PUBLICACIONES INVESTIGACION REUMATOLOGIA · J Eur Acad Dermatol Venereol. 2015 Feb 4. doi: 10.1111/jdv.13005. ... Taboada VM, Ortiz AM, Tornero J, Marsal S, Moreno-Muelas JV. 2014

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PUBLICACIONES de los últimos 5 años, INVESTIGACIÓN, PROYECTOS COMPETITIVOS, ENSAYOS CLÍNICOS y TESIS

SERVICIO DE REUMATOLOGÍA.

PUBLICACIONES de los últimos 5 años:

Robinson PC, Costello ME, Leo P, Bradbury LA, Hollis K, Cortes A, Lee S, Joo KB, Shim SC, Weisman M, Ward M, Zhou X, Garchon HJ, Chiocchia G, Nossent J, Lie BA, Førre Ø, Tuomilehto J, Laiho K, Jiang L, Liu Y, Wu X, Elewaut D, Burgos-Vargas R, Gensler LS, Stebbings S, Haroon N, Mulero J, Fernandez-Sueiro JL, Gonzalez-Gay MA, Lopez-Larrea C, Bowness P, Gafney K, Gaston JS, Gladman DD, Rahman P, Maksymowych WP, Xu H, van der Horst-Bruinsma IE, Chou CT, Valle-Oñate R, Romero-Sánchez MC, Hansen IM, Pimentel-Santos FM, Inman RD, Martin J, Breban M, Evans D, Reveille JD, Kim TH, Wordsworth BP, Brown MA. ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients. Ann Rheum Dis. 2015 Aug;74(8):1627-9. doi: 10.1136/annrheumdis-2015-207416. Epub 2015 Apr 27. No abstract available. PMID:25917849.

Wistuba MR, Alonso-Pérez M, Al-Sibbai AZ, González-Gay M, Alvarez Marcos F, Camblor LA, Llaneza-Coto JM. "Lower limbs revascularization from supraceliac and thoracic aorta". Ann Vasc Surg. 2015 Jul;29(5):1035-9. doi: 10.1016/j.avsg.2015.02.002. Epub 2015 Mar 12. PMID:25771745.

Ortiz-Fernández L, García-Lozano JR, Montes-Cano MA, Conde-Jaldón M, Ortego-Centeno N, García-Hernández FJ, Espinosa G, Graña-Gil G, Sánchez-Bursón J, Blanco R, Barnosi-Marín AC, Solans R, Fanlo P, Rodríguez-Carballeira M, Camps T, Castañeda S, Núñez-Roldán A, Martín J, González-Escribano MF. Variants of the IFI16 gene affecting the levels of expression of mRNA are associated with susceptibility to Behçet disease. J Rheumatol. 2015 Apr;42(4):695-701. doi: 10.3899/jrheum.140949. Epub 2015 Feb 1. PMID:25641891.

Rodriguez-Rodriguez L, López-Mejias R, Fernández-Gutiérrez B, Balsa A, González-Gay MA, Martín J. Rheumatoid arthritis: genetic variants as biomarkers of cardiovascular disease. Curr Pharm Des. 2015;21(2):182-201. Review. PMID:25163740.

Emery P, Gottenberg JE, Rubbert-Roth A, Sarzi-Puttini P, Choquette D, Taboada VM, Barile-Fabris L, Moots RJ, Ostor A, Andrianakos A, Gemmen E, Mpofu C, Chung C, Gylvin LH, Finckh A. Rituximab versus an alternative TNF inhibitor in patients with rheumatoid arthritis who failed to respond to a single previous TNF inhibitor: SWITCH-RA, a global, observational, comparative effectiveness study. Ann Rheum Dis. 2015 Jun;74(6):979-84. doi: 10.1136/annrheumdis-2013-203993. Epub 2014 Jan 17. PMID:24442884.

González-Gay MA, Llorca J, González-Juanatey C, Dessein PH. Is the Homeostatic Model Assessment of Insulin Resistance a Poor Predictor of Cardiovascular Disease in Rheumatoid Arthritis? Comment on the Article by Giles et al. Arthritis Rheumatol. 2015 Sep;67(9):2548-50. doi: 10.1002/art.39222. PMID:26017092.

CONTINÚA EN LA SIGUIENTE PÁGINA

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Maehlen MT, Olsen IC, Andreassen BK, Viken MK, Jiang X, Alfredsson L, Källberg H, Brynedal B, Kurreeman F, Daha N, Toes R, Zhernakova A, Gutierrez-Achury J, de Bakker PI, Martin J, Teruel M, Gonzalez-Gay MA, Rodríguez-Rodríguez L, Balsa A, Uhlig T, Kvien TK, Lie BA. Genetic risk scores and number of autoantibodies in patients with rheumatoid arthritis. Ann Rheum Dis. 2015 Apr;74(4):762-8. doi: 10.1136/annrheumdis-2013-204173. Epub 2013 Dec 13. PMID:24336335.

Pina T, Genre F, Lopez-Mejias R, Armesto S, Ubilla B, Mijares V, Dierssen-Sotos T, Corrales A, Gonzalez-Lopez MA, Gonzalez-Vela MC, Blanco R, Llorca J, Gonzalez-Gay MA. Anti-TNF-α therapy reduces retinol-binding protein 4 serum levels in non-diabetic patients with psoriasis: a 6-month prospective study. J Eur Acad Dermatol Venereol. 2015 Feb 4. doi: 10.1111/jdv.13005. [Epub ahead of print] PubMed PMID: 25650695.

Rodriguez-Rodriguez L, López-Mejias R, Fernández-Gutiérrez B, Balsa A, González-Gay MA, Martín J. Rheumatoid arthritis: genetic variants as biomarkers of cardiovascular disease. Curr Pharm Des. 2015;21(2):182-201. PubMed PMID: 25163740.

Sanmartí R, García-Rodríguez S, Álvaro-Gracia JM, Andreu JL, Balsa A, Cáliz R, Fernández-Nebro A, Ferraz-Amaro I, Gómez-Reino JJ, González-Álvaro I, Martín-Mola E, Martínez-Taboada VM, Ortiz AM, Tornero J, Marsal S, Moreno-Muelas JV. 2014 update of the Consensus Statement of the Spanish Society of Rheumatology on the use of biological therapies in rheumatoid arthritis. Reumatol Clin. 2015 Sep-Oct;11(5):279-94. doi: 10.1016/j.reuma.2015.05.001. Epub 2015 Jun 6. English, Spanish. PMID:26051464.

Sánchez-González A, Riancho-Zarrabeitia L, Salmón-González Z, Riancho JA, Valero C. Clinical spectrum of patients with spontaneous retroperitoneal hematomas. Med Clin (Barc). 2015 Oct 5;145(7):301-4. doi: 10.1016/j.medcli.2015.04.033. Epub 2015 Jul 18. Spanish. PMID:26198361.

Loricera J, Blanco R, Hernández JL, Martínez-Rodríguez I, Carril JM, Lavado C, Jiménez M, González-Vela C, González-Gay MÁ. Use of positron emission tomography (PET) for the diagnosis of large-vessel vasculitis. Rev Esp Med Nucl Imagen Mol. 2015 Nov-Dec;34(6):372-7. doi: 10.1016/j.remn.2015.07.002. Epub 2015 Aug 10. English, Spanish. PMID:26272121.

Lavado-Pérez C, Martínez-Rodríguez I, Martínez-Amador N, Banzo I, Quirce R, Jiménez-Bonilla J, De Arcocha-Torres M, Bravo-Ferrer Z, Jiménez-Alonso M, López-Defilló JL, Blanco R, González-Gay MA, Carril JM. (18)F-FDG PET/CT for the detection of large vessel vasculitis in patients with polymyalgia rheumatica. Rev Esp Med Nucl Imagen Mol. 2015 Sep-Oct;34(5):275-81. doi: 10.1016/j.remn.2015.05.011. Epub 2015 Jul 6. PMID:26159505.

Aloice O. Aluoch, Leyre Riancho-Zarrabeitia and Heather Gladue. Rituximab for treatment of rheumatoid hyperviscosity syndrome: Pulmonary arterial hypertension and post-partum cardiomyopathy cases. Clin Case Rep Rev. 2015; 1 (4): 81-84.

Zarco P, González CM, Rodríguez de la Serna A, Peiró E, Mateo I, Linares L, Calvo J, Cea-Calvo L, Arteaga MJ, Vanaclocha F, Marín-Jiménez I, García-Vicuña R. Extra-articular disease in patients with spondyloarthritis. Baseline characteristics of the spondyloarthritis cohort of the AQUILES study. Reumatol Clin. 2015 Mar-Apr;11(2):83-9. doi: 10.1016/j.reuma.2014.04.003. Epub 2014 Nov 11. English, Spanish.PMID:25441489.


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Torices S, Alvarez-Rodríguez L, Grande L, Varela I, Muñoz P, Pascual D, Balsa A, López-Hoyos M, Martinez-Taboada V, Fernández-Luna JL. A Truncated Variant of ASCC1, a Novel Inhibitor of NF-κB, Is Associated with Disease Severity in Patients with Rheumatoid Arthritis. J Immunol. 2015 Dec 1;195(11):5415-20. doi: 10.4049/jimmunol.1501532. Epub 2015 Oct 26. PMID:26503956.

López-Mejías R, Genre F, Remuzgo-Martínez S, Robustillo-Villarino M, García-Bermúdez M, Llorca J, Corrales A, González-Juanatey C, Ubilla B, Miranda-Filloy JA, Mijares V, Pina T, Blanco R, Alegre-Sancho JJ, Ramírez Huaranga MA, Mínguez Sánchez MD, Tejera Segura B, Ferraz-Amaro I, Vicente E, Carmona FD, Castañeda S, Martín J, González-Gay MA. Protective Role of the Interleukin 33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Rheumatoid Arthritis Patients. PLoS One. 2015 Nov 16;10(11):e0143153. doi: 10.1371/journal.pone.0143153. eCollection 2015. PMID:26571131.

González-Gay MA, Llorca J. Clinical guidelines: Best practices and uncertainties in the management of PMR. Nat Rev Rheumatol. 2016 Jan;12(1):3-4. doi: 10.1038/nrrheum.2015.142. Epub 2015 Oct 20. No abstract available. PMID:26481433.

López-Mejías R, Genre F, Remuzgo-Martínez S, Pérez BS, Castañeda S, Llorca J, Ortego-Centeno N, Ubilla B, Mijares V, Pina T, Calvo-Río V, Palmou N, Miranda-Filloy JA, Parejo AN, Argila D, Sánchez-Pérez J, Rubio E, Luque ML, Blanco-Madrigal JM, Galíndez-Aguirregoikoa E, Ocejo-Vinyals JG, Martín J, Blanco R, González-Gay MA. Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schönlein purpura (IgA vasculitis). Arthritis Res Ther. 2015 Oct 13;17:286. doi: 10.1186/s13075-015-0796-x. PMID:26458874.

González-López MA, Blanco R, Mata C, López-Escobar M, Lacalle M, Consuegra G, González-Vela MC, González-Gay MA. Coexistence of Hidradenitis Suppurativa with Autoimmune Thyroiditis: Report of Three Cases. Dermatology. 2016;232(2):162-4. doi: 10.1159/000439562. Epub 2015 Oct 8. PMID:26444851.

Ortiz-Sanjuán F, Blanco R, Riancho-Zarrabeitia L, Castañeda S, Olivé A, Riveros A, Velloso-Feijoo ML, Narváez J, Jiménez-Moleón I, Maiz-Alonso O, Ordóñez C, Bernal JA, Hernández MV, Sifuentes-Giraldo WA, Gómez-Arango C, Galíndez-Agirregoikoa E, Blanco-Madrigal J, Ortiz-Santamaria V, del Blanco-Barnusell J, De Dios JR, Moreno M, Fiter J, de los Riscos M, Carreira P, Rodriguez-Valls MJ, González-Vela MC, Calvo-Río V, Loricera J, Palmou-Fontana N, Pina T, Llorca J, González-Gay MA. Efficacy of Anakinra in Refractory Adult-Onset Still's Disease: Multicenter Study of 41 Patients and Literature Review. Medicine (Baltimore). 2015 Sep;94(39):e1554. doi: 10.1097/MD.0000000000001554. PMID:26426623.

González-Quintanilla V, Toriello M, Palacio E, González-Gay MA, Castillo J, Montes S, Martínez-Nieto R, Fernandez J, Rojo A, Gutiérrez S, Pons E, Oterino A. Systemic and cerebral endothelial dysfunction in chronic migraine. A case-control study with an active comparator. Cephalalgia. 2016 May;36(6):552-60. doi: 10.1177/0333102415607857. Epub 2015 Sep 22. PMID:26395894.

Leon Rodriguez DA, Serrano Lopera A, Cordero-Coma M, Márquez A, Fonollosa A, Ruiz-Arruza I, Callejas JL, García Serrano JL, Díaz Valle D, Pato E, Cañal J, del Rio MJ, Capella MJ, Blanco A, Olea JL, Cordero Y, Martín-Villa JM, Gorroño-Echebarría MB, Molins B, Adán A, Martin J. Study of association of CTLA4 gene variants to non-anterior uveitis. Tissue Antigens. 2015 Nov;86(5):373-6. doi: 10.1111/tan.12668. Epub 2015 Sep 16. PMID:26373706.

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Carmona FD, Martín J, González-Gay MA. New insights into the pathogenesis of giant cell arteritis and hopes for the clinic. Expert Rev Clin Immunol. 2016;12(1):57-66. doi: 10.1586/1744666X.2016.1089173. Epub 2015 Sep 14. PMID:26367100.

Pina T, Genre F, Lopez-Mejias R, Armesto S, Ubilla B, Mijares V, Dierssen-Sotos T, Corrales A, Gonzalez-Lopez MA, Gonzalez-Vela MC, Blanco R, Hernández JL, Llorca J, Gonzalez-Gay MA. Asymmetric dimethylarginine but not osteoprotegerin correlates with disease severity in patients with moderate-to-severe psoriasis undergoing anti-tumor necrosis factor-α therapy. J Dermatol. 2016 Apr;43(4):389-94. doi: 10.1111/1346-8138.13094. Epub 2015 Sep 14. PMID:26364678.

Dejaco C, Singh YP, Perel P, Hutchings A, Camellino D, Mackie S, Abril A, Bachta A, Balint P, Barraclough K, Bianconi L, Buttgereit F, Carsons S, Ching D, Cid M, Cimmino M, Diamantopoulos A, Docken W, Duftner C, Fashanu B, Gilbert K, Hildreth P, Hollywood J, Jayne D, Lima M, Maharaj A, Mallen C, Martinez-Taboada V, Maz M, Merry S, Miller J, Mori S, Neill L, Nordborg E, Nott J, Padbury H, Pease C, Salvarani C, Schirmer M, Schmidt W, Spiera R, Tronnier D, Wagner A, Whitlock M, Matteson EL, Dasgupta B; European League Against Rheumatism; American College of Rheumatology. 2015 Recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. Ann Rheum Dis. 2015 Oct;74(10):1799-807. doi: 10.1136/annrheumdis-2015-207492. PMID:26359488.

Dejaco C, Singh YP, Perel P, Hutchings A, Camellino D, Mackie S, Abril A, Bachta A, Balint P, Barraclough K, Bianconi L, Buttgereit F, Carsons S, Ching D, Cid M, Cimmino M, Diamantopoulos A, Docken W, Duftner C, Fashanu B, Gilbert K, Hildreth P, Hollywood J, Jayne D, Lima M, Maharaj A, Mallen C, Martinez-Taboada V, Maz M, Merry S, Miller J, Mori S, Neill L, Nordborg E, Nott J, Padbury H, Pease C, Salvarani C, Schirmer M, Schmidt W, Spiera R, Tronnier D, Wagner A, Whitlock M, Matteson EL, Dasgupta B; European League Against Rheumatism; American College of Rheumatology. 2015 recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. Arthritis Rheumatol. 2015 Oct;67(10):2569-80. doi: 10.1002/art.39333. PMID:26352874.

López-Isac E, Campillo-Davo D, Bossini-Castillo L, Guerra SG, Assassi S, Simeón CP, Carreira P, Ortego-Centeno N, García de la Peña P; Spanish Scleroderma Group, Beretta L, Santaniello A, Bellocchi C, Lunardi C, Moroncini G, Gabrielli A, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Distler JH, Voskuyl AE, de Vries-Bouwstra J, Herrick A, Worthington J, Denton CP, Fonseca C, Radstake TR, Mayes MD, Martín J. Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway. Ann Rheum Dis. 2016 Aug;75(8):1521-6. doi: 10.1136/annrheumdis-2015-208154. Epub 2015 Sep 2. PMID:26338038.

Ochoa E, Martin JE, Assasi S, Beretta L, Carreira P, Guillén A, Simeón CP, Koumakis E, Dieude P, Allanore Y, García-Hernández FJ, Espinosa G, Castellví I, Trapiella JL, Rodriguez L, González-Gay MÁ, Egurbide MV, Sáez L, Callejas-Rubio JL, Vargas-Hitos JA, Hunzelmann N, Riemekasten G, Witte T, Distler JH, Kreuter A, Lunardi C, Santaniello A, Tan FK, Shiels PG, Herrick A, Worthington J, Vonk MC, Koeleman BP, Radstake TR, Mayes MD, Martin J; Spanish Scleroderma Group. Confirmation of CCR6 as a risk factor for anti-topoisomerase I antibodies in systemic sclerosis. Clin Exp Rheumatol. 2015 Jul-Aug;33(4 Suppl 91):S31-5. Epub 2015 Aug 27. PMID:26314374.


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Urruticoechea-Arana A, Martín-Martínez MA, Castañeda S, Piedra CA, González-Juanatey C, Llorca J, Díaz-Gonzalez F, González-Gay MA; CARMA Project Collaborative Group. Vitamin D deficiency in chronic inflammatory rheumatic diseases: results of the cardiovascular in rheumatology [CARMA] study. Arthritis Res Ther. 2015 Aug 14;17:211. doi: 10.1186/s13075-015-0704-4. PMID:26271333.

Fernández-Nebro A, Rúa-Figueroa Í, López-Longo FJ, Galindo-Izquierdo M, Calvo-Alén J, Olivé-Marqués A, Ordóñez-Cañizares C, Martín-Martínez MA, Blanco R, Melero-González R, Ibáñez-Rúan J, Bernal-Vidal JA, Tomero-Muriel E, Uriarte-Isacelaya E, Horcada-Rubio L, Freire-González M, Narváez J, Boteanu AL, Santos-Soler G, Andreu JL, Pego-Reigosa JM; EAS-SER (Systemic Diseases Study Group of Spanish Society of Rheumatology). Cardiovascular Events in Systemic Lupus Erythematosus: A Nationwide Study in Spain From the RELESSER Registry. Medicine (Baltimore). 2015 Jul;94(29):e1183. doi: 10.1097/MD.0000000000001183. PMID:26200625.

Delgado-Frías E, González-Gay MA, Muñiz-Montes JR, Gómez Rodríguez-Bethencourt MA, González-Díaz A, Díaz-González F, Ferraz-Amaro I. Relationship of abdominal adiposity and body composition with endothelial dysfunction in patients with rheumatoid arthritis. Clin Exp Rheumatol. 2015 Jul-Aug;33(4):516-23. Epub 2015 Jul 6. PMID:26148347.

Blanco R, González-Gay MA, González-López MA, Fernández-Llaca H, González-Vela MC. Refractory highly disfiguring lupus pernio: a dramatic and prolonged response to infliximab. Int J Dermatol. 2015 Aug;54(8):e321-2. doi: 10.1111/ijd.12861. Epub 2015 Jul 3. No abstract available. PMID:26147319.

