35
慈濟藥訊(123)-1/35 鮑氏不動桿菌(Acinetobacter baumannii,簡 AB 菌)為造成院內感染常見的菌種之一,近年 來隨著抗藥性細菌的增加,對 carbapenem 具有抗 藥性的 AB 菌(Carbapenem-resistant A. baumannii, CRAB)也成為醫療人員頭痛的問題。 治療 CRAB 感染,目前以 colistin 為最主要藥 物,其他如 tigecycline sulbactam 等,也是常用的 抗生素。但因為藥物動力學及抗生素最小抑菌濃度 minimum inhibitory concentrationMIC)提高的 關係,目前建議以合併療法治療 CRAB 感染,一些 常見的處方組合如 colistin 加上 tigecycline sulbactam carbapenem 類藥品的二合一療法,以 colistin 加上 tigecycline carbapenem 類的三合 一療法等。 本院新進藥品 Brosym ® cefoperazone 500 mg sulbactam 500 mg 之複方注射劑。 Cefoperazone 為第三代頭孢菌素(cephalosporins), Sulbactam 為β-lactamase 抑制劑,可防止細菌對 cefoperazone 的分解,故可強化 cefoperazone 的效 果,也可與 AB 菌或 Bacteroides 屬之 penicillin binding protein PBP)結合而產生直接的抗菌作 用。 Brosym ® 之抗菌範圍廣泛,對於葡萄球菌等革 蘭氏陽性菌,大腸桿菌、CitrobactorKlebsiellaEnterobactor SerratiaProteus Pseudomonas Haemophilus influenza Acinetobacter 屬的革蘭氏 陰性菌,和 Bacteroides 屬等厭氧菌,具有抗菌及 殺菌作用。 有許多研究指出 Brosym ® 對於 CRAB 具有抗菌 效果,但僅止於體外試驗或回溯性研究,而缺乏隨 機控制試驗(randomized-controlled trial, RCT)的 實證。 在一個回溯性試驗中,針對 71 CRAB 院內 感染肺炎且年齡大於 60 歲的病人,評估未使用與 使用 cefoperazone/sulbactam ,其 30 天存活率分別 73.3% 95.1% p<0.05 ),顯示使用 cefoperazone/sulbactam 或可降低 CRAB 造成的院 內感染肺炎之死亡率,但此研究的病人有可能合併 minocyclinelevofloxacin meropenem 等藥,為 研究結果增添許多變數。 Brosym ® 除了對中樞神經系統的穿透力不佳 外,在身體組織分佈佳,於衛福部核准之適應症為 用於治療由感受性細菌所引起的上、下呼吸道感染、 上、下泌尿道感染、腹膜炎、膽囊炎、膽管炎及其 他腹腔內感染、骨盆發炎、子宮內膜炎及其他生殖 道感染、以及創傷燙傷、手術後之二次感染。 常用劑量為每日 cefoperazone/sulbactam 1 g/1 g 至每日 2 g/2 g,間隔 12 小時。嚴重感染可增加 至每日 4 g/4 g ,針對 CRAB 甚至可使用至 sulbactam 最多每日 6 g。此藥主要經由腎臟排除,故於腎功 能不全患者(肌酸酐廓清率小於 30 mL/min)需進 行劑量調整。給藥時可靜脈注射超過三分鐘,或以 靜脈輸注方式給予。 Brosym ® 的主要副作用包含腹瀉(0.75%)、發 疹(0.45%),發燒(0.21%),肝功能檢查值上升(AST 3.18% ALT 3.41% ALP 1.05%)等。值得一提的是, cefoperazone NMTT N-methylthiotetrazole side chain),而抑制維他命 K 環氧化物還原酵素(vitamin K epoxide reductase), 進而影響凝血因子的功能,在老人或營養狀態不佳 的病人,可能產生凝血異常的情形而造成出血,因 此在這類病人使用時,應事先給予補充維他命 K以預防嚴重的出血。 Brosym ® 於今年 2 月取得衛福部之許可證,屬 於新療效複方藥品,並於 9 1 日起獲得健保給付, CRAB 感染的病人,或許多了一個新的選擇,但 希望未來能有更多的臨床試驗支持其療效。 慈濟藥訊 TZU CHI HOSPITAL PHARMACY BULLETIN 第一百二十三期 中華民國一百零三年九月 新藥介紹 對抗CRAB的新複方藥品 -Brosym ® 陳鈴潔 藥師 出版單位 : 花蓮慈濟醫院藥劑部 總 編 輯 : 劉采艷 執行編輯 : 陳仲揚 輯 : 陳怡珊、黃欣怡、 黃詠銘、陳鈴潔、 彭鳳宜

