1. binding catalysis switch structure

2.

N-C C-C N-C C-C

3. 1.EXC-C 2.CysEXCys-S-S-Cys 3.EXN-O 4.EXH-N 5.EXO-O 6. 4.-helix 3.6 Pro (Ramachandran Plot)

5.-sheet

NC (parallel) (antiparallel) R(

Ala,Gly,Ser)

6. a. Turn 180 turnsturn ( Gly)turn Pro Turns b. (random coil) 7.

chaperoninchaperonin

chaperonin

MHC

8.

(globular)

a.

(tertiary structure)

b.

c. Cys -SH (-S-S-)

9. -helix -sheet -helix -helix -helix turn bc1 -sheet -sheet -helix 4 -helix 10.domain

domain ()domain

domainsdomain

domain

domain

11.motif

, 88

(motif)

12.

a.

(quaternary structure) (subunit)

b.

(positive cooperativity)

c. 13.X-ray

14.NMR

1.

tubulin

1. 2.dynein 3. 4.

Rubisco

2.

pH

DNA Fis

Fis DNA - -

PrionPrPc

PrPc PrPSc

PrPSc PrPc

Serpin

1.

Hidden-Markov

E E 10-50 E 10-10

E

Protein Profiling

40

Kinome Superfamily

2.

benzoylformate decarboxyase

21

homology

modeling

Profile-Based Threading

Rosetta

Monte Carlo procedure

3.

probe

X X

1.

DNARNA

G

1.X X

3D

2.

14 1

21

2.Phosphorylation

Ras-GTP Ras-GTP c-Raf c-Raf

MKK1 MKK1 ERK1/2ERK1/2

p90R6K

STAT

STAT STAT

ATP ATP

ADP

SH2 PHB

3.Sulfuryl transfer

ADP-O-SO3-

CCR5 HIV gp120 T CD4

HIV T CCR5 7 gp120

CCR5

20

GSH

GSSG GSH -SH S-S

GSH GSSGGSH GSSG NADPH

4.Methylation

DNA DNA

S-

SAMS- S-SAH

5.N-Acetylation

DNA

HAT HDACHAT

HDAC

6.Lipidation

14-20

G GPCR

7.Proteolysis

DNA

8.Glycosylation N link

O link N-link dolichol

phosphate 2

5

3 9 2

trim

selectin

9.ADP-ADP-Ribosylation

ADP-ADP- NAD

ADP- GTPase ADP-

AB5 B A A GTPase

ADP- G

10.Hydroxylation

gly-X-Y X Y

HIF HIF

HIF HIF

11.AutomodificationRNA RNA-splicing

Intein intron extein