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The Cognitive Neuroscience of Memory and its Relevance to Meme Research Morris Moscovitch Rotman Research Institute and Department of Psychology Baycrest Centre for Geriatric Care University of Toronto. Memory, Social Networks, and Language: Probing the Meme Hypothesis II May 15-17 - PowerPoint PPT Presentation
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The Cognitive Neuroscience of Memory and its Relevance to Meme Research
Morris Moscovitch
Rotman Research Institute andDepartment of Psychology
Baycrest Centre for Geriatric Care University of Toronto
Memory, Social Networks, and Language: Probing the Meme Hypothesis II
May 15-17Victoria College, University of Toronto
U of T
Collaborators
• Gordon Winocur – Rotman Research Inst., Trent U.• Lynn Nadel – U of Arizona• Carlo Umiltà – U of Padova• Cheryl Grady - Rotman Research Inst.• Brian Levine - Rotman Research Inst.• Morris Freedman – Rotman Research Inst.• Mary Pat McAndrews - Toronto Western• Sandra Black – Sunnybrook • Fuqiang Gao – Sunnybrook• Marilyne Ziegler- University of Toronto• Baycrest Psychologists – Baycrest Psychology
Collaborators• Robyn Westmacott – Hospital for Sick
Children• Shayna Rosenbaum – York University and
Rotman Research Inst.• Asaf Gilboa – Haifa University• Donna Addis – Harvard University• Lillian Park – Rotman Research Institute• Signy Sheldon – University of Toronto
Meme – A unit of cultural information that can be transmitted
and replicated, but also altered in the process.
Memory would seem to be crucial to meme formation and transmission.
But what kind of memory? And what kind of memory processes?
Types of Memory: HumanTypes of Memory: Human
Explicit Implicit
Episodic Perceptual
Conceptual
Semantic Motor (procedural)
Dissociation between Episodic and Semantic Memory: Comparison of
Two Patients
Patient K.C.
• right-handed man with bilateral hippocampal damage from head injury that occurred in 1981, when he was 31 years old
• preserved remote semantic memory
• cursory evidence of impaired autobiographical episodic memory for all times in his life
Remote Memory in Amnesia
ACB
KC’s MTL lesions
A m n esic P a tien t K .C . N o rm a l C o n tro l S u b jec t
MTL & Related Structures
Anterior thalamicnucleus
Mediodorsal thalamicnucleus
CingulateGyrus
Fornix
Corpus Callosum
Alveus of thehippocampus
SubiculumDentategyrus
ParahippocampalGyrus
Pes HippocampiAmygdala
PrecommissuralFornix
PostcommissuralFornix
Anteriorcommissure
Septalnuclei
Mammillarybodies
HPC-neocortical connections (from
Treves and Rolls, 1993).
Patient KC: scores on Autobiographical Memory Interview
Personalsemantics
(maximum=21)
AutobiographicalInterview
(maximum=9)
Childhood 16.0 2
Early adult life 13.5 3
Recent life 8.0 1
Semantic Dementia
Patient E.L.
65 year-old man, originally from England who worked as a graphic artist at the CBC.
Video of EL being interviewed by Morris Freedman and Morris
Moscovitch
Robyn WestmacottShayna Rosenbaum
Sandra BlackMorris Freedman
Peter GaoStefan KohlerLarry Leach
Sandra PriselacJill Rich
Shayna RosenbaumKathy Stokes
Westmacott et al., Neurocase, 2001; Cog. Neuropsychol., 2002, 2004; Neuropsychologia, 2004; Rosenbaum et al, Neuropsychologia, 2005.
K.C.'s scores on semantic and episodic variables in the photograph description task
0%
20%
40%
60%
80%
100%
Late 50's Early 60's Late 60's Early 70's Late 70's 80's 90's
Sco
re
Semantic
Episodic
E.L.'s scores on recognition, naming and episodic variables in the photograph description task
0%
20%
40%
60%
80%
100%
Late 30's 40's 50's 60's 70's 80's 90's
Sco
re Recognition
Episodic
Naming
Asaf Gilboawith
Shayna Rosenbaumand Amir Poreh and Gordon Winocur
Poreh, et al, Neuropsychologia, 2006; Gilboa et al, Hippocampus, 2006.