慈濟藥訊hlm.tzuchi.com.tw/drug/images/stories/files/DrugLetter/123.pdf · pneumonia and the in vitro therapeutic benefit of cefoperazone/sulbactam. Int J Infect Dis. 2014;23:90-3

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  • (123)-1/35

    Acinetobacter baumannii

    AB

    carbapenem

    AB Carbapenem-resistant A. baumannii,

    CRAB

    CRAB colistin

    tigecyclinesulbactam

    minimum inhibitory concentrationMIC

    CRAB

    colistin tigecycline

    sulbactam carbapenem

    colistin tigecycline carbapenem

    Brosym cefoperazone 500

    mg sulbactam 500 mg

    Cefoperazone cephalosporins

    Sulbactam -lactamase

    cefoperazone cefoperazone

    AB Bacteroides penicillin

    binding proteinPBP

    Brosym

    CitrobactorKlebsiella

    EnterobactorSerratiaProteusPseudomonas

    Haemophilus influenza Acinetobacter

    Bacteroides

    Brosym CRAB

    randomized-controlled trial, RCT

    71 CRAB

    60

    cefoperazone/sulbactam 30

    73.3% 95.1% p

  • (123)-2/35

    1. Brosym

    2. Viehman JA, Nguyen MH, Doi Y. Treatment Options for

    Carbapenem-Resistant and Extensively Drug-Resistant Acinetobacter

    baumannii Infections. Drugs. 2014;74(12):1315-33.

    3. Xia J, Zhang D, Xu Y, Gong M, Zhou Y, Fang X. A retrospective analysis of

    carbapenem-resistant Acinetobacter baumannii-mediated nosocomial

    pneumonia and the in vitro therapeutic benefit of

    cefoperazone/sulbactam. Int J Infect Dis. 2014;23:90-3

    103 6 8 ADR

    1 Omnipaque 350 mg/ml, 200 ml/bot ( Iohexol ) (

    )

    2 Hyzaar 100 mg & 12.5 mg ( Losartan & hydrochlorthiazide )

    3 Cravit 250 mg/50 ml/vial ( Levofloxacin )

    4 Covina 2mg & 1mg/tab ( Estradiol & Norethindrone )

    5 Vidaza 100mg/vial ( Azacitidine )

    6 Cravit 250 mg/50 ml/vial ( Levofloxacin )

    7 Anbicyn 600 mg/vial ( Amoxicillin & Clavulanic Acid )

    Allopurinol 100 mg/tab

    8 PROPOFOL-LIPURO 200 mg/20 ml/amp ( Propofol )

    9 Celebrex 200mg/cap ( Celecoxib )

    ==

    FDA testosterone

    ( Food and Drug Administration, FDA )

    testosterone

    ( European Medicine Agency, EMA ) ( Health Canada )

    2014 1 2 testosterone

    FDA testosterone

    testosterone

    2014 6 FDA testosterone

    ( venous blood clots as a possible consequence of

    polycythemia )

    ( venous thromboembolism, VTE ) ( deep

    vein thrombosis, DVT ) ( pulmonary embolism, PE )

    Androgel Gel 5 g/pk ( Testosterone )

    Testosterone Cypionate 200 mg/ml/amp

    32973097

  • (123)-3/35

    ( 86/1/1 )

    1. Insulin

    2. CAPD

    3. CAPD

    4. Desferrioxamine Desferal

    5.

