0740.8697.6573.1237.0249.91362.3

NS16.337.59.628.312.313.654.341.613.26.952.126.918.913.054.327.452.1

30THCspec1225.1147.4335.0365.2235.0200.2235.0129.0101.8470.6225.1335.0365.2235.0200.2235.0101.8470.6225.1350.1235.0217.6101.8470.6194.2315.6222.3172.964.2444.9332.4164.3328.8182.4149.0218.9

spec2

stim1913.3965.5827.71019.8522.3532.9187.9205.81463.3870.6909.6827.7966.0532.8532.9188.9205.81444.5870.6868.7966.0532.8197.41444.5839.6834.2953.4488.1159.71418.9

stim2827.8853.7912.2543.2190.0205.91425.7

NS30.131.744.524.515.210.144.742.532.819.925.730.934.512.644.737.725.7

32THCspec1244.5229.3257.0167.5173.6181.9188.172.0127.4365.3244.5229.3257.0167.5173.6181.9188.1127.4365.3244.5243.1170.5185.0127.4365.3213.9218.6147.2138.486.1298.2288.5281.2486.9291.8120.6318.7

spec2

stim1745.0872.4783.4871.7623.6259.5286.31319.0829.6893.8866.1849.5870.9903.9588.8218.6243.81315.6861.7857.8887.4588.8231.21315.6831.1833.3864.1542.2189.91248.5

stim2914.1893.8859.8915.7870.1903.9554.0177.6201.31312.3

NS32.828.432.316.824.222.446.652.929.724.067.130.624.623.346.641.367.1

34THCspec1304.9395.0301.2192.8228.4397.8304.9395.0326.7297.6249.0192.8198.868.2404.0304.9360.9273.3195.868.2404.0258.3314.3244.9150.730.0334.2205.3135.4236.8160.2243.7276.1

spec2273.7326.7294.1249.0169.170.868.2410.3

stim1943.2796.3773.5736.6824.2432.8433.31347.0850.4819.8773.5799.6824.2882.2437.2437.3158.6124.11326.5835.1786.5853.2437.2141.41326.5788.5740.0824.8392.1103.11256.6

stim2757.6843.2862.6882.2441.6441.3158.6124.11306.0

NS52.940.346.646.628.428.445.146.629.935.569.946.646.628.445.138.269.9

36THCspec1238.8261.3218.8222.791.3348.1238.8240.5261.3218.8237.791.982.4348.1238.8250.9228.287.1252.4192.7237.5181.463.5193.4313.3187.5177.1104.3

spec2348.1240.5252.791.973.5

stim1899.6892.6877.0854.3716.4695.1645.5544.8173.1855.4817.4830.4854.3716.4676.1554.5544.8173.9132.9836.4842.3696.2549.7153.4740.8796.2682.9502.9129.8

stim2811.2742.1783.7657.2463.5174.7132.9

NS95.695.640.651.621.75.044.848.822.524.795.646.113.446.823.6

38THCspec1243.9157.6230.4231.2168.6181.599.8114.2510.4224.4146.9231.4189.9231.2168.6181.9113.9494.0224.4189.2210.6175.3113.9494.0184.4145.9180.1130.593.1414.4274.6325.6350.1192.0116.3205.8

spec2204.9136.3232.4189.9182.4113.6477.5

stim1745.1672.8655.5800.0946.4430.4421.2224.4193.51346.7716.5745.1672.8655.5735.6946.4430.4421.2241.3203.01346.7730.8664.1841.0425.8222.11346.7690.8620.8810.5381.0201.31267.1

stim2716.5671.1258.2212.4

NS43.336.743.328.332.745.244.425.616.079.640.043.330.544.820.879.6

THC-her

RattreatmentslideDS RDS LNACc RNACc LNACs RNACs LSN RSN LVTA RVTA LIP%diff L-R DS%diff L-R NACc%diff L-R NACs%diff L-R SN%diff L-R VTA%diff 1-2 DS R%diff 1-2 DS L%diff 1-2 NACc R%diff 1-2 NACc L%diff 1-2 NACs R%diff 1-2 NACs L%diff 1-2 SN R%diff 1-2 SN L%diff 1-2 VTA R%diff 1-2 VTA L%diff 1-2 IP

8veh-herspec1463.1810.0408.31019.9312.9496.0519.6630.0256.2216.0956.0-74.9-149.8-58.5-21.215.7-14.417.3-85.733.2-12.517.6-40.9-12.4-7.25.41.9

spec2529.6669.9758.0681.3351.9408.7731.9708.2274.7204.4937.7-26.510.1-16.13.225.6

stim11918.92243.31812.82269.62741.82827.01745.31520.3496.8493.42998.2-16.9-25.2-3.112.90.7-3.818.817.27.810.48.129.27.810.018.33.2

stim21992.81822.21501.12093.02457.42596.81235.21401.8447.3403.22902.98.6-39.4-5.7-13.59.9

NS

9veh-herspec1823.9829.81093.8698.1678.4510.4454.4532.4122.2200.7945.5-0.736.224.8-17.2-64.2-19.410.9-10.5-41.0-29.0-95.2-12.6-24.1-19.526.2-9.0

spec2984.0739.31209.0984.5875.5996.4511.7660.6146.1148.11030.424.918.6-13.8-29.1-1.3

stim12396.62519.12277.22049.52256.62488.21426.11485.9367.9315.53029.8-5.110.0-10.3-4.214.26.220.710.027.411.225.4-26.2-8.2-16.4-0.21.8

stim22248.91998.42048.71487.52002.81855.41799.31607.5428.2316.12973.911.127.47.410.726.2

NS131.7109.769.8102.0122.4106.4109.9121.825.442.291.1-46.313.10.0

11veh-herspec1607.5780.1715.9855.1590.5692.1681.0608.0312.3394.8921.8-28.4-19.4-17.210.7-26.4-15.0-6.52.25.99.710.130.829.017.634.37.8

spec2698.4830.6699.8804.7533.4622.4471.0431.9257.5259.3849.8-18.9-15.0-16.78.3-0.7

stim11384.91362.11302.81126.31237.11180.61005.1466.8413.4318.21880.41.613.54.653.623.0-31.5-10.6-38.0-12.1-31.8-8.9-1.9-138.5-14.9-63.0-24.1

stim21820.61506.51798.11262.11630.71285.41024.31113.2474.8518.62332.817.329.821.2-8.7-9.2

NS84.556.382.543.147.765.196.2113.154.244.1132.7-36.50.052.1

14veh-herspec1719.2816.6648.6829.3848.0770.1665.7628.4358.6350.51236.2-13.5-27.89.25.62.34.76.12.5-0.118.20.3-9.9-29.1-37.6-3.6-1.8

spec2685.1767.2632.7830.0693.8767.7731.3811.0493.5362.91258.9-12.0-31.2-10.7-10.926.5

stim11898.62112.01813.02041.22769.02544.31241.11564.1853.6964.63284.5-11.2-12.68.1-26.0-13.014.97.01.914.4-2.5-7.3-8.828.28.329.211.0

stim21615.41964.51779.11747.62838.52729.21350.31123.6782.9683.02922.1-21.61.83.916.812.8

NS75.4118.075.7149.541.0117.852.772.622.158.137.30.069.6

16veh-herspec1794.4792.81118.31033.3769.4949.2600.0645.2282.8314.11090.50.27.6-23.4-7.5-11.17.3-2.23.78.1-0.720.941.74.011.432.88.5

spec2736.8810.31076.6949.5775.1751.3349.8619.4250.7211.1997.6-10.011.83.1-77.115.8

stim12072.62432.21885.22325.22196.52644.1942.61115.0422.4370.62458.9-17.4-23.3-20.4-18.312.313.723.9-5.213.57.117.1-28.2-10.9-7.1-60.2-9.3

stim21788.61850.81983.92011.72040.22193.01208.51237.0452.2593.82688.0-3.5-1.4-7.5-2.4-31.3

NS58.7160.655.097.920.296.8109.0140.559.771.2111.0-77.90.0

5THC-herspec1673.6781.2859.11062.7847.71036.8822.1995.9361.5331.51308.6-16.0-23.7-22.3-21.18.3-7.5-18.1-12.7-1.1-19.83.037.541.43.218.623.2

spec2724.0922.6968.01074.51015.61006.1514.1583.6349.9269.91005.5-27.4-11.00.9-13.522.8

stim11718.51848.51776.01736.02214.81831.01482.51043.7469.6712.02183.2-7.62.317.329.6-51.6-4.45.58.18.26.10.3-16.6-20.9-60.2-19.5-22.9

stim21793.51747.01631.41593.92080.01826.11729.31261.9752.4850.82683.92.62.312.227.0-13.1

NS94.480.948.930.837.525.490.1123.365.49.520.737.132.20.0

7THC-herspec1586.2490.9650.5781.7532.2662.1719.8721.9190.6240.71212.416.3-20.2-24.4-0.3-26.3-8.8-61.2-36.2-55.6-27.7-36.911.20.5-25.9-10.612.0

spec2637.6791.3886.11216.1679.6906.6639.5718.1240.0266.21067.1-24.1-37.2-33.4-12.3-10.9

stim12433.72216.02084.62902.02536.82944.51457.01434.7338.6578.32885.28.9-39.2-16.11.5-70.822.022.213.125.610.121.43.822.49.450.315.2

stim21898.71723.41811.12158.52280.92313.01401.61113.1306.8287.52445.79.2-19.2-1.420.66.3

NS73.238.274.590.729.537.836.585.524.228.066.2-21.8-28.271.7

10THC-herspec1573.9576.0705.3784.8413.4403.5738.5703.5230.9222.91070.5-0.4-11.32.44.73.533.53.219.3-1.82.3-24.434.1-2.16.6-16.23.4

spec2381.7557.8568.9798.6404.0501.8486.8718.1215.6258.91033.9-46.1-40.4-24.2-47.5-20.1

stim11087.81371.41339.31639.12059.21927.21454.81348.8442.9303.72406.7-26.1-22.46.47.331.43.7-3.222.65.811.711.649.330.133.121.326.6

stim21048.11415.61036.71543.61818.31703.4737.9943.5296.1239.01766.6-35.1-48.96.3-27.919.3