Genre F, López-Mejías R, Miranda-Filloy JA, Ubilla B, Mijares V, Carnero-López B, Gómez-Acebo I, Dierssen-Sotos T, Remuzgo-Martínez S, Blanco R, Pina T, González-Juanatey C, Llorca J, González-Gay MA. Anti-TNF-α therapy reduces endothelial cell activation in non-diabetic ankylosing spondylitis patients. Rheumatol Int. 2015 Dec;35(12):2069-78. doi: 10.1007/s00296-015-3314-1. Epub 2015 Jul 5. PMID:26143161.

Riancho-Zarrabeitia L, Calvo-Río V, Blanco R, Mesquida M, Adan AM, Herreras JM, Aparicio Á, Peiteado-Lopez D, Cordero-Coma M, García Serrano JL, Ortego-Centeno N, Maíz O, Blanco A, Sánchez-Bursón J, González-Suárez S, Fonollosa A, Santos-Gómez M, González-Vela C, Loricera J, Pina T, González-Gay MA. Anti-TNF-α therapy in refractory uveitis associated with sarcoidosis: Multicenter study of 17 patients. Semin Arthritis Rheum. 2015 Dec;45(3):361-8. doi: 10.1016/j.semarthrit.2015.05.010. Epub 2015 May 21. PMID:26092330.

Castañeda S, Martín-Martínez MA, González-Juanatey C, Llorca J, García-Yébenes MJ, Pérez-Vicente S, Sánchez-Costa JT, Díaz-Gonzalez F, González-Gay MA; CARMA Project Collaborative Group. Cardiovascular morbidity and associated risk factors in Spanish patients with chronic inflammatory rheumatic diseases attending rheumatology clinics: Baseline data of the CARMA Project. Semin Arthritis Rheum. 2015 Jun;44(6):618-26. doi: 10.1016/j.semarthrit.2014.12.002. Epub 2014 Dec 25. Erratum in: Semin Arthritis Rheum. 2015 Oct;45(2):e7-8. PMID:26058345.

Loricera J, Blanco R, Hernández JL, Calvo-Río V, Ortiz-Sanjuán F, Mata C, Rueda-Gotor J, Álvarez L, González-Vela MC, González-López MA, Armesto S, Pina T, González-Gay MA. Cutaneous vasculitis associated with severe bacterial infections. A study of 27 patients from a series of 766 cutaneous vasculitis. Clin Exp Rheumatol. 2015 Mar-Apr;33(2 Suppl 89):S-36-43. Epub 2015 May 26. PMID:26016750.

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Rueda-Gotor J, Corrales A, Blanco R, Fuentevilla P, Portilla V, Expósito R, Mata C, Pina T, González-Juanatey C, Llorca J, González-Gay MA. Atherosclerotic disease in axial spondyloarthritis: increased frequency of carotid plaques. Clin Exp Rheumatol. 2015 May-Jun;33(3):315-20. Epub 2015 May 25. PMID:26005760.

Julià A, Pinto JA, Gratacós J, Queiró R, Ferrándiz C, Fonseca E, Montilla C, Torre-Alonso JC, Puig L, Pérez Venegas JJ, Fernández Nebro A, Fernández E, Muñoz-Fernández S, Daudén E, González C, Roig D, Sánchez Carazo JL, Zarco P, Erra A, López Estebaranz JL, Rodríguez J, Ramírez DM, de la Cueva P, Vanaclocha F, Herrera E, Castañeda S, Rubio E, Salvador G, Díaz-Torné C, Blanco R, Willisch Domínguez A, Mosquera JA, Vela P, Tornero J, Sánchez-Fernández S, Corominas H, Ramírez J, López-Lasanta M, Tortosa R, Palau N, Alonso A, García-Montero AC, Gelpí JL, Codó L, Day K, Absher D, Myers RM, Cañete JD, Marsal S. A deletion at ADAMTS9-MAGI1 locus is associated with psoriatic arthritis risk. Ann Rheum Dis. 2015 Oct;74(10):1875-81. doi: 10.1136/annrheumdis-2014-207190. Epub 2015 May 19. PMID:25990289.

Dessein PH, Lopez-Mejias R, Ubilla B, Genre F, Corrales A, Hernandez JL, Ferraz-Amaro I, Tsang L, Pina T, Llorca J, Blanco R, Gonzalez-Juanatey C, Gonzalez-Gay MA. TNF-related apoptosis-inducing ligand and cardiovascular disease in rheumatoid arthritis. Clin Exp Rheumatol. 2015 Jul-Aug;33(4):491-7. Epub 2015 May 11. PMID:25962765.

López-Mejías R, Genre F, Pérez BS, Castañeda S, Ortego-Centeno N, Llorca J, Ubilla B, Remuzgo-Martínez S, Mijares V, Pina T, Calvo-Río V, Márquez A, Miranda-Filloy JA, Parejo AN, Conde-Jaldón M, Ortiz-Fernández L, Argila D, Aragües M, Rubio E, Luque ML, Blanco-Madrigal JM, Galíndez-Aguirregoikoa E, González Escribano F, Ocejo-Vinyals JG, Martín J, Blanco R, González-Gay MA. Association of HLA-B*41:02 with Henoch-Schönlein Purpura (IgA Vasculitis) in Spanish individuals irrespective of the HLA-DRB1 status. Arthritis Res Ther. 2015 Apr 14;17:102. doi: 10.1186/s13075-015-0622-5. PMID:25889603.

Dessein PH, Semb AG, González-Gay MA, Popa CD. Enhanced cardiovascular risk in rheumatoid arthritis: elucidation, assessment, and management. Biomed Res Int. 2015;2015:850671. doi: 10.1155/2015/850671. Epub 2015 Mar 12. No abstract available. PMID:25861648.

Loricera J, Blanco R, Hernández JL, Pina T, González-Vela MC, González-Gay MA. Biologic therapy in ANCA-negative vasculitis. Int Immunopharmacol. 2015 Aug;27(2):213-9. doi: 10.1016/j.intimp.2015.03.020. Epub 2015 Mar 28. Review. PMID:25828585.

Pina T, Genre F, Lopez-Mejias R, Armesto S, Ubilla B, Mijares V, Dierssen-Sotos T, Gonzalez-Lopez MA, Gonzalez-Vela MC, Blanco R, Hernández JL, Llorca J, Gonzalez-Gay MA. Relationship of leptin with adiposity and inflammation and resistin with disease severity in psoriatic patients undergoing anti-TNF-alpha therapy. J Eur Acad Dermatol Venereol. 2015 Oct;29(10):1995-2001. doi: 10.1111/jdv.13131. Epub 2015 Mar 30. PMID:25823684.

Carmona FD, Mackie SL, Martín JE, Taylor JC, Vaglio A, Eyre S, Bossini-Castillo L, Castañeda S, Cid MC, Hernández-Rodríguez J, Prieto-González S, Solans R, Ramentol-Sintas M, González-Escribano MF, Ortiz-Fernández L, Morado IC, Narváez J, Miranda-Filloy JA; Spanish GCA Group, Beretta L, Lunardi C, Cimmino MA, Gianfreda D, Santilli D, Ramirez GA, Soriano A, Muratore F, Pazzola G, Addimanda O, Wijmenga C, Witte T, Schirmer JH, Moosig F, Schönau V, Franke A, Palm Ø, Molberg Ø, Diamantopoulos AP, Carette S, Cuthbertson D, Forbess LJ, Hoffman GS, Khalidi NA, Koening CL, Langford CA, McAlear CA, Moreland L, Monach PA, Pagnoux C, Seo P, Spiera R, Sreih AG, Warrington KJ, Ytterberg SR, Gregersen

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PK, Pease CT, Gough A, Green M, Hordon L, Jarrett S, Watts R, Levy S, Patel Y, Kamath S, Dasgupta B, Worthington J, Koeleman BP, de Bakker PI, Barrett JH, Salvarani C, Merkel PA, González-Gay MA, Morgan AW, Martín J. A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility. Am J Hum Genet. 2015 Apr 2;96(4):565-80. doi: 10.1016/j.ajhg.2015.02.009. Epub 2015 Mar 26. PMID:25817017.

García-Bermúdez M, López-Mejías R, Genre F, Castañeda S, Corrales A, Llorca J, González-Juanatey C, Ubilla B, Miranda-Filloy JA, Pina T, Gómez-Vaquero C, Rodríguez-Rodríguez L, Fernández-Gutiérrez B, Balsa A, Pascual-Salcedo D, López-Longo FJ, Carreira P, Blanco R, Martín J, González-Gay MA. Lack of association between JAK3 gene polymorphisms and cardiovascular disease in Spanish patients with rheumatoid arthritis. Biomed Res Int. 2015;2015:318364. doi: 10.1155/2015/318364. Epub 2015 Mar 1. PMID:25815310.

Cavagna L, Nuño L, Scirè CA, Govoni M, Longo FJ, Franceschini F, Neri R, Castañeda S, Sifuentes Giraldo WA, Caporali R, Iannone F, Fusaro E, Paolazzi G, Pellerito R, Schwarting A, Saketkoo LA, Ortego-Centeno N, Quartuccio L, Bartoloni E, Specker C, Murcia TP, La Corte R, Furini F, Foschi V, Corral JB, Airò P, Cavazzana I, Martínez-Barrio J, Hinojosa M, Giannini M, Barsotti S, Menke J, Triantafyllias K, Vitetta R, Russo A, Bajocchi G, Bravi E, Barausse G, Bortolotti R, Selmi C, Parisi S, Montecucco C, González-Gay MA; AENEAS (American, European NEtwork of Antisynthetase Syndrome) collaborative group. Clinical Spectrum Time Course in Anti Jo-1 Positive Antisynthetase Syndrome: Results From an International Retrospective Multicenter Study. Medicine (Baltimore). 2015 Aug;94(32):e1144. doi: 10.1097/MD.0000000000001144. PMID:26266346.

Montes A, Corrales A, Calaza M, Lopez-Mejias R, Parra JA, González-Gay MA, González A. Brief report: lack of replication of an association between anti-citrullinated fibrinogen and subclinical atherosclerosis in patients with rheumatoid arthritis. Arthritis Rheumatol. 2015 Nov;67(11):2861-5. doi: 10.1002/art.39302. PMID:26246227.

Dessein PH, Hsu HC, Tsang L, Millen AM, Woodiwiss AJ, Norton GR, Solomon A, Gonzalez-Gay MA. Kidney function, endothelial activation and atherosclerosis in black and white Africans with rheumatoid arthritis. PLoS One. 2015 Mar 25;10(3):e0121693. doi: 10.1371/journal.pone.0121693. eCollection 2015. PMID:25806966.

Delgado-Frías E, López-Mejias R, Genre F, Ubilla B, Gómez Rodríguez-Bethencourt MA, González-Díaz A, de Vera-González AM, González-Rivero AF, Díaz-González F, González-Gay MA, Ferraz-Amaro I. Relationship between endothelial dysfunction and osteoprotegerin, vitamin D, and bone mineral density in patients with rheumatoid arthritis. Clin Exp Rheumatol. 2015 Mar-Apr;33(2):241-9. Epub 2015 Mar 10. PMID:25797915.

Loricera J, Blanco R, Hernández JL, Castañeda S, Mera A, Pérez-Pampín E, Peiró E, Humbría A, Calvo-Alén J, Aurrecoechea E, Narváez J, Sánchez-Andrade A, Vela P, Díez E, Mata C, Lluch P, Moll C, Hernández Í, Calvo-Río V, Ortiz-Sanjuán F, González-Vela C, Pina T, González-Gay MÁ. Tocilizumab in giant cell arteritis: Multicenter open-label study of 22 patients. Semin Arthritis Rheum. 2015 Jun;44(6):717-23. doi: 10.1016/j.semarthrit.2014.12.005. Epub 2014 Dec 27. PMID:25697557.


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Ortego-Jurado M, Callejas-Rubio JL, Ríos-Fernández R, González-Moreno J, González Ramírez AR, González-Gay MA, Ortego-Centeno N. Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A "Real-Life" Study. J Osteoporos. 2015;2015:729451. doi: 10.1155/2015/729451. Epub 2015 Jun 1. PMID:26124976.

Ortiz-Sanjuán F, Blanco R, Hernández JL, González-López MA, Loricera J, Lacalle-Calderón M, Pina T, Calvo-Río V, Álvarez L, González-Vela MC, Rueda-Gotor J, González-Gay MA. Applicability of the 2006 European League Against Rheumatism (EULAR) criteria for the classification of Henoch-Schönlein purpura. An analysis based on 766 patients with cutaneous vasculitis. Clin Exp Rheumatol. 2015 Mar-Apr;33(2 Suppl 89):S-44-7. Epub 2015 Feb 9. PMID:25665133.

Pina T, Genre F, Lopez-Mejias R, Armesto S, Ubilla B, Mijares V, Dierssen-Sotos T, Corrales A, Gonzalez-Lopez MA, Gonzalez-Vela MC, Blanco R, Llorca J, Gonzalez-Gay MA. Anti-TNF-α therapy reduces retinol-binding protein 4 serum levels in non-diabetic patients with psoriasis: a 6-month prospective study. J Eur Acad Dermatol Venereol. 2016 Jan;30(1):92-5. doi: 10.1111/jdv.13005. Epub 2015 Feb 4. PMID:25650695.

Martín-Martínez MA, Castañeda S, González-Juanatey C, Llorca J, Díaz-Gonzalez F, González-Gay MA. Cardiovascular risk assessment in rheumatoid arthritis: What goals should be achieved?. Semin Arthritis Rheum. 2015 Jun;44(6):e20-1. doi: 10.1016/j.semarthrit.2014.11.007. Epub 2014 Dec 3. No abstract available. PMID:25648677.

González-Gay MA, Pina T. Giant cell arteritis and polymyalgia rheumatica: an update. Curr Rheumatol Rep. 2015 Feb;17(2):6. doi: 10.1007/s11926-014-0480-1. Review. PMID:25618572.

Mucientes A, Márquez A, Cordero-Coma M, Martín-Villa JM, Gorroño-Echebarría MB, Blanco R, Díaz Valle D, Benítez-del-Castillo JM, del Rio MJ, Blanco A, Olea JL, Cordero Y, Capella MJ, Gonzalez J, Díaz-Llopis M, Ortego-Centeno N, Adán A, Ruiz-Arruza I, Llorenç V, Fonollosa A, Martín J. Specific association of IL17A genetic variants with panuveitis. Br J Ophthalmol. 2015 Apr;99(4):566-70. doi: 10.1136/bjophthalmol-2014-306106. Epub 2015 Jan 16. PMID:25595174.

Rúa-Figueroa Í, Richi P, López-Longo FJ, Galindo M, Calvo-Alén J, Olivé-Marqués A, Loza-Santamaría E, Vicente SP, Erausquin C, Tomero E, Horcada L, Uriarte E, Sánchez-Atrio A, Rosas J, Montilla C, Fernández-Nebro A, Rodríguez-Gómez M, Vela P, Blanco R, Freire M, Silva L, Díez-Álvarez E, Ibáñez-Barceló M, Zea A, Narváez J, Martínez-Taboada V, Marenco JL, de Castro MF, Fernández-Berrizbeitia O, Hernández-Beriain JÁ, Gantes M, Hernández-Cruz B, Pérez-Venegas JJ, Pecondón Á, Marras C, Carreira P, Bonilla G, Torrente V, Castellví I, Alegre J, Moreno M, Raya E, de la Peña PG, Vázquez T, Aguirre Á, Quevedo V, Pego-Reigosa JM; EAS-SER (Systemic Diseases Study Group of the Spanish Society ofRheumatology). Comprehensive description of clinical characteristics of a large systemic lupus erythematosus cohort from the Spanish Rheumatology Society Lupus Registry (RELESSER) with emphasis on complete versus incomplete lupus differences. Medicine (Baltimore). 2015 Jan;94(1):e267. doi: 10.1097/MD.0000000000000267. PMID:25569641.


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Pego-Reigosa JM, Rúa-Figueroa Í, López-Longo FJ, Galindo-Izquierdo M, Calvo-Alén J, Olivé-Marqués A, del Campo V, García-Yébenes MJ, Loza-Santamaría E, Blanco R, Melero-González R, Vela-Casasempere P, Otón-Sánchez T, Tomero-Muriel E, Uriarte-Isacelaya E, Fito-Manteca MC, Freire-González M, Narváez J, Fernández-Nebro A, Zea-Mendoza A, Rosas J; RELESSER Group, from the Spanish Society of Rheumatology Systemic Autoimmune Diseases Study Group (EASSER). Analysis of disease activity and response to treatment in a large Spanish cohort of patients with systemic lupus erythematosus. Lupus. 2015 Jun;24(7):720-9. doi: 10.1177/0961203314563818. Epub 2014 Dec 15. Erratum in: Lupus. 2015 Aug;24(9):1008. Carlos Rosas, J [corrected to Rosas, J]. PMID:25516473.

Riancho-Zarrabeitia L, Zurbano F, Gómez-Román J, Martínez-Meñaca A, López M, Hernández MA, Pina T, González-Gay MA. Isolated pulmonary vasculitis: case report and literature review. Semin Arthritis Rheum. 2015 Apr;44(5):514-7. doi: 10.1016/j.semarthrit.2014.10.003. Epub 2014 Oct 31. Review. PMID:25455685.

Loricera J, Blanco R, Hernández JL, Carril JM, Martínez-Rodríguez I, Canga A, Peiró E, Alonso-Gutiérrez J, Calvo-Río V, Ortiz-Sanjuán F, Mata C, Pina T, González-Vela MC, Martínez-Amador N, González-Gay MA. Non-infectious aortitis: a report of 32 cases from a single tertiary centre in a 4-year period and literature review. Clin Exp Rheumatol. 2015 Mar-Apr;33(2 Suppl 89):S-19-31. Epub 2014 Dec 1. Review. PMID:25437450.

Carmona FD, Martín J, González-Gay MA. Genetics of vasculitis. Curr Opin Rheumatol. 2015 Jan;27(1):10-7. doi: 10.1097/BOR.0000000000000124. Review. PMID:25405820.

López-Mejias R, Ubilla B, Genre F, Corrales A, Hernández JL, Ferraz-Amaro I, Tsang L, Llorca J, Blanco R, González-Juanatey C, Gonzalez-Gay MA, Dessein PH. Osteoprotegerin concentrations relate independently to established cardiovascular disease in rheumatoid arthritis. J Rheumatol. 2015 Jan;42(1):39-45. doi: 10.3899/jrheum.140690. Epub 2014 Nov 1. PMID:25362655.

Pina T, Armesto S, Lopez-Mejias R, Genre F, Ubilla B, Gonzalez-Lopez MA, Gonzalez-Vela MC, Corrales A, Blanco R, Garcia-Unzueta MT, Hernandez JL, Llorca J, Gonzalez-Gay MA. Anti-TNF-α therapy improves insulin sensitivity in non-diabetic patients with psoriasis: a 6-month prospective study. J Eur Acad Dermatol Venereol. 2015 Jul;29(7):1325-30. doi: 10.1111/jdv.12814. Epub 2014 Oct 29. PMID:25353352.

González-Gay MA, Alonso MD, Martínez-Vázquez F, Llorca J. Sex disparities in systemic lupus erythematosus in Northwestern Spain are not due to ethnic diversity. Rheumatol Int. 2015 May;35(5):939-40. doi: 10.1007/s00296-014-3124-x. Epub 2014 Sep 12. No abstract available. PMID:25213024.