    20,000 U EprexRecormon 100 mcg AranespMircera(98/9/1)

    6. -interferon

    7. G-CSF ( filgrastimlenograstim( ( 98/11/1 )

    8. ( human growth hormone )

    9. ~ ( )

    86/9/192/5/1100/4/1 )

    10. ( TPN ) 85/10/193/12/1

    11. octreotidelanreotide ( SandostatinSomatuline ) octreotide

    ( Sandostatin ) ( 93/12/1 )lanreotide inj 30 mg ( Somatuline )

    ( 88/6/1 )octreotide LAR ( Sandostatin LAR Microspheres for Inj. ) ( 89/7/1 )

    12. streptomycinkanamycin enviomycin 86/9/1

    13. 87/4/1

    14.

    90/11/1

    15. Apomorphine hydrochloride 10mg/mL Apo-Go Pen

    on-and-off 20 91/2/199/11/1

    16. pernicious anemia B12 B12

    ( 91/4/1 )

    17. aldesleukin ( Proleukin Inj )

    ( 91/12/1 )

    18. B C

    ( 92/10/1 )

    19. etanerceptadalimumab

    (93/8/1)

    20. exenatide ( 103/9/1 )

    21. liraglutide ( 103/9/1 )

    22. teriparatide ( 103/9/1 )

    23. interferon beta-1a ( 103/9/1 )

    24. interferon beta-1b ( 103/9/1 )

    25. glatiramer ( 103/9/1 )

  • (123)-4/35

    Bydureon 2 mg/vial(Exenatide)

    Victoza 6 mg/ml, 3 ml/vial ( Liraglutide)

    Forteo 250 ug/ml, 2.4 ml/amp( Teriparatide )

    Rebif 44 mcg/12 MIU/vial ( Interferon beta-la )

    3.3.13. Agalsidase alfa agalsidase beta ( Replagal Infusion Fabrazyme Injection)

    ( 102/1/1103/9/1 )

    1.

    (1) alpha- galactosidase A alpha- galactosidase A

    I.

    II. ( Microalbuminuria)

    (2) ( Cardiac Variant )

    I. ( )

    ( )

    II. Cardiac Variant 1 9

    ( cardiac biopsy ) GL3 lyso-Gb3

    ( 103/9/1 )

    (I)III Cardiac Variant

    (II)IV

    2. Fabryzyme 1 mg/Kg/every 2 weeksReplagal 0.2 mg/Kg/every 2 weeks

    3. 1

    (1) MRI

    (2) MRI 10% 20%

    (3)

    (4)

    4.

    (1)

    (2) agalsidase alfa

    agalsidase beta

    (3) Cornea Verticillata

    5.

    (1) ( EGFR )

    (2) ( )

    (3) GL3

    (4) lyso-Gb3

    (5)

    (6)

    (7) (

  • (123)-5/35

    )

    (8) ( NYHA functional class 6 )

    (9)24 Holter :

    ()

    (10) ( MRI )

    Replagal 1 mg/ml,3.5 ml/vial ( Agalsidase alfa )

    9.26. Pemetrexed ( Alimta( 95/3/195/7/197/11/198/9/1103/4/1103/9/1 )

    1.

    (1) cisplatin

    (2) 70 ( )

    ( 95/7/197/11/198/9/1 )

    (3)

    ECOG performance status 0~1 ( 98/9/1 )

    2. 6 4

    103/4/1103/9/1

    Alimta 500 mg/vial ( Pemetrexed )

    Alimta 100 mg/vial ( Pemetrexed )

    9.47. lapatinib Tykerb103/9/1

    1. capecitabine anthracycline,taxane trastuzumab

    HER2

    2.

    Tykerb 250 mg/tab ( Lapatinib )

    8.2.4.Etanercept ( Enbrel ) ; adalimumab Humira ; golimumab Simponi

    abatacept Orenciatocilizumab Actemra( 92/3/193/8/193/9/198/3/1

    99/2/1100/12/1101/1/1101/6/1101/10/1102/1/1102/2/1102/4/1102/10/1

    103/9/1 )

    ( )

    103/9/1

  • (123)-6/35

    ENBREL 25mg/0.5ml/vial ( Etanercept )

    Humira 40 mg/vial ( Adalimumab )

    Simponi 50 mg/0.5 ml/vial ( Golimumab )

    Abatacept ( Orencia ) 250 mg/vial

    Actemra ( Tocilizumab ) 80 mg/4 ml/vial

    Actemra ( Tocilizumab ) 200 mg/10 ml/vial

    9.20.Rituximab ( Mabthera) (91/4/193/1/195/3/197/2/1102/1/1103/2/1

    103/9/1 )

    1. B ( 91/4/1 )

    2. CHOP CD20 B ( 93/1/195/3/1 )

    3. CVP B ( 95/3/1 )

    4.