NS66.699.033.526.925.11.7104.2106.420.332.7136.819.6

15THC-herspec1668.1901.2830.8912.7712.2687.8407.6725.5180.0295.81031.0-34.9-9.93.4-78.0-64.30.0-2.5-1.09.12.915.1-11.716.145.5-0.8-11.2

spec2668.0923.9839.2829.6691.5583.8455.2609.198.1298.31146.5-38.31.115.6-33.8-203.9

stim12114.32186.43136.32743.22304.71977.21143.41545.6403.3389.13139.5-3.412.514.2-35.23.53.82.020.29.822.74.6-33.3-0.433.0-14.07.8

stim22033.82143.22504.02474.21781.81885.41524.01552.1270.1443.52894.4-5.41.2-5.8-1.8-64.2

NS113.3129.969.635.576.859.984.3132.967.467.196.10.049.3

23vehspec1567.2691.2877.5794.6565.9496.6419.9464.5314.8178.31076.0-21.99.412.2-10.643.4-34.6-10.916.1-2.0-32.6-75.0-8.5-8.97.5-41.9-5.6

spec2763.5766.6736.3810.5750.4869.0455.7506.0291.3253.01136.4-0.4-10.1-15.8-11.013.1

stim11434.31537.71498.01126.62078.51869.8781.6836.5281.6234.92947.7-7.224.810.0-7.016.6-17.6-16.9-20.0-44.7-31.1-28.4-23.76.9-12.99.83.9

stim21686.71798.31797.61630.22724.22401.1966.8778.6318.0211.82832.7-6.69.311.919.533.4

NS88.293.772.7102.037.140.7122.996.172.665.691.3-6.2-40.3-9.821.89.7

25vehspec1792.2526.01091.7543.2727.9477.4463.6372.3310.5238.91416.333.650.234.419.723.134.60.865.7-5.793.761.116.9-32.434.90.65.8

spec2517.8521.9375.0573.945.9185.9385.1493.0202.1237.51333.5-0.8-53.0-304.8-28.0-17.5

stim12265.41698.12653.62202.32840.32521.1733.4885.8390.8464.32450.725.017.011.2-20.8-18.855.932.067.756.563.266.7-35.66.34.410.419.6

stim2998.21153.9857.7959.11045.9838.6994.6829.6373.8416.01971.3-15.6-11.819.816.6-11.3

NS67.370.059.947.844.739.157.460.627.111.387.6-4.020.112.5-5.558.2

27vehspec1771.6535.9863.9505.9736.3363.2470.0625.3176.6296.81135.930.541.450.7-33.0-68.016.085.30.086.16.688.1-28.235.4-124.5-10.316.6

spec2647.779.0863.970.4687.843.4602.6403.8396.5327.5947.087.891.993.733.017.4

stim12040.81821.61856.21448.92411.72117.11137.61102.1420.2435.52678.710.721.912.23.1-3.64.2-6.6-4.6-24.1-9.0-7.2-22.4-17.363.0-18.7-3.4

stim21954.31942.11942.51798.12629.32269.21392.71292.5155.5517.02769.60.67.413.77.2-232.4

NS0.00.00.00.00.00.072.6130.560.444.955.1-79.825.7

29vehspec11088.6551.91246.9802.3893.5951.3532.7172.7677.349.335.7-6.553.843.862.140.754.146.72.80.0-21.80.020.1

spec2502.9310.4472.5476.1409.8507.2518.0210.3541.438.3-0.8-23.8

stim11963.21565.51685.51600.91822.61737.2820.1339.72539.520.35.04.7-16.8-25.1-13.4-32.0-25.2-33.8-18.70.0-8.90.0-4.2

stim22292.91958.31911.92112.62282.72324.6973.3370.12645.814.6-10.5-1.8

NS0.014.90.00.014.80.058.981.149.542.074.9100.0-37.815.2

33vehspec1767.1514.7451.6510.1338.5374.9438.5479.8310.4416.732.9-12.9-10.8-9.4-34.340.023.6-56.6-12.2-88.66.212.53.5-16.6-27.10.0

spec2460.0393.3707.2572.5638.5351.7383.6462.9361.8529.814.519.144.9-20.7-46.4

stim11896.01612.81360.51336.31811.02116.91209.71481.0414.4914.014.91.8-16.9-22.4-120.54.0-2.5-15.2-11.8-23.9-11.218.810.3-65.6-11.20.0

stim21819.91652.41567.21493.62243.22353.6982.11328.1686.31016.19.24.7-4.9-35.2-48.1

NS9.30.09.42.40.02.254.653.348.40.0100.075.02.3100.0

35vehspec1524.6562.3369.3370.7325.3381.3544.5650.0203.1296.51094.7-7.2-0.4-17.2-19.4-46.0-82.36.2-86.0-43.7-22.220.121.031.7-26.927.32.3

spec2956.2527.2686.7532.9397.7304.8430.3443.7257.8215.51069.044.922.423.4-3.116.4

stim12470.01943.62025.21911.92720.32476.81118.71279.6318.6512.72976.621.35.69.0-14.4-60.98.0-8.67.147.011.926.0-1.021.6-2.832.37.8

stim22271.82110.91881.91013.82396.01831.71129.71003.2327.6347.12744.47.146.123.611.2-6.0

NS2.78.623.058.68.368.50.08.60.00.00.0-223.4-154.3-723.7

28THCspec1424.8302.6350.7373.5205.5326.3355.2408.7232.9232.3910.928.8-6.5-58.8-15.10.3100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

spec2

stim11943.11480.01314.41328.31507.71378.71323.31066.3400.9446.43224.323.8-1.18.619.4-11.321.2-1.5-1.418.0-9.0-12.23.9-41.6-31.1-24.16.3

stim21530.51501.91332.21088.91642.81547.11271.01509.9525.6554.13021.01.918.35.8-18.8-5.4

NS0.048.00.09.90.00.063.745.10.00.057.129.1

30THCspec1638.2465.8919.41070.0765.31093.7444.0521.1286.2225.81043.527.0-16.4-42.9-17.421.1100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

spec2

stim12025.41429.52141.21835.72261.72464.51158.41181.7416.6456.33245.129.414.3-9.0-2.0-9.59.414.811.627.010.630.9-4.023.5-1.1-0.12.6

stim21835.81218.21893.21339.52022.91703.21204.7903.9421.4456.63161.833.629.215.825.0-8.4

NS0.00.01.30.00.00.0117.0106.240.348.7125.0100.09.3-21.0

32THCspec1198.7542.3508.4570.0286.1236.7403.4417.2159.6282.5810.2-172.9-12.117.3-3.4-77.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

spec2

stim11652.11403.71934.71737.31933.12160.31013.21383.0575.4635.02925.115.010.2-11.8-36.5-10.4-22.7-41.21.4-16.90.27.230.911.231.529.70.5

stim22027.21982.21906.82030.61929.72004.4700.51228.5394.0446.32910.12.2-6.5-3.9-75.4-13.3

NS0.016.025.411.60.00.80.017.20.00.00.054.3

34THCspec1676.1927.0875.9968.5667.9955.5427.5506.574.6139.0882.3-37.1-10.6-43.1-18.5-86.234.334.527.125.22.442.219.325.9-110.3-8.8-3.1

spec2444.1607.0638.6724.6652.2552.1344.8375.1157.0151.3909.8-36.7-13.515.3-8.83.6

stim12091.61765.91715.31633.51827.81428.3959.7960.9266.2266.42987.215.64.821.9-0.1-0.119.7-5.924.9-17.1-32.1-37.0-2.0-1.8-32.1-3.33.0

stim21680.11869.91288.51912.92415.01956.4979.3978.6351.7275.22896.3-11.3-48.519.00.121.7

NS55.714.382.819.331.325.282.857.926.225.788.174.476.719.630.11.8

36THCspec1496.9957.5529.51031.8311.7579.4485.2493.9118.2202.4-92.7-94.9-85.9-1.8-71.2-55.3-5.0-90.4-15.1-71.1-7.2-53.6-13.5-72.319.50.0

spec2771.91004.91008.11187.6533.3621.3745.3560.5203.8163.0-30.2-17.8-16.524.820.0

stim11995.01979.41945.01894.61588.61541.41431.61208.2383.8279.20.82.63.015.627.39.816.910.619.115.15.528.219.2-1.0-5.50.0

stim21798.91645.81738.01532.91348.11457.31028.0976.1387.5294.68.511.8-8.15.024.0

NS212.1212.190.1114.40.011.113.20.00.00.00.0-26.9100.0

38THCspec1540.9651.3349.5510.990.6349.5374.0402.4221.3253.21131.9-20.4-46.2-285.7-7.6-14.416.030.913.5-0.9-272.8-50.34.3-0.520.90.56.4

spec2454.3450.0302.3515.5337.8525.3358.0404.4175.2251.91059.00.9-70.5-55.5-13.0-43.8

stim11462.21541.31380.91342.61663.11987.6954.5934.1497.6429.22986.6-5.42.8-19.52.113.7-8.714.229.331.310.540.010.721.0-15.1-9.712.5

stim21589.01322.6976.1921.91488.21191.8852.3738.4572.6471.02612.916.85.619.913.417.8