González-Gay MA, Pina T, Blanco R. The search for improvement in the sensitivity of temporal artery biopsy in giant cell arteritis. Rheumatology (Oxford). 2015 Mar;54(3):379-80. doi: 10.1093/rheumatology/keu312. Epub 2014 Aug 22. No abstract available. PMID:25150177.

Loricera J, Blanco R, Ortiz-Sanjuán F, Hernández JL, Pina T, González-Vela MC, Calvo-Río V, Rueda-Gotor J, Alvarez L, González-López MA, Marcellán M, González-Gay MA. Single-organ cutaneous small-vessel vasculitis according to the 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides: a study of 60 patients from a series of 766 cutaneous vasculitis cases. Rheumatology (Oxford). 2015 Jan;54(1):77-82. doi: 10.1093/rheumatology/keu295. Epub 2014 Jul 26. PMID:25065012.

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Bossini-Castillo L, de Kovel C, Kallberg H, van 't Slot R, Italiaander A, Coenen M, Tak PP, Posthumus MD, Wijmenga C, Huizinga T, van der Helm-van Mil AH, Stoeken-Rijsbergen G, Rodriguez-Rodriguez L, Balsa A, González-Álvaro I, González-Gay MÁ, Gómez-Vaquero C, Franke B; LifeLines Cohort Study, Vermeulen S, van der Horst-Bruinsma Ie, Dijkmans BA, Wolbink GJ, Ophoff RA, Maehlen MT, van Riel P, Merriman M, Klareskog L, Lie BA, Merriman T, Crusius JB, Brouwer E, Martin J, de Vries N, Toes R, Padyukov L, Koeleman BP. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. Ann Rheum Dis. 2015 Mar;74(3):e15. doi: 10.1136/annrheumdis-2013-204591. Epub 2014 Feb 14. PMID:24532677.

Kim K, Bang SY, Lee HS, Cho SK, Choi CB, Sung YK, Kim TH, Jun JB, Yoo DH, Kang YM, Kim SK, Suh CH, Shim SC, Lee SS, Lee J, Chung WT, Choe JY, Shin HD, Lee JY, Han BG, Nath SK, Eyre S, Bowes J, Pappas DA, Kremer JM, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Ärlestig L, Okada Y, Diogo D, Liao KP, Karlson EW, Raychaudhuri S, Rantapää-Dahlqvist S, Martin J, Klareskog L, Padyukov L, Gregersen PK, Worthington J, Greenberg JD, Plenge RM, Bae SC. High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. Ann Rheum Dis. 2015 Mar;74(3):e13. doi: 10.1136/annrheumdis-2013-204749. Epub 2014 Feb 14. PMID:24532676.

Gazal S, Sacre K, Allanore Y, Teruel M, Goodall AH; (The CARDIOGENICS consortium), Tohma S, Alfredsson L, Okada Y, Xie G, Constantin A, Balsa A, Kawasaki A, Nicaise P, Amos C, Rodriguez-Rodriguez L, Chiocchia G, Boileau C, Zhang J, Vittecoq O, Barnetche T, Gonzalez Gay MA, Furukawa H, Cantagrel A, Le Loët X, Sumida T, Hurtado-Nedelec M, Richez C, Chollet-Martin S, Schaeverbeke T, Combe B, Khoryati L, Coustet B, El-Benna J, Siminovitch K, Plenge R, Padyukov L, Martin J, Tsuchiya N, Dieudé P. Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene. Ann Rheum Dis. 2015 Mar;74(3):e19. doi: 10.1136/annrheumdis-2013-204581. Epub 2014 Jan 21. PMID:24448344.

Cortes A, Pulit SL, Leo PJ, Pointon JJ, Robinson PC, Weisman MH, Ward M, Gensler LS, Zhou X, Garchon HJ, Chiocchia G, Nossent J, Lie BA, Førre Ø, Tuomilehto J, Laiho K, Bradbury LA, Elewaut D, Burgos-Vargas R, Stebbings S, Appleton L, Farrah C, Lau J, Haroon N, Mulero J, Blanco FJ, Gonzalez-Gay MA, Lopez-Larrea C, Bowness P, Gaffney K, Gaston H, Gladman DD, Rahman P, Maksymowych WP, Crusius JB, van der Horst-Bruinsma IE, Valle-Oñate R, Romero-Sánchez C, Hansen IM, Pimentel-Santos FM, Inman RD, Martin J, Breban M, Wordsworth BP, Reveille JD, Evans DM, de Bakker PI, Brown MA. Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1. Nat Commun. 2015 May 21;6:7146. doi: 10.1038/ncomms8146. PMID:25994336.

Rueda-Gotor J, Corrales A, Blanco R, Fuentevilla P, Portilla V, Expósito R, Mata C, Pina T, González-Juanatey C, Llorca J, González-Gay MA. Atherosclerotic disease in axial spondyloarthritis: increased frequency of carotid plaques. Clin Exp Rheumatol. 2015 May-Jun;33(3):315-20. Epub 2015 May 25. PMID:26005760.

Dessein PH, Lopez-Mejias R, Ubilla B, Genre F, Corrales A, Hernandez JL, Ferraz-Amaro I, Tsang L, Pina T, Llorca J, Blanco R, Gonzalez-Juanatey C, Gonzalez-Gay MA. TNF-related apoptosis-inducing ligand and cardiovascular disease in rheumatoid arthritis. Clin Exp Rheumatol. 2015 Jul-Aug;33(4):491-7. Epub 2015 May 11. PMID:25962765.


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Robinson PC, Costello ME, Leo P, Bradbury LA, Hollis K, Cortes A, Lee S, Joo KB, Shim SC, Weisman M, Ward M, Zhou X, Garchon HJ, Chiocchia G, Nossent J, Lie BA, Førre Ø, Tuomilehto J, Laiho K, Jiang L, Liu Y, Wu X, Elewaut D, Burgos-Vargas R, Gensler LS, Stebbings S, Haroon N, Mulero J, Fernandez-Sueiro JL, Gonzalez-Gay MA, Lopez-Larrea C, Bowness P, Gafney K, Gaston JS, Gladman DD, Rahman P, Maksymowych WP, Xu H, van der Horst-Bruinsma IE, Chou CT, Valle-Oñate R, Romero-Sánchez MC, Hansen IM, Pimentel-Santos FM, Inman RD, Martin J, Breban M, Evans D, Reveille JD, Kim TH, Wordsworth BP, Brown MA. ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients. Ann Rheum Dis. 2015 Aug;74(8):1627-9. doi: 10.1136/annrheumdis-2015-207416. Epub 2015 Apr 27. No abstract available. PMID:25917849.

López-Mejías R, Genre F, Pérez BS, Castañeda S, Ortego-Centeno N, Llorca J, Ubilla B, Remuzgo-Martínez S, Mijares V, Pina T, Calvo-Río V, Márquez A, Miranda-Filloy JA, Parejo AN, Conde-Jaldón M, Ortiz-Fernández L, Argila D, Aragües M, Rubio E, Luque ML, Blanco-Madrigal JM, Galíndez-Aguirregoikoa E, González Escribano F, Ocejo-Vinyals JG, Martín J, Blanco R, González-Gay MA. Association of HLA-B*41:02 with Henoch-Schönlein Purpura (IgA Vasculitis) in Spanish individuals irrespective of the HLA-DRB1 status. Arthritis Res Ther. 2015 Apr 14;17:102. doi: 10.1186/s13075-015-0622-5. PMID:25889603.

Corrales A, Dessein PH, Tsang L, Pina T, Blanco R, Gonzalez-Juanatey C, Llorca J, Gonzalez-Gay MA. Carotid artery plaque in women with rheumatoid arthritis and low estimated cardiovascular disease risk: a cross-sectional study. Arthritis Res Ther. 2015 Mar 11;17:55. doi: 10.1186/s13075-015-0576-7. PMID:25888724.

Dessein PH, Semb AG, González-Gay MA, Popa CD. Enhanced cardiovascular risk in rheumatoid arthritis: elucidation, assessment, and management. Biomed Res Int. 2015;2015:850671. doi: 10.1155/2015/850671. Epub 2015 Mar 12. No abstract available. PMID:25861648.

Wistuba MR, Alonso-Pérez M, Al-Sibbai AZ, González-Gay M, Alvarez Marcos F, Camblor LA, Llaneza-Coto JM. Lower limbs revascularization from supraceliac and thoracic aorta. Ann Vasc Surg. 2015 Jul;29(5):1035-9. doi: 10.1016/j.avsg.2015.02.002. Epub 2015 Mar 12. PMID:25771745.

Ortiz-Fernández L, García-Lozano JR, Montes-Cano MA, Conde-Jaldón M, Ortego-Centeno N, García-Hernández FJ, Espinosa G, Graña-Gil G, Sánchez-Bursón J, Blanco R, Barnosi-Marín AC, Solans R, Fanlo P, Rodríguez-Carballeira M, Camps T, Castañeda S, Núñez-Roldán A, Martín J, González-Escribano MF. Variants of the IFI16 gene affecting the levels of expression of mRNA are associated with susceptibility to Behçet disease. J Rheumatol. 2015 Apr;42(4):695-701. doi: 10.3899/jrheum.140949. Epub 2015 Feb 1. PMID:25641891.

Rodriguez-Rodriguez L, López-Mejias R, Fernández-Gutiérrez B, Balsa A, González-Gay MA, Martín J. Rheumatoid arthritis: genetic variants as biomarkers of cardiovascular disease. Curr Pharm Des. 2015;21(2):182-201. Review. PMID:25163740.

Emery P, Gottenberg JE, Rubbert-Roth A, Sarzi-Puttini P, Choquette D, Taboada VM, Barile-Fabris L, Moots RJ, Ostor A, Andrianakos A, Gemmen E, Mpofu C, Chung C, Gylvin LH, Finckh A. Rituximab versus an alternative TNF inhibitor in patients with rheumatoid arthritis who failed to respond to a single previous TNF inhibitor: SWITCH-RA, a global, observational, comparative effectiveness study. Ann Rheum Dis. 2015 Jun;74(6):979-84. doi: 10.1136/annrheumdis-2013-203993. Epub 2014 Jan 17. PMID:24442884.

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González-Gay MA, Llorca J, González-Juanatey C, Dessein PH. Is the Homeostatic Model Assessment of Insulin Resistance a Poor Predictor of Cardiovascular Disease in Rheumatoid Arthritis? Comment on the Article by Giles et al. Arthritis Rheumatol. 2015 Sep;67(9):2548-50. doi: 10.1002/art.39222. No abstract available. PMID:26017092.

Maehlen MT, Olsen IC, Andreassen BK, Viken MK, Jiang X, Alfredsson L, Källberg H, Brynedal B, Kurreeman F, Daha N, Toes R, Zhernakova A, Gutierrez-Achury J, de Bakker PI, Martin J, Teruel M, Gonzalez-Gay MA, Rodríguez-Rodríguez L, Balsa A, Uhlig T, Kvien TK, Lie BA. Genetic risk scores and number of autoantibodies in patients with rheumatoid arthritis. Ann Rheum Dis. 2015 Apr;74(4):762-8. doi: 10.1136/annrheumdis-2013-204173. Epub 2013 Dec 13. PMID:24336335.

Rúa-Figueroa Í, Richi P, López-Longo FJ, Galindo M, Calvo-Alén J, Olivé-Marqués A, Loza-Santamaría E, Vicente SP, Erausquin C, Tomero E, Horcada L, Uriarte E, Sánchez-Atrio A, Rosas J, Montilla C, Fernández-Nebro A, Rodríguez-Gómez M, Vela P, Blanco R, Freire M, Silva L, Díez-Álvarez E, Ibáñez-Barceló M, Zea A, Narváez J, Martínez-Taboada V, Marenco JL, de Castro MF, Fernández-Berrizbeitia O, Hernández-Beriain JÁ, Gantes M, Hernández-Cruz B, Pérez-Venegas JJ, Pecondón Á, Marras C, Carreira P, Bonilla G, Torrente V, Castellví I, Alegre J, Moreno M, Raya E, de la Peña PG, Vázquez T, Aguirre Á, Quevedo V, Pego-Reigosa JM; EAS-SER (Systemic Diseases Study Group of the Spanish Society of Rheumatology). Comprehensive description of clinical characteristics of a large systemic lupus erythematosus cohort from the Spanish Rheumatology Society Lupus Registry (RELESSER) with emphasis on complete versus incomplete lupus differences. Medicine (Baltimore). 2015 Jan;94(1):e267. doi: 10.1097/MD.0000000000000267. PMID:25569641.

Díez E, Mata C, Lluch P, Moll C, Hernández Í, Calvo-Río V, Ortiz-Sanjuán F, González-Vela C, Pina T, González-Gay MÁ. Tocilizumab in giant cell arteritis: Multicenter open-label study of 22 patients. Semin Arthritis Rheum. 2014 Dec 27. pii: S0049-0172(14)00328-X. doi: 10.1016/j.semarthrit.2014.12.005. [Epub ahead of print] PubMed PMID: 25697557.

López-Mejías R, Genre F, Pérez BS, Castañeda S, Ortego-Centeno N, Llorca J, Ubilla B, Remuzgo-Martínez S, Mijares V, Pina T, Calvo-Río V, Márquez A, Sala-Icardo L, Miranda-Filloy JA, Conde-Jaldón M, Ortiz-Fernández L, Rubio E, León Luque M, Blanco-Madrigal JM, Galíndez-Aguirregoikoa E, González-Vela MC, Ocejo-Vinyals JG, González Escribano F, Martín J, Blanco R, González-Gay MA. HLA-DRB1 association with Henoch-Schonlein purpura. Arthritis Rheumatol. 2014 Dec 2. doi: 10.1002/art.38979. [Epub ahead of print] PubMed PMID: 25470797.

Márquez A, Solans R, Hernández-Rodríguez J, Cid MC, Castañeda S, Ramentol M, Rodriguez-Rodriguez L, Narváez J, Blanco R, Ortego-Centeno N; Spanish GCA Consortium, Palm O, Diamantopoulos AP, Braun N, Moosig F, Witte T, Beretta L, Lunardi C, Cimmino MA, Vaglio A, Salvarani C, González-Gay MA, Martín J. A candidate gene approach identifies an IL33 genetic variant as a novel genetic risk factor for GCA. PLoS One. 2014 Nov 19;9(11):e113476. doi: 10.1371/journal.pone.0113476. eCollection 2014. PubMed PMID: 25409453; PubMed Central PMCID: PMC4237421.


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Cenit MC, Martínez-Florensa M, Consuegra M, Bonet L, Carnero-Montoro E, Armiger N, Caballero-Baños M, Arias MT, Benitez D, Ortego-Centeno N, de Ramón E, Sabio JM, García-Hernández FJ, Tolosa C, Suárez A, González-Gay MA, Bosch E, Martín J, Lozano F. Analysis of ancestral and functionally relevant CD5 variants in systemic lupus erythematosus patients. PLoS One. 2014 Nov 17;9(11):e113090. doi: 10.1371/journal.pone.0113090. eCollection 2014. PubMed PMID: 25402503; PubMed Central PMCID: PMC4234640.

López-Mejias R, Ubilla B, Genre F, Corrales A, Hernández JL, Ferraz-Amaro I, Tsang L, Llorca J, Blanco R, González-Juanatey C, Gonzalez-Gay MA, Dessein PH. Osteoprotegerin concentrations relate independently to established cardiovascular disease in rheumatoid arthritis. J Rheumatol. 2015 Jan;42(1):39-45. doi: 10.3899/jrheum.140690. Epub 2014 Nov 1. PubMed PMID: 25362655.

Genre F, López-Mejías R, Rueda-Gotor J, Miranda-Filloy JA, Ubilla B, Villar-Bonet A, Carnero-López B, Gómez-Acebo I, Blanco R, Pina T, González-Juanatey C, Llorca J, González-Gay MA. IGF-1 and ADMA levels are inversely correlated in nondiabetic ankylosing spondylitis patients undergoing anti-TNF-alpha therapy. Biomed Res Int. 2014;2014:671061. doi: 10.1155/2014/671061. Epub 2014 Sep 11. PubMed PMID: 25295265; PubMed Central PMCID: PMC4176640.

Calvo-Río V, de la Hera D, Blanco R, Beltrán-Catalán E, Loricera J, Cañal J, Ventosa J, Cifrián JM, Ortiz-Sanjuán F, Rueda-Gotor J, González-Vela MC, González-López M, González-Gay MA. Golimumab in uveitis previously treated with other anti-TNF-alpha drugs: a retrospective study of three cases from a single centre and literature review. Clin Exp Rheumatol. 2014 Nov-Dec;32(6):864-8. Epub 2014 Oct 2. PubMed PMID: 25288110.

Ortiz-Sanjuán F, Blanco R, Hernández JL, Pina T, González-Vela MC, Fernández-Llaca H, Calvo-Río V, Loricera J, Armesto S, González-López MA, Rueda-Gotor J, González-Gay MA. Drug-associated cutaneous vasculitis: study of 239 patients from a single referral center. J Rheumatol. 2014 Nov;41(11):2201-7. doi: 10.3899/jrheum.140390. Epub 2014 Sep 15. PubMed PMID: 25225278.

González-Gay MA, Alonso MD, Martínez-Vázquez F, Llorca J. Sex disparities in systemic lupus erythematosus in Northwestern Spain are not due to ethnic diversity. Rheumatol Int. 2014 Sep 12. [Epub ahead of print] PubMed PMID: 25213024.

Genre F, López-Mejías R, Miranda-Filloy JA, Ubilla B, Carnero-López B, Palmou-Fontana N, Gómez-Acebo I, Blanco R, Rueda-Gotor J, Pina T, González-Juanatey C, Llorca J, González-Gay MÁ. Osteoprotegerin correlates with disease activity and endothelial activation in non-diabetic ankylosing spondylitis patients undergoing TNF-α antagonist therapy. Clin Exp Rheumatol. 2014 Sep-Oct;32(5):640-6. Epub 2014 Sep 5. PubMed PMID: 25190453.

Genre F, López-Mejías R, García-Bermúdez M, Castañeda S, González-Juanatey C, Llorca J, Corrales A, Ubilla B, Miranda-Filloy JA, Pina T, Gómez-Vaquero C, Rodríguez-Rodríguez L, Fernández-Gutiérrez B, Balsa A, Pascual-Salcedo D, López-Longo FJ, Carreira P, Blanco R, González-Álvaro I, Martín J, González-Gay MA. Osteoprotegerin CGA haplotype protection against cerebrovascular complications in anti-CCP negative patients with rheumatoid arthritis. PLoS One. 2014 Sep 3;9(9):e106823. doi: 10.1371/journal.pone.0106823. eCollection 2014. PubMed PMID: 25184828; PubMed Central PMCID: PMC4153690.


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Amor-Dorado JC, Barreira-Fernandez MP, Pina T, Vázquez-Rodríguez TR, Llorca J, González-Gay MA. Investigations into audiovestibular manifestations in patients with psoriatic arthritis. J Rheumatol. 2014 Oct;41(10):2018-26. doi: 10.3899/jrheum.140559. Epub 2014 Sep 1. PubMed PMID: 25179845.

Anaya JM, Shoenfeld Y, Buttgereit F, Gonzalez-Gay MA. Autoimmune rheumatic diseases. Biomed Res Int. 2014;2014:952159. doi: 10.1155/2014/952159. Epub 2014 Aug 5. PubMed PMID: 25162038; PubMed Central PMCID: PMC4138892.

González-Gay MA, Pina T, Blanco R. The search for improvement in the sensitivity of temporal artery biopsy in giant cell arteritis. Rheumatology (Oxford). 2014 Aug 22. pii: keu312. [Epub ahead of print] PubMed PMID: 25150177.