    ( 97/2/1 )

    5. ( 103/2/1 )

    (1) Rai Stage / ( Binet C ) CLL Rai Stage / ( Binet A/B )

    ()

    CD20 50%

    (2) CD20 CD20

    50%

    (3)

    6. ( ANCA ) ( 103/9/1 )

    (1)

    (2) cyclophosphamide 4

    (3) ( GPA Wegeners granulomatosis )

    ( MPA ) cyclophosphamide

    (4) cyclophosphamide

    (5) 4

    ( ) cyclophosphamide 4

    cyclophosphamide 4 :

    A

    B

    C

    D

    7. 14 5 6 ( 102/1/1103/2/1103/9/1 )

    Mabthera 100 mg/10 ml/vial ( Rituximab )

    Mabthera 500 mg/50 ml/vial ( Rituximab )

  • (123)-7/35

    103 08

    Generic Name

    Brand Name

    /

    Appearance

    /

    Use

    Caution

    Pramipexole

    0.375 mg/tab

    Mirapex PR

    ( )

    025258

    /

    P1/

    ( 1030801 )

    20.2

    Ciclesonide

    160 mcg/dose ;

    60 doses/ bot

    Alvesco 160 Inhaler

    ( )

    024786

    /

    ( 1030805 )

    524

  • (123)-8/35

    Generic Name

    Brand Name

    /

    Appearance

    /

    Use

    Caution

    Crizotinib

    250 mg/cap

    Xalkori

    ( )

    025938

    / pfizer CRZ250

    ALK

    ALK

    ( 1030801 )

    4153

    Macitentan

    10 mg/tab

    Opsumit

    ( Patheon Italia )

    / 10

    WHO II

    IV

    ( 1030807 )

    3784

  • (123)-9/35

    103 08

    Generic Name

    Before New /

    Use

    Caution

    Brand Name

    /

    Appearance

    Brand Name

    /

    Appearance

    Ceftazidime

    1 g/vial

    Cetazine

    ( )

    041754

    / Sintum

    ( )

    042091

    / Ceftazidime

    ( 1030807 )

    72

    Folic Acid

    5 mg/tab

    Folic Acid

    ( )

    007543

    /

    124/

    Folacin

    ( )

    034670

    /

    ( 1030809 )

    2

  • (123)-10/35

    Generic Name

    Before New /

    Use

    Caution

    Brand Name

    /

    Appearance

    Brand Name

    /

    Appearance

    Procaterol

    25 mcg /tab

    Pocathma- Mini

    ( )

    045416

    /

    S T/273

    Meptin-Mini

    ( )

    043700

    /

    OG/22

    ( 1030809 )

    2

    Montelukast

    10 mg/tab

    Singulair

    ( )

    022778

    /

    SINGULAIR/

    MSD 117

    Anxokast

    ( )

    047813

    /

    AX 010

    ( ALLERGIC RHINITIS )

    ( 1030809 )

    25.6

  • (123)-11/35

    Generic Name

    Before New /

    Use

    Caution

    Brand Name

    /

    Appearance

    Brand Name

    /

    Appearance

    Dipyridamole

    25 mg/tab

    Solantin

    ( )

    032530

    /

    Dipyridamole

    ( )

    013801

    /

    STD 129

    ( 1030811 )

    2

    Levothyroxine

    100 mcg/tab

    Eltroxin

    ( GSK )

    024708

    /

    GS 21C/100

    Thyroid-S

    ( )

    048191

    /

    /

    ( 1030811 )

    2

  • (123)-12/35

    Generic Name

    Before New /

    Use

    Caution

    Brand Name

    /

    Appearance

    Brand Name

    /

    Appearance

    Clarithromycin

    500 mg/tab

    Klaricid

    ( )

    022420

    /

    e

    Klarith

    ( )

    046638

    /

    PBF436

    OMEPRAZOLE

    ( H.