NS74.066.183.1118.637.348.8135.4127.444.546.2183.610.7-42.7-30.75.9-3.9

veh

RATGroupRegionAreaMeanMinMaxDpm-BGCi/mg-BG

8veh-pretreatedSpecific1DS R113498.26601341357.0463.1611.8927326242208.8

DS L1209113.14761501703.9810.0768.3343777917365.3

NACc R13795.72591161302.1408.3587.1728582687184.1

NACc L128121.22991441913.81019.9862.9699991768459.9

NACs R57191.17501231206.8312.9x544.160938031141.1

NACs L636102.77651381457.3563.4657.1244403992254.1

BG rost3775.035792893.9403.0688285455

SN R42689.04571191163.3519.6524.556199535234.3

SN L33094.38591311273.7630.0574.3401429308284.1

VTA R8175.3648102899.9256.2405.7953152359115.5

VTA L7873.155393859.7216.0387.648180288797.4

IP158108.88791501599.7956.0721.3562242287431.1

BG dors860.755271643.7290.2502217499

Specific2DS R116599.56601321385.5529.6624.7509610189238.8

DS L1318105.75701421525.8669.9688.0085069407302.1

NACc R150109.47771321613.9758.0727.7507328795341.8

NACc L199106.24861271537.2681.3693.1663264645307.2

NACs R40698.55691311363.3507.4614.7487999933228.8

NACs L59399.03671351373.8517.9619.4915651017233.6

BG rost3172.946088855.9385.9373075224

SN R23397.31641231336.3731.9602.5854988696330.1

SN L22096.21641311312.6708.2591.9009430537319.4

VTA R8674.225592879.1274.7396.401627633123.9

VTA L11170.314787808.8204.4364.702537447392.2

IP143106.45761461542.1937.7695.3838493079422.9

BG dors2058.44476604.4272.5322650794

Stim1DS R1339152.751052162937.71918.91324.6892809815865.3

DS L1675160.591162153262.02243.31470.94419224351011.6

NACc R268149.991201932831.51812.81276.8060585327817.4

NACc L336161.191252053288.42269.61482.81621745411023.4

NACs R469171.131232063760.62741.81695.75446107841236.4

NACs L625172.771112113845.72827.01734.14586482561274.8

BG rost2381.767931018.8459.3836435985

SN R302146.45971762700.81745.31217.8634954483787.0

SN L322139.96961732475.81520.31116.3945380029685.5

VTA R71102.55701341452.3496.8654.8766469692224.0

VTA L84102.4671271448.9493.4653.3465524422222.5

IP179174.79922273953.72998.21782.85393888561352.0

BG dors1178.367085955.5430.8604735028

Stim2DS R1303149.061062092796.61992.81261.0591690899898.6

DS L1632144.351072042626.01822.21184.1338588284821.7

NACc R306134.67831712304.91501.11039.3645231645676.9

NACc L238151.71081922896.82093.01306.2660667556943.8

NACs R444160.571011883261.22457.41470.55022288821108.1

NACs L528163.691151953400.62596.81533.41368632981171.0

BG rost4070.035291803.8362.4622785364

SN R301124.71841492009.91235.2906.3119109858557.0

SN L287130.47861572176.51401.8981.4664554313632.1

VTA R9591.91641131222.0447.3551.0493851469201.7

VTA L8089.76671111177.9403.2531.1466181829181.8

IP130169.491222143677.62902.91658.35075437451309.0

BG dors1368.384687774.7349.338195909

9veh-pretreatedNSDS R133840.431969315.9131.7142.425745696459.4

DS L118439.031769293.9109.7132.531619232249.5

NACc R32236.482451254.069.8114.51549452331.5

NACc L32238.541756286.2102.0129.070224392446.0

NACs R43439.842163306.6122.4138.254963290155.2

NACs L40738.821760290.6106.4131.048115231648.0

BG rost5732.052048184.283.0552606062

SN R41139.882360307.2109.9138.537667705149.6

SN L43840.642061319.1121.8143.91078364954.9

VTA R11034.492149222.725.4100.426911945611.4

VTA L10035.561754239.542.2108.007815424419.0

IP21238.681559288.491.1130.059157192841.1

BG dors2432.882351197.388.9814672784

Specific1DS R1225107.22691451560.2823.9703.5511611608371.5

DS L1156107.47671371566.1829.8706.2152740492374.2

NACc R227118.08901421830.21093.8825.2841802229493.2

NACc L249101.76691261434.5698.1646.8407163962314.8

NACs R411100.88671371414.8678.4637.9543151697305.9

NACs L42593.1591201246.8510.4562.2124915308230.2

BG rost5166.185379736.3332.039170113

SN R43886.18481171106.0454.4498.7353319865204.9

SN L36990.06461261184.0532.4533.9035659742240.1

VTA R10468.334988773.8122.2348.942533571555.1

VTA L13772.745298852.3200.7384.310047034890.5

IP207108.77781481597.1945.5720.1679029743426.3

BG dors2361.224576651.6293.8192364235

Specific2DS R1303110.58671441640.8984.0739.8770748378443.7

DS L1147100.04701331396.1739.3629.5348278204333.4

NACc R294119.43951411865.81209.0841.3395824588545.2

NACc L204110.6831311641.3984.5740.0967289732443.9

NACs R316106.03731361532.3875.5690.9530278235394.8

NACs L305111.09871321653.2996.4745.4912225777449.3

BG rost3461.534781656.8296.1780475605

SN R49890.86581261200.4511.7541.287229083230.7

SN L37197.91571311349.3660.6608.4550760889297.9

VTA R9771.775091834.8146.1376.447200823765.9

VTA L9871.884990836.8148.1377.336433836766.8

IP146113.75771441719.21030.4775.2187271642464.7

BG dors2263.415076688.7310.566513693

Stim1DS R1446160.79862163270.82396.61474.8901283621080.7

DS L1383163.531012233393.32519.11530.11953443731135.9

NACc R290158.011291893151.42277.21421.0391683781026.9

NACc L191152.391101882923.62049.51318.3436374611924.2

NACs R421157.521232003130.82256.61411.7650592111017.6

NACs L556162.851162173362.42488.21516.20582493081122.0

BG rost3873.955292874.2394.1870744075

SN R347131.43891552205.41426.1994.4599173491643.1

SN L266133.39921612265.21485.91021.4268332981670.0

VTA R5088.24701031147.1367.9517.276519677165.9

VTA L6485.61641071094.8315.5493.655853171142.3

IP128172.071032223809.13029.81717.63578129351366.2

BG dors2268.645298779.3351.3975518055

Stim2DS R1351160.711102043267.32248.91473.3103904021014.1

DS L1362154.741162113016.71998.41360.3272011674901.1

NACc R341155.981041933067.12048.71383.0269518682923.8

NACc L385140.861041762505.91487.51129.9879733172670.8

NACs R473154.851211933021.22002.81362.3253405934903.1

NACs L436151.11151982873.71855.41295.8534506597836.6

BG rost3881.68691061018.4459.2108319424

SN R387139.02791792444.61799.31102.3529599723811.3

SN L368132.99531642252.91607.51015.8747727478724.9

VTA R13884.53621151073.5428.2484.0906877904193.1

VTA L9978.6858105961.5316.1433.5644637671142.6

IP154168.311192183619.32973.91632.02654559611341.0

BG dors2660.853888645.4291.0088597997

11veh-pretreatedNSDS R110939.991857309.084.5139.315146738938.1

DS L103138.192157280.756.3126.597942597325.4

NACc R26439.862454306.982.5138.396314507337.2

NACc L29837.352262267.643.1120.663987035919.5

NACs R45837.642368272.147.7122.712776845721.5

NACs L39738.751863289.565.1130.553632492629.3

BG rost6534.62753224.4101.20702857

SN R37036.141156248.696.2112.111352628743.4

SN L28637.222259265.6113.1119.745475567851.0

VTA R13333.472149206.654.293.182420040224.4

VTA L12632.831650196.544.188.625040495819.9

IP25338.471655285.1132.7128.575764611159.8

BG dors3130.061742152.468.741112469

Specific1DS R1222106.15761421535.1607.5692.2172535678274.0

DS L1148113.29811441707.6780.1770.0234970633351.8

NACc R307110.69801401643.5715.9741.0856850709322.8

NACc L450116.25771471782.7855.1803.8638435054385.6

NACs R386105.42841281518.1590.5684.5477338897266.3

NACs L531109.71741401619.7692.1730.3619703144312.1

BG rost3776.866288927.6418.2643223312

SN R507102.18591301443.9681.0651.1060559908307.1

SN L41198.9651241371.0608.0618.2051532544274.2

VTA R5884.62641061075.3312.3484.8848571485140.8

VTA L6588.77681171157.8394.8522.0942761453178.0

IP123112.37801411684.8921.8759.7017847157415.7

BG dors1767.715982763.0344.0461046155

Specific2DS R1193108.82821341598.3698.4720.7078985948314.9

DS L1074114.2831451730.5830.6780.3234359555374.5

NACc R411108.88641341599.7699.8721.3562242287315.6

NACc L543113.17841421704.6804.7768.6720064899362.9

NACs R468101.71741271433.3533.4646.3339802973240.5

NACs L478105.6731301522.3622.4686.4341499075280.6

BG rost4475.365892899.9405.7953152359

SN R29589.47601161172.0471.0528.4877013458212.4

SN L27687.53561101132.9431.9510.8532223619194.7

VTA R6578.525498958.5257.5432.2117218116.1

VTA L6978.626199960.4259.3433.0570101999116.9

IP142106.82751411550.8849.8699.3012392284383.2

BG dors1564.135775701.0316.1159167549

Stim1DS R1455147.111001842724.71384.91228.6504802184624.5

DS L1254146.481061812701.91362.11218.3518514013614.2

NACc R185144.821241652642.61302.81191.6058033957587.5

NACc L166139.671221542466.11126.3blurry1112.0456964479507.9

NACs R323142.941021722576.91237.11161.9782153145557.8

NACs L452141.291101642520.41180.61136.535003548532.4

BG rost1597.47861121339.8604.1478244498

SN R376133.85881622279.41005.11027.8430093273453.2