MTL & Related Structures
Anterior thalamicnucleus
Mediodorsal thalamicnucleus
CingulateGyrus
Fornix
Corpus Callosum
Alveus of thehippocampus
SubiculumDentategyrus
ParahippocampalGyrus
Pes HippocampiAmygdala
PrecommissuralFornix
PostcommissuralFornix
Anteriorcommissure
Septalnuclei
Mammillarybodies
Fornix lesions are a crucial test of EHS hypothesis
Patients with fornix lesion
• Fornix lesions prevent major hippocampal output while leaving the hippocampus, the rest of MTL, and neocortex intact.
• According to our hypothesis that the hippocampus is necessary for recollection, autobiographical memories, whether recent or remote, should be impaired in people with fornix lesions.
The Case of D.A. p.s.
• An educated 45-year-old right-handed male. Arrived with a one-month history of excruciating headaches.
• Continued working up to the time of his surgery.
• An MRI T1 revealed a typical colloid-cyst situated in the anterior part of the IIIrd ventricle, with a mild degree of obstructive hydrocephalus.
Colloid cyst
ADFAge-matched control
ADF’s Fornix lesions
Other memory-related lesionsBasal forebrain Basal ganglia
ADF ADFControlControl
Famous Faces and Events
TASKTASK YEARSYEARS % Correct % Correct
Famous Faces 1970-80 951981-90 961991-99 99
Famous Events 1970-80 1001981-90 951991-99 90
Personal Episodes 1970-80 501981-90 501991-99 40
Reaction to Photos from Significant Personal Events
• His Photograph of an Army Camp 73
• Army base, these are T. type tanks. When was the picture taken? Why was it taken? I don’t know.
• Group photograph of a graduation ceremony in 1984
• This is the graduation ceremony of some kind of training. I can't remember the ceremony.
• Photograph of the circumcision of his son 1987
• Looks at the picture for 5min: This is a circumcision rite. I can see the baby. He didn’t identify his son.
• A picture from a trip to Greece 97
• A trip to Turkey (Wife =No). Rhodes? (wife =no) …we went on a train (wife= by a boat).
Summary of Studies of Patients with Hippocampal Complex
Lesions
•Autobiographical Memory: Extensive RA, sometimes even without a temporal gradient
Summary of Studies of Patients with Hippocampal Complex
Lesions
•Autobiographical Memory: Extensive RA, sometimes even without a temporal gradient
•Semantic Memory:
Limited RA, most often with a temporal gradient
Two Components of Episodic Memory(Tulving, 1985)
• Recollection: Re-experiencing or reliving a past event in the mind; mental time travel. Characterized by recovering and recreating the context in which a stimulus or event occurred.
• Familiarity: A stimulus is recognized or experienced as old, but little or no information is associated about the context in which it was encountered. Resembles semantic memory
Two Components of Episodic Memory(Tulving, 1985)
• Recollection: re-experiencing or reliving a past event in the mind; mental time travel. Characterized by recovering and recreating the context in which a stimulus or event occurred.
• Familiarity: A stimulus is recognized or experienced as old, but little or no information is associated about the context in which it was encountered. Resembles semantic memory.
Why should recollection be associated with the
hippocampus?
Carlo Umiltà & Gordon Winocur
A component process of memory based on modules and central systems
Moscovitch and Umiltà (1990, 1991); Moscovitch and Winocur (1992); Moscovitch (1992)
A. Encoding B. Cohesion C. Consolidation Remembering
A
A B C
HIPPOCAMPALCOMPLEX
Event
A B C
HIPPOCAMPALCOMPLEX
Event
HIPPOCAMPALCOMPLEX
HIPPOCAMPALCOMPLEX
B
HIPPOCAMPALCOMPLEX
Event
Hi Hi
B BB C A CACA B C B
HIPPOCAMPALCOMPLEX
Hi
CBA
NE
OC
OR
TE
X
The hippocampus is essential for encoding, retaining, and
recovering experiences (i.e. recollection).