Kerekes G, Nurmohamed MT, González-Gay MA, Seres I, Paragh G, Kardos Z, Baráth Z, Tamási L, Soltész P, Szekanecz Z. Rheumatoid arthritis and metabolic syndrome. Nat Rev Rheumatol. 2014 Nov;10(11):691-6. doi: 10.1038/nrrheum.2014.121. Epub 2014 Aug 5. PubMed PMID: 25090948.

Martínez-Rodríguez I, Martínez-Amador N, Banzo I, Quirce R, Jiménez-Bonilla J, De Arcocha-Torres M, Ibáñez-Bravo S, Lavado-Pérez C, Bravo-Ferrer Z, Blanco R, González-Gay MA, Carril JM. Assessment of aortitis by semiquantitative analysis of 180-min 18F-FDG PET/CT acquisition images. Eur J Nucl Med Mol Imaging. 2014 Dec;41(12):2319-24. doi: 10.1007/s00259-014-2863-y. Epub 2014 Jul 24. PubMed PMID: 25056634.

Conde-Jaldón M, Montes-Cano MA, García-Lozano JR, Ortiz-Fernández L, Ortego-Centeno N, González-León R, Espinosa G, Graña-Gil G, Sánchez-Bursón J, González-Gay MA, Barnosi-Marín AC, Solans R, Fanlo P, Carballeira MR, Camps T, Castañeda S, Martín J, González-Escribano MF. Epistatic interaction of ERAP1 and HLA-B in Behçet disease: a replication study in the Spanish population. PLoS One. 2014 Jul 14;9(7):e102100. doi: 10.1371/journal.pone.0102100. eCollection 2014. PubMed PMID: 25019531; PubMed Central PMCID: PMC4096596.

García-Bermúdez M, López-Mejías R, Genre F, Castañeda S, Llorca J, González-Juanatey C, Corrales A, Ubilla B, Miranda-Filloy JA, Pina T, Gómez-Vaquero C, Rodríguez-Rodríguez L, Fernández-Gutiérrez B, Balsa A, Pascual-Salcedo D, López-Longo FJ, Carreira P, Blanco R, Martín J, González-Gay MA. Interferon regulatory factor 5 genetic variants are associated with cardiovascular disease in patients with rheumatoid arthritis. Arthritis Res Ther. 2014 Jul 10;16(4):R146. doi: 10.1186/ar4608. PubMed PMID: 25011482; PubMed Central PMCID: PMC4227041.

Calvo-Río V, de la Hera D, Beltrán-Catalán E, Blanco R, Hernandez M, Martínez-Costa L, Loricera J, Cañal J, Ventosa J, Ortiz-Sanjuán F, Pina T, González-Vela MC, Rodríguez-Cundín P, González-Gay MA. Tocilizumab in uveitis refractory to other biologic drugs: a study of 3 cases and a literature review. Clin Exp Rheumatol. 2014 Jul-Aug;32(4 Suppl 84):S54-7. Epub 2014 Jul 8. Review. PubMed PMID: 25005576.


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Calvo-Río V, Blanco R, Beltrán E, Sánchez-Bursón J, Mesquida M, Adán A, Hernandez MV, Hernandez Garfella M, Valls Pascual E, Martínez-Costa L, Sellas-Fernández A, Cordero Coma M, Díaz-Llopis M, Gallego R, Salom D, García Serrano JL, Ortego N, Herreras JM, Fonollosa A, García-Aparicio AM, Maíz O, Blanco A, Torre I, Fernández-Espartero C, Jovani V, Peiteado-Lopez D, Pato E, Cruz J, Fernández-Cid C, Aurrecoechea E, García M, Caracuel MA, Montilla C, Atanes A, Hernandez FF, Insua S, González-Suárez S, Sánchez-Andrade A, Gamero F, Linares L, Romero-Bueno F, García AJ, Almodovar R, Minguez E, Carrasco Cubero C, Olive A, Vázquez J, Ruiz Moreno O, Jiménez-Zorzo F, Manero J, Muñoz Fernández S, Rueda-Gotor J, González-Gay MA. Anti-TNF-α therapy in patients with refractory uveitis due to Behçet's disease: a 1-year follow-up study of 124 patients. Rheumatology (Oxford). 2014 Dec;53(12):2223-31. doi: 10.1093/rheumatology/keu266. Epub 2014 Jul 4. PubMed PMID: 24996907.

Genre F, López-Mejías R, Rueda-Gotor J, Miranda-Filloy JA, Ubilla B, Carnero-López B, Palmou-Fontana N, Gómez-Acebo I, Blanco R, Pina T, Ochoa R, González-Juanatey C, Llorca J, González-Gay MA. Patients with ankylosing spondylitis and low disease activity because of anti-TNF-alpha therapy have higher TRAIL levels than controls: a potential compensatory effect. Mediators Inflamm. 2014;2014:798060. doi: 10.1155/2014/798060. Epub 2014 May 21. PubMed PMID: 24976690; PubMed Central PMCID: PMC4055458.

Cordero-Coma M, Calvo-Río V, Adán A, Blanco R, Álvarez-Castro C, Mesquida M, Calleja S, González-Gay MA, Ruíz de Morales JG. Golimumab as rescue therapy for refractory immune-mediated uveitis: a three-center experience. Mediators Inflamm. 2014;2014:717598. doi: 10.1155/2014/717598. Epub 2014 May 28. PubMed PMID: 24976689; PubMed Central PMCID: PMC4058145.

Márquez A, Hernández-Rodríguez J, Cid MC, Solans R, Castañeda S, Fernández-Contreras ME, Ramentol M, Morado IC, Narváez J, Gómez-Vaquero C, Martínez-Taboada VM, Ortego-Centeno N, Sopeña B, Monfort J, García-Villanueva MJ, Caminal-Montero L, de Miguel E, Blanco R; Spanish GCA Consortium, Palm O, Molberg O, Latus J, Braun N, Moosig F, Witte T, Beretta L, Santaniello A, Pazzola G, Boiardi L, Salvarani C, González-Gay MA, Martín J. Influence of the IL17A locus in giant cell arteritis susceptibility. Ann Rheum Dis. 2014 Sep;73(9):1742-5. doi: 10.1136/annrheumdis-2014-205261. Epub 2014 Jun 11. PubMed PMID: 24919468.

González-Gay MA, González-Juanatey C. Inflammation and lipid profile in rheumatoid arthritis: bridging an apparent paradox. Ann Rheum Dis. 2014 Jul;73(7):1281-3. doi: 10.1136/annrheumdis-2013-204933. PubMed PMID: 24907362.

Loricera J, Blanco R, Castañeda S, Humbría A, Ortego-Centeno N, Narváez J, Mata C, Melchor S, Aurrecoechea E, Calvo-Alén J, Lluch P, Moll C, Mínguez M, Herrero-Beaumont G, Bravo B, Rubio E, Freire M, Peiró E, González-Vela C, Rueda-Gotor J, Pina T, Palmou-Fontana N, Calvo-Río V, Ortiz-Sanjuán F, González-Gay MÁ. Tocilizumab in refractory aortitis: study on 16 patients and literature review. Clin Exp Rheumatol. 2014 May-Jun;32(3 Suppl 82):S79-89. Epub 2014 May 15. PubMed PMID: 24854377.

Ortiz-Sanjuán F, Blanco R, Loricera J, Hernández JL, Pina T, Calvo-Río V, Alvarez L, González-Vela MC, Rueda-Gotor J, González-López MA, González-Gay MA. Reappraisal of the 1990 American College of Rheumatology criteria for the classification of cutaneous vasculitis: an analysis based on 766 patients. Clin Exp Rheumatol. 2014 May-Jun;32(3 Suppl 82):S51-4. Epub 2014 May 16. PubMed PMID: 24854373.

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López-Mejías R, Genre F, Corrales A, González-Juanatey C, Ubilla B, Llorca J, Miranda-Filloy JA, Pina T, Blanco R, Castañeda S, Martín J, González-Gay MA. Investigation of a PON1 gene polymorphism (rs662 polymorphism) as predictor of subclinical atherosclerosis in patients with rheumatoid arthritis. Ann Rheum Dis. 2014 Sep;73(9):1749-50. doi: 10.1136/annrheumdis-2014-205543. Epub 2014 May 15. PubMed PMID: 24833785.

Ortego-Jurado M, Ríos-Fernández R, Callejas-Rubio JL, Gonzalez-Gay MA, Ortego-Centeno N. Vitamin D levels and response to biphosphonates in postmenopausal women receiving glucocorticoid therapy. Osteoporos Int. 2014 Aug;25(8):2157-8. doi: 10.1007/s00198-014-2713-6. Epub 2014 May 7. PubMed PMID: 24803328.

López-Mejías R, Genre F, García-Bermúdez M, Ubilla B, Castañeda S, Llorca J, González-Juanatey C, Corrales A, Miranda-Filloy JA, Pina T, Gómez-Vaquero C, Rodríguez-Rodríguez L, Fernández-Gutiérrez B, Balsa A, Pascual-Salcedo D, López-Longo FJ, Carreira P, Blanco R, Martín J, González-Gay MA. Lack of association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and carotid intima-media thickness, carotid plaques, and cardiovascular disease in patients with rheumatoid arthritis. Mediators Inflamm. 2014;2014:756279. doi: 10.1155/2014/756279. Epub 2014 Mar 25. PubMed PMID: 24795506; PubMed Central PMCID: PMC3984817.

Genre F, López-Mejías R, Miranda-Filloy JA, Ubilla B, Carnero-López B, Blanco R, Pina T, González-Juanatey C, Llorca J, González-Gay MA. Adipokines, biomarkers of endothelial activation, and metabolic syndrome in patients with ankylosing spondylitis. Biomed Res Int. 2014;2014:860651. doi: 10.1155/2014/860651. Epub 2014 Mar 18. Review. PubMed PMID: 24757680; PubMed Central PMCID: PMC3976882.

Márquez A, Solans R, Hernández-Rodríguez J, Cid MC, Castañeda S, Ramentol M, Morado IC, Rodriguez-Rodriguez L, Narváez J, Gómez-Vaquero C, Miranda-Filloy JA, Martínez-Taboada VM, Ríos R, Sopeña B, Monfort J, García-Villanueva MJ, Martínez-Zapico A, Marí-Alfonso B, Sánchez-Martín J, Unzurrunzaga A, Raya E, de Miguel E, Hidalgo-Conde A, Blanco R, González-Gay MÁ, Martín J; Spanish GCA Consortium. Analysis of two autoimmunity genes, IRAK1 and MECP2, in giant cell arteritis. Clin Exp Rheumatol. 2014 May-Jun;32(3 Suppl 82):S30-3. Epub 2014 Apr 7. PubMed PMID: 24709033.

Han B, Diogo D, Eyre S, Kallberg H, Zhernakova A, Bowes J, Padyukov L, Okada Y, González-Gay MA, Rantapää-Dahlqvist S, Martin J, Huizinga TW, Plenge RM, Worthington J, Gregersen PK, Klareskog L, de Bakker PI, Raychaudhuri S. Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity. Am J Hum Genet. 2014 Apr 3;94(4):522-32. doi: 10.1016/j.ajhg.2014.02.013. Epub 2014 Mar 20. PubMed PMID: 24656864; PubMed Central PMCID: PMC3980428. Calvo-Río V, Loricera J, Mata C, Martín L, Ortiz-Sanjuán F, Alvarez L, González-Vela MC, González-Lamuño D, Rueda-Gotor J, Fernández-Llaca H, González-López MA, Armesto S, Peiró E, Arias M, González-Gay MA, Blanco R. Henoch-Schönlein purpura in northern Spain: clinical spectrum of the disease in 417 patients from a single center. Medicine (Baltimore). 2014 Mar;93(2):106-13. doi: 10.1097/MD.0000000000000019. PubMed PMID: 24646467.

López-Mejías R, Genre F, González-Juanatey C, González-Gay MA. Autoantibodies and biomarkers of endothelial cell activation in atherosclerosis. Vasa. 2014 Mar;43(2):83-5. doi: 10.1024/0301-1526/a000333. PubMed PMID: 24627313.

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Ortiz-Fernández L, Conde-Jaldón M, García-Lozano JR, Montes-Cano MA, Ortego-Centeno N, Castillo-Palma MJ, Espinosa G, Graña-Gil G, Sánchez-Bursón J, González-Gay MA, Barnosi-Marín AC, Solans R, Fanlo P, Rodríguez Carballeira M, Camps T, Castañeda S, Martín J, González-Escribano MF. GIMAP and Behçet disease: no association in the European population. Ann Rheum Dis. 2014 Jul;73(7):1433-4. doi: 10.1136/annrheumdis-2013-205156. Epub 2014 Mar 13. PubMed PMID: 24625627.

Martín-Martínez MA, González-Juanatey C, Castañeda S, Llorca J, Ferraz-Amaro I, Fernández-Gutiérrez B, Díaz-González F, González-Gay MA. Recommendations for the management of cardiovascular risk in patients with rheumatoid arthritis: scientific evidence and expert opinion. Semin Arthritis Rheum. 2014 Aug;44(1):1-8. doi: 10.1016/j.semarthrit.2014.01.002. Epub 2014 Jan 24. pubmed PMID: 24560170.

Ferraz-Amaro I, González-Gay MA, Diaz-González F. Retinol-binding protein 4 in rheumatoid arthritis-related insulin resistance and β-cell function. J Rheumatol. 2014 Apr;41(4):658-65. doi: 10.3899/jrheum.130834. Epub 2014 Feb 15. PubMed PMID: 24532832.

Bossini-Castillo L, de Kovel C, Kallberg H, van 't Slot R, Italiaander A, Coenen M, Tak PP, Posthumus MD, Wijmenga C, Huizinga T, van der Helm-van Mil AH, Stoeken-Rijsbergen G, Rodriguez-Rodriguez L, Balsa A, González-Álvaro I, González-Gay MÁ, Gómez-Vaquero C, Franke B; LifeLines Cohort Study, Vermeulen S, van der Horst-Bruinsma Ie, Dijkmans BA, Wolbink GJ, Ophoff RA, Maehlen MT, van Riel P, Merriman M, Klareskog L, Lie BA, Merriman T, Crusius JB, Brouwer E, Martin J, de Vries N, Toes R, Padyukov L, Koeleman BP. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. Ann Rheum Dis. 2015 Mar;74(3):e15. doi: 10.1136/annrheumdis-2013-204591. Epub 2014 Feb 14. PubMed PMID: 24532677.

López-Mejías R, Sevilla Pérez B, Genre F, Castañeda S, Ortego-Centeno N, Miranda-Filloy JA, Llorca J, Martín J, Blanco R, González-Gay MA. Lack of association between IL6 gene and Henoch-Schönlein purpura. Clin Exp Rheumatol. 2014 May-Jun;32(3 Suppl 82):S141-2. Epub 2014 Feb 11. PubMed PMID: 24528956.

Calvo-Río V, Loricera J, Ortiz-Sanjuán F, Mata C, Martín L, Alvarez L, González-Vela MC, Rueda-Gotor J, González-López MA, Armesto S, Peiró E, Arias M, Pina T, González-Gay MA, Blanco R**. Revisiting clinical differences between hypersensitivity vasculitis and Henoch-Schönlein purpura in adults from a defined population. Clin Exp Rheumatol. 2014 May-Jun;32(3 Suppl 82):S34-40. Epub 2014 Feb 11. PubMed PMID: 24528895.

Ortiz-Sanjuán F, Blanco R, Calvo-Rio V, Narvaez J, Rubio Romero E, Olivé A, Castañeda S, Gallego Flores A, Hernández MV, Mata C, Ros Vilamajo I, Sifuentes Giraldo WA, Caracuel MA, Freire M, Gómez Arango C, Llobet J, Manrique Arija S, Marras C, Moll-Tuduri C, Plasencia-Rodriguez C, Roselló R, Urruticoechea A, Velloso-Feijoo ML, Del Blanco J, González-Vela MC, Rueda-Gotor J, Pina T, Loricera J, González-Gay MA. Efficacy of tocilizumab in conventional treatment-refractory adult-onset Still's disease: multicenter retrospective open-label study of thirty-four patients. Arthritis Rheumatol. 2014 Jun;66(6):1659-65. doi: 10.1002/art.38398. PubMed PMID: 24515813.

Gonzalez-Gay MA, Lopez-Mejias R, Gonzalez-Juanatey C, Llorca J. Response to Adipokines, inflammation, insulin resistance, and carotid atherosclerosis in patients with rheumatoid arthritis'. Arthritis Res Ther. 2014 Feb 10;16(1):401. doi: 10.1186/ar4478. PubMed PMID: 24507828; PubMed Central PMCID: PMC3978462.

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Tam LS, Kitas GD, González-Gay MA. Can suppression of inflammation by anti-TNF prevent progression of subclinical atherosclerosis in inflammatory arthritis? Rheumatology (Oxford). 2014 Jun;53(6):1108-19. Review. PubMed PMID: 24501245

López-Mejías R, Sevilla Pérez B, Genre F, Castañeda S, Ortego-Centeno N, Llorca J, Ubilla B, Ochoa R, Pina T, Marquez A, Sala-Icardo L, Miranda-Filloy JA, Rueda-Gotor J, Martín J, Blanco R, González-Gay MA. No evidence of association between functional polymorphisms located within IL6R and IL6ST genes and Henoch-Schönlein purpura. Tissue Antigens. 2013 Dec;82(6):416-9. doi: 10.1111/tan.12251. PubMed PMID: 24498998.

Dessein PH, López-Mejias R, González-Juanatey C, Genre F, Miranda-Filloy JA, Llorca J, González-Gay MA. Independent relationship of osteoprotegerin concentrations with endothelial activation and carotid atherosclerosis in patients with severe rheumatoid arthritis. J Rheumatol. 2014 Mar;41(3):429-36. doi: 10.3899/jrheum.131037. Epub 2014 Feb 1. PubMed PMID: 24488413.

Dessein PH, Solomon A, Woodiwiss AJ, Norton GR, Tsang L, Gonzalez-Gay MA. Marked independent relationship between circulating interleukin-6 concentrations and endothelial activation in rheumatoid arthritis. Mediators Inflamm. 2013;2013:510243. doi: 10.1155/2013/510243. Epub 2013 Dec 21. PubMed PMID: 24453423; PubMed Central PMCID: PMC3880757.

González-Gay MA, González-Juanatey C, Llorca J, Castañeda S. The influence of inflammation in the development of subclinical atherosclerosis in psoriatic arthritis: comment on Cardiovascular comorbidities in patients with psoriatic arthritis: a systematic review by Jamnistki et al. Ann Rheum Dis. 2014 May;73(5):e27. doi: 10.1136/annrheumdis-2013-205154. Epub 2014 Jan 17. PubMed PMID: 24442882.

López-Isac E, Bossini-Castillo L, Simeon CP, Egurbide MV, Alegre-Sancho JJ, Callejas JL, Roman-Ivorra JA, Freire M, Beretta L, Santaniello A, Airó P, Lunardi C, Hunzelmann N, Riemekasten G, Witte T, Kreuter A, Distler JH, Schuerwegh AJ, Vonk MC, Voskuyl AE, Shiels PG, van Laar JM, Fonseca C, Denton C, Herrick A, Worthington J, Assassi S, Koeleman BP, Mayes MD, Radstake TR, Martin J, González-Gay MA; Spanish Scleroderma Group. A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility. Arthritis Res Ther. 2014 Jan 9;16(1):R6. doi: 10.1186/ar4432. PubMed PMID: 24401602; PubMed Central PMCID: PMC3978735.

Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieudé P, Mariette X, Bridges SL Jr, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantapää-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M; RACI consortium; GARNET consortium, Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM. Genetics of rheumatoid arthritis contributes to biology

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and drug discovery. Nature. 2014 Feb 20;506(7488):376-81. doi: 10.1038/nature12873. Epub 2013 Dec 25. PubMed PMID: 24390342; PubMed Central PMCID: PMC3944098.

Rosales-Alexander JL, Salvatierra J, Llorca J, Magro-Checa C, González-Gay MA, Cantero-Hinojosa J, Raya-Álvarez E. Cardiovascular risk assessment in rheumatoid arthritis: impact of the EULAR recommendations on a national calibrated score risk index. Clin Exp Rheumatol. 2014 Mar-Apr;32(2):237-42. Epub 2014 Jan 3. PubMed PMID: 24388041.

Mayes MD, Bossini-Castillo L, Gorlova O, Martin JE, Zhou X, Chen WV, Assassi S, Ying J, Tan FK, Arnett FC, Reveille JD, Guerra S, Teruel M, Carmona FD, Gregersen PK, Lee AT, López-Isac E, Ochoa E, Carreira P, Simeón CP, Castellví I, González-Gay MÁ; Spanish Scleroderma Group, Zhernakova A, Padyukov L, Alarcón-Riquelme M, Wijmenga C, Brown M, Beretta L, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Distler JH, Voskuyl AE, Schuerwegh AJ, Hesselstrand R, Nordin A, Airó P, Lunardi C, Shiels P, van Laar JM, Herrick A, Worthington J, Denton C, Wigley FM, Hummers LK, Varga J, Hinchcliff ME, Baron M, Hudson M, Pope JE, Furst DE, Khanna D, Phillips K, Schiopu E, Segal BM, Molitor JA, Silver RM, Steen VD, Simms RW, Lafyatis RA, Fessler BJ, Frech TM, Alkassab F, Docherty P, Kaminska E, Khalidi N, Jones HN, Markland J, Robinson D, Broen J, Radstake TR, Fonseca C, Koeleman BP, Martin J. Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis. Am J Hum Genet. 2014 Jan 2;94(1):47-61. doi: 10.1016/j.ajhg.2013.12.002. PubMed PMID: 24387989; PubMed Central PMCID: PMC3882906.

Loricera J, Calvo-Río V, Mata C, Ortiz-Sanjuán F, González-López MA, Alvarez L, González-Vela MC, Armesto S, Fernández-Llaca H, Rueda-Gotor J, González-Gay MA, Blanco R. Urticarial vasculitis in northern Spain: clinical study of 21 cases. Medicine (Baltimore). 2014 Jan;93(1):53-60. doi: 10.1097/MD.0000000000000013. PubMed PMID: 24378743.

Genre F, López-Mejías R, Miranda-Filloy JA, Ubilla B, Carnero-López B, Gómez-Acebo I, Blanco R, Ochoa R, Rueda-Gotor J, González-Juanatey C, Llorca J, González-Gay MA. Gelsolin levels are decreased in ankylosing spondylitis patients undergoing anti-TNF-alpha therapy. Clin Exp Rheumatol. 2013 Dec 16. [Epub ahead of print] PubMed PMID: 24351434.

Maehlen MT, Olsen IC, Andreassen BK, Viken MK, Jiang X, Alfredsson L, Källberg H, Brynedal B, Kurreeman F, Daha N, Toes R, Zhernakova A, Gutierrez-Achury J, de Bakker PI, Martin J, Teruel M, Gonzalez-Gay MA, Rodríguez-Rodríguez L, Balsa A, Uhlig T, Kvien TK, Lie BA. Genetic risk scores and number of autoantibodies in patients with rheumatoid arthritis. Ann Rheum Dis. 2013 Dec 13. doi: 10.1136/annrheumdis-2013-204173. [Epub ahead of print] PubMed PMID: 24336335.

García-Bermúdez M, López-Mejías R, Genre F, Castañeda S, González-Juanatey C, Llorca J, Corrales A, Miranda-Filloy JA, Pina T, Gómez-Vaquero C, Rodríguez-Rodríguez L, Fernández-Gutiérrez B, Pascual-Salcedo D, Balsa A, López-Longo FJ, Carreira P, Blanco R, González-Álvaro I, Martín J, González-Gay MA. Single-nucleotide polymorphisms at the 9p21.3 genomic region not associated with the risk of cardiovascular disease in patients with rheumatoid arthritis. Tissue Antigens. 2013 Dec;82(6):405-9. doi: 10.1111/tan.12227. Epub 2013 Oct 15. PubMed PMID: 24498997.

Genre F, López-Mejías R, Miranda-Filloy JA, Ubilla B, Carnero-López B, Gómez-Acebo I, Blanco R, Ochoa R, Rueda-Gotor J, Pina T, González-Juanatey C, Llorca J, González-Gay MA. Antitumour necrosis factor α treatment reduces retinol-binding protein 4 serum levels in non-diabetic ankylosing spondylitis patients. Ann Rheum Dis. 2013 Dec 9. doi: 10.1136/annrheumdis-2013-204484. [Epub ahead of print] PubMed PMID: 24323393.

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Riancho-Zarrabeitia L, Delgado-Alvarado M, Riancho J, Oterino A, Sedano MJ, Rueda-Gotor J, Pérez-Martín I, González-Vela MC, Berciano J, González-Gay MA, Blanco R. Anti-TNF-α therapy in the management of severe neurosarcoidosis: a report of five cases from a single centre and literature review. Clin Exp Rheumatol. 2013 Dec 9. [Epub ahead of print] Review. PubMed PMID: 24321604.

Gonzalez-Gay MA, Lopez-Mejias R, Garcia-Porrua C. HLA-DRB1 association with sarcoidosis. Clin Exp Rheumatol. 2013 Dec 2. [Epub ahead of print] PubMed PMID: 24295517.

Genre F, López-Mejías R, Miranda-Filloy JA, Ubilla B, Carnero-López B, Gómez-Acebo I, Blanco R, Ochoa R, Arias-Bajo M, Rueda-Gotor J, Paz-Carreira J, González-Juanatey C, Llorca J, González-Gay MA. Correlation between two biomarkers of atherosclerosis, osteopontin and angiopoyetin-2, in non-diabetic ankylosing spondylitis patients undergoing TNF-α antagonist therapy. Clin Exp Rheumatol. 2013 Dec 2. [Epub ahead of print] PubMed PMID: 24295386.

López-Mejías R, Genre F, García-Bermúdez M, Corrales A, González-Juanatey C, Llorca J, Miranda-Filloy JA, Rueda-Gotor J, Blanco R, Castañeda S, Martín J, González-Gay MA. The ZC3HC1 rs11556924 polymorphism is associated with increased carotid intima-media thickness in patients with rheumatoid arthritis. Arthritis Res Ther. 2013 Oct 11;15(5):R152. doi: 10.1186/ar4335. PubMed PMID: 24286297.

Montes-Cano M, Conde-Jaldón M, García-Lozano J, Ortiz-Fernández L, Ortego-Centeno N, Castillo-Palma M, Espinosa G, Graña-Gil G, González-Gay M, Barnosi-Marín A, Solans R, Fanlo P, Camps T, Castañeda S, Sánchez-Bursón J, Núñez-Roldán A, Martín J, González-Escribano M. HLA and non-HLA genes in Behçet's disease: a multicentric study in the Spanish population. Arthritis Res Ther. 2013 Oct 4;15(5):R145. doi: 10.1186/ar4328. PubMed PMID: 24286189; PubMed Central PMCID: PMC3978908.

García-Bermúdez M, López-Mejías R, Genre F, Castañeda S, González-Juanatey C, Llorca J, Corrales A, Miranda-Filloy JA, Rueda-Gotor J, Gómez-Vaquero C, Rodríguez-Rodríguez L, Fernández-Gutiérrez B, Pascual-Salcedo D, Balsa A, López-Longo FJ, Carreira P, Blanco R, González-Álvaro I, Martín J, González-Gay MA. SMAD3 rs17228212 Gene Polymorphism Is Associated with Reduced Risk to Cerebrovascular Accidents and Subclinical Atherosclerosis in Anti-CCP Negative Spanish Rheumatoid Arthritis Patients. PLoS One. 2013 Oct 21;8(10):e77695. doi: 10.1371/journal.pone.0077695. PubMed PMID: 24204921; PubMed Central PMCID: PMC3804609.

Labrador S, Gonzalez-Gay MA. Images in clinical medicine. Cold hands associated with scleroderma. N Engl J Med. 2013 Oct 24;369(17):1638. doi: 10.1056/NEJMicm1304702. PubMed PMID: 24152263.

Loricera J, Calvo-Río V, Ortiz-Sanjuán F, González-López MA, Fernández-Llaca H, Rueda-Gotor J, Gonzalez-Vela MC, Alvarez L, Mata C, González-Lamuño D, Martínez-Taboada VM, González-Gay MA**, Blanco R**. The spectrum of paraneoplastic cutaneous vasculitis in a defined population: incidence and clinical features. Medicine (Baltimore). 2013 Nov;92(6):331-43. doi: 10.1097/MD.0000000000000009. PubMed PMID: 24145696.


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López-Mejías R, Genre F, García-Bermúdez M, Castañeda S, González-Juanatey C, Llorca J, Corrales A, Miranda-Filloy JA, Rueda-Gotor J, Gómez-Vaquero C, Rodríguez-Rodríguez L, Fernández-Gutiérrez B, Balsa A, Pascual-Salcedo D, López-Longo FJ, Carreira P, Blanco R, González-Álvaro I, Martín J, González-Gay MA. The 11q23.3 genomic region-rs964184-is associated with cardiovascular disease in patients with rheumatoid arthritis. Tissue Antigens. 2013 Nov;82(5):344-7. doi: 10.1111/tan.12217. PubMed PMID: 24131021.

Genre F, López-Mejías R, Miranda-Filloy JA, Carnero-López B, Gómez-Acebo I, Blanco R, Ochoa R, Rueda J, González-Juanatey C, Llorca J, González-Gay MA. Correlation between insulin resistance and serum ghrelin in non-diabetic ankylosing spondylitis patients undergoing anti-TNF-α therapy. Clin Exp Rheumatol. 2013 Aug 26. [Epub ahead of print] PubMed PMID: 23981480.

Gomez-Vaquero C, Corrales A, Zacarias A, Rueda-Gotor J, Blanco R,Gonzalez-Juanatey C, Llorca J, Gonzalez-Gay MA.SCORE and REGICOR function charts underestimate the cardiovascular risk in Spanish patients with rheumatoid arthritis. Arthritis Res Ther. 2013 Aug 21;15(4):R91.

Serrano A, Márquez A, Mackie SL, Carmona FD, Solans R, Miranda-Filloy JA, Hernández-Rodríguez J, Cid MC, Castañeda S, Morado I, Narváez J, Blanco R, Sopeña B, García-Villanueva MJ, Monfort J, Ortego-Centeno N, Unzurrunzaga A, Marí-Alfonso B, Sánchez-Martín J, de Miguel E, Magro C, Raya E, Braun N, Latus J, Molberg O, Lie BA, Moosig F, Witte T, Morgan AW, González-Gay MA, Martín J; UK GCA Consortium; Spanish GCA Consortium. Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis. Ann Rheum Dis. 2013 Aug 14. doi: 10.1136/annrheumdis-2013-203641. [Epub ahead of print].

van Bon L, Broen JC, Schijvenaars MM, Rueda B, Simeón CP, Ortego-Centeno N, González-Gay MA, Radstake TR, Hunzelmann N, Riemekasten G, Witte T, Wagener FA, Vonk MC, Coenen MJ, Martin J. Heme oxygenase-1 promoter polymorphisms do not influence susceptibility to systemic sclerosis and its clinical phenotypes. Clin Exp Rheumatol. 2013 Mar-Apr;31(2 Suppl 76):186.

Rosales Alexander JL, Cantero-Hinojosa J, Salvatierra J, Magro Checa C, González-Gay MA, Raya Álvarez E. Cardiovascular risk assessment according to a national calibrated score risk index in psoriatic arthritis patients without clinically evident cardiovascular disease or classic atherosclerosis risk factors. Joint Bone Spine. 2013 Aug 8. pii: S1297-319X(13)00193-0. doi: 10.1016/j.jbspin.2013.07.008. [Epub ahead of print].

López-Mejías R, Corrales A, Genre F, Hernández JL, Ochoa R, Blanco R, González-Juanatey C, Martín J, Llorca J, González-Gay MA. Angiopoietin-2 serum levels correlate with severity, early onset and cardiovascular disease in patients with rheumatoid arthritis. Clin Exp Rheumatol. 2013 Jul 24. [Epub ahead of print].

Calvo-Río V, Loricera J, Martín L, Ortiz-Sanjuán F, Alvarez L, González-Vela MC, González-Lamuño D, Mata C, Gortázar P, Rueda-Gotor J, Arias M, Peiró E, Martínez-Taboada VM, González-Gay MA, Blanco R. Henoch-Schönlein purpura nephritis and IgA nephropathy: a comparative clinical study. Clin Exp Rheumatol. 2013 Jan-Feb;31(1 Suppl 75):S45-51.


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Teruel M, McKinney C, Balsa A, Pascual-Salcedo D, Rodriguez-Rodriguez L, Ortiz AM, Gómez-Vaquero C, González-Gay MA, Smith M, Witte T, Merriman T, Lie BA, Martin J. Association of CD247 Polymorphisms with Rheumatoid Arthritis: A Replication Study and a Meta-Analysis. PLoS One. 2013 Jul 5;8(7):e68295.

Corrales A, Parra JA, González-Juanatey C, Rueda-Gotor J, Blanco R, Llorca J, González-Gay MA. Cardiovascular risk stratification in rheumatic diseases: carotid ultrasound is more sensitive than Coronary Artery Calcification Score to detect subclinical atherosclerosis in patients with rheumatoid arthritis. Ann Rheum Dis. 2013 Jul 13. doi: 10.1136/annrheumdis-2013-203688. [Epub ahead of print].

Carmona FD, González-Gay MA, Martín J. Genetic component of giant cell arteritis. Rheumatology (Oxford). 2013 Jul 10. [Epub ahead of print].

Pina T, Blanco R, González-Gay MA. Cutaneous Vasculitis: A Rheumatologist Perspective. Curr Allergy Asthma Rep. 2013 Jul 7. [Epub ahead of print].

Alonso MD, Martínez-Vázquez F, Riancho-Zarrabeitia L, Díaz de Terán T, Miranda-Filloy JA, Blanco R, González-Juanatey C, Llorca J, González-Gay MA. Sex differences in patients with systemic lupus erythematosus from Northwest Spain. Rheumatol Int. 2013 Jun 28. [Epub ahead of print] PubMed PMID: 23812032.

Genre F, López-Mejías R, Miranda-Filloy JA, Carnero-López B, Gómez-Acebo I, Blanco R, Ochoa R, Rueda J, González-Juanatey C, Llorca J, González-Gay MA. Asymmetric dimethylarginine serum levels in non-diabetic ankylosing spondylitis patients undergoing TNF-α antagonist therapy. Clin Exp Rheumatol. 2013 Jun 14.[Epub ahead of print] PubMed PMID: 23806325.

International Genetics of Ankylosing Spondylitis Consortium (IGAS), Cortes A, Hadler J, Pointon JP, Robinson PC, Karaderi T, Leo P, Cremin K, Pryce K, Harris J, Lee S, Joo KB, Shim SC, Weisman M, Ward M, Zhou X, Garchon HJ, Chiocchia G, Nossent J, Lie BA, Førre O, Tuomilehto J, Laiho K, Jiang L, Liu Y, Wu X, Bradbury LA, Elewaut D, Burgos-Vargas R, Stebbings S, Appleton L, Farrah C, Lau J, Kenna TJ, Haroon N, Ferreira MA, Yang J, Mulero J, Fernandez-Sueiro JL, Gonzalez-Gay MA, Lopez-Larrea C, Deloukas P, Donnelly P; Australo-Anglo-American Spondyloarthritis Consortium (TASC); Groupe Française d'Etude Génétique des Spondylarthrites (GFEGS); Nord-Trøndelag Health Study (HUNT); Spondyloarthritis Research Consortium of Canada (SPARCC); Wellcome Trust Case Control Consortium 2 (WTCCC2), Bowness P, Gafney K, Gaston H, Gladman DD, Rahman P, Maksymowych WP, Xu H, Crusius JB, van der Horst-Bruinsma IE, Chou CT, Valle-Oñate R, Romero-Sánchez C, Hansen IM, Pimentel Santos FM, Inman RD, Videm V, Martin J, Breban M, Reveille JD, Evans DM, Kim TH, Wordsworth BP, González-Gay MA, Brown MA. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet. 2013 Jun 9;45(7):730-8. doi: 10.1038/ng.2667. Epub 2013 Jun 9. PubMed PMID: 23749187.


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Martin JE, Assassi S, Diaz-Gallo LM, Broen JC, Simeon CP, Castellvi I, Vicente-Rabaneda E, Fonollosa V, Ortego-Centeno N, González-Gay MA, Espinosa G, Carreira P; Spanish Scleroderma Group; SLEGEN consortium; U.S. Scleroderma GWAS group; BIOLUPUS, Camps M, Sabio JM, D'alfonso S, Vonk MC, Voskuyl AE, Schuerwegh AJ, Kreuter A, Witte T, Riemekasten G, Hunzelmann N, Airo P, Beretta L, Scorza R, Lunardi C, Van Laar J, Chee MM, Worthington J, Herrick A, Denton C, Fonseca C,Tan FK, Arnett F, Zhou X, Reveille JD, Gorlova O, Koeleman BP, Radstake TR, Vyse T, Mayes MD, Alarcón-Riquelme ME, Martin J. A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. Hum Mol Genet. 2013 Jun 10. [Epub ahead of print] PubMed PMID: 23740937.

Miranda-Filloy JA, López-Mejias R, Genre F, Carnero-López B, Ochoa R, Diaz de Terán T, González-Juanatey C, Blanco R, Llorca J, González-Gay MA. Leptin and visfatin serum levels in non-diabetic ankylosing spondylitis patients undergoing TNF-α antagonist therapy. Clin Exp Rheumatol. 2013 May 27. [Epub ahead of print] PubMed PMID: 23711190.

Ferraz-Amaro I, González-Gay MA, García-Dopico JA, Díaz-González F. Cholesteryl Ester Transfer Protein in Patients with Rheumatoid Arthritis. J Rheumatol. 2013 May 15. [Epub ahead of print] PubMed PMID: 23678159.

Génin E, Coustet B, Allanore Y, Ito I, Teruel M, Constantin A, Schaeverbeke T, Ruyssen-Witrand A, Tohma S, Cantagrel A, Vittecoq O, Barnetche T, Le Loët X, Fardellone P, Furukawa H, Meyer O, Fernández-Gutiérrez B, Balsa A, González-Gay MA, Chiocchia G, Tsuchiya N, Martin J, Dieudé P. Epistatic Interaction between BANK1 and BLK in Rheumatoid Arthritis: Results from a Large Trans-Ethnic Meta-Analysis. PLoS One. 2013 Apr 30;8(4):e61044. doi: 10.1371/journal.pone.0061044. Print 2013. PubMed PMID: 23646104; PubMed Central. PMCID: PMC3639995.