SN L229114.62821361741.1466.8785.1079953767210.5

VTA R59112.49941301687.7413.4761.0429357865186.4

VTA L53108.58801311592.5318.2718.1182017067143.5

IP230158.091181933154.71880.41422.5593727989847.9

BG dors2294.41801081274.3574.625901907

Stim2DS R1234158.71102003180.61820.61434.207416172820.9

DS L1353150.911161912866.51506.51292.5733139707679.3

NACc R306158.171291803158.11798.11424.0812879619810.8

NACc L388144.241101742622.11262.11182.3914250371569.1

NACs R457154.091171752990.71630.71348.5809331174735.3

NACs L543144.91161762645.41285.41192.8820019961579.6

BG rost4098.4811151360.0613.27064739

SN R450127.66971752093.91024.3944.2159185739461.9

SN L410130.68991552182.81113.2984.296916054502.0

VTA R91106.55731321544.5474.8696.4413018148214.1

VTA L72108.4861301588.2518.6716.1797042366233.9

IP165163.731242003402.42332.81534.23844346451051.9

BG dors1584.33691011069.6482.3277580891

14veh-pretreatedNSDS R90637.091256263.575.4118.826897418534.0

DS L77739.811960306.1118.0138.042940126853.2

NACc R26237.111649263.875.7118.968221818234.1

NACc L30041.822359337.7149.5152.26184572567.4

NACs R26334.92053229.241.0103.333648680718.5

NACs L22639.82064306.0117.8137.972266703953.1

BG rost5632.32753188.284.8424966401

SN R51230.641451161.752.772.931483058623.8

SN L34631.891055181.672.681.910329317132.7

VTA R14128.741849131.122.159.13061977710.0

VTA L11330.981543167.258.175.380256300726.2

IP42229.681250146.337.365.985786295516.8

BG dors8727.391740109.049.1625686372

Specific1DS R1192104751311485.3719.2669.7724819315324.3

DS L1037108.17691361582.8816.6713.7074261882368.2

NACc R317100.88711261414.8648.6637.9543151697292.5

NACc L362108.7751351595.4829.3719.4123297891373.9

NACs R329109.48731401614.1848.0727.8594176237382.4

NACs L316106.2741281536.3770.1692.7444205746347.3

BG rost2767.895780766.1345.4657899989

SN R42291.52521251214.0665.7547.4139389095300.2

SN L39989.7541241176.7628.4530.5960038824283.3

VTA R9275.7450106906.9358.6408.9423095888161.7

VTA L11575.345103898.8350.5405.2991471315158.0

IP194116.32871511784.51236.2804.6760618648557.4

BG dors10554467548.3247.2493544112

Specific2DS R1355106.7651331548.0685.1698.0292869714308.9

DS L1223110.14771521630.1767.2735.0551272258345.9

NACc R273104.45761331495.7632.7674.4344618743285.3

NACc L439112.7671431692.9830.0763.393661343374.3

NACs R283107.07721501556.7693.8701.955618968312.8

NACs L378110.16861401630.6767.7735.273874374346.2

BG rost2773.335685862.9389.1164839803

SN R46890.97541231202.6731.3542.3061262338329.8

SN L44694.79611281282.4811.0578.2515899475365.7

VTA R9578.864799964.9493.5435.0880895763222.5

VTA L7371.745389834.3362.9376.2047898621163.7

IP182114.19831461730.21258.9780.2097557963567.7

BG dors1250.254563471.3212.5408446665

Stim1DS R1577148.37742042770.91898.61249.4983004962856.1

DS L1527153.93842052984.32112.01345.7054164043952.3

NACc R130146.021081872685.31813.01210.8840973404817.5

NACc L171152.131072052913.52041.21313.7796255013920.4

NACs R338168.761232043641.42769.01642.0085250211248.6

NACs L350164.041282163416.62544.31540.64691416821147.3

BG rost2073.856782872.4393.3678573132

SN R294126.02971912046.91241.1922.9960869675559.7

SN L317136.721011862369.91564.11068.6495483645705.3

VTA R64111.34751491659.4853.6748.2531583849384.9

VTA L64115.77901381770.4964.6798.3094305651435.0

IP200177.251042264090.23284.51844.40728564611481.1

BG dors770.146380805.8363.341919631

Stim2DS R1277144.421062062628.51615.41185.2439248314728.4

DS L1512153.761042002977.51964.51342.65700036885.9

NACc R246148.94952002792.11779.11259.0411556977802.2

NACc L309148.091021972760.61747.61244.8362469266788.0

NACs R354172.881122133851.52838.51736.75728533631280.0

NACs L446170.771302103742.22729.21687.46072634031230.7

BG rost2581.470941013.0456.7940653804

SN R390129.1991912136.01350.3963.1616295328608.9

SN L268121.05851841909.21123.6860.8986417451506.6

VTA R68107.57661301568.5782.9707.28263081353.0

VTA L77103.27731421468.6683.0662.2493081261308.0

IP199170.091352073707.72922.11671.92306792171317.7

BG dors5696181785.6354.2542883374

16veh-pretreatedNSDS R120834.21259218.158.798.369249450526.4

DS L149440.71968320.1160.6144.335137005972.4

NACc R32533.971355214.555.096.736215007424.8

NACc L30236.71965257.497.9116.07067586144.1

NACs R30431.771658179.720.281.05104143169.1

NACs L29036.631956256.396.8115.575879261943.7

BG rost10830.51949159.571.9215796469

SN R52633.391257205.4109.092.613300071449.1

SN L39235.392254236.9140.5106.804384933263.3

VTA R14730.29647156.159.770.404891675226.9

VTA L13631.011749167.671.275.596073349732.1

IP21633.521354207.4111.093.538044997750.1

BG dors4126.63154596.443.4680114633

Specific1DS R1705104.91671411506.3794.4679.2194679603358.2

DS L1911104.84771551504.7792.8678.4900416515357.5

NACc R405118.08941431830.21118.3825.2841802229504.3

NACc L566114.78801401745.11033.3786.9358376283465.9

NACs R472103.82691321481.2769.4667.9129191119346.9

NACs L622111.41691411661.1949.2749.0276736544428.0

BG rost1764.764780711.8320.9898294606

SN R31889.92471261181.2600.0532.6161853196270.5

SN L33692.12641211226.4645.2553.0116193582290.9

VTA R11473.395197864.0282.8389.6062974149127.5

VTA L12175.115598895.3314.1403.7292484813141.7

IP137111.84771451671.71090.5753.7967217973491.7

BG dors14574372581.2262.0733610155

Specific2DS R1662105.84531521527.9736.8688.9541463879332.2

DS L1670108.95791421601.4810.3722.1130608474365.4

NACc R538119.5771461867.71076.6842.1780718274485.5

NACc L613114.6641461740.6949.5784.8797154753428.2

NACs R241107.47811371566.1775.1706.2152740492349.5

NACs L482106.46691401542.4751.3695.4895512663338.8

BG rost3269.315684791.1356.7192414731

SN R23681.12511161007.7349.8454.3821284543157.7

SN L38994.55591261277.3619.4575.9603704072279.3

VTA R8075.835099908.5250.7409.6888172687113.1

VTA L7773.6644102868.9211.1391.812810300795.2

IP136111.18791391655.4997.6746.484766273449.8

BG dors3461.594482657.8296.6350339912

Stim1DS R1615156.061102153070.32072.61384.5047821706934.6

DS L1812164.331142183430.02432.21546.66869880871096.8

NACc R335151.341121882883.01885.21300.0085700642850.1

NACc L267161.971281863322.92325.21498.40474977121048.5

NACs R302159.021222043194.22196.51440.3581158148990.4

NACs L599168.771242103641.92644.11642.23113893741192.3

BG rost3580.66692997.8449.91554466

SN R418112.61601441690.7942.6x762.3856283369425.0

SN L469119.33761951863.11115.0840.1427722814502.8

VTA R8489.4571141170.6422.4527.8467935446190.5

VTA L6886.82631121118.7370.6x504.464650472167.1

IP111159.32891973207.12458.91446.14979391051108.8

BG dors3766.8644106748.2337.362349871

Stim2DS R1745143.87982032609.21788.61176.5479856592806.5

DS L1928145.63962102671.41850.81204.58668305834.6

NACc R288149.271231792804.41983.91264.5982667431894.6

NACc L289150.011271742832.32011.71277.1468050218907.1

NACs R566150.761101912860.72040.21289.9895335964920.0

NACs L579154.661111923013.52193.01358.8758913222988.9

BG rost2970.975789820.5369.9985212305

SN R347128.43901552116.31208.5954.3095647273545.0

SN L468129.4792022144.81237.0967.1463704881557.8

VTA R8098.4721201360.0452.2613.27064739203.9

VTA L59104.71781351501.7593.8677.1366072229267.8

IP110167.831192053595.82688.01621.45537250161212.1

BG dors1975.796794907.8409.356980748

THC

RATGroupRegionAreaMeanMinMaxDpm-BGCi/mg-BG

5THC-pretreatedSpecific1DS R1595109.58781441616.5673.6728.9468233187303.7

DS L1612113.95871571724.2781.2777.4847384774352.3

NACc R295117821451802.1859.1812.5955411704387.4

NACc L473124.56831632005.71062.7904.4162808116479.2

NACs R374116.56871411790.7847.7807.4650819387382.2

NACs L408123.63911531979.81036.8892.7301134616467.5

BG rost3277.696889943.0425.2182423072

SN R34596.32611251315.0728.3592.9649943713328.4

SN L215104.15681311488.8902.1x671.3243961655406.8

VTA R9372.865289854.4267.8385.2861530389120.8

VTA L8871.194290824.5237.8371.7686865847107.2

IP133116.98751471801.51214.9812.3618520838547.8

BG dors2257.333673586.6264.5324197967

0

Specific2DS R1389110.08761541628.6724.0734.3991320708326.5

DS L1536117.97801521827.3922.6823.9855455104416.0

NACc R225119.69761471872.7968.0844.4569763873436.5

NACc L210123.61851551979.21074.5892.4800518855484.5y=2915,55044973*((21,50549286-x)/(x-282,85982350))^(1/1,14744784)