The hippocampal complex (or medial temporal lobe) is a ‘stupid’ module that automatically encodes all information that is apprehended consciously, and retrieves information obligatorily in response to a proper, proximal cue.
Strategic Memory Processes:The Frontal Lobe as a
Working-with-Memory Structure(Moscovitch & Winocur, 1992, 2002:Moscovitch, 1992)
A. Encoding B. Cohesion C. Consolidation Remembering
A
A B C
HIPPOCAMPALCOMPLEX
Event
A B C
HIPPOCAMPALCOMPLEX
Event
HIPPOCAMPALCOMPLEX
HIPPOCAMPALCOMPLEX
B
HIPPOCAMPALCOMPLEX
Event
Hi Hi
B BB C A CACA B C B
HIPPOCAMPALCOMPLEX
Hi
CBA
NE
OC
OR
TE
X
FR
ON
TA
L
FR
ON
TA
L
The hippocampus is essential for encoding, retaining, and recovering
experiences (i.e. recollection) which the prefrontal cortex selects, organizes, monitors, and verifies.
Retrieval from the Hippocampus is also ‘stupid’ (automatic and
unorganized), needing the prefrontal cortex to make
retrieval ‘intelligent’ (goal-directed).
Summary
• Memories are not stored as whole representations of events, but as elements of the event which need to be reconstructed into a coherent narrative. Storage is random.
• Memories are represented as beads in a jar which need the prefrontal cortex to string into a necklace.
• Narratives are better suited than single items for investigations of reconstructive memory.
Memory is reconstructive: Bartlett, Remembering (1932)
“The first notion to get rid of is that memory is primarily reduplicative, or reproductive…re-excitement of individual traces did not look to be in the least what was happening... remembering appears to be far more decisively an affair of construction than one of mere reproduction.” pp204-205.
Implications• Recollection: Detailed re-experiencing of a past
event always will depend on the hippocampus, no matter when the event occurred.
• Automaticity: A proper cue will reactivate “hippocampal” memories automatically and influence performance even on non-episodic tasks.
• Random Storage: Allows for recombination of elements needed for construction of scenarios in many domains, from reconstructing the past, imagining the future, and solving problems.
Implications• Recollection: Detailed re-experiencing of a past
event always will depend on the hippocampus, no matter when the event occurred.
• Automaticity: A proper cue will reactivate “hippocampal” memories automatically and influence performance even on non-episodic tasks.
• Random Storage: Allows for recombination of elements needed for construction of scenarios in many domains, from reconstructing the past, imagining the future, and solving problems.
Implications• Recollection: Detailed re-experiencing of a past
event always will depend on the hippocampus, no matter when the event occurred.
• Automaticity: A proper cue will reactivate “hippocampal” memories automatically and influence performance even on non-episodic tasks.
• Random Storage: Allows for recombination of elements needed for construction of scenarios in many domains, from reconstructing the past, imagining the future, and solving problems.
Implications• Recollection: Detailed re-experiencing of a past
event always will depend on the hippocampus, no matter when the event occurred.
• Automaticity: A proper cue will reactivate “hippocampal” memories automatically and influence performance even on non-episodic tasks.
• Random Storage: Allows for recombination of elements needed for construction of scenarios in many domains, from reconstructing the past, imagining the future, and solving problems.
Asaf GilboaCheryl Grady
Gordon WinocurMorris Moscovitch
Gilboa et al., Cerebral Cortex, 2004.
Remote Autobiographical Memory
In normal people, the hippocampus should be much more activated for vivid memories (recollection) than for those that are not (familiarity) no matter how long ago the memory occurred.
