KT_THUC_HANH_HUU_CO

7/27/2019 KT_THUC_HANH_HUU_CO

1/99

K THUT THC HNH

TNG HP HU C


2/99

BI 1:

K THUT C BN


3/99

AN TON PHNG TH NGHIM

Cc cht d chy khng c t gn ngn

la, ngun sinh nhit.

Khng c ngi trc tip cc ho cht khicha bit cht l g.

Khng c ci mt st nhn khi un hockhuy trn cc cht.

X l khib ho cht ri ln da.


4/99

VIDEO AN TON PTN

X l khi ho cht vng vo mt.

S dng t ht.

X l khi ho cht.
http://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Fumehood.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Fumehood.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Fumehood.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Spillkit.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Spillkit.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Spillkit.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Spillkit.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Spillkit.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Spillkit.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Spillkit.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Spillkit.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Fumehood.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmv


5/99

S DNG DNG C THU TINH

Cc c nhm cn phi c bi trn bng

silicone hoc vaseline.

Khng lm thay i nhit t ngt cc dngc thu tinh.

Dng c thu tinh rt d v khi un trc tiptrnbp in.

X l khib t tay do mnh thu tinh.


6/99

BNH CU


7/99

NG SINH HN


8/99

PHU LC


9/99

PHU CHIT


10/99

H THNG PHN NG


11/99

H THNG PHN NG


12/99

H THNG LC CHN KHNG


13/99

S DNG PHU CHIT


14/99

H THNG SOXHLET


15/99

H

THN

GC

GiM

P


16/99

CC TC NHN LM KHAN

Hp cht hu c Tc nhn lm khan

R-X (X=Cl, Br, I) CaCl2, CaSO4, P2O5, MgSO4

Alcohol CaSO4, MgSO4, K2CO3, CaO

Ether, hydrocarbon no,

hydrocarbon thmCaCl2, CaSO4, P2O5

Aldehyde CaCl2, MgSO4, NaSO4

Ketone CaSO4, MgSO4, Na2SO4, K2CO3

Acid hu c MgSO4, Na2SO4, CaSO4

Amine KOH, NaOH, K 2CO3, CaO


17/99

VIDEO K THUT C BN

Trch ly lng lng.

Lc trng lc.

Lc ht chn khng.

C quay gim p.

un hon lu.
http://localhost/var/www/apps/conversion/tmp/scratch_3/video/EXTRACTION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/EXTRACTION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/EXTRACTION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/FLUTED_FILTRATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/FLUTED_FILTRATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/FLUTED_FILTRATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/VACUUM_FILTRATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/VACUUM_FILTRATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/VACUUM_FILTRATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Rotavap.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Rotavap.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Rotavap.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Rotavap.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Reflux.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Reflux.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Reflux.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Reflux.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Reflux.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Reflux.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Rotavap.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/VACUUM_FILTRATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/FLUTED_FILTRATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/EXTRACTION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/EXTRACTION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/EXTRACTION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/EXTRACTION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/EXTRACTION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/EXTRACTION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/EXTRACTION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/EXTRACTION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/EXTRACTION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/EXTRACTION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/EXTRACTION.wmv


18/99

BI 2:

K THUT TINH CHHP CHT HU C


19/99

CHNG CTChng ct l qu trnh tch mt hn hp lng thnh

cc cu t ring bit da vo bay hi khc

nhau ca cu t trong hn hp.

Ccphng php chng ct:

Chng ct n gin (simple distillation)

Chng ct chn khng (vacuum distillation) Chng ct phn on (fractional distillation)

Chng ct li cun hi nc (steam distillation


20/99

Thermometeradapter Multiple adapter Claisen adapter

Claisen - Vigreuxadapter

Three-way adapter

Wurtz flask Claisen flask Receiver adapter Vacuumdistillation

adapter

multi-limbvacuumreceiver

Vigreuxcolumn

Dufton column Hempel column(ct m)

Raschig ring(vng mRaschig)


21/99

CHNG CT N GiNChng ct n gin c dng phn ring cc

cu t c nhit i si di 150oC (1 atm).iu kin chng ct thng:

Cc cu t trong hn hp em chng ct phitan ln hon ton vo nhau.

Chnh lch nhit si (1atm) gia cu t

cn phn ring vi cc cu t khc phi lnhn 25oC.

Cc cu t khngb phn hu nhit si.


22/99

CHNG CT N GiN


23/99

CHNG CT CHN KHNGChng ct chn khng thng c dng phn ring

cc cu t c nhit i si ln hn 150oC (1 atm).iu kin chng ct chn khng:

Cc cu t trong hn hp em chng ct phi tan ln

hon ton vo nhau. Chnh lch nhit si (1atm) gia cu t cn phn

ring vi cc cu t khcphi ln hn 25oC.