NACs R578121.46831481920.31015.6865.9004448745458.0

NACs L381121.11981451910.81006.1861.6292956983453.7924.0018.262.0044.00

BG rost3775.626194904.7407.9476623895924.0023.015.0042.00

SN R26190.13561231185.4514.1534.5477857531231.8924.0027.679.0047.00

SN L19493.49681181255.0583.6565.8943079351263.2924.0032.9917.0054.00

VTA R10481.83581001021.2349.9460.5075237566157.8924.0041.8321.0062.00

VTA L6477.65899941.3269.9424.4623018801121.7924.0059.5032.0089.00

IP147112.05591391676.81005.5756.1328928178453.4924.0089.6768.00118.00

BG dors2362.394676671.4302.742043784924.00138.28117.00157.00

0924.00191.36177.00207.00

Stim1DS R1614147.41092112735.31718.51233.4189964074774.9924.00230.33220.00238.00

DS L1868150.881082002865.31848.51292.0561490559833.5

NACc R411148.961201902792.91776.01259.3772731594800.9

NACc L441147.881071832752.91736.01241.3507188309782.8

NACs R608159.891201903231.62214.8x1457.2223235439998.7

NACs L706150.421071932847.81831.01284.1518215773825.6

BG rost5281.6571041016.8458.5198329221

SN R369143.11081722582.41482.51164.4729339137668.5

SN L366129.36941562143.61043.7x966.6143120357470.6

VTA R83107.61751361569.5469.6x707.7098480019211.7

VTA L66117.38881401811.9712.0x817.0444791263321.1

IP154161.071101953283.12183.2x1480.43358225984.5

BG dors3085.8776951099.9495.9701132058

0

Stim2DS R1545146.3882072695.41793.51215.4245018077808.7

DS L2043145902192648.91747.01194.4790495232787.8

NACc R402141.671071802533.31631.41142.3492787822735.6

NACc L364140.561001812495.81593.91125.4404214702718.7

NACs R566153.871171952981.92080.01344.6287037692937.9

NACs L582147.21001802728.01826.11230.1284741128823.4

BG rost4075.476289901.9406.7054699093

SN R435141.43771772525.21729.31138.673978644779.8

SN L283126.4831592057.71261.9x927.8795923897569.0

VTA R89106.71711401548.2752.4698.1352298396339.3

VTA L84110.82861431646.6850.8742.5156598487383.6

IP121165.41232093479.72683.91569.11388703121210.2

BG dors2469.585193795.8358.8699213187

0

NSDS R1073412269324.894.4146.457310174342.6

DS L107840.142062311.380.9140.375450083836.5

NACc R33738.12459279.348.9125.962211531322.1

NACc L33336.941960261.230.8117.766905411813.9

NACs R50037.371957267.937.5120.805291117316.9

NACs L61236.61355255.825.4115.363814164411.5

BG rost12434.981947230.4103.9005209945

SN R35735.361354236.490.1106.591979588840.6

SN L24837.481853269.6123.3121.582440320155.6

VTA R9833.791650211.765.495.457460516729.5

VTA L9030.271850155.89.570.26032702314.3

IP23730.971348167.020.775.30830847449.3

BG dors3129.681953146.365.9857862955

0

7THC-pretreatedSpecific1DS R1594104.41731371494.7586.2674.019304791264.3

DS L907100.19711281399.4490.9x631.0338368749221.3

NACc R303107.17841371559.1650.5703.0190703994293.3

NACc L251112.59921311690.2781.7762.1617390572352.5

NACs R248102.04731261440.8532.2649.6825339137240.0

NACs L192107.66761371570.6662.1708.2440903097298.6

BG rost75.836188908.5409.6888172687

SN R41592.53471531234.9719.8556.8521587251324.6

SN L40292.63641271237.0721.9557.7907918607325.5

VTA R7564.44987705.7190.6318.202640793185.9

VTA L10467.34887755.8240.7340.8180088284108.6

IP192114.08811891727.51212.4778.9600020434546.7

BG dors2852.964068515.1232.261840749

0

Specific2DS R1285113.68821511717.4637.6774.4266587668287.5

DS L1049119.63831521871.1791.3x843.7368472849356.8

NACc R275123.131001491965.9886.1886.4942714421399.6

NACc L265134.38991672295.91216.1x1035.277463121548.4

NACs R135115.34921361759.4679.6793.355828371306.4

NACs L167123.87551581986.4906.6x895.7349525543408.8

BG rost2084.8575961079.8486.9168083788

SN R36389.58521251174.2639.5529.495548338288.4

SN L36493.39611411252.9718.1564.9491454123323.8

VTA R8068.384693774.7240.0349.338195909108.2

VTA L7969.875088801.0266.2361.1838613026120.0

IP217108.97671981601.91067.1722.3293903002481.2

BG dors2454.174069534.8241.1358869125

0124230

Stim1DS R1267166.11192303512.72433.71583.99409142531097.4124210

DS L1235161.341242103295.02216.01485.8003325602999.2119230

NACc R298158.31211973163.62084.61426.5580569547940.0

NACc L199175.291502003981.02902.0x1795.16153562561308.6

NACs R179168.241252163615.82536.81630.48003382051143.9103165

NACs L165176.061322074023.52944.5x1814.31588572381327.8108170

BG rost84.8172991079.0486.563176552574112

SN R363136.581031652365.41457.01066.6273250132657.076126

SN L313135.881081702343.11434.71056.5655732237647.0138219

VTA R5693.11741121247.0338.6562.3067522581152.7

VTA L51104.06761261486.7578.3670.3929987059260.8103219

IP192171.771032193793.52885.21710.6166525051301.0

BG dors1775.826595908.4409.6058498347

0

Stim2DS R153.431052022964.51898.7x1336.7594485653856.2

DS L148.861071952789.11723.4x1257.6975570082777.1

NACc R318151.181141842876.81811.11297.2370253879816.7

NACc L310159.721291993224.32158.51453.9105677442973.3

NACs R161162.51261903346.72280.91509.0983916761028.5

NACs L149163.211321883378.72313.01523.55454101151043.0

BG rost84.1373991065.7480.5674290458

SN R353130.881001542188.81401.6x986.9987452018632.0

SN L290120.72891491900.31113.1x856.8880810319501.9

VTA R10985.57591121094.0306.8x493.300212966138.3

VTA L10084.59631091074.7287.5x484.6200752474129.7

IP212159.921151963232.92445.7x1457.80758632161102.8

BG dors2369.095982787.2354.969443034

0

NSDS R131042.542370349.073.2157.364109360733.0

DS L109540.311964314.038.2141.577284356117.2

NACc R23742.622964350.274.5157.931392393633.6

NACc L24343.652362366.490.7165.242477363840.9

NACs R27939.752459305.229.5137.618906694413.3

NACs L34440.281960313.537.8141.365183246917.0

BG rost6337.872251275.7124.3375340925

SN R61734.081557216.336.597.517357713316.5

SN L54937.21855265.285.5119.604160407338.6

VTA R16933.32250204.024.291.97285973810.9

VTA L15833.541649207.828.093.680279055112.6

IP31535.972259246.066.2110.908926066829.9

BG dors5631.772152179.781.0510414316

0

10THC-pretreatedSpecific1DS R1697106.98721351554.6573.9700.9993438073258.8

DS L1799107.07761351556.7576.0701.955618968259.7

NACc R495112.42861351686.0705.3760.2604105419318.0

NACc L486115.58921441765.5784.8796.1180499609353.9

NACs R39999.95731301394.1413.4628.6363503676186.4

NACs L42999.5671331384.2403.5624.1543608833181.9

BG rost3779.767100980.7442.2236073818

SN R42699.41601271382.2738.5623.2600349001333.0

SN L36797.81581251347.2703.5607.4747530129317.2

VTA R10173.975194874.5230.9394.350981792104.1

VTA L11573.534897866.5222.9390.7499340341100.5

IP164113.55761451714.11070.5772.9570957683482.7

BG dors2860.754580643.7290.2502217499

0

Specific2DS R1331101.79741341435.1381.7x647.1448642731172.1

DS L1650109.36741481611.2557.8726.5558697223251.5

NACc R389109.82861341622.3568.9x731.5607468093256.5

NACc L446118.91901581852.0798.6835.1293770938360.1

NACs R400102.78671431457.5404.0657.2267163259182.2

NACs L482107.01751411555.3501.8x701.3180147896226.3

BG rost3683.5701001053.5475.0392850094

SN R39988.46551171151.6486.8x519.2739534473219.5

SN L30999.44661261382.8718.1623.5580670521323.8

VTA R12574.294997880.4215.6396.976408348797.2

VTA L10376.655395923.7258.9416.5110922449116.7

IP144112.93731401698.71033.9765.9737032078466.2

BG dors24625275664.8299.76164201

0

Stim1DS R1601127.04931742076.11087.8x936.1496461468490.5

DS L1822136.41031872359.71371.41064.0321760584618.4

NACc R284135.391031732327.61339.3x1049.5708697972603.9

NACc L286144.391151842627.41639.11184.7680636106739.1

NACs R401155.51241913047.52059.21374.1940963716928.6

NACs L438152.181091912915.41927.21314.6560907778869.0

BG rost2080.16997988.3445.6362302161

SN R386137.24971812386.61454.81076.1897390552656.0

SN L264133.891081802280.61348.81028.4025297627608.2

VTA R7699.07691291374.7442.9619.8876708948199.7

VTA L5592.56761071235.5303.7557.1336695585136.9

IP176162.321111993338.62406.71505.45730199611085.3

BG dors2277.096591931.8420.1873863369

0

Stim2DS R1403131.14931772196.61048.1x990.5201354453472.6

DS L1672142.571031832564.11415.61156.2279633743638.3

NACc R357130.761041802185.21036.7x985.3769260879467.5

NACc L413146.211231762692.11543.61213.9633302642696.1

NACs R487153.491021882966.81818.31337.8297772511819.9

NACs L429150.531131772852.01703.4x1286.0376374308768.1

BG rost2688.31711001148.5517.9116998811

SN R326114.33791411733.8737.9x781.8022832895332.7

SN L242122.16891591939.3943.5x874.4891639026425.4

VTA R8895.24741171291.9296.1x582.5598035225133.5

VTA L6492.53731171234.9239.0x556.8521587251107.8

IP187148.141061832762.51766.6x1245.6675234995796.6

BG dors1480.56996995.9449.0584725366

0

NSDS R144041.71886335.866.6151.41200632230.0

DS L95743.7622103368.299.0166.024131499344.7

NACc R30739.592569302.733.5136.488230590915.1

NACc L30439.172177296.126.9133.520679391412.2

NACs R40239.051758294.225.1132.672910431811.3

NACs L30837.561568270.91.7122.14761705190.8

BG rost4037.453253269.2121.3704942864

SN R32237.611472271.7104.2122.500843786547.0

SN L34837.751852273.9106.4123.489847406148.0

VTA R9632.281446187.820.384.69959236389.2

VTA L9033.062050200.232.790.264048022914.7

IP17939.691566304.3136.8137.194889923661.7

BG dors32312747167.575.5241387276

0

15THC-pretreatedSpecific1DS R1892108.54641431591.6668.1717.68714531301.3

DS L945117.87741591824.7901.2x822.8062097149406.4

NACc R504115.14791421754.3830.8791.0589364006374.6

NACc L319118.31741461836.2912.7828.0041418076411.6

NACs R362110.37651411635.7712.2737.573201988321.1

NACs L287109.36641391611.2687.8726.5558697223310.1

BG rost1476.645792923.5416.4276670821

SN R42587.29351181128.1407.6x508.6898419636183.8

SN L437102.27681301446.0725.5652.0221000699327.2

VTA R16175.3950106900.5180.0x406.043473339881.2

VTA L9381.57571081016.3295.8458.2608103438133.4

IP152115.03731461751.51031.0789.7975612023464.9

BG dors1965.265478720.4324.8702835204

0

Specific2DS R1858110.98581501650.5668.0744.2780396456301.2

DS L1003120.95901551906.5923.9x859.6818856126416.6

NACc R226117.76821471821.8839.2821.5103030201378.4

NACc L287117.39871451812.2829.6817.1617839586374.1

NACs R107111.94771351674.1691.5754.9086011665311.8

NACs L333107.48831401566.4583.8x706.321965645263.2

BG rost3579.86399982.6443.0758652219

SN R38491.97491281223.3455.2551.6096878744205.3

SN L29999.18711281377.1609.1620.9776587871274.6

VTA R9573.515599866.298.1x390.586493987544.3

VTA L7584.16591101066.3298.3480.8313129828134.5

IP121121.25911581914.61146.5863.3359089619517.0

BG dors24685595768.0346.3341222011

0

Stim1DS R1991161.491072233301.62114.31488.7909370305953.4

DS L1053163.11092133373.72186.41521.3049688671985.9

NACc R266181.231392114323.53136.3x1949.60567849871414.2

NACc L306174.361431993930.52743.21772.35023024261237.0

NACs R352165.661202083492.02304.71574.62248542871039.2

NACs L318158.321292033164.51977.21426.9395009031891.6

BG rost2790.22721011187.3535.3765878937

SN R542130.96761962191.21143.4x988.0811628296515.6

SN L495143.42951802593.51545.61169.477171709697.0

VTA R123102.5791351451.2403.3654.3663913193181.9

VTA L121101.87741311436.9389.1647.9563151071175.5

IP249178.941072274187.43139.51888.19726109361415.7

BG dors1983.21621031047.8472.5031442074

0

Stim2DS R2216158.061152123153.52033.81421.9890958332917.1

DS L968160.611142083262.92143.21471.3382749395966.4

NACc R217168.41212063623.72504.01634.01737924631129.1

NACc L139167.791091973593.92474.21620.57796660041115.7

NACs R505151.821081932901.51781.8x1308.3585520539803.4

NACs L409154.451042043005.11885.41355.0737226137850.2

BG rost2386.8777981119.7504.9134225632

SN R141.98841732543.91524.01147.1124810063687.2

SN L142.81011822572.01552.11159.7993662117699.9

VTA R95.15641261290.0270.1x581.6968857004121.8

VTA L103.04731291463.4443.5659.8890584365200.0

IP174.061302163914.32894.41765.06584548741305.2

BG dors081.76701001019.9459.902227276

0

NSDS R90640.642062319.1113.3143.91078364951.1

DS L97841.72167335.8129.9151.41200632258.6

NACc R30437.851957275.469.6124.19625465431.4

NACc L34635.682053241.435.5108.857100336216.0

NACs R48238.311561282.676.8127.445579760534.6

NACs L60237.231660265.759.9119.816132554427.0

BG rost5533.422360205.992.8267375401

SN R51035.61458240.284.3108.290927823838.0

SN L47638.71863288.7132.9130.200435156459.9

VTA R15734.521450223.267.4100.639690807830.4

VTA L19534.51654222.967.1100.497839900330.2

IP33836.351360251.996.1113.596368139843.3

BG dors8030.271546155.870.2603270231

RATGroupRegionAreaMeanMinMaxDpm-BGCi/mg-BG

23veh-pretreatedSpecific1DS R177194.25481321270.9567.2573.1026624229255.8y=2915,55044973*((21,50549286-x)/(x-282,85982350))^(1/1,14744784)