Gonzalez-Lopez MA, Blanco R, Garcia-Ibarbia C, Gonzalez-Vela CM, Gonzalez-Gay MA. Etanercept-induced hypertriglyceridemia during the treatment of recurrent aphthous stomatitis. Indian J Dermatol Venereol Leprol. 2013 May-Jun;79(3):432-3. doi: 10.4103/0378-6323.110788. PubMed PMID: 23619454.

Casanueva B, Rivas P, Rodero B, Quintial C, Llorca J, González-Gay MA.Short-term improvement following dry needle stimulation of tender points in fibromyalgia. Rheumatol Int. 2013 Apr 23. [Epub ahead of print] PubMed PMID:23609584.

Diaz-Gallo LM, Sánchez E, Ortego-Centeno N, Sabio JM, García-Hernández FJ, de Ramón E, González-Gay MA, Torsten Witte, Anders HJ, González-Escribano MF, Martín J. Evidence of new risk genetic factor to systemic lupus erythematosus: the UBASH3A gene. PLoS One. 2013;8(4):e60646. doi: 10.1371/journal.pone.0060646. Epub 2013 Apr 2. PubMed PMID: 23565265; PubMed Central PMCID: PMC3614928.

Ortiz-Sanjuán FM, Blanco R, Corral-Nieri LF, González-Gay MA. Acute monoarthritis as presenting manifestation of acute Q fever: report of a new case and literature review. Clin Exp Rheumatol. 2013 Apr 3. [Epub ahead of print] PubMed PMID: 23558160.

Corrales A, González-Juanatey C, Peiró ME, Blanco R, Llorca J, González-Gay MA. Carotid ultrasound is useful for the cardiovascular risk stratification of patients with rheumatoid arthritis: results of a population-based study. Ann Rheum Dis. 2013 Mar 16. [Epub ahead of print] PubMed PMID: 23505241.

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Genre F, Miranda-Filloy JA, López-Mejias R, Carnero-López B, Ochoa R, Rueda J, González-Juanatey C, Blanco R, Llorca J, González-Gay MA. Apelin serum levels in non-diabetic ankylosing spondylitis patients undergoing TNF-α antagonist therapy. Clin Exp Rheumatol. 2013 Mar 13. [Epub ahead of print] PubMed PMID: 23484462.

Genre F, Miranda-Filloy JA, López-Mejias R, Carnero-López B, Ochoa R, Rueda J, González-Juanatey C, Blanco R, Llorca J, González-Gay MA. Antitumour necrosis factor-α therapy modulates angiopoietin-2 serum levels in non-diabetic ankylosing spondylitis patients. Ann Rheum Dis. 2013 Mar 12. [Epub ahead of print] PubMed PMID: 23482472.

Carmona FD, Cénit MC, Diaz-Gallo LM, Broen JC, Simeón CP, Carreira PE, Callejas-Rubio JL, Fonollosa V, López-Longo FJ, González-Gay MA, Hunzelmann N, Riemekasten G, Witte T, Kreuter A, Distler JH, Madhok R, Shiels P, van Laar JM, Schuerwegh AJ, Vonk MC, Voskuyl AE, Fonseca C, Denton CP, Herrick A, Worthington J, Arnett FC, Tan FK, Assassi S, Radstake TR, Mayes MD, Martín J; Spanish Scleroderma Group. New insight on the Xq28 association with systemic sclerosis.Ann Rheum Dis. 2013 Feb 26. [Epub ahead of print] PubMed PMID: 23444193.

Ferraz-Amaro I, González-Juanatey C, López-Mejias R, Riancho-Zarrabeitia L, González-Gay MA. Metabolic syndrome in rheumatoid arthritis. Mediators Inflamm.2013;2013:710928. doi: 10.1155/2013/710928.

Blanco R, González-López MA, González-Vela MC, Fernández-Llaca H, González-Gay MA. Disparate results in studies of adalimumab in the treatment of hidradenitis suppurativa: comment on the article by Amano et al. Int J Dermatol. 2013 Mar;52(3):380-1.

van Bon L, Broen JC, Schijvenaars MM, Rueda B, Simeón CP, Ortego-Centeno N, González-Gay MA, Hunzelmann N, Riemekasten G, Witte T, Wagener FA, Vonk MC, Coenen MJ, Martin J, Radstake TR. Heme oxygenase-1 promoter polymorphisms do not influence susceptibility to systemic sclerosis and its clinical phenotypes. Clin Exp Rheumatol. 2013 Feb 7. [Epub ahead of print] PubMed PMID: 23406650.

Carmona FD, Martin JE, Beretta L, Simeón CP, Carreira PE, Callejas JL, Fernández-Castro M, Sáez-Comet L, Beltrán E, Camps MT, González-Gay MA, Egurbide MV; Spanish Scleroderma Group, Airó P, Scorza R, Lunardi C, Hunzelmann N, Riemekasten G, Witte T, Kreuter A, Distler JH, Madhok R, Shiels P, van Laar JM, Fonseca C, Denton C, Herrick A, Worthington J, Schuerwegh AJ, Vonk MC, Voskuyl AE, Radstake TR, Martín J. The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis. PLoS One. 2013;8(1):e54419. doi: 10.1371/journal.pone.0054419.

Ferraz-Amaro I, Garcia-Dopico JA, Medina-Vega L, Gonzalez-Gay MA, Diaz-Gonzalez F. Impaired beta cell function is present in non-diabetic rheumatoid arthritis patients. Arthritis Res Ther. 2013 Jan 22;15(1):R17. [Epub ahead of print] PubMed PMID: 23339356.

Serrano A, Carmona FD, Castañeda S, Miranda-Filloy JA, Morado IC, Gomez-Vaquero C, Solans R, Sopeña B, Blanco R, Unzurrunzaga A, Ortego-Centeno N, Marí-Alfonso B, Hidalgo-Conde A, Hernández-Rodríguez J, Cid MC, Martín, Gonzalez-Gay MA. A case-control study suggests that the CCR6 locus is not involved in the susceptibility to giant cell arteritis. Clin Exp Rheumatol. 2013 Jan 7. [Epub ahead of print] PubMed PMID: 23306142.


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Gulín Dávila J, González-Gay MA. Infectious events during the first year of treatment with an antagonist of the tumor necrosis factor. Farm Hosp. 2013 Sep-Oct;37(5):351-7. doi: 10.7399/FH.2013.37.5.717. Spanish. PubMed PMID: 24128096.

Pérez-Esteban S, González-Gay MA, Castañeda S. Therapeutic update in large vessel vasculitides.Rev Clin Esp. 2013 Oct;213(7):338-46. doi: 10.1016/j.rce.2013.03.008.

Morales-Angulo C, Vergara Pastrana S, Obeso-Agüera S, Acle L, González-Gay MA. Otorhinolaryngological manifestations in patients with Behçet disease. Acta Otorrinolaringol Esp. 2013 Oct 1. doi:pii: S0001-6519(13)00138-6. 10.1016/j.otorri.2013.06.007. [Epub ahead of print] English, Spanish. pubmed PMID: 24094428.

Miranda-Filloy JA, López-Mejias R, Genre F, Carnero-López B, Ochoa R, Diaz de Terán T, González-Juanatey C, Blanco R, Llorca J, González-Gay MA. Adiponectin and resistin serum levels in non-diabetic ankylosing spondylitis patients undergoing TNF-α antagonist therapy. Clin Exp Rheumatol. 2012 Dec 13. [Epub ahead of print] PubMed PMID: 23294554.

Bossini-Castillo L, Simeon CP, Beretta L, Broen J, Vonk MC, Callejas JL, Carreira P, Rodriguez-Rodriguez L, Garcia-Portales R, Gonzalez-Gay MA, Castellvi I, Camps MT, Tolosa C, Vicente-Rabaneda E, Egurbide MV, Ssg SS, Schuerwegh AJ, Hesselstrand R, Lunardi C, van Laar JM, Shiels P, Herrick A, Worthington J, Denton C, Radstake TR, Fonseca C, Martin J. KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor. Arthritis Res Ther. 2012 Dec 27;14(6):R273. [Epub ahead of print] PubMed PMID: 23270786.

Serrano A, Carmona FD, Castañeda S, Solans R, Hernández-Rodríguez J, Cid MC, Prieto-González S, Miranda-Filloy JA, Rodríguez-Rodríguez L, Morado IC, Gomez-Vaquero C, Blanco R, Sopeña B, Ortego-Centeno N, Unzurrunzaga A, Marí-Alfonso B, Sánchez-Martín J, García-Villanueva MJ, Hidalgo-Conde A, Pazzola G, Boiardi L, Salvarani C, González-Gay MA, Martín J. Evidence of association of the NLRP1 gene with giant cell arteritis. Ann Rheum Dis. 2012 Dec 19. [Epub ahead of print] PubMed PMID: 23253924.

González-Gay MA, García-Porrúa C. Brucellosis is not only responsible for monoarthritis but it is also associated with other osteoarticular complications. Rheumatol Int. 2012 Dec 14. [Epub ahead of print] PubMed PMID: 23239040.

Diaz-Gallo LM, Simeon CP, Broen JC, Ortego-Centeno N, Beretta L, Vonk MC, Carreira PE, Vargas S, Román-Ivorra JA, González-Gay MA, Tolosa C, López-Longo FJ, Espinosa G, Vicente EF, Hesselstrand R, Riemekasten G, Witte T, Distler JH, Voskuyl AE, Schuerwegh AJ, Shiels PG, Nordin A, Padyukov L, Hoffmann-Vold AM, Scorza R, Lunardi C, Airo P, van Laar JM, Hunzelmann N, Gathof BS, Kreuter A, Herrick A, Worthington J, Denton CP, Zhou X, Arnett FC, Fonseca C, Koeleman BP, Assasi S, Radstake TR, Mayes MD, Martín J; The Spanish Scleroderma Group. Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility. Ann Rheum Dis. 2012 Nov 21. [Epub ahead of print] PubMed PMID: 23172754.

García-Bermúdez M, González-Juanatey C, López-Mejías R, Teruel M, Corrales A, Miranda-Filloy JA, Castañeda S, Balsa A, Fernández-Gutierrez B, González-Álvaro I, Gómez-Vaquero C, Blanco R, Llorca J, Martín J, González-Gay MA. Study of association of CD40-CD154 gene polymorphisms with disease susceptibility and cardiovascular risk in Spanish rheumatoid arthritis patients. PLoS One. 2012;7(11):e49214. doi: 10.1371/journal.pone.0049214. Epub 2012 Nov 15. PubMed PMID: 23166616; PubMed Central PMCID: PMC3499567.

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González-Gay MA, González-Juanatey C, Miranda-Filloy JA, García-Unzueta MT, Llorca J. Lack of association between carotid intima-media wall thickness and carotid plaques and markers of endothelial cell activation in rheumatoid arthritis patients undergoing anti-TNF therapy. Acta Reumatol Port. 2012 Apr;37(2):155-159. PubMed PMID: 23149638.

Eyre S, Bowes J, Diogo D, Lee A, Barton A, Martin P, Zhernakova A, Stahl E, Viatte S, McAllister K, Amos CI, Padyukov L, Toes RE, Huizinga TW, Wijmenga C, Trynka G, Franke L, Westra HJ, Alfredsson L, Hu X, Sandor C, de Bakker PI, Davila S, Khor CC, Heng KK, Andrews R, Edkins S, Hunt SE, Langford C, Symmons D. Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate; Wellcome Trust Case Control Consortium, Concannon P, Onengut-Gumuscu S, Rich SS, Deloukas P, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Arlsetig L, Martin J, Rantapää-Dahlqvist S, Plenge RM, Raychaudhuri S, Klareskog L, Gregersen PK, Worthington J. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet. 2012 Nov 11. doi: 10.1038/ng.2462. [Epub ahead of print] PubMed PMID: 23143596.

Cénit MC, Ortego-Centeno N, Raya E, Callejas JL, García-Hernandez FJ, Castillo-Palma MJ, Fernandez-Sueiro JL, Magro C, Solans R, Castañeda S, Camps M, Hidalgo A, Espinosa G, González-Gay MA, González-Escribano MF, Martín J. Influence of the STAT3 genetic variants in the susceptibility to psoriatic arthritis and Behcet's disease. Hum Immunol. 2012 Nov 2. doi:pii: S0198-8859(12)00590-3. 10.1016/j.humimm.2012.10.019. [Epub ahead of print] PubMed PMID: 23127549.

González-Gay MA, Szekanecz Z, Popa CD, Dessein P. Atherosclerosis in rheumatoid arthritis. Mediators Inflamm. 2012;2012:489608. doi: 10.1155/2012/489608. Epub 2012 Oct 17. PubMed PMID: 23125485;

García-Bermúdez M, López-Mejías R, González-Juanatey C, Corrales A, Castañeda S, Ortiz AM, Miranda-Filloy JA, Gómez-Vaquero C, Fernández-Gutiérrez B, Balsa A, Pascual-Salcedo D, Blanco R, Llorca J, Martín J, González-Gay MA. CARD8 rs2043211 (p.C10X) Polymorphism Is Not Associated with Disease Susceptibility or Cardiovascular Events in Spanish Rheumatoid Arthritis Patients. DNA Cell Biol. 2012 Oct 22. [Epub ahead of print] PubMed PMID: 23088220.

García-Bermúdez M, López-Mejías R, González-Juanatey C, Corrales A, Robledo G, Castañeda S, Miranda-Filloy JA, Blanco R, Fernández-Gutiérrez B, Balsa A, González-Alvaro I, Gómez-Vaquero C, Llorca J, Martín J, González-Gay MA. Analysis of the Interferon Gamma (rs2430561, +874T/A) Functional Gene Variant in Relation to the Presence of Cardiovascular Events in Rheumatoid Arthritis. PLoS One. 2012;7(10):e47166. doi: 10.1371/journal.pone.0047166. Epub 2012 Oct 15. PubMed PMID: 23077565; PubMed Central PMCID: PMC3471910.

Cénit MC, Simeón CP, Vonk MC, Callejas-Rubio JL, Espinosa G, Carreira P, Blanco FJ, Narvaez J, Tolosa C, Román-Ivorra JA, Gómez-García I, García-Hernández FJ, Gallego M, García-Portales R, Egurbide MV, Fonollosa V, de la Peña PG, López-Longo FJ, González-Gay MA. The Spanish Scleroderma Group, Hesselstrand R, Riemekasten G, Witte T, Voskuyl AE, Schuerwegh AJ, Madhok R, Fonseca C, Denton C, Nordin A, Palm O, van Laar JM, Hunzelmann N, Distler JH, Kreuter A, Herrick A, Worthington J, Koeleman BP, Radstake TR, Martín J. Influence of the IL6 Gene in Susceptibility to Systemic Sclerosis. J Rheumatol. 2012 Oct 1. [Epub ahead of print] PubMed PMID: 23027890.


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González-Gay MA, González-Juanatey C. Carotid ultrasound as predictor of atherosclerosis in rheumatoid arthritis. Vasa. 2012 Sep;41(5):311-2. PubMed PMID: 23025038.

González-Gay MA, González-Juanatey C. Rheumatoid arthritis: Obesity impairs efficacy of anti-TNF therapy in patients with RA. Nat Rev Rheumatol. 2012 Nov;8(11):641-2. doi: 10.1038/nrrheum.2012.158. Epub 2012 Sep 25. PubMed PMID: 23007743.

Amor-Dorado JC, Barreira-Fernández MP, Aran-Gonzalez I, Casariego-Vales E, Llorca J, González-Gay MA. Particle Repositioning Maneuver Versus Brandt-Daroff Exercise for Treatment of Unilateral Idiopathic BPPV of the Posterior Semicircular Canal: A Randomized Prospective Clinical Trial With Short- and Long-Term Outcome. Otol Neurotol. 2012 Oct;33(8):1401-7. PubMed PMID: 22935812.

RÍos-Fernández R, Callejas-Rubio JL, Fernández-Roldán C, Simeón-Aznar CP, García-Hernández F, Castillo-García MJ, Fonollosa Pla V, Barnosi Marín AC, González-Gay MA, Ortego-Centeno N. Bone mass and vitamin D in patients with systemic sclerosis from two Spanish regions. Clin Exp Rheumatol. 2012 Aug 4. [Epub ahead of print] PubMed PMID: 22935485.

Rodríguez-Rodríguez L, López-Mejías R, García-Bermúdez M, González-Juanatey C, González-Gay MA, Martín J. Genetic markers of cardiovascular disease in rheumatoid arthritis. Mediators Inflamm. 2012;2012:574817. Epub 2012 Aug 2. PubMed PMID: 22927710; PubMed Central PMCID: PMC3419432.

Gonzalez-Juanatey C, Vazquez-Rodriguez TR, Miranda-Filloy JA, Gomez-Acebo I, Testa A, Garcia-Porrua C, Sanchez-Andrade A, Llorca J, González-Gay MA. Anti-TNF-Alpha-Adalimumab Therapy Is Associated with Persistent Improvement of Endothelial Function without Progression of Carotid Intima-Media Wall Thickness in Patients with Rheumatoid Arthritis Refractory to Conventional Therapy. Mediators Inflamm. 2012;2012:674265. Epub 2012 Jul 31. PubMed PMID: 22899879; PubMed Central PMCID: PMC3415105.

Bossini-Castillo L, Martin JE, Broen J, Simeon CP, Beretta L, Gorlova OY, Vonk MC, Ortego-Centeno N, Espinosa G, Carreira P, García de la Peña P, Oreiro N, Román-Ivorra JA, Castillo MJ, González-Gay MA, Sáez-Comet L, Castellví I, Schuerwegh AJ, Voskuyl AE, Hoffmann-Vold AM, Hesselstrand R, Nordin A, Lunardi C, Scorza R, van Laar JM, Shiels PG, Herrick A, Worthington J, Fonseca C, Denton C, Tan FK, Arnett FC, Assassi S, Koeleman BP, Mayes MD, Radstake TR, Martin J; the Spanish Scleroderma Group*. Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study. Ann Rheum Dis. 2012 Aug 15. [Epub ahead of print] PubMed PMID: 22896740.

Rueda-Gotor J, González-Gay MA, Blanco Alonso R, Gonzalez-Vela C, Lopez-Obregon C, González-López MA. Successful effect of tocilizumab in anti-TNF-α-induced palmoplantar pustulosis in rheumatoid arthritis. Joint Bone Spine. 2012 Aug 1. [Epub ahead of print] PubMed PMID: 22857979.

Casanueva B, Rodero B, Quintial C, Llorca J, González-Gay MA. Short-term efficacy of topical capsaicin therapy in severely affected fibromyalgia patients. Rheumatol Int. 2012 Jul 28. [Epub ahead of print] PubMed PMID: 22842953.


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Bejerano C, Blanco R, González-Vela C, Pérez-Martín I, Martinez-Rodriguez I, Jimenez-Bonilla J, González-Gay MA. Polymyalgia rheumatica as presenting manifestation of vasculitis involving the lower extremities in a patient with ulcerative colitis. Clin Exp Rheumatol. 2012 Jan-Feb;30(1 Suppl 70):S110-3.

González-Gay MA, González-Juanatey C. Inflammation, endothelial function and atherosclerosis in rheumatoid arthritis. Arthritis Res Ther. 2012 Jul19;14(4):122.

Miranda-Filloy JA, Llorca J, Carnero-López B, González-Juanatey C, Blanco R, González-Gay MA. TNF-α antagonist therapy improves insulin sensitivity in non-diabetic ankylosing spondylitis patients. Clin Exp Rheumatol. 2012 Jul 5. [Epub ahead of print] PubMed PMID: 22765845.

