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© 2001 By Default! A Free sample background from www.pptbackgrounds.fsnet.co.uk Slide 1 Introduction of diverse devices to measure arterial stiffness PARK, Jeong Bae, MD, PhD, Medicine/Cardiology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine 2005 5 27일 혈관연구회 부산 집담회, 부산 롯데 호텔

Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Page 1: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

© 2001 By Default!

A Free sample background from www.pptbackgrounds.fsnet.co.uk

Slide 1

Introduction of diverse devices to measure arterial stiffness

PARK, Jeong Bae, MD, PhD,

Medicine/Cardiology, Samsung Cheil Hospital,

Sungkyunkwan University School of Medicine

2005 5 27일 혈관연구회 부산 집담회, 부산 롯데 호텔

Page 2: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 2

Flow Pressure Diameter

Fluctuations in amplitude of flow,

pressure, and diameter in a large artery

HeartSV

C

Page 3: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 3

Pressure pulsations

Asc

aorta

Aorta

arch

Abd.

aorta

Fem.

artery

Sap.

artery

Pressure

100

80

60mm

Hg

Page 4: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 4

A Model of the Systematic Circulation.

Page 5: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 5

Systole

Compliance, D/P or A/P

vs. pulse wave velocity

PWV = D / T

Augmentation index

AI=Augmentation pr.

SBP - DBP

Page 6: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 6

Parameter Definition Formula

Distensibility The relative change in vessel diameter (or area) for a given change in pressure

D/(PxD), A/(PxA)

Compliance The absolute change in vessel diameter (or area) for a given change in pressure

D/P, A/P

Elastic modulus The pressure change required for (theoretical) 100% stretch from resting diameter (inverse of distensibility)

(PxD)/D

Pulse wave velocity The speed with which the pulse wave travels along a length of artery

Distance/t

Stiffness index (ß ) The ratio of the natural logarithm of SBP/DBP to the relative change in diameter

ln(Ps/Pd)/ [(Ds-Dd)/Dd)]

Augmentation index Size of increase or decrease in the pulse height as a result of the reflected wave, or Size of reflected peak (P2/P1)

(P2-P1)/(Ps-Pd), (P2/P1)

Terminology

Page 7: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 7

Elastic a.

Muscular a.

Heart SV

C

Resistance a.

Def: The absolute change in vessel

diameter (or area) for a given

change in pressure. D/P or A/P

I. Compliance

dV/dPVo

lum

e (

V)

Pressure (P)

Page 8: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 8

I-2. Local Arterial (Aortic) Stiffness: Stiffness index

= Ln (SBP/DBP) / (Dsys-Ddia/Ddia)

DsDd

Page 9: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 9

II. Pulse wave velocity

The speed with which the pulse wave travels along a length of artery

(Distance/t)

* *a b

distance

A B

A

B

t

Page 10: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 10

P2

P1

SBP

DBP

AI=P

SBP - DBP

P = P2 - P1

III. Augmentation pressure and

augmentation index

incisura

ejection duration

pp

Page 11: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 11

VP-1000,2000 (COLIN)

Page 12: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 12

BaPWV and ABI by Colin

Page 13: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 13

Arterial stiffness index (ASI)

Page 14: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 14

• 두 동맥부위 사이의 PWV (pulse wave velocity) 측정

• 동맥경화, 혈관노화 등의 혈관관련질환 조기 발견

• 환자들에게 거부감 없이 접근할 수 있는 비침습적 혈관관련질환 진단 시스템

• 기 능

• 심장에서 특정부위 혈관까지의 펄스전달속도 실시간 디스플레이

• 심전도, 심음, 4채널 동맥펄스 동시 측정

• 혈관관련 질환별 데이터베이스 내장

• 용 도

• 혈관노화 및 동맥경화 등의 혈관 관련 질환 분석

• 동맥탄력성 및 혈관 질환별 위험도 분석

• 환자의 치료효과 및 호전상태 추적

• 동맥경화, 고혈압, 당뇨 등의 혈관 질환 조기진단

한별-혈관질환 진단시스템 (PP-1000)

Page 15: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 15

한별-혈관질환 진단시스템 (PP-1000)

Page 16: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 16

Complior, Micro-system, Omron

Page 17: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 17

Radial artery

Systemic Arterial stiffness; Augmentation index (AIx) by Sphygmocor

Aorta

Pressure transfer function(Degree of amplification)

Radial pulse

applanation tonometry

Augmentation index

Page 18: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 18

Applanation tonometry (SphygmoCor)

Page 19: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 19

주요 혈관경직도 측정기의 특징

VP-1000,2000 (COLIN)

VaSera-1000

(FUKUDA)

CardioVision Complior SphygmoCor(AtCor)

PP-1000(Hanbyul

Meditech)

측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt)

Brachial PP ECG, Carotid, Radial & Femoral PP

ECG, P ECG, PCG, Carotid, Radial, Femoral, Dorsalis Pedis Pulse waves (lt/rt)

측정원리 Cuff에 자동으로 압력을 인가했다가 감소시키면서4 부위에서의 혈압 값(최고, 최저, 평균)을측정하고 맥파 파형을 검출

각 동맥부위에서의 맥파파형 검출

특정 동맥부위에서의 맥파파형을 검출한후 다른 부위

에서 맥파 검출

각 부위에압력센서를위치하고 4 채널로부터 동시에맥파 파형을 검출

측정변수및진단내용

사지혈압, baPWV, ABI 좌우 상완 혈압ASI (arterial

Stiffnessindex)

Framingham

위험도

ASI/CHD위험도

PWV,

경동맥-대퇴동맥경동맥-요골동맥

경동맥-족배동맥

PWV

PWA

PWV,

경동맥-대퇴동맥경동맥-요골동맥

경동맥-족배동맥hcPWV, hbPWV, faPWV, hfPWV

CAVI

(cardio-ankle vascular index),

TBI

(toe-brachial index)

PWV;대동맥,상하지

동맥경화의 수준

추정 혈관 나이

Page 20: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 20

주요 혈관경직도 측정기의 특징

Pulse Prace (MML) DPA (digital arterial pulsewave analyzer,

MERIDIAN)

PDL/PVL (Biomedix) & Unetixs(Unextis)

측정신호 Volume Pulse PTG(plethysmogram) PPG, pressure volume, Doppler waveform

측정원리 손가락끝에서지첨용적맥파 검출

손가락으로부터 맥파(지첨용적맥파) 를검출하고 이로부터 APG (가속도 맥파) 산출

사지에서 부위별로 혈압측정, 도플러로 tibial, dorsal 혈류상태 파악, 양쪽발가락에서 PPG 측정

측정변수 및진단내용

동맥 경화도와 반사도 측정,손 가 락 끝 에 서 측 정 된용 적 맥 파 의 형 태 를분 석 하 여 경 화 도 정 도나타냄

가속도 맥파 파형의 모양변화를 분석

심박변이도(HRV)

부위별 혈압으로 동맥패색이있는 곳 파악

도플러 주로 말초동맥질환이발생하는 곳을 중심으로 정확한부위 검출 가능

발가락PPG 최단말초부위의혈관상태 파악

Page 21: Introduction of diverse devices to measure arterial stiffness · 2015. 7. 7. · Meditech) 측정신호 ECG, PCG, Brachial & Ankle PP (lt/rt) Brachial PP ECG, Carotid, Radial & Femoral

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Slide 21

To order to estimate arterial

stiffness, systemic arterial stiffness

(eg. augmentation index), in addition

to one-site stiffness (eg. compliance

or -index) or one-segment stiffness

(eg. pulse wave velocity) would be

the best.

Conclusion