Nhit si ca cc cu t cn phn ring ln hn150oC (1 atm).

Cc cu t trong hn hp em chng ct d b phn huti nhit si ca chng (1atm).


24/99

CHNG CT CHN KHNG


25/99

CHNG CT PHN ON

Chng ct phn ondng phn ring cc cu

t tan ln vo nhau vchnh lch nhit sigia cu t cn tch v

cc cu t khc nh hn25oC (1 atm).


26/99

CHNG CTPHN ON


27/99

CHNG CT LI CUN HI NC

Phn tch cht cht hu ckhng tan (hoc t

tan) trong nc, khngphn ng vi nc, cp sut hi ln (100oC, 1atm).

Nhit si ca hn hp chng ct thp hnnhit si ca cc cu t thnhphn v thphn 100oC (nhit si ca nc).

Chng cc cht c nhit si cao nh du,cc cht d b nha ho, tinh du t thc vt


28/99



29/99



30/99

KT TINH LI

K thut kt tinh li c dng tu thuc:

tan ca cht, cht bn trong cc dung mi khc

nhau theo nhit

tinh khit ca hn hp em kt tinh.

iu quan trng trong kt tinh lphi la chnc dung mi thch hp.


31/99

KT TINH LIDung mi kt tinhphi p ng yu cu sau:

Ho tan c cc cht nhit si ca dungmi.

Khng ho tan cc cht nhit thp. nhit thp, dung miphi ho tan hon ton

cc cht bn hoc gi cc cht bn kt tinh chm

hn cht cn lm tinh. Dung mi khng phn ng ho hc vi cht tan,

dung mi c chn c nhit si cao hn nhit nng chy ca cht rn khong 10-15oC.


32/99

VIDEO K THUT TINH CHTHP CHT HU C

Chng ct n gin.

Chng ct chn khng.

Chng ct phn on.

Kt tinh li.
http://localhost/var/www/apps/conversion/tmp/scratch_3/video/SIMPLE_DISTILLATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/SIMPLE_DISTILLATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/VACUUM_DISTILLATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/VACUUM_DISTILLATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/VACUUM_DISTILLATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/FRACTION_DISTILLATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/RECRYSTALLIZATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/RECRYSTALLIZATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/RECRYSTALLIZATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/RECRYSTALLIZATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/RECRYSTALLIZATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/RECRYSTALLIZATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/Eyewash.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/FRACTION_DISTILLATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/VACUUM_DISTILLATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/SIMPLE_DISTILLATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/SIMPLE_DISTILLATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/SIMPLE_DISTILLATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/SIMPLE_DISTILLATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/SIMPLE_DISTILLATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/SIMPLE_DISTILLATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/SIMPLE_DISTILLATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/SIMPLE_DISTILLATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/SIMPLE_DISTILLATION.wmvhttp://localhost/var/www/apps/conversion/tmp/scratch_3/video/SIMPLE_DISTILLATION.wmv


33/99

BI 3:

TNG HP NITROBENZENE


34/99

C S L THUYT Nitro ho: th nguyn t hydro, halogene, nhm

sulfonic hoc carbonyl bng nhmNO2.

Tc nhn nitro ho:

HNO3

Hn hp HNO3 c v H2SO4 c (t l 1:1)

Nitrate ca kim loi kim v H2SO4 hoc anhydrideacetic.

Cc nitrate hu c


35/99

NITRO HO HP CHT THM Phn ng theo c ch th i in t vi tc

nhn NO2+.

S to thnh nitronium ion

chm nhanh- H+


36/99

NG DNG Vai tr ca hp cht nitro:

Dung mi

Sn phm trung gian cho cc qu trnh tng hp

hu c

K ngh nhum

Thuc n Cht do

Y hc


37/99

AN TON Nitrobenzene

Mc c cao (TLV 5 mg/m3).

Hp thu qua da.

Gy nguy hi n h thn kinh, gan,phi, thn v

h tun hon mu.

Triu chng khi nhim c nitrobenzene: au u,

bun nn, mt ti xanh, chn tay yu.


38/99

Benzene

Gybnh bch cu, ung th mu

Hu hoi no, gan, thn, phi, tim v gy ph huAND.

Gy cht nu nhim c nng.