    PYLORI )

    ( 1030812 )

    25.1

    Meclizine

    25 mg/tab

    Semper

    ( )

    034272

    /

    148/

    Meclizine

    ( )

    004781

    /

    FY T069

    ( 1030812 )

    0.66

  • (123)-13/35

    Generic Name

    Before New /

    Use

    Caution

    Brand Name

    /

    Appearance

    Brand Name

    /

    Appearance

    Disterile Water

    1000 mL/bot

    Water for inj

    ( )

    032379

    / Water for inj

    ( )

    003133

    /

    ( 1030813 )

    33.75

    Fludiazepam

    0.25 mg/tab

    Flupine

    ( )

    041519

    /

    G 38/JCP

    Erispan

    ( )

    009391

    /

    017

    ( 1030813 )

    2.86

  • (123)-14/35

    Generic Name

    Before New /

    Use

    Caution

    Brand Name

    /

    Appearance

    Brand Name

    /

    Appearance

    Albumin 20%

    10 g/ 50mL/bt

    Plasbumin-20

    ( )

    000777

    / Albumin

    ( TBSF )

    000842

    /

    ( 1030813 )

    1212

    Ramipril

    10 mg/tab

    Tritace

    ( )

    023603

    /

    HMO HMO

    Syntace

    ( )

    051029

    /

    SY/11

    ( 1030813 )

    10.5

  • (123)-15/35

    Generic Name

    Before New /

    Use

    Caution

    Brand Name

    /

    Appearance

    Brand Name

    /

    Appearance

    Amoxicillin &

    Clavulanate

    Potassium

    500 mg &

    100 mg/ vial

    Anbicyn

    ( )

    042697

    / Augmentin

    ( )

    018304

    /

    ( 1030814 )

    56

    Prednisolone

    5 mg/tab

    Donison

    ( )

    002531

    /

    CCP C03

    Compesolon

    ( )

    031676

    /

    PLt

    (1030814 )

    2

  • (123)-16/35

    Generic Name

    Before New /

    Use

    Caution

    Brand Name

    /

    Appearance

    Brand Name

    /

    Appearance

    Allopurinol

    100 mg/tab

    Allopurinol

    ( )

    014228

    /

    YUNG SHIN

    Urinol

    ( )

    020894

    /

    ( 1030814 )

    2

    Lubricant K-Y Jelly

    ( )

    000852

    /

    82 gm/tube

    Water Gel

    ( )

    001229

    /

    82 mL/tube

    ( 1030815 )

    144

  • (123)-17/35

    Generic Name

    Before New /

    Use

    Caution

    Brand Name

    /

    Appearance

    Brand Name

    /

    Appearance

    Cefepime

    Maxipime

    ( )

    021777

    /

    500 mg/vial

    Cefim

    ( )

    048834

    /

    1000 mg/vial

    Cefepime

    :

    Maxipime

    500 mg/vial,

    Cefim 1000

    mg/vial

    (1030815 )

    432

    Fexofenadine

    60 mg/tab

    Fexofenadine

    ( )

    057127

    /

    CC P/138

    Allegra

    ()

    023016

    /

    06

    (1030814 )

    3.33

  • (123)-18/35

    Generic Name

    Before New /

    Use

    Caution

    Brand Name

    /

    Appearance

    Brand Name

    /

    Appearance

    Mirtazapine

    30 mg/tab

    Remeron

    ( )

    024009

    /

    TZ 2

    Mirtapine

    ( )

    049656

    /

    PLT33/MTZ

    ( 1030815 )

    23.5

    Pyridostigmine

    60 mg/tab

    Mestinon

    ( )

    036008

    /

    Antilon

    ( )

    048908

    /

    PR/

    ( 1030815 )

    3

  • (123)-19/35

    Generic Name

    Before New /

    Use

    Caution

    Brand Name

    /

    Appearance

    Brand Name

    /

    Appearance

    Cimetidine

    300 mg/tab

    Defense

    ( )

    22836

    /

    C

    Stogamet

    ( )

    038419

    /

    SPC/S86

    ( 1030816 )

    2

    Nicorandil

    5 mg/tab

    Sigmart

    ( )

    020991

    /

    C-21F 5

    Nirandil

    ( )

    048991

    /

    ST/1001

    ( 1030818 )