DS L160999.99621421395.0691.2629.0355878563311.7

NACc R466108.11841301581.3877.5713.0633472475395.7

NACc L383104.57641341498.4794.6675.6808245281358.3

NACs R54894.19681271269.7565.9572.5319600616255.2

NACs L41490.86541161200.4496.6541.287229083223.9

BG rost1764.295473703.8317.3521159896

SN R36575.3137100899.0419.9405.3818281095189.4

SN L24477.7246104943.5464.5425.4703257723209.5

VTA R9069.475191793.9314.8357.9932915366142.0

VTA L8861.564078657.3178.3x296.406522786580.4

IP126107791271555.01076.0701.2117814212485.2

BG dors2250.733579479.1216.0191949954

Specific2DS R1356102.01561391440.1763.5649.3777204656344.3

DS L1513102.15611461443.2766.6650.8008685449345.7

NACc R387100.8681321413.0736.3637.1498235067332.0

NACc L409104.08681351487.2810.5670.5999113542365.5

NACs R34599.33701291380.4703.8622.4656561674317.4

NACs L598101.21641301422.1745.5641.2787488679336.2

BG rost8362.74085676.6305.1155149341

SN R28082.14541101027.2455.7463.1917853757205.5

SN L19684.73571121077.5506.0485.8562276405228.2

VTA R10973.3251102862.7291.3389.0348668466131.3

VTA L9071.194987824.5253.0371.7686865847114.1

IP166113.3721491707.91136.4770.1361918184512.4

BG dors1756.414468571.5257.6862625328

Stim1DS R1808127.03851972075.81434.3x936.0199875267646.8

DS L1804130.56851922179.21537.7982.6787013444693.4

NACc R272129.22921682139.51498.0964.7539495773675.5

NACc L388115.68811651768.11126.6x797.2708979896508.0

NACs R316146.981161772720.02078.51226.518594875937.3

NACs L388141.02911762511.31869.8x1132.420091531843.2

BG rost2660.624476641.5289.2645762479

SN R323110.95831381649.8781.6743.9473904848352.5

SN L351113.17891451704.6836.5768.6720064899377.2

VTA R5988.37691051149.8281.6518.4564124677127.0

VTA L7486.03691051103.1234.9497.3965183234105.9

IP145172.21192163815.92947.71720.68790222791329.2

BG dors1373.626490868.2391.4856761234

Stim2DS R2132142.09891952547.71686.71148.8069882888760.6

DS L1926145.291012072659.21798.31199.1218301888810.9

NACc R198145.271061692658.51797.61198.8010954415810.6

NACc L165140.421121742491.11630.21123.3238629757735.1

NACs R462167.611202023585.12724.21616.63631243111228.4

NACs L532160.591161953262.02401.11470.94419224351082.7

BG rost3473.225191860.9388.2189849245

SN R344114.6821411740.6966.8784.8797154753435.9

SN L174106.89781311552.5778.6x700.0438547319351.1

VTA R8385.46521031091.8318.0492.32275077143.4

VTA L7679.9659103985.6211.8x444.44072171495.5

IP125168.051282103606.52832.71626.29077821231277.3

BG dors2168.335388773.8348.9425335715

NSDS R137437.921263276.564.7124.690730114829.2

DS L125938.811770290.578.6130.977474342335.4

NACc R41235.342256236.124.2106.450369968410.9

NACc L32738.21863280.969.1126.668579149631.1

NACs R68434.771457227.115.3102.41228204336.9

NACs L38034.391555221.19.399.71753934344.2

BG rost5433.81647211.895.5285198916

SN R29740.072062310.2139.1139.880626317362.7

SN L28839.772160305.5134.4137.760249289160.6

VTA R12035.222256234.263.0105.600608100928.4

VTA L9936.652157256.685.5115.717252821338.5

IP20338.11658279.3108.2125.962211531348.8

BG dors2631.232343171.277.1775456548

25veh-pretreatedSpecific1DS R1963100.75521391411.9717.7x636.6472991676323.6

DS L194388.17581181145.7451.5x516.6416813265203.6hoppar ver s lnge pga uneven

NACc R409110.54791401639.8945.6739.4378906959426.4

NACc L33889.02601121162.9468.7x524.3736582218211.3

NACs R52197.83641301347.6653.4607.6707515011294.6

NACs L45685.73551141097.1402.9x494.7234129268181.7

BG rost4563.734682694.2313.0302020854

SN R33181.83581021021.2463.6460.5075237566209.0

SN L40876.995299930.0372.3419.3509033973167.9

VTA R14173.625691868.2310.5391.4856761234140.0

VTA L15469.624885796.6238.9359.1888416439107.7

IP146123.42821661973.91416.3890.1070813154638.6

BG dors2155.574868557.7251.4606022726

Specific2DS R201589.59541271174.4517.8529.5872136377233.5

DS L190189.79571221178.5521.9531.4220220854235.3

NACc R16782.37421041031.6375.0465.1872108164169.1

NACc L21492.32661121230.5573.9554.8834780103258.8

NACs R46164.2236100702.645.9x316.811143732220.7

NACs L44972.243104842.5185.9379.926814704783.8

BG rost2961.525074656.7296.101897142

SN R27779.3547105974.1385.1439.2453965452173.7

SN L25484.96631051082.0493.0487.8898376152222.3

VTA R9969.315284791.1202.1356.719241473191.1

VTA L9371.33897826.4237.5372.6546826878107.1

IP140121.54861491922.41333.5866.8788718367601.3

BG dors1557.474573589.0265.5768102946

Stim1DS R2233157.281112153120.82265.41407.24579307141021.6

DS L2180142.261002022553.51698.11151.4302606978765.7

NACc R228166.021412053509.02653.61582.28552387981196.6

NACc L197155.751271923057.72202.31378.7872589785993.1

NACs R536169.851182063695.72840.31666.47880709421280.8

NACs L494163.16952023376.42521.11522.53155643191136.8

BG rost3272.916389855.3385.6930854378

SN R41499.83661291391.4733.4627.4394607984330.7

SN L316106.52791291543.8885.8696.1239650118399.4

VTA R12583.26621111048.8390.8472.9400268787176.2

VTA L10287681121122.3464.3506.0810268498209.4

IP155156.991012053108.72450.71401.80516814831105.1

BG dors1061.64981658.0296.7112123932

Stim2DS R1970118.29801801835.7998.2827.7673740137450.1

DS L2050124.05871731991.41153.9897.9935630559520.3

NACc R173112.79641631695.2857.7764.4025647032386.7

NACc L289116.79881551796.6959.1810.144119355432.5

NACs R515120.09771811883.41045.9849.2690835513471.6

NACs L475112.02781601676.1838.6755.7988677534378.1

BG rost3771.925388837.5377.6599445361

SN R334107.18631361559.3994.6703.1254690699448.5

SN L30499.96721351394.3829.6628.7361468722374.1

VTA R6277.4550102938.5373.8423.2034326015168.6

VTA L6379.76099980.7416.0442.2236073818187.6

IP95141.75971912536.11971.31143.5767683118888.9

BG dors8565260564.7254.6445921871

NSDS R190933.351558204.8105.292.32868377247.4

DS L184633.31560204.0104.491.97285973847.1

NACc R37032.11551185.085.483.41287252738.5

NACc L38533.641352209.3109.894.391315078449.5

NACs R42729.931454150.450.867.799435011622.9

NACs L45630.561349160.560.972.35451249427.5

BG rost7226.82184199.644.8982811719

SN R39932.771251195.692.488.197237413841.6

SN L30833.861255212.8109.695.954832525649.4

VTA R8729.751448147.544.266.493979233619.9

VTA L9329.731746147.143.966.348811197319.8

IP31733.611657208.9105.694.178027561147.6

BG dors4627.041746103.246.5486791022

27veh-pretreatedSpecific1DS R1838102.46681341450.3565.3653.9583482375254.9

DS L167991.55471211214.6329.7547.6931882892148.7

NACc R172106.47731301542.6657.7695.5952628407296.6

NACc L31690.09591161184.6299.7534.1796169011135.1

NACs R695104.42661401495.0610.1674.1230801459275.1

NACs L60688.38561311150.0265.0518.5472223664119.5

BG rost4474.546099884.9399.0313472796

SN R39690.31611191189.1470.0536.2059754131212.0

SN L36797.68611211344.3625.3606.2015676814282.0

VTA R5275.1352113895.7176.6x403.894408035379.6

VTA L4481.55621061015.9296.8458.0881595256133.8

IP172119.02791551854.91135.9836.4403521653512.2

BG dors1165.185174719.1324.2486748686

Specific2DS R1987106.03601421532.3647.7690.9530278235292.1

DS L186278.7948102963.679.0x434.495342690735.6

NACc R255114.91771381748.4863.9788.4230618014389.6

NACc L26178.3359105954.970.4x430.607280363731.7

NACs R624107.73551371572.3687.8708.9924421233310.1

NACs L56876.8854104927.943.4x418.431426430919.6

BG rost2774.526087884.5398.8668282529

SN R43686.03461171103.1602.6497.3965183234271.7

SN L35975.65698904.3403.8x407.781965114182.1

VTA R8275.25496897.0396.5x404.4726385639178.8

VTA L4971.395389828.0327.5373.3800428778147.7

IP180102.34411391447.5947.0652.7350789379427.0

BG dors1852.063871500.5225.6896053832

Stim1DS R1948154.021052142987.92040.81347.3221271332920.3

DS L1980148.311072052768.71821.61248.4978720285821.4

NACc R362149.24961852803.31856.21264.0920898864837.0

NACc L328137.531111762396.01448.9x1080.414872555653.3

NACs R341162.771171873358.82411.71514.57805081151087.5