López-Mejías R, García-Bermúdez M, González-Juanatey C, Castañeda S, Miranda-Filloy JA, Gómez-Vaquero C, Fernández-Gutiérrez B, Balsa A, Pascual-Salcedo D, Blanco R, González-Álvaro I, Llorca J, Martín J, González-Gay MA. NFKB1-94ATTG ins/del polymorphism (rs28362491) is associated with cardiovascular disease in patients with rheumatoid arthritis. Atherosclerosis. 2012 Jun 13. [Epub ahead of print] PubMed PMID: 22742859.

Cénit MC, Simeón CP, Fonollosa V, Espinosa G, Beltrán E, Sáez-Comet L, Vicente-Rabaneda E, García-Hernández FJ, Martínez-Estupiñán L, Rodríguez-Carballeira M, Hernández V, de la Peña PG, Fernández-Castro M, Narváez FJ, Pros A, Gallego M, Ríos-Fernández R, Camps MT, Fernández-Nebro A, Egurbide MV, Carreira P, González-Gay MA, Martín J. Spanish Scleroderma Group. No evidence of association between functional polymorphisms located within IL6R and IL6ST genes and systemic sclerosis. Tissue Antigens. 2012 Jun 29; 9999(9999). doi: 10.1111/j.1399-0039.2012.01915.x. [Epub ahead of print] PubMed PMID: 22742541.

Teruel M, Simeon CP, Broen J, Vonk MC, Carreira P, Camps MT, García-Portales R, Delgado-Frías E, Gallego M, Espinosa G; the Spanish Scleroderma Group, Beretta L, Airó P, Lunardi C, Riemekasten G, Witte T, Krieg T, Kreuter A, Distler JH, Hunzelmann N, Koeleman BP, Voskuyl AE, Schuerwegh AJ, González-Gay MA, Radstake TR, Martin J. Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis. Arthritis Res Ther. 2012 Jun 25;14(3):R154.

García-Bermúdez M, López-Mejías R, González-Juanatey C, Castañeda S, Miranda-Filloy J, Blanco R, Fernández-Gutiérrez B, Balsa A, González-Álvaro I, Gómez-Vaquero C, Llorca J, Martín J, González-Gay M. Association of the methionine sulfoxide reductase A rs10903323 gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis. Scand J Rheumatol. 2012 Jun 3. [Epub ahead of print] PubMed PMID: 22657383.

Alonso MD, Martinez-Vazquez F, Diaz de Teran T, Miranda-Filloy JA, Dierssen T, Blanco R, Gonzalez-Juanatey C, Llorca J, Gonzalez-Gay M. Late-onset systemic lupus erythematosus in northwestern Spain: differences with early-onset systemic lupus erythematosus and literature review. Lupus. 2012 May 31. [Epub ahead of print] PubMed PMID: 22652632.

Carmona FD, Serrano A, Rodríguez-Rodríguez L, Callejas JL, Simeón CP, Carreira P, Castañeda S, Solans R, Blanco R; The Spanish Scleroderma Group; The Spanish Giant Cell Arteritis Group, González-Gay MA, Martín J. Evaluation of a Shared Autoimmune Disease-associated Polymorphism of TRAF6 in Systemic Sclerosis and Giant Cell Arteritis. J Rheumatol. 2012 Jun;39(6):1275-1279. Epub 2012 May 15. PubMed PMID: 22589256.

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García-Bermúdez M, López-Mejías R, González-Juanatey C, Corrales A, Castañeda S, Miranda-Filloy JA, Gómez-Vaquero C, Fernández-Gutiérrez B, Balsa A, Pascual-Salcedo D, Blanco R, González-Álvaro I, Llorca J, Martín J, González-Gay MA. Association Study of MIA3 rs17465637 Polymorphism with Cardiovascular Disease in Rheumatoid Arthritis Patients. DNA Cell Biol. 2012 May 11. [Epub ahead of print] PubMed PMID: 22577832.

González-Gay MA, González-Juanatey C, Llorca J. Carotid ultrasound in the cardiovascular risk stratification of patients with rheumatoid arthritis: when and for whom? Ann Rheum Dis. 2012 Jun;71(6):796-8. Epub 2012 May 5. PubMed PMID: 22562981.

McKinney C, Broen JC, Vonk MC, Beretta L, Hesselstrand R, Hunzelmann N, Riemekasten G, Scorza R, Simeon CP, Fonollosa V, Carreira PE, Ortego-Centeno N, Gonzalez-Gay MA, Airo P, Coenen M, Martin J, Radstake TR, Merriman TR. Evidence that deletion at FCGR3B is a risk factor for systemic sclerosis. Genes Immun. 2012 May 3. doi: 10.1038/gene.2012.15. [Epub ahead of print] PubMed PMID: 22551723.

Robledo G, González-Gay MA, Fernández-Gutiérrez B, Lamas JR, Balsa A, Pascual-Salcedo D, Castañeda S, Blanco R, González-Alvaro I, García A, Raya E, Gómez-Vaquero C, Delgado M, Martín J. NPSR1 Gene Is Associated with Reduced Risk of Rheumatoid Arthritis. J Rheumatol. 2012 Jun;39(6):1166-70.

Bossini-Castillo L, Simeon CP, Beretta L, Broen JC, Vonk MC, Ríos-Fernández R, Espinosa G, Carreira P, Camps MT, Castillo MJ, González-Gay MA, Beltrán E, Carmen Freire MD, Narváez J, Tolosa C, Witte T, Kreuter A, Schuerwegh AJ, Hoffmann-Vold AM, Hesselstrand R, Lunardi C, van Laar JM, Chee MM, Herrick A, Koeleman BP, Denton CP, Fonseca C, Radstake TR, Martin J; the Spanish Scleroderma Group. A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis. Arthritis Res Ther. 2012 Apr 24;14(2):R85. Serrano A, Carmona FD, Miranda-Filloy JA, Castañeda S, Rodríguez-Rodríguez L, Morado IC, Gómez-Vaquero C, Solans R, Sopeña B, Blanco R, Unzurrunzaga A, Ortego-Centeno N, Marí-Alfonso B, de Miguel E, Hidalgo-Conde A, Martín J**, González-Gay MA. Autoimmune disease-associated CD226 gene variants are not involved in giant cell arteritis susceptibility in the Spanish population. Clin Exp Rheumatol. 2012 Jan-Feb;30(1 Suppl 70):S29-33.

González-Gay MA*, González-Juanatey C, Miranda-Filloy JA, Llorca J. The Potential Effect of TNF-α Antagonist Therapy in Rheumatoid Arthritis may Depend on the Degree and Severity of Insulin Resistance Before the Onset of this Therapy. Horm Metab Res. 2012 Jun;44(7):558-9.

González-Gay MA, González-Vela C, González-Juanatey C. Psoriasis: a Skin Disease Associated With Increased Cardiovascular Risk. Actas Dermosifiliogr. 2012 Mar 30. [Epub ahead of print] English, Spanish. PubMed PMID: 22465257.

González-Gay MA, González-Juanatey C. Implication of new atherosclerotic carotid plaques in the cardiovascular outcome of patients with rheumatoid arthritis. Arthritis Res Ther. 2012 Mar 12;14(2):105. [Epub ahead of print] PubMed PMID: 22414597.

Bejerano C, Blanco R, González-Vela C, Agüero R, Carril JM, González-Gay MA. Refractory polymyalgia rheumatica as presenting manifestation of large-vessel vasculitis associated to sarcoidosis. Successful response to adalimumab. Clin Exp Rheumatol. 2012 Jan-Feb;30(1 Suppl 70):S94-7.

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Martin JE, Broen JC, Carmona FD, Teruel M, Simeon CP, Vonk MC, van 't Slot R, Rodriguez-Rodriguez L, Vicente E, Fonollosa V, Ortego-Centeno N, González-Gay MA, García-Hernández FJ, de la Peña PG, Carreira P; Spanish Scleroderma Group, Voskuyl AE, Schuerwegh AJ, van Riel PL, Kreuter A, Witte T, Riemekasten G, Airo P, Scorza R, Lunardi C, Hunzelmann N, Distler JH, Beretta L, van Laar J, Chee MM, Worthington J, Herrick A, Denton C, Tan FK, Arnett FC, Assassi S, Fonseca C, Mayes MD, Radstake TR, Koeleman BP, Martin J. Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up. Hum Mol Genet. 2012 Jun 15;21(12):2825-35.

López-Mejías R, García-Bermúdez M, González-Juanatey C, Castañeda S, Miranda-Filloy JA, Gómez-Vaquero C, Fernández-Gutiérrez B, Balsa A, Pascual-Salcedo D, Blanco R, González-Álvaro I, Llorca J, Martín J, González-Gay MA. Lack of association between the CXCL12 rs501120 polymorphism and cardiovascular disease in Spanish patients with rheumatoid arthritis. Hum Immunol. 2012 May;73(5):543-6. Epub 2012 Feb 16. PubMed PMID: 22386691.

López-Mejías R, González-Juanatey C, García-Bermúdez M, Castañeda S, Miranda-Filloy JA, Blanco R, Llorca J, Martín J, González-Gay MA. The lp13.3 genomic region -rs599839- is associated with endothelial dysfunction in patients with rheumatoid arthritis. Arthritis Res Ther. 2012 Mar 1;14(2):R42. [Epub ahead of print] PubMed PMID: 22380622.

García-Bermúdez M, López-Mejías R, González-Juanatey C, Castañeda S, Miranda-Filloy JA, Blanco R, Fernández-Gutiérrez B, Balsa A, González-Alvaro I, Gómez-Vaquero C, Llorca J, Martín J, González-Gay MA. Lack of Association Between TLR4 rs4986790 Polymorphism and Risk of Cardiovascular Disease in Patients with Rheumatoid Arthritis. DNA Cell Biol. 2012 Feb 23. [Epub ahead of print] PubMed. PMID: 22360682.

Kerekes G, Soltész P, Nurmohamed MT, Gonzalez-Gay MA, Turiel M, Végh E, Shoenfeld Y, McInnes I, Szekanecz Z. Validated methods for assessment of subclinical atherosclerosis in rheumatology. Nat Rev Rheumatol. 2012 Feb 21. doi: 10.1038/nrrheum.2012.16. [Epub ahead of print] PubMed PMID: 22349611. IF: 6.448.

Garcia-Bermudez M, González-Juanatey C, Lopez-Mejias R, Rodriguez-Rodriguez L, Pérez-Esteban S, Castañeda S, Urcelay E, Miranda-Filloy JA, Gómez-Vaquero C, Fernández-Gutierrez B, Balsa A, González-Alvaro I, Blanco R, Llorca J, Martín J, Gonzalez-Gay MA. Influence of MHCIITA rs3087456 and rs4774 polymorphisms in the susceptibility to cardiovascular disease of patients with rheumatoid arthritis. Clin Exp Rheumatol. 2012 Jan 23. [Epub ahead of print] PubMed PMID: 22272574. IF: 2.358.

Baerlecken NT, Linnemann A, Gross WL, Moosig F, Vazquez-Rodriguez TR, Gonzalez-Gay MA, Martin J, Kötter I, Henes JC, Melchers I, Vaith P, Schmidt RE, Witte T. Association of ferritin autoantibodies with giant cell arteritis/polymyalgia rheumatica. Ann Rheum Dis. 2012 Jan 5. [Epub ahead of print] PubMed PMID: 22228484. IF: 9.082.

Blanco R, González-Vela MC, González-López MA, Fernández-Llaca H, Cañal J, González-Gay MA. Interstitial keratitis secondary to severe Hidradenitis suppurativa responding to adalimumab. Cornea. 2012 Feb;31(2):206; author reply 206. IF: 1.762.

Morales-Angulo C, García-Zornoza R, Obeso-Agüera S, Calvo-Alén J, González-Gay MA. Ear, nose and throat manifestations of Wegener's granulomatosis (granulomatosis with polyangiitis). Acta Otorrinolaringol Esp. 2012 May;63(3):206-211. Epub 2012 Mar 20. English, Spanish. PubMed PMID: 22439922.

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Ferraz Amaro I, Díaz González F, González Juanatey C, González Gay MA. Reumatol Clin. 2011;7:124-9. Insulin resistance and rheumatoid arthritis.

Teruel M, Martin JE, Ortego-Centeno N, Jiménez-Alonso J, Sánchez-Román J, de Ramón E, Gonzalez-Escribano MF, Pons-Estel BA, D'Alfonso S, Sebastiani GD, Witte T, Bottini N, González-Gay MA, Alarcón-Riquelme ME, Martin J. Novel association of acid phosphatase locus 1*C allele with systemic lupus erythematosus. Hum Immunol. 2011 Oct 21. [Epub ahead of print] PubMed PMID: 22064183. IF: 2.872.

González-Gay MA, González-Juanatey C, Miranda-Filloy JA, García-Unzueta MT, Llorca J. Lack of association between flow-mediated endothelium-dependent vasodilatation and biomarkers of endothelial dysfunction in patients with severe rheumatoid arthritis. Rheumatol Int. 2011 Nov 6. [Epub ahead of print] PubMed PMID: 22057149. IF: 1.431.

Broen JC, Dieude P, Vonk MC, Beretta L, Carmona FD, Herrick A, Worthington J, Hunzelmann N, Riemekasten G, Kiener H, Scorza R, Simeon CP, Fonollosa V, Carreira P, Ortego-Centeno N, Gonzalez-Gay MA, Airo P, Coenen MJ, Tsang K, Aliprantis AO, Martin J, Allanore Y, Radstake TR. Polymorphisms in the Interleukin 4, Interleukin 13, and Corresponding Receptor Genes Are Not Associated with Systemic Sclerosis and Do Not Influence Gene Expression. J Rheumatol. 2011 Nov 1. [Epub ahead of print] PubMed PMID: 22045834. IF: 3.551.

Martin JE, Carmona FD, Broen JC, Simeón CP, Vonk MC, Carreira P, Ríos-Fernández R, Espinosa G, Vicente-Rabaneda E, Tolosa C, García-Hernández FJ, Castellví I, Fonollosa V, González-Gay MA, Sáez-Comet L, Portales RG, de la Peña PG, Fernández-Castro M, Díaz B, Martínez-Estupiñán L, Coenen M, Voskuyl AE, Schuerwegh AJ, Vanthuyne M, Houssiau F, Smith V, de Keyser F, De Langhe E, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Palm O, Chee MM, van Laar JM, Denton C, Herrick A, Worthington J, Koeleman BP, Radstake TR, Fonseca C, Martín J. The autoimmune disease-associated IL2RA locus is involved in the Clinical manifestations of systemic sclerosis. Genes Immun. 2011 Oct 20. doi: 10.1038/gene.2011.72. [Epub ahead of print] PubMed PMID: 22012429. IF: 4.367.

Carmona FD, Serrano-Lopera A, López-Isac E, Simeón CP, Carreira P, Rios-Fernandez R, Espinosa G, Camps MT, Navarrete N, González-Escribano MF, Vicente-Rabaneda E, Rodríguez-Rodríguez L, Tolosa C, Beltrán E, Gómez-Garcia I, Fernández-Castro M, López-Longo FJ, García-Hernández FJ, Castellví I, Trapiella L, Fernández-Nebro A, García-Portales R, Egurbide MV, Fonollosa V, García de la Peña P, Pros A, Rodríguez-Carballeira M, Díaz-Gónzalez F, Sáez-Comet L, González-Gay MA, Martín J. No evidence for association between the CCR5/Delta32CCR5 polymorphism and systemic sclerosis. Clin Exp Rheumatol. 2011 Sep-Oct;29(5):895-6. IF: 2.358.

López-Mejías R, García-Bermúdez M, González-Juanatey C, Castañeda S, Miranda-Filloy JA, Gómez-Vaquero C, Fernández-Gutiérrez B, Balsa A, Pascual-Salcedo D, Blanco R, González-Álvaro I, Llorca J, Martín J, González-Gay MA. Lack of association of IL6R rs2228145 and IL6ST/gp130 rs2228044 gene polymorphisms with cardiovascular disease in patients with rheumatoid arthritis. Tissue Antigens. 2011 Dec;78(6):438-441 IF: 3.024.

Martín JE, Alizadeh BZ, González-Gay MA, Balsa A, Pascual-Salcedo D, González-Escribano MF, Rodriguez-Rodriguez L, Fernández-Gutiérrez B, Raya E, Coenen MJ, van Riel P, Radstake TR, Kvien TK, Viken MK, Lie BA, Koeleman BP, Martín J. Evidence for PTPN22 R620W Polymorphism As the Sole Common Risk Variant for Rheumatoid Arthritis in the 1p13.2 Region. J Rheumatol. 2011Nov;38(11):2290-6. IF: 3.551.

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Carmona FD, Serrano A, Rodríguez-Rodríguez L, Castañeda S, Miranda-Filloy JA, Morado IC, Narváez J, Solans R, Sopeña B, Marí-Alfonso B, Unzurrunzaga A, Ortego-Centeno N, Blanco R, DE Miguel E, Hidalgo-Conde A, Martín J, González-Gay MA. A Nonsynonymous Functional Variant of the ITGAM Gene Is Not Involved in Biopsy-proven Giant Cell Arteritis. J Rheumatol. 2011 Dec;38(12):2598-601. Epub 2011 Oct 1. PubMed PMID: 21965647. IF: 3.551.

Perez-Ruiz F, Carmona L, Yébenes MJ, Pascual E, de Miguel E, Ureña I, González-Gay MA; GEMA Study Group, Sociedad Española de Reumatología. An audit of the variability of diagnosis and management of gout in the rheumatology setting: the gout evaluation and management study. J Clin Rheumatol. 2011 Oct;17(7):349-55. PubMed PMID: 21946457. IF: 1.283.

Chen-Xu M, Topless R, McKinney C, Merriman ME, Phipps-Green A, Dalbeth N, Gow PJ, Harrison AA, Highton J, Jones PB, Nissen M, Smith MD, van Rij A, Jones GT, Rodriguez-Rodriguez L, Fernandez-Gutierrez B, Teruel M, Balsa A, Pascual-Salcedo D, Ortiz AM, Gonzalez-Gay MA, Steer S, Maehlen M, Lie B, Wordsworth BP, Stamp LK, Martin J, Merriman TR. Replication of association of the interleukin 23 receptor rs1343151 variant with rheumatoid arthritis in Caucasian sample sets. Ann Rheum Dis. 2012 Jan;71(1):155-7. Epub 2011 Sep 16. PubMed PMID: 21926184. IF: 2.358: 9.082.

García-Bermúdez M, González-Juanatey C, Rodríguez-Rodríguez L, Miranda-Filloy JA, Perez-Esteban S, Vazquez-Rodriguez TR, Castañeda S, Balsa A, Fernández-Gutierrez B, Llorca J, González-Alvaro I, Martín J, González-Gay MA. Lack of association of NAMPT rs9770242 and rs59744560 polymorphisms with disease susceptibility and cardiovascular risk in patients with rheumatoid arthritis. Clin Exp Rheumatol. 2011 Jul-Aug; 29(4):681-8. IF: 2.358.

Broen J, Bossini-Castillo L, Van Bon L, Vonk M, Knaapen H, Beretta L, Rueda B, Hesselstrand R, Herrick A, Worthington J, Hunzelman N, Denton C, Fonseca C, Riemekasten G, Kiener H, Scorza P, Simeon C, Ortego-Centeno N; (for the Spanish Systemic Sclerosis group), Gonzalez-Gay M, Airo P, Coenen M, Martin J, Radstake T. A rare polymorphism in Toll like Receptor 2 is associated with systemic sclerosis phenotype and increases production of inflammatory mediators. Arthritis Rheum. 2011 Sep 8. doi: 10.1002/art.33325. [Epub ahead of print]. IF: 8.435.