    4.82

  • (123)-20/35

    Generic Name

    Before New /

    Use

    Caution

    Brand Name

    /

    Appearance

    Brand Name

    /

    Appearance

    Cephradine

    1 g/vial

    S-60

    ( )

    033149

    / Lofadine

    ( )

    029504

    /

    ( 1030818 )

    28.4

    Tramadol &

    Acetaminophen

    37.5 mg &

    325 mg/tab

    Ultracet

    ( )

    023917

    /

    JANSSEN/T/A

    Tramacet

    ( )

    057779

    /

    UC75

    ( 1030818 )

    7.4

  • (123)-21/35

    Generic Name

    Before New /

    Use

    Caution

    Brand Name

    /

    Appearance

    Brand Name

    /

    Appearance

    Hydrocortisone Na

    Succinate

    100 mg/ vial

    Hydrocortisone

    ( )

    057749

    / Solu-Cortef

    ( )

    018167

    /

    ( 1030818 )

    35.3

    Trihexyphenidyl

    2 mg/tab

    Benzox

    ( )

    038846

    /

    L

    Switane

    ( )

    039597

    /

    SWISS 2

    ( 1030818 )

    1.5

  • (123)-22/35

    Generic Name

    Before New /

    Use

    Caution

    Brand Name

    /

    Appearance

    Brand Name

    /

    Appearance

    Aceclofenac

    100 mg/tab

    Tonec

    ( )

    046613

    /

    UC 25

    Ascofen

    ( )

    057798

    /

    STD/777

    ( 1030818 )

    6

    Diltiazem

    30 mg / tab

    Diltisser

    ( )

    033224

    /

    CCP

    Cartil

    ( )

    036966

    /

    SYG30

    ( 1030819 )

    2

  • (123)-23/35

    Generic Name

    Before New /

    Use

    Caution

    Brand Name

    /

    Appearance

    Brand Name

    /

    Appearance

    Cetirizine

    10 mg/tab

    Cety

    ( )

    044710

    /

    YSP38

    Cemine

    ( )

    043403

    /

    SC/C18

    ( 1030819 )

    2

    Mephenoxalone

    200 mg/tab

    Doflex

    ( )

    042919

    /

    GP/277

    Mefno

    ( )

    043257

    /

    OB 02

    ( 1030819 )

    2

  • (123)-24/35

    Generic Name

    Before New /

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    Brand Name

    /

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    Brand Name

    /

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    Sodium Chloride

    0.9%500 mL/bot

    Saline

    ( )

    029836

    / Sodium Chloride

    ( )

    009997

    / ( 1030819 )

    25

    Azathioprine

    50 mg/tab

    Azathioprine

    ( )

    022229

    /

    AZP 50

    Azamun

    ( )

    025754

    /

    AZA50

    ( 1030820 )

    18

  • (123)-25/35

    Generic Name

    Before New /

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    Brand Name

    /

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    Brand Name

    /

    Appearance

    Rocuronium

    50 mg/5 mL/vial

    Esmeron

    ( )

    022140

    / Rocurin

    ( )

    052611

    /

    ( 1030820 )

    307.5

    Metformin

    500 mg/tab

    Loditon

    ( )

    043706

    /

    STD/L 09

    Uformin

    ( )

    036349

    /

    MF1

    ( 1030820 )

    2

  • (123)-26/35

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    Before New /

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    Brand Name

    /

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    Brand Name

    /

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    Phenytoin

    100 mg

    Dilantin

    ( )

    00817

    /

    /

    PARKE/PD100

    Aleviatin

    ( )

    002320

    /

    Ptsh/

    ( 1030820 )

    2

    Atorvastatin

    40 mg/tab

    Lipitor

    ( )

    022889

    /

    PD 157/40

    Atorva

    ( )

    055268

    /

    STD/290

    ( 1030820 )

    35

  • (123)-27/35

    Generic Name

    Before New /

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    Brand Name

    /

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    Brand Name

    /

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    Zoledronic Acid

    4 mg/vial

    Zometa

    ( )

    023733

    / Zobonic

    ( )

    055020

    /

    ( HCM )

    ( 1030820 )