Gy v sinh

Tnh cht vt l

Tn cht Dng Tnc (o C) Ts (o C) (g/cm3) tamtrong nc

Benzene Lng, khng mu 5.5 80.1 0.869 0.8g/l (25o C)

Nitrobenzene Lng, vng nht 5.85 210.9 1.199 1.9g/l (20o C)


39/99

S LP RP DNG C


40/99

S LP RP DNG C

Khng khKhng kh

Sinh hn

Khng kh


41/99

S KHI TiN TRNH TH NGHIM

HNO3

- Lm lnh < 30O CTo cation +NO2

Nitro ho

Ra

Lm khan

Chng ct

Nitrobenzen

H2SO4

-Nhit : 60oC- Thi gian; 1gi- Khuy trn

CaCl2

- Phn on: 207211oC

- Chit loi acid- Ra nc- Trung ho bng Na2 CO3- Ra nc


42/99

IR

1


43/99

H1NMR


44/99

BI 4:

TNG HP ANILINE


45/99

C S L THUYT Amine thm bc nht thng c iu ch bng cch kh ho hp

cht nitro:

Cc giai on trung gian:

Cc cht trung gian nitroso benzen trong qu trnh kh khng c lp

c do nb kh thnh phenyl hydroxylamin.


46/99

C S L THUYT Ccphn ng ph c th xy ra trong qu trnh kh:


47/99

C S L THUYT

Tc nhn kh thng dng l hydro mi sinh do acidhoc kim tc dng vi cc kim loi nh Sn, Fe, Zn,

Al

Cc tc nhn kh sulfur hoc polysulfur nh Na2S,

(NH4)2S, Na2S2 dng kh mt nhm nitro trong

cc hp cht polynitro.


48/99

C S L THUYT Tc nhn st Fe-HCl

Lng acid cn dng ch 1/40 l thuyt


49/99

C S L THUYT Trong mi trng chlohydric acid, sn phm

aniline s tn ti di dng mui aniline

chloride v c ti to khi cho thm base vo.



50/99


Fe, HCl, H2O

C6H5NO2

-un si, 1gi 30 phtKh ho

Kim ho

Chit

Lm khan

Chng ct

Aniline

- Phn on: 180185oC

Kim tra - Nh vi gt vo nc

Trong

c

- Giy qu ho xanhDd NaOH 50%

- Ly lp di


51/99

IR


52/99

IR

H1 NMR


53/99

H1NMR

C13 NMR


54/99

C13NMR


55/99

BI 5:

TNG HP ACETANILIDE


56/99

C S L THUYT

Phn ng acyl ho l qu trnh thay th nguyn t Hca nhm chc (-OH, -NH2 )bng nhm acyl

Nu nhm R = -CH3 ta cphn ng acetyl.

Amin thm c acetyl ho bng cc tc nhn nh

acetyl chloride (CH3COCl), acetic anhydride, acetic

acid.


57/99

C S L THUYT

Acetyl hobng acetyl chloride:Aminebc 1 vbc 2phn ng mnh lit vi acetyl

chloride to thnh sn phm acetyl ho v mui

amine chloride.

C S


58/99

C S L THUYT

Acetyl hobng acetyl chlorideAcetyl ho aminbc 1bng acetic anhydride xy ra

nhanh chng vi hiu sut cao cho sn phm mt ln

acetyl ho.

C S L THUYT


59/99

C S L THUYT

Acetyl hobng acetic acid

Cn bng chuyn sang chiu thun bng cch chngloi nc v dng d mt trong hai tc cht.



60/99


CH3COOH,

Zn, C6H5NH2

-un si, 2gi- Chng loi nc: 102106oCAcetyl ho

Ra acid, kt tinh

Lc, ra

Kt tinh li

Lc, ra

Acetanilide

- Phn on: 180185oC

Kim tra

Nhit tri sc

Chng loi nc:102106oC

Nc

- Dung mi: nc-Kh mu bng than hot tnh- Lc nng

S LP


61/99

S LPRP DNG C

IR


62/99

IR

H1 NMR


63/99

H1NMR

C13 NMR


64/99

C NMR


65/99

BI 6:

TNG HP ETHYL ACETATE

C S L THUYT


66/99

C S L THUYT

Ester c th c iu ch trc tip t ru bngphn ng vi carboxylic acid kh c mt xc tc acid

mnh nh H2SO4 hoc kh HCl kh.

C S L THUYT


67/99

C S L THUYT

Khi s dng acid chloride hoc anhydride thay chocarboxylic acid iu ch ester, phn ng xy ra

theo 1 chiu v khng cn s dng xc tc.