NACs L432155.911111923064.22117.11381.7351875532954.7

BG rost4777.916493947.1427.0680564701

SN R440124.28791561997.81137.6900.8858039287513.0

SN L298123881551962.41102.1884.8782889484497.0

VTA R5794.7681211280.5420.2577.3918548611189.5

VTA L6495.42731171295.7435.5584.2875588929196.4

IP142166.651032163538.92678.71595.79676387161207.9

BG dors1173.185582860.2387.8927793433

Stim2DS R1802153.581052122970.41954.31339.4368959798881.3

DS L1821153.271072032958.11942.11333.9094678352875.7

NACc R146153.281121842958.51942.51334.0874116948875.9

NACc L271149.531011792814.21798.11268.9934197108810.8

NACs R539168.841362003645.42629.31643.79040500131185.6

NACs L606161.121222023285.32269.21481.42584473261023.3

BG rost4581.56711111016.1458.1744818454

SN R412146.861111722715.61392.71224.5538344424628.0

SN L358144.05881772615.51292.51179.3873820146582.8

VTA R82103.7771251478.5155.5x666.67486332670.1

VTA L51118.45931531839.9517.0829.6628494766233.1

IP178177.291172254092.52769.61845.42926776281248.9

BG dors5496.69741181322.9596.551232741

NSDS R143231.721457178.940.480.692851508118.2

DS L127334.491362222.784.1100.426911945637.9

NACc R29531.251455171.532.977.321214614714.8

NACc L33432.621551193.254.687.127285372924.6

NACs R31030.451253158.720.171.56066602329.1

NACs L31832.371652189.350.785.342562222222.8

BG rost4429.21853138.662.4927783745

SN R31634.231455218.6103.398.582180520546.6

SN L31837.421954268.7153.4121.158545498169.2

VTA R7033.511851207.392.093.466924569641.5

VTA L9831.981351183.167.882.554461729730.6

IP23034.371253220.8105.599.575644223347.6

BG dors3027.771646115.351.9855380115

29veh-pretreatedSpecific1DS R2086126.64771732064.61088.6x930.974189058490.9

DS L1829105.84631431527.9551.9688.9541463879248.9

NACc R335132.01981622222.91246.9x1002.377970428562.3

NACc L442116.08701771778.3802.3x801.8936487963361.8

NACs R515119.57751541869.5893.5x843.0171568606402.9

NACs L590121.72771631927.3951.3x869.0832880567429.0

BG rost5579.456693976.0440.0955708704

SN R41593.27521451250.3532.7563.8159591735240.2

SN L0

VTA R8074.845596890.4172.7401.501728221877.9

VTA L0

IP13599.99661361395.0677.3629.0355878563305.4

BG dors2065.15275717.7323.6273473815

Specific2DS R1691103.28621361468.9502.9662.3520366224226.8

DS L169194.51651271276.4310.4x575.5789378412140.0

NACc R304101.94631441438.5472.5648.6668002138213.1

NACc L561102.1701311442.1476.1650.2924010471214.7

NACs R45999.12581331375.8409.8620.3829931498184.8

NACs L490103.47761331473.2507.2664.3056073602228.7

BG rost6478.926098966.0435.5963873536

SN R26784.73541211077.5518.0485.8562276405233.6

SN L0

VTA R12968.14891769.8210.3347.124008122894.8

VTA L0

IP10385.92371151100.9541.4496.4156807114244.1

BG dors3155.683968559.5252.2745265253

Stim1DS R1707148.731072072784.31963.21255.5171770414885.3

DS L1539137.24962152386.61565.5x1076.1897390552705.9

NACc R242140.881081822506.61685.51130.2917304627760.1

NACc L320138.331001872422.01600.91092.1455651162721.9

NACs R394144.85921952643.61822.61192.0842280889821.8

NACs L445142.4971922558.31737.21153.5947069408783.4

BG rost31715384821.1370.2397642897

SN R32196.95621441328.5820.1599.0779213373369.8

SN L0

VTA R11572.5152100848.1339.7382.4412697606153.2

VTA L0

IP94155.51841943047.92539.51374.37751997031145.1

BG dors1152.554564508.4229.2649012259

Stim2DS R1878158.851062143187.02292.91437.08708743191033.9

DS L1565150.541072022852.41958.31286.2092104658883.1

NACc R175149.311201852805.91911.91265.2734764649862.1

NACc L235154.491241953006.72112.61355.7971071676952.6

NACs R348158.611212003176.72282.71432.48254271681029.3

NACs L444159.591121953218.72324.61451.38346399141048.2

BG rost9475.046392894.0403.1513619494

SN R335112.03701441676.3973.3755.910198824438.9

SN L0

VTA R4984.51671051073.2370.1483.9142775204166.9

VTA L0

IP96162.55922073348.92645.81510.11150851761193.1

BG dors2064.255380703.1317.0429632275

NSDS R162935.171576233.491.6105.246486607141.3

DS L166435.181659233.691.7105.317313503541.4

NACc R24133.691593210.168.394.746750563330.8

NACc L23634.612055224.682.8101.277938472637.3

NACs R57134.761659227.085.1102.341397199938.4

NACs L40834.251755218.977.198.724125432134.8

BG rost5529.41854141.863.9499998689

SN R21639.791559305.869.1137.901593758731.2

SN L0

VTA R8037.762051274.037.3123.560488945116.8

VTA L0

IP25638.381960283.747.0127.940034672921.2

BG dors2935.381649236.7106.7335843566

33veh-pretreatedSpecific1DS R1987104.75691381502.6767.1x677.5528805916345.9

DS L195893.26651371250.1514.7563.7215765951232.1

NACc R28990.21601171187.1451.6x535.2844698765203.6

NACc L43193.04671221245.5510.1561.64708681230.0

NACs R40888.38601161150.0414.5518.5472223664186.9

NACs L59388.57601171153.8418.3520.2739407393188.6

BG rost4766.135186735.5331.6485853453

SN R47473.7747108870.9271.3x ?392.7128669125122.4

SN L35977.2244103934.2334.7x ?421.2756628914150.9

VTA R8366.135086735.5135.9x331.648585345361.3

VTA L8874.2254100879.1279.5x396.401627633126.0

level?IP5976.6459102923.5323.9x416.4276670821146.1

BG dors4558.114274599.6270.3600268349

Specific2DS R1989100.76501431412.1460.0636.7477866353207.4

DS L192997.73601351345.4393.3606.6910893482177.3

NACc R476111.34801341659.4707.2x748.2531583849318.9

NACc L396105.7661371524.6572.5687.4834841372258.1

NACs R499108.5711381590.6638.5x717.2562485397287.9

NACs L56998.23721261356.3404.2611.5976776113182.3

BG rost5778.186390952.1429.3420988849

SN R39891.65481231216.7473.2x ?548.6245006964213.4

SN L28695.43581301296.0552.5x ?584.3836204765249.1

VTA R6785.46511131091.8348.3x492.32275077157.1

VTA L8288.79531221158.2414.8x522.2764644643187.0

level?IP6693.76681241260.6517.2x568.4500750898233.2

BG dors2266.595281743.5335.2462216085

Stim1DS R2112147.141032142725.81896.01229.1429561559855.0

DS L2045138.96972062442.71612.81101.4620315581727.3

NACc R335130.93961722190.31360.5987.6751431371613.5

NACc L281130.121071702166.11336.3976.7636548453602.6

NACs R432144.771161802640.81811.0x1190.8088279616816.6

NACs L485152.981051902946.72116.91328.759497377954.6

BG rost4071.495295829.8374.1864791873

SN R269121.13841651911.31125.2x ?861.8729471726507.4

SN L350129.22951692139.51353.3x ?964.7539495773610.3

level?VTA R6183.85641071060.3274.1x478.1073194678123.6

VTA L7098.96641311372.3586.1x618.7987047947264.3

IP61112.1761651678.1891.9x756.689813697402.2

BG dors3069.035787786.1354.4926299752

Stim2DS R1997150.251042152841.31819.91281.2427317117820.6

DS L1810145.71032182673.91652.41205.7147072508745.1

NACc R339143.28961802588.61567.21167.2853837177706.7

NACc L294141.13921772515.01493.61134.0949102142673.5

NACs R431160.651001973264.72243.21472.12678056761011.5

NACs L571163.131112063375.12353.61521.91812720031061.3

BG rost11081.84611011021.4460.5940195118

SN R206100.59741311408.3729.4x ?635.0406814404328.9

SN L248110.59771461641.0962.2x ?739.9868967319433.9

level?VTA R8379.1144107969.6290.7x437.2073944797131.1

VTA L8682.34451211031.0352.2x464.9267500729158.8

IP4384.33561111069.6390.8x482.3277580891176.2

BG dors1262.834973678.8306.1120189881

NSDS R151634.11579216.6100.197.659358534445.2

DS L147833.941558214.197.696.523134818144.0

NACc R33433.541659207.891.393.680279055141.2

NACc L29933.281355203.687.291.830513254839.3

NACs R33332.871457197.280.788.910187383936.4

NACs L31132.781859195.779.388.268544879435.8

BG rost5127.842046116.452.5039776415

SN R32336.091765247.8103.0111.757724104546.4

SN L36336.431757253.2108.3114.161998822848.8

VTA R7832.651755193.748.887.341327384922.0

VTA L6831.41752173.929.078.398210882913.1

IP25832.251746187.442.584.485212039119.2

BG dors3229.591942144.965.3319592291

35veh-pretreatedSpecific1DS R189784.5481211073.0524.6483.8260821704236.6

DS L167486.41531191110.6562.3500.7911191308253.5

NACc R39680.81581021001.8453.4451.7173729014204.5