    10928

  • (123)-28/35

    Generic Name

    Before New /

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    Brand Name

    /

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    Brand Name

    /

    Appearance

    Enalapril

    20 mg/tab

    Sintec

    ( )

    039414

    /

    ST/

    Enalatec

    ( )

    039401

    /

    CCP/

    ( 1030820 )

    2

    Dextromethor-

    phan HBr

    60 mg/S.R.tab

    Detosiv

    ( )

    044781

    /

    LO/06

    Regrow

    ( )

    042687

    /

    ( 1030821 )

    2.8

  • (123)-29/35

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    /

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    /

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    Pilocarpine

    2% 15 mL/bot

    Pilocarpine

    ( )

    032283

    /

    Isopto Carpine

    ( )

    016483

    /

    ( 1030821 )

    83

    Fenofibrate

    160 mg/tab

    Lipanthyl

    ( )

    023770

    /

    160/

    Fenolip-U

    ( )

    047228

    /

    CH/60

    ( TYPE IIaIIbIIIIVV )

    ( 1030822 )

    7.4

  • (123)-30/35

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    /

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    /

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    Polycresolsulf-

    onate & Cinchocaine

    100 mg &

    2.5 mg/ Supp.

    Ebodyl

    ( )

    047550

    / Posuline

    ( )

    047029

    /

    ( 1030822 )

    9.4

    Calcium Gluconate Glucal Black

    ( )

    005603

    /

    20%

    5 mL/amp [Ca

    =0.898

    mEq/mL]

    Calglon

    ( )

    058006

    /

    10%

    10 mL/amp

    [Ca = 0.465

    mEq/mL]

    Calglon

    Glucal Black

    ( 1030822 )

    12.5

  • (123)-31/35

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    Brand Name

    /

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    /

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    Sevoflurane

    250 mL/bt

    Sevoflurane

    ( BAXTER )

    024308

    / Ultane

    ( Aesica )

    022836

    /

    Sevoflurane

    ( 1030822 )

    3516

    .

  • (123)-32/35

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    Brand Name

    /

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    /

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    Ampicillin &

    Sulbactam

    1.5 g/vial

    Subacillin

    ( )

    046544

    /

    Sulampi

    ( )

    052553

    /

    ( Bacteroides,

    Fusobacterium,

    Clostridium difficile )

    Branhamella catarrhalis

    (1030822 )

    108

  • (123)-33/35

    103 08

    Generic Name

    Brand Name

    /

    Appearance

    /

    Use

    Caution

    Pramipexole

    0.25 mg/tab

    Mirapex

    ( )

    023280

    /

    P7 P7/

    ( PRIMARY RESTLESS LEGS

    SYNDROME )

    :

    Mirapex PR

    0.375 mg/tab ( Pramipexole)

    Mirapex

    0.25mg/tab ( Pramipexole )

    ( 1030801 )

    12.8

    Fluticasone 250mcg/dose ;

    60 doses/bot

    Flixotide Accuhaler

    ( )

    021921

    / :

    Alvesco inhaler

    160mcg/dose 60doses

    ( Ciclesonide )

    Flixotid Accuhaler

    250ug/dose 60dose/bt

    ( Fluticasone )

    ( 1030805 )

    516

  • (123)-34/35

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    Brand Name

    /

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    /

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    Caution

    Ornithine Aspartate

    250 mg/cap

    Hepacure

    ( )

    015826

    /

    ( 1030809 )

    720

    Haloperidol

    mg/drop

    30 mg/15 mL/bot

    Haldomin

    ( )

    030383

    /

    : Paliperidone

    ( Invega sustenna 100mg/vial

    & 150mg/vial )

    Haldomin

    ( 1030809 )

    :

    1. Haloperidol ( Binin-U ) 5

    mg/tab

    2. Haloperidol ( Binin-U ) 5

    mg/mL/amp

    45.5

  • (123)-35/35

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    /

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    /

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    Caution

    Hyaluronic acid

    16 mg/2 mL/syringe

    Synvisc

    ( )

    010770

    /

    ACETAMINOPHEN

    ( 1030819 )

    :

    Hyaluronic acid ( ArtiAid )

    25 mg/2.5 mL/amp

    Hyaluronic acid ( Hya-Joint )

    25 mg/2.5 mL/amp

    6600