Autobiographical memory
SELF OTHER
A. Family Photos
B. Rating scales (e.g. vividness/re-experiencing)
C. Semi-structured interviews (Levine et al., 2002)
Gilboa et al., 2004
Experiment
• Measure brain activity with fMRI (1.5 T)• Three to four time periods
– childhood– teen/ early adult– middle years– recent
• Photos matched for content as much as possible
fMRI Design
30 sec stimulus presentation (5 blocks of each type of photo per run)6 sec fixation in between each photo
Self SelfOther Other
fix fix fix
Activations in vividly vs. poorly recalled Activations in vividly vs. poorly recalled remote events: Hippocampusremote events: Hippocampus
X=-27 Y=-21 Z=-16
Hippocampal activation is mediated by extent of re-experiencing
X= -27, Y= –21, Z= –16; t=5. 75
High vividness vs. low vividness remote memories
Foci of left hippocampal activations across subjects
Remote events
Recent events
The hippocampus and remote episodic memories- comment
• Active specifically when re-experiencing
• Active for both remote and recent AM
• Different distribution of activation- may
account for gradients in retrograde amnesia
Autobiographical Memory Network
Donna Addis
Mary Pat McAndrews
Randy McIntosh
Morris Moscovitch
Hippocampus, 2007
The hippocampus is a hub linking other areas which represent different
aspects of autobiographical re-experiencing
Semantic memory
• Generic: Facts and general knowledge about the world, language, etc.
• Personal: Facts and knowledge about oneself.
For both types, there is little or no information about the context in which the knowledge was acquired. There is no experiential component.
Semantic Memory
The hippocampus slowly “nurtures” the development of neocortical (NC) traces that reflect the statistical properties of the world and/or of memories - the gist is extracted
Names of famous People
1940s: Joseph Cotten; Johnny Longden
1950s: Althea Gibson; Buddy Holly
1960s: Janet Leigh; Barbara Billinglsly
1970s: Loretta Switt; Phil Esposito
1980s: Gary Coleman; Ben Johnson
1990s: Tonya Harding; Monica Lewinsky
K.C.'s performance on the name categorization task
0%
20%
40%
60%
80%
100%
Time Period
Pe
rce
nta
ge
Cor
rect
Control
K.C. Guess
K.C. Explicit
Words Entering the Language1940s: Gasser; Hep-cat
1950s: Honcho; Univac
1960s: Hippie; Psychedelic
1970s: Velcro; Disco
1980s: Microwave; Nuke
1990s: Homophobia; Viagra
The hippocampus contributes, but is not necessary, for the retention and
recovery of semantic memory and of items which are merely familiar.
What accounts for both temporal gradients?
• For the first 5-10 years, memories retain their experiential qualities which contribute to recovery of semantic memory.
Multiple Trace Theory(Nadel & Moscovitch, Current Opinion in Neurobiology,
1997; Moscovitch et al, Journal of Anatomy, 2005)
Episodic
Semantic
Loves
Swims
BBQs
Cycles
HIPPOCAMPAL COMPLEX
NEOCORTICAL MODULES
Episodic
Semantic
Loves
Swims
BBQs
Cycles
HIPPOCAMPAL COMPLEX
NEOCORTICAL MODULES
Episodic
Semantic
Loves
Swims
BBQs
Cycles
HIPPOCAMPAL COMPLEX
NEOCORTICAL MODULES
Episodic
Semantic
Loves
Swims
BBQs
Cycles
Cue:
“KNOW”
HIPPOCAMPAL COMPLEX
NEOCORTICAL MODULES
Episodic
Multiple Trace Formation
Semantic
BBQs
Paints
Loves
Golfs
NEOCORTICAL MODULES
HIPPOCAMPAL COMPLEX
Episodic
Multiple Trace Formation
Semantic
BBQs
Paints
Loves
Golfs
HIPPOCAMPAL COMPLEX
NEOCORTICAL MODULES
Episodic
Multiple Trace Formation
SemanticLoves
Golfs
BBQs
Paints
HIPPOCAMPAL COMPLEX
NEOCORTICAL MODULES
Episodic
SemanticBBQs
Paints
Loves
Golfs
Cue:
“REMEMBER”
HIPPOCAMPAL COMPLEX
NEOCORTICAL MODULES
Episodic
Multiple Trace Formation
Semantic
Loves
Golfs
BBQs
Paints
HIPPOCAMPAL COMPLEX
NEOCORTICAL MODULES
Loves
Swims
BBQs
Cycles
Implications• Recollection: Detailed re-experiencing of a past
event always will depend on the hippocampus, no matter when the event occurred.