López-Mejías R, García-Bermúdez M, González-Juanatey C, Castañeda S, Pérez-Esteban S, Miranda-Filloy JA, Gómez-Vaquero C, Fernández-Gutiérrez B, Balsa A, Pascual-Salcedo D, Blanco R, González-Álvaro I, Llorca J, Martín J, González-Gay MA. Lack of association between IL6 single nucleotide polymorphisms and cardiovascular disease in Spanish patients with rheumatoid arthritis. Atherosclerosis. 2011 Aug 5. [Epub ahead of print] PubMed PMID: 21889771. IF: 4.086.

Gonzalez-Gay MA, Gonzalez-Juanatey C, Llorca J. Subclinical atherosclerosis in ankylosing spondylitis. J Rheumatol. 2011 Sep; 38(9):2073. PubMed PMID: 21885520. IF: 3.551.

Alonso MD, Llorca J, Martinez-Vazquez F, Miranda-Filloy JA, Diaz de Teran T, Dierssen T, Vazquez-Rodriguez TR, Gomez-Acebo I, Blanco R, Gonzalez-Gay MA. Systemic Lupus Erythematosus in Northwestern Spain: A 20-Year Epidemiologic Study. Medicine (Baltimore). 2011 Sep;90(5):350-358. PubMed PMID: 21857367. IF: 4.256.


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Díaz-Gallo LM, Garcia S, Ortego-Centeno N, Jiménez-Alonso J, Sánchez-Román J, de Ramón E, González-Escribano MF, Balsa A, Fernández-Gutierrez B, González-Alvaro I, González-Gay MA, Martin J. Association study of BAK1 gene polymorphisms in Spanish rheumatoid arthritis and systemic lupus erythematosus cohorts. Ann Rheum Dis. 2011 Aug 17. [Epub ahead of print] PubMed PMID: 21852253. IF: 9.082.

Rodriguez-Rodriguez L, Gonzalez-Juanatey C, Garcia-Bermudez M, Vazquez-Rodriguez TR, Miranda-Filloy JA, Fernandez-Gutierrez B, Llorca J, Martin J, Gonzalez-Gay MA. CCR5Delta32 variant and cardiovascular disease in patients with rheumatoid arthritis: a cohort study. Arthritis Res Ther. 2011 Aug 16;13(4):R133. [Epub ahead of print] PubMed PMID: 21846359. IF: 4.357.

Casanueva-Fernández B, Llorca J, Rubió JB, Rodero-Fernández B, González-Gay MA. Efficacy of a multidisciplinary treatment program in patients with severe fibromyalgia. Rheumatol Int. 2011 Jul 23. [Epub ahead of print] PubMed PMID: 21785956. IF: 1.431.

Gorlova O, Martin JE, Rueda B, Koeleman BP, Ying J, Teruel M, Diaz-Gallo LM, Broen JC, Vonk MC, Simeon CP, Alizadeh BZ, Coenen MJ, Voskuyl AE, Schuerwegh AJ, van Riel PL, Vanthuyne M, van 't Slot R, Italiaander A, Ophoff RA, Hunzelmann N, Fonollosa V, Ortego-Centeno N, González-Gay MA, García-Hernández FJ, González-Escribano MF, Airo P, van Laar J, Worthington J, Hesselstrand R, Smith V, de Keyser F, Houssiau F, Chee MM, Madhok R, Shiels PG, Westhovens R, Kreuter A, de Baere E, Witte T, Padyukov L, Nordin A, Scorza R, Lunardi C, Lie BA, Hoffmann-Vold AM, Palm O, García de la Peña P, Carreira P; Spanish Scleroderma Group, Varga J, Hinchcliff M, Lee AT, Gourh P, Amos CI, Wigley FM, Hummers LK, Hummers J, Nelson JL, Riemekasten G, Herrick A, Beretta L, Fonseca C, Denton CP, Gregersen PK, Agarwal S, Assassi S, Tan FK, Arnett FC, Radstake TR, Mayes MD, Martin J. Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy. PLoS Genet. 2011 Jul;7(7):e1002178. Epub 2011 Jul 14. PubMed PMID: 21779181; PubMed Central PMCID: PMC3136437. IF: 9.543.

Teruel M, Martin JE, Gonzalez-Juanatey C, Lopez-Mejias R, Miranda-Filloy JA, Blanco R, Balsa A, Pascual-Salcedo D, Rodriguez-Rodriguez L, Fernandez-Gutierrez B, Ortiz AM, Gonzalez-Alvaro I, Gomez-Vaquero C, Bottini N, Llorca J, Gonzalez-Gay MA, Martin J. Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients. Arthritis Res Ther. 2011 Jul 18; 13(4):R116. [Epub ahead of print] PubMed PMID: 21767392. IF: 4.357.

González-Juanatey C, Llorca J, González-Gay MA. Correlation between endothelial function and carotid atherosclerosis in rheumatoid arthritis patients with long-standing disease. Arthritis Res Ther. 2011 Jun 22; 13(3):R101. [Epub ahead of print] PubMed PMID: 21696620. IF: 4.357.

García-Bermúdez M, López-Mejias R, Rodriguez-Rodriguez L, Fernández-Gutierrez B, García A, Raya E, Ortiz AM, Coenen MJ, van Riel PL, Radstake TR, González-Gay MA, Martín J. No evidence of association of the KLF12 gene with rheumatoid arthritis in Spanish and Dutch cohorts and a meta-analysis of published data. Hum Immunol. 2011 May 24. [Epub ahead of print] PubMed PMID: 21658422. IF: 2.872.

Carmona FD, Simeon CP, Beretta L, Carreira P, Vonk MC, Ríos-Fernández R, Espinosa G, Navarrete N, Vicente-Rabaneda E, Rodríguez-Rodríguez L, Tolosa C, García-Hernández FJ, Castellví I, Egurbide MV, Fonollosa V, González-Gay MA, Rodríguez-Carballeira M, Díaz-Gónzalez F, Sáez-Comet L, Hesselstrand R Riemekasten G, Witte T, Voskuyl AE, Schuerwegh AJ, Madhok R, Shiels P, Fonseca C, Denton C, Nordin A, Palm O, Hoffmann-Vold AM, Airó P,

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Scorza R, Lunardi C, van Laar JM, Hunzelmann N, Kreuter A, Herrick A, Worthington J, Koeleman BP, Radstake TR, Martín J. Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis. Ann Rheum Dis. 2011 May 13. [Epub ahead of print] PubMed PMID: 21571730. IF: 9.082.

Gómez-Vaquero C, Robustillo M, Narváez J, Rodríguez-Moreno J, González-Juanatey C, Llorca J, Nolla JM, González-Gay MA. Assessment of cardiovascular risk in rheumatoid arthritis: impact of the new EULAR recommendations on the score cardiovascular risk index. Clin Rheumatol. 2011 May 13. [Epub ahead of print] PubMed PMID: 21567119. IF: 1.687.

Gonzalez-Gay MA, Gonzalez-Juanatey C, Miranda-Filloy JA, Martin J, Garcia-Unzueta MT, Llorca J. Response to 'Infliximab therapy increases body fat mass in early rheumatoid arthritis independently of changes in disease activity and levels of leptin and adiponectin: a randomized study over 21 months'. Arthritis Res Ther. 2011 Apr 27; 13(2):404. [Epub ahead of print] PubMed PMID:21542887; PubMed Central PMCID: PMC3132047. IF: 4.357.

Martinez-Lado L, Calviño-Díaz C, Piñeiro A, Dierssen T, Vazquez-Rodriguez TR, Miranda-Filloy JA, Lopez-Diaz MJ, Blanco R, Llorca J, Gonzalez-Gay MA. Relapses and Recurrences in Giant Cell Arteritis: A Population-Based Study of Patients with Biopsy-Proven Disease From Northwestern Spain. Medicine (Baltimore). 2011 Apr 21. [Epub ahead of print] PubMed PMID: 21512412. IF: 4.256.

Rodríguez-Rodríguez L, González-Juanatey C, Palomino-Morales R, Vázquez-Rodríguez TR, Miranda-Filloy JA, Fernández-Gutiérrez B, Llorca J, Martin J, González-Gay MA. TNFA -308 (rs1800629) polymorphism is associated with a higher risk of cardiovascular disease in patients with rheumatoid arthritis. Atherosclerosis. 2011 Feb 24. [Epub ahead of print] PubMed PMID: 21420089. IF: 4.086.

Gonzalez-Gay MA, Gonzalez-Juanatey C, Rodriguez-Rodriguez L, Miranda-Filloy JA, Martin J, Llorca J. Lack of association between adipokines and ghrelin and carotid intima-media thickness in patients with severe rheumatoid arthritis. Clin Exp Rheumatol. 2011 Mar,Apr;29(2):358-359. Epub 2011 Apr 19. PubMed PMID:21418784. IF: 2.358.

Docampo E, Giardina E, Riveira-Muñoz E, de Cid R, Escaramís G, Perricone C, Fernández-Sueiro JL, Maymó J, González-Gay MA, Blanco FJ, Hüffmeier U, Lisbona MP, Martín J, Carracedo A, Reis A, Rabionet R, Novelli G, Estivill X. Deletion of the LCE3C and LCE3Bgenes is a susceptibility factor for psoriatic arthritis: A study in Spanish and Italian populations and meta-analysis. Arthritis Rheum. 2011 Mar 11. doi: 10.1002/art.30340. [Epub ahead of print] PubMed PMID: 21400479. IF: 8.435.

Rodríguez-Rodríguez L, García-Bermúdez M, González-Juanatey C, Vazquez-Rodriguez TR, Miranda-Filloy JA, Fernández-Gutierrez B, Llorca J, Martín J, González-Gay MA. Vascular endothelial growth factor A and cardiovascular disease in rheumatoid arthritis patients. Tissue Antigens. 2011 Apr;77(4):291-7. doi: 10.1111/j.1399-0039.2010.01625.x. PubMed PMID: 21388351. IF: 3.024.

Amoli MM, Miranda-Filloy JA, Vazquez-Rodriguez TR, Ollier WE, Gonzalez-Gay MA. Interleukin-1 beta gene polymorphism in patients with biopsy-proven erythema nodosum. Clin Exp Rheumatol. 2011 Feb 2. [Epub ahead of print] PubMed PMID: 21385549. IF: 2.358.


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García-Bermúdez M, González-Juanatey C, Rodríguez-Rodríguez L, Vazquez-Rodriguez TR, Miranda-Filloy JA, Fernández-Gutierrez B, Llorca J, Martin J, González-Gay MA. Lack of association between LEP rs2167270 (19 G>A) polymorphism and disease susceptibility and cardiovascular disease in patients with rheumatoid arthritis. Clin Exp Rheumatol. 2011 Mar-Apr;29(2):293-8. Epub 2011 Apr 19. PubMed PMID: 21385539. IF: 2.358.

Amor-Dorado JC, Barreira-Fernandez MP, Vazquez-Rodriguez TR, Gomez-Acebo I, Miranda-Filloy JA, Diaz de Teran T, Llorca J, Gonzalez-Gay MA. Audiovestibular manifestations in patients with ankylosing spondylitis. Medicine (Baltimore). 2011 Mar;90(2):99-109. PubMed PMID: 21358443. IF: 4.256.

Carmona FD, Rodríguez-Rodríguez L, Castañeda S, Miranda-Filloy JA, Morado IC, Narváez J, Marí-Alfonso B, Unzurrunzaga A, Ríos-Fernández R, Blanco R, de Miguel E, Martín J, González-Gay MA. Role of the CCR5/Δ32CCR5 polymorphism in biopsy-proven giant cell arteritis. Hum Immunol. 2011 May;72(5):458-61. Epub 2011 Feb 25. PubMed PMID: 21354457. IF: 2.872.

Rodriguez-Rodriguez L, Garcia-Bermudez M, Gonzalez-Juanatey C,Vazquez-Rodriguez TR, Miranda-Filloy JA, Fernandez-Gutierrez B, Llorca J, Martin J, Gonzalez-Gay MA. Lack of association between RETN rs1862513 polymorphism and cardiovascular disease in rheumatoid arthritis patients. Clin Exp Rheumatol. 2011 Jan-Feb;29(1):19-25. Epub 2011 Feb 23. PubMed PMID: 21345288. IF: 2.358.

Rodríguez-Rodríguez L, Carmona FD, Castañeda S, Miranda-Filloy JA, Morado IC, Narváez J, Marí-Alfonso B, Gómez-Vaquero C, Amigo-Díaz E, Ríos-Fernández R, Blanco R, Llorca J, Fernández-Gutiérrez B, Martín J, González-Gay MA. Role of rs1343151 IL23R and rs3790567 IL12RB2 Polymorphisms in Biopsy-proven Giant Cell Arteritis. J Rheumatol. 2011 Feb 1. [Epub ahead of print] PubMed PMID: 21285166. IF: 3.551.

Rodríguez-Rodríguez L, Taib WR, Topless R, Steer S, González-Escribano MF, Balsa A, Pascual-Salcedo D, González-Gay MA, Raya E, Fernandez-Gutierrez B, González-Álvaro I, Bottini N, Witte T, Viken MK, Coenen MJ, van Riel PL, Franke B, den Heijer M, Radstake TR, Wordsworth P, Lie BA, Merriman TR, Martín J. The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples. Arthritis Rheum. 2011 Feb;63(2):365-72. doi:10.1002/art.30145. PubMed PMID: 21279993. IF: 8.435.

Rodríguez-Rodríguez L, García-Bermúdez M, Gonzalez-Juanatey C, Vazquez-Rodriguez TR, Miranda-Filloy JA, Fernandez-Gutierrez B, Llorca J, Martin J, Gonzalez-Gay MA. Analysis of the influence of the ghrelin receptor rs509035, rs512692 and rs2922126 polymorphisms in the risk of cardiovascular disease in patients with rheumatoid arthritis. Clin Exp Rheumatol. 2011 Jan 19. [Epub ahead of print] PubMed PMID: 21269581. IF: 2.358.

INVESTIGACIÓN:

Nuestro Servicio es líder Nacional en Investigación en Reumatología. Actualmente la mayor parte de los facultativos del Servicio están incluidos en un grupo IDIVAL propio “Epidemiología genética y arteriosclerosis en enfermedades inflamatorias sistémicas” que durante el año 2013 ha conseguido más de 250 puntos de factor de impacto. Nuestro Servicio tiene en la actualidad tres proyectos FIS del ISCIII en activo, está incluido en la RIER/RETICS de Artritis Reumatoide liderando el Dr. González-Gay una de las 4 líneas de investigación de la citada red.

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Ensayos Clínicos: Un criterio de valoración actual para determinar la calidad de un Servicio moderno es su disponibilidad y capacidad para realizar ensayos clínicos. Ello redunda en una mejor atención al paciente, posibilidad de administrar fármacos sin coste alguno para el Servicio Cántabro de Salud, publicación en las mejores revistas de la especialidad y tener acceso a un alto nivel de conocimiento en el manejo de las diferentes enfermedades autoinmunes. Distintos médicos del servicio han sido IP, en especial el Dr. Blanco.

LÍNEAS DE INVESTIGACIÓN ACTUALES

1. Epidemiología de las enfermedades autoinmunes (Artritis Reumatoide, Artritis Psoriásica, Arteritis de Células Gigantes, Esclerodermia, Espondiloartropatías y Lupus Eritematoso Sistémico) en Cantabria. Estudio de la incidencia, espectro clínico y curso evolutivo de estas enfermedades en la población de Cantabria. En muchos casos, estos datos se desconocen en población española, hecho que situará al centro como referencia para el conocimiento de estas enfermedades en la población del sur de Europa.

2. Riesgo cardiovascular y Enfermedad vascular en las enfermedades autoinmunes (Artritis Reumatoide, Artritis Psoriásica, Arteritis de Células Gigantes, Esclerodermia, espondiloartropatías y Lupus Eritematoso Sistémico, psoriasis). Papel de la inflamación y la genética en su desarrollo y presentación clínica. Siguiendo la línea estudios ya publicados por el propio grupo, analizarán los marcadores (analíticos, clínicos y de imagen) asociados a inflamación que pueden estar implicados en el desarrollo de eventos cardiovasculares y mortalidad precoz en pacientes con enfermedades inflamatorias reumatológicas crónicas. Dichos estudios les situarán de nuevo como referencia para la población española.

3. Estudio genético de las enfermedades autoinmunes (Artritis Reumatoide, Artritis Psoriásica, Espondiloartropatías y Vasculitis: Arteritis de Células Gigantes, y Púrpura de Schonlein Henoch) en Cantabria. Como continuación de estudios ya realizados por el grupo, también se estudiará el patrón de predisposición genética de susceptibilidad a enfermedades autoinmunes inflamatorias reumatológicas. Es un objetivo de gran importancia establecer si determinados genes se asocian en la población de Cantabria con una mayor severidad de estas enfermedades. Dichos datos deberán ser extrapolables al resto de la población española.

4. Estrategia terapéutica con fármacos bloqueadores del TNF-alfa en pacientes con enfermedades autoinmunes (Artritis Psoriásica y psoriasis). Efecto sobre parámetros clínicos de la enfermedad y el desarrollo de enfermedad cardiovascular. Basados estrictamente en indicación clínica por falta de respuesta a terapia convencional estándar, en aquellos pacientes que por la severidad de la enfermedad requieran tratamientos biológicos con bloqueadores del TNF-alfa se analizará el impacto de estas terapias biológicas en la progresión de la enfermedad aterosclerótica, analizando de forma específica marcador séricos y parámetros clínicos asociados a un mayor riesgo de mortalidad cardiovascular y la implicación de estos fármacos en su patogénesis como terapias potencialmente “protectoras” contra el desarrollo de progresión de la enfermedad cardiovascular.

PROYECTOS COMPETITIVOS EN CURSO

MIGUEL ÁNGEL GONZÁLEZ-GAY MANTECÓN. Red de Investigación en Inflamación y Enfermedades Reumáticas. RD12/0009/0013. INSTITUTO DE SALUD CARLOS III. MINISTERIO DE ECONOMÍA Y COMPETITIVIDAD.

MIGUEL ÁNGEL GONZÁLEZ-GAY MANTECÓN. Estudio de marcadores genéticos de enfermedad cardiovascular y arteriosclerosis subclínica en pacientes con artritis reumatoide.

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PI12/00060. INSTITUTO DE SALUD CARLOS III. MINISTERIO DE ECONOMÍA Y COMPETITIVIDAD.

RICARDO BLANCO ALONSO. Estudio de marcadores genéticos de susceptibilidad en pacientes con vasculitis de Schönlein-Henoch. PI12/00193. INSTITUTO DE SALUD CARLOS III. MINISTERIO DE ECONOMÍA Y COMPETITIVIDAD.

MIGUEL ÁNGEL GONZÁLEZ-GAY MANTECÓN. Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases. EU13/01- PRECISESADS. COMISIÓN EUROPEA, INNOVATIVE MEDICINES INITIATIVE.

MIGUEL ÁNGEL GONZÁLEZ-GAY MANTECÓN. Marcadores genéticos de enfermedad aterosclerótica en la Artritis Reumatoide. PI15/00525. INSTITUTO DE SALUD CARLOS III. MINISTERIO DE ECONOMÍA Y COMPETITIVIDAD.

MIGUEL ÁNGEL GONZÁLEZ-GAY MANTECÓN. Contratos para la Intensificación de la actividad investigadora en el SNS. INT15/00099. INSTITUTO DE SALUD CARLOS III. MINISTERIO DE ECONOMÍA Y COMPETITIVIDAD.

ENSAYOS CLÍNICOS ACTIVOS