C S L THUYT


68/99

C S L THUYT

C ch phn ng:

C S L THUYT


69/99

C S L THUYT



70/99


CH3COOH,

C2H5 OH

-un si, 1giEster ho

Chng ct ln 1

Ra acid

Lm khan

Chng ct ln 2

Ethylacetate

- Phn on: 71

Na2CO3 10%

- Phn on:


71/99

S LP RP DNG C

nc vo

nc ra

IR


72/99

IR


73/99


74/99

BI 7:

TNG HP X PHNG

C S L THUYT


75/99

C S L THUYT

X phng l mui natri hoc kali ca acid bo mch

di (RCOOH).

Mch carbon di gy ra c tnh hot ng b mt cax phng thng l mch C12C18.

X phng rn thng l mui natri ca acid bo(RCOONa), cn x phng lng l mui kali vi acid

bo (RCOOK).

C S L THUYT


76/99

C S L THUYT

X phng c cu trc gm 2phn:phn ho nc lnhm COO- vphn khng phn cc, k nc l gcRmch di.

phn k nc phn ho nc(ho tan trong du) (ho tan trong nc)

C S L THUYT


77/99

C S L THUYT

C S L THUYT


78/99

C S L THUYT

C S L THUYT


79/99

C S L THUYT

C S L THUYT


80/99

C S L THUYT Khi thu phn cc cht bo (triglyceride) nh du

thc vt, m ng vt vi xc tc l cc base mnhnh KOH, NaOH s to thnh glycerol v muica acid bo mnh di (x phng).

CC THNH PHN CA DU DA


81/99

CC THNH PHN CA DU DA

STT Acid bo Cng thc % khi lng

1 Caproic CH3(CH2)4COOH 0.5

2 Caprilic CH3(CH2)6COOH 8.0

3 Capric CH3(CH2)8COOH 7.0

4 Lauric CH3(CH2)10COOH 48.0

5 Myristic CH3(CH2)12COOH 17.0

6 Palmitoleic CH3(CH2)5CH=CH(CH2)7COOH 0.2

7 Oleic CH3(CH2)7CH=CH(CH2)7COOH 6.0

8 LinoleicCH3(CH2)4CH=CH-CH2-

CH=CH(CH2)7COOH

2.3

9 Palmitic CH3(CH2)14COOH 9.0

10 Stearic CH3(CH2)16COOH 2.0

Du da c t trng: 0.86-0.90 15oC


82/99

QUY TRNHSN XUTX PHNG


83/99

QUY TRNHSN XUTX PHNG

QUY TRNH SN XUT X PHNG


84/99

QUY TRNH SN XUT X PHNG

QUY TRNH SN XUT X BNG CC


85/99




86/99




87/99


Du da,NaOH

-un 80oC, 1gi 30 phtX phng ho

Ra, tch lpNaCl bo ho

Lc ra

X phng

S LP RP DNG C


88/99

S NG C


89/99

BI 8:

TNG HP 2-NAPHTHOL DA CAM

PHN NG DIAZO HO


90/99

PHN NG DIAZO HO

Phn ng diazo ho xy ra khi amin thm bc 1 tc

dng vi nitrous acid (HNO2) trong mi trng acid

to thnh mui diazonium.

PHN NG DIAZO HO


91/99

PHN NG DIAZO HO

Trnh s to thnh hp cht diazoamino, ngi ta

dng d HCl (2.3-3 ng lng HCl). Khi d acid:

Mui diazonium rt km bn d phn hu khi tng

nhit phn ng diazo ho c thc hin 0-5oC.

PHN NG DIAZO HO


92/99

PHN NG DIAZO HO

Kim traphn ng diazo ho

Mi trng acidbng giy congo : ho xanh.

Nitrous acidbng gy KI tm h tinhbt: mu lam xm

PHN NG GHP I


93/99

PHN NG GHP I

Phn ln diazonium cation ca hp cht hu cl tc

nhn i in t yu cho nn phn ng th hydro

nhn thm v hydro cc hp cht khc th hin tnh

chn lc cao.

Tc nhn diazonium cation ch c kh nng th hydro

nhn thm c hot ho mnh v hydro linh ngtrong cc hp cht khc.

PHN NG GHP I


94/99

PHN NG GHP I

Phn ng ghp i hp cht diazonium vi phenol v

dn xut ca chng thng c thc hin trong mi

trng kim c pH khong 6-10, vi cc amin thm

thng thc hin trong mi trng acid pH=4-7.

Nhit phn ng ghp i thp nh phn ng diazo

ho (0-5o

C). Phn ng ghp i v phn ng diazo ho iu l

phn ng to nhit.

PHN NG GHP I


95/99

PHN NG GHP I

TNG HP 2-NAPHTHOL DA CAM


96/99

KHNG GIAN MU


97/99

MY NHUM


98/99

My nhum ch siMy nhum vi

MY NHUM


99/99

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