• Automaticity: A proper cue will reactivate “hippocampal” memories automatically and influence performance even on non-episodic tasks.
• Random Storage: Allows for recombination of elements needed for construction of scenarios in many domains, from reconstructing the past, imagining the future, and solving problems.
Robyn WestmacottLillian Park
Signy SheldonMary Pat McAndrews
Remember/Know (Re-experiencing/Familiarity)
Judgementsof Famous People
Westmacott & Moscovitch, Memory & Cognition, 2003;
Westmacott et al, Neuropsychologia, 2004.
ProcedureNorms were derived by having participants rate about 300 names of famous people on familiarity, facts known about them, emotionality, and personal significance.
50 famous names were selected, half of which were associated with high R responses and half with low R (K) responses in the general population. The R and K items were matched for familiarity and facts known about them.
Procedure
Participants Reaction times to read the names and make fame judgments about them were recorded.
After the tasks were completed, each subject rated the names on the extent to which they evoked a personal memory.
Remember vs. Know Left anterior hippocampal activation
Know vs. Non-famous
No MTL activation
Peak Hippocampal Activation
-0.20-0.15
-0.10-0.050.00
0.050.10
0.150.20
1
Remember Know
% S
igna
l Cha
nge
Conclusion
Recollection influences semantic judgment and reading times.
The influence of recollection on semantics is mediated by the hippocampus.
Conclusions
1. The Hippocampus is needed for storage and retrieval of rich, autobiographical memories as long as they exist. Such memories are NOT transferred to neocortex. The hippocampus plays the same role for remote memories as it does for recent memories.
Conclusions
2. The HP Complex contributes to the Neocortical strengthening and development of semantic memories of words, concepts, events, people and space - and even the gist of autobiographical memories.
Conclusions
3.Semantic memories may retain an autobiographical component which remains HP dependent.
Implications• Recollection: Detailed re-experiencing of a past
event always will depend on the hippocampus, no matter when the event occurred.
• Automaticity: A proper cue will reactivate “hippocampal” memories automatically and influence performance even on non-episodic tasks.
• Random Storage: Allows for recombination of elements needed for construction of scenarios in many domains, from reconstructing the past, imagining the future, and solving problems.
Recollection in the Service of Problem Solving
Signy Sheldon
Aida Ramos
Morris Moscovitch
Why do we need this detailed autobiographical memory?
• Planning for the future
• Imagination
• Problem solving
Episodic Memory• Captures co-occurring, often unrelated
elements of a consciously experienced event in a single memory trace. Therefore, the memory trace is informationally rich. Ideal for cross-domain pattern matching and completion.
• Extended episodes are not stored as single representations, but as separate units and need to be reconstructed into a coherent narrative. Underlies flexibility.
Current Study
• Episodic memory may be important when solving problems that are low frequency and not well-defined.
• Such problems are frequent in social settings.
The Role of EM in Social Problem Solving
• Do episodic memories contribute to social problem solving?
• Specifically, does impaired episodic memory lead to impaired ability to solve problems in which the solutions must be re-constructed from past personal experience?
Means-End Problem Solving (MEPS; Spivak & Platt, 1975)
• Measure of real-life problem solving, typically used in clinical setting.
• Requires one to orient self and conceptualize means of moving towards a goal.
• Consists of 10 vignettes that are of a personal nature; each describes an initial problem followed by an end state. The participant is to fill in the steps taken to get from the starting position to the end state/goal.
MEPS example
H. loved her boyfriend very much, but they had many arguments. One day he left her. H. wanted things to be better. The story ends with everything being fine between
her and her boyfriend. You begin the story when H.’s boyfriend left.
Analysis: Means
- Score the number of means taken to get to the end state.