NACc L34276.453106919.1370.7414.4271485957167.2

NACs R42375.2252102897.3349.0404.6378964907157.4

NACs L37176.8750113927.7379.4418.3478715552171.1

BG rost22554678548.3247.2493544112

SN R26687.22601141126.7544.5508.0596009673245.5

SN L27392.4591171232.2650.0555.6330609275293.1

VTA R5768.984892785.3203.1354.095417926691.6

VTA L6674.25399878.7296.5396.2374528508133.7

IP148112.05821431676.81094.7756.1328928178493.6

BG dors3157.064471582.2262.5201799513

Specific2DS R1800112.56681471689.5956.2x761.8259855622431.2

DS L178493.75581261260.4527.2568.3553171998237.7

NACc R427101.11641301419.9686.7x640.2703389896309.6

NACc L45294.02581301266.1532.9570.916484497240.3

NACs R48693.05651231245.7512.5561.7413019317231.1

NACs L36086.4591101110.4377.2500.7016629237170.1

BG rost34664991733.2330.6335905796

SN R30579.5958103978.6430.3441.2868129005194.0

SN L22080.347103992.1443.7447.3461444113200.1

VTA R8370.1645106806.1257.8363.5019183495116.3

VTA L7267.765385763.8215.5344.440309797597.2

IP150109.61821361617.31069.0729.2732431173482.0

BG dors16554376548.3247.2493544112

Stim1DS R1796163.061092203371.92470.01520.4878454831113.8

DS L1152150.36972002845.51943.61283.1243426988876.4

NACc R312152.481161892927.12025.21319.9271839233913.2

NACc L327149.521031952813.81911.91268.8241000453862.1

NACs R459168.371202053622.22720.3x1633.35346002421226.6

NACs L526163.211052093378.72476.81523.55454101151116.8

BG rost5975.475696901.9406.7054699093

SN R382121.4821481918.61118.7865.1671540893504.5

SN L358127.16891572079.51279.6937.7066419485577.0

VTA R8986.81551191118.5318.6504.3749164625143.7

VTA L8696.21681221312.6512.7591.9009430537231.2

IP162171.441062303776.52976.61702.93440130981342.2

BG dors2769.815778799.9360.7047781738

Stim2DS R1727155.271082133038.12271.81369.9822952171024.4

DS L1463151.191012122877.22110.91297.4100751288951.9

NACc R247144.981131802648.21881.91194.1594799025848.6

NACc L321116.15791521780.11013.8x802.7045051388457.2

NACs R459158.27931993162.32396.01425.98609246981080.4

NACs L485143.55911832598.01831.7x1171.5158041805826.0

BG rost3167.95281766.3345.5447058489

SN R481117.17621531806.51129.7814.5837756384509.4

SN L445112.18871391680.11003.2757.5814399713452.4

VTA R5680.95621151004.4327.6452.9200838138147.7

VTA L7581.97531141023.9347.1461.7190299325156.5

IP137164.141012223421.22744.41542.72045948761237.5

BG dors1462.715870676.8305.1921443202

NSDS R142536.461462253.645.3114.374098362620.4

DS L162236.571461255.447.0115.151743255921.2

NACc R39036.611965256.047.6115.434503170321.5

NACc L33939.972062308.6100.3139.173782231145.2

NACs R42235.831960243.835.4109.918493292516.0

NACs L34539.152063295.887.4133.379381847939.4

BG rost6233.582250208.493.9647201597

SN R39037.61860271.589.4122.430198946440.3

SN L34140.111659310.8128.7140.163379356958.0

VTA R10734.481954222.640.4100.355982316118.2

VTA L8535.731853242.260.1109.210923634927.1

IP25337.731956273.591.4123.348563741741.2

BG dors2531.922357182.182.1250714821

RATGroupRegionAreaMeanMinMaxDpm-BGCi/mg-BG

28THC-pretreatedSpecific1DS R166592.55601271235.3424.8557.0398250835191.5

DS L171886.54581221113.2302.6501.9546646343136.5

NACc R51088.94601191161.3350.7523.6437758425158.1

NACc L60990.06591251184.0373.5533.9035659742168.4

NACs R58981.56461181016.1205.5458.174481845492.7

NACs L60387.73521191136.9326.3512.6590695918147.2

BG rost8370.415185810.6365.503567763

SN R41470.5842105813.6355.2366.8664566178160.2

SN L35373.564796867.1408.7390.9951337665184.3

VTA R7063.564187691.3232.9311.7208297903105.0

VTA L9463.524184690.6232.3311.4129195291104.7

IP15998.82441211369.2910.9617.4142226338410.7

BG dors1649.444060458.4206.6845666571

Stim1DS R1571151.591002192892.61943.1x1304.3508828637876.2

DS L1510138.56991902429.51480.01095.5387379107667.4

NACc R348139.191131802450.21500.71104.8807205436676.7

NACc L326136.471101692361.91412.41065.0407530477636.9

NACs R628139.4891802457.21507.71108.0103379141679.8

NACs L626135.41841822328.21378.71049.8555917304621.7

BG rost8178.0454111949.5428.1624396576

SN R477125.52711622032.71323.3916.6005984217596.7

SN L393115.98531621775.81066.3x800.7362531695480.8

VTA R7586.4681081110.4400.9500.7016629237180.8

VTA L8588.67671171155.8446.4521.1837569241201.3

IP140174.421082143933.73224.31773.81141153651453.9

BG dors1364.624975709.4319.9052559652

Stim2DS R1557139.32912162454.51530.51106.8171768886690.1

DS L1622138.45961882425.91501.91093.9147612686677.2

NACc R367133.11061612256.21332.21017.399077318600.7

NACc L306124.82861562013.01088.9x907.703954359491.0

NACs R519142.651041742566.91642.81157.4690456313740.8

NACs L550139.82891812471.11547.11114.2932081373697.6

BG rost7676.6761100924.0416.6779594544

SN R383127.14841662078.91271.0937.4470025043573.1

SN L276135.08921552317.81509.91045.1660821834680.9

VTA R4997.18811201333.5525.6601.3176530442237.0

VTA L6898.49701291362.0554.1614.1573132947249.9

IP181172.45562223828.93021.01726.57531239331362.3

BG dors2370.266180807.9364.3022076982

NSDS R235834.191258218.036.298.298268749516.3

DS L211237.181762264.983.1119.462843637537.5

NACc R70133.241949203.021.291.54579106659.6

NACc L54835.882351244.562.7110.272240824728.3

NACs R49033.631452209.227.494.320221437812.3

NACs L55533.811455212.030.295.599577179113.6

BG rost9831.92348181.881.9819135469

SN R31137.351958267.6120.5120.663987035954.3

SN L22435.551754239.492.2107.937034549141.6

VTA R7731.561647176.429.379.546020750913.2

VTA L12830.691344162.515.473.29193350796.9

IP20237.042153262.7115.6118.473578552352.1

BG dors3729.731946147.166.3488111973

30THC-pretreatedSpecific1DS R2031102.92591331460.7499.2658.6595263304225.1

DS L212195.07631351288.3326.8580.930383744147.4

NACc R413113.16811341704.4742.9768.5594527569335.0

NACc L421115.81901421771.4809.9798.7712957813365.2

NACs R494103.88691291482.6521.1668.532442484235.0

NACs L362113701461700.4738.9x766.7600651606333.2

BG rost7178.6853103961.5433.5644637671

SN R50585.83521231099.1444.0495.6137795538200.2

SN L48089.68631271176.3521.1530.4125230797235.0

VTA R14077.660106941.3286.2424.4623018801129.0

VTA L9074.3260104880.9225.8397.2228234718101.8

IP168112.93761401698.71043.5765.9737032078470.6

BG dors1461.434969655.1295.4167229357

Stim1DS R1844153.99972172986.72025.41346.7830044572913.3

DS L1977137.371012022390.81429.51078.081983326644.6

NACc R249156.841281863102.52141.21398.9996616349965.5

NACc L339149.071191872797.01835.71261.2274787524827.7

NACs R461159.691081953223.02261.71453.32697403621019.8

NACs L494164.241212093425.82464.51544.79708902861111.3

BG rost7578.6758100961.3433.4798735478

SN R521120.19311821886.11158.4850.4751769704522.3

SN L444121.06581571909.41181.7861.0203861185532.9

VTA R10488.1621241144.3416.6516.007184402187.9

VTA L12690.06631101184.0456.3533.9035659742205.8

IP207175.14722353972.83245.11791.45857229361463.3

BG dors1965.685474727.7328.1383636795

Stim2DS R2157152.37962222922.81835.81317.9919968498827.8

DS L2051134.68822012305.31218.2x1039.5056991989549.3

NACc R374153.831221952980.31893.21343.9113811085853.7

NACc L395138.471041792426.61339.5x1094.209872118604.0

NACs R575157.021191983110.02022.91402.3669724924912.2

NACs L643148.891121852790.21703.2x1258.2012432571768.0

BG rost13185.22611151087.1490.1928911091

SN R392126.88931722071.51204.7934.0767858031543.2

SN L366115.78701571770.6903.9x798.4248798291407.6

VTA R6895.06671261288.1421.4580.8346064398190.0

VTA L7996.71651251323.4456.6596.7453986969205.9

IP187176.15912274028.53161.81816.57078063971425.7

BG dors2873.545589866.7390.8316619888

NSDS R169738.871386291.466.8131.401322362730.1

DS L140539.11865295.070.4133.026142835631.7

NACc R29640.92163323.298.6145.74984154544.5

NACc L28538.081556279.054.4125.820937295124.5

NACs R45536.761863258.333.7116.494763627715.2

NACs L40336.031857246.922.3111.3333411922