- Three types of means:- Relevant a step or action that gets the
individual closer to achieving his/her goal- Irrelevant a step or action that may be
directed toward a specific goal but that is not effective within the context of the story
- No means doesn’t provide steps to achieve a goal. e.g. a miracle solution
Example
You begin the story when H.’s boyfriend left…. The story ends with everything fine between her and her boyfriend
• Relevant: talked things over
• Irrelevant: realizes cannot make it work, so H gives up
• No Mean: Waited a little while and then everything was fine
• Score = total number of relevant means
• Total Means = Relevant + Irrelevant + No Means
• Relevancy Ratio: total number relevant means/ (relevant + irrelevant + no means)
• Effectiveness Ratings: 07
MEPS and Episodic Memory
• Significant correlations between the number of specific memories generated on an autobiographical memory test and – (a) the means MEPS scores – (b) the effectiveness MEPS scores
(Beaman, et al., 2006; Goddard, et al., 1996)
• Groups with dampened specific memory recall also have lower MEPS scores– Depressed, schizophrenia
Current Study: Participants
• 12 Younger adults: mean age = 23.0
• 12 Older adults: mean age = 76.8
• So far, 4 Patients with medial temporal lobe lesions
Method
• Full MEPS protocol: 10 stories
• **After completed, asked:– Have you experienced an event like this?– Vividness of recall– What information did you use to complete the
story?
Results: Means
*
0
5
10
15
20
25
30
35
40
Revelant Means Total Means
Younger
Older
*
Analysis: Details
• To account for the richness of detail, we adapted the Autobiographical Interview of Levine et al (2002).
• segmented into distinct details (i.e., chunks of information)• Internal Details:
– Reflects episodic autobiographical memory– “H then went to her friends house, down the street, to talk
about her problem”• External Details:
– including semantic details, extended events and repetitions– “H always hates it when she fights with her boyfriend”
Results: Number of DetailsOlder vs Younger
0
20
40
60
80
100
120
140
160
180
Internal Details External Details
Older
Younger
*
Proportion of internal details/total details: Older vs Younger
0.5
0.55
0.6
0.65
0.7
0.75
0.8
0.85
0.9
Younger Older
*
Correlation of Internal Details to Relevant Means
40.0035.0030.0025.0020.0015.0010.00
relevant means
200.00
150.00
100.00
inte
rnal
det
ails
r=.690**
Correlation of External Details to Relevant Means
40.0035.0030.0025.0020.0015.0010.00
Relevant Means
120.00
100.00
80.00
60.00
40.00
20.00
0.00
Ext
ern
al d
etai
lsr=-.109 (ns)
Correlation of Internal Details to Relevant Means: Older Adults
30.0025.0020.0015.0010.00
Relevant Means
150.00
125.00
100.00
75.00
Inte
rna
l De
tails
r=0.65**
Correlation of Internal Details to Relevant Means: Older Adults
30.0025.0020.0015.0010.00
Relevant Means
100.00
80.00
Inte
rnal
Det
ails
r=0.713**
Correlation of External Details to Relevant Means: Older Adults
30.0025.0020.0015.0010.00
Relevant Means
120.00
100.00
80.00
60.00
40.00
20.00
0.00
Ext
ern
al D
eta
ils
r=0.38 (ns)
Correlation of External Details to Relevant Means: Older Adults
30.0025.0020.0015.0010.00
Relevant Means
120.00
100.00
80.00
60.00
40.00
20.00
0.00
Ext
ern
al D
eta
ils
r=0.38 (ns)
Conclusions…Thus Far
• Older adults produce the same overall number of means as younger adults, BUT they produce fewer relevant means.
• Older adults produce fewer internal (episodic) details when describing solutions to social problems.
• Number of internal details is correlated with relevant means, especially in older adults
• Number of internal details in autobiographical memory is also correlated with relevant means
Broad Conclusions
• Recollection is implicated in problem solving and possibly in expertise.
• A re-evaluation of the function of the hippocampus and, by extension, what constitutes memory.
What about the creative imagination?
Memory is reconstructive: Bartlett, Remembering (1932)
“The first notion to get rid of is that memory is primarily reduplicative, or reproductive…re-excitement of individual traces did not look to be in the least what was happening... remembering appears to be far more decisively an affair of construction than one of mere reproduction.” pp204-205.
“Don’t make love to a novelist because you’ll find a description of
your body in the next book”
From an interview with a French-Canadian novelist on CBC.
Thank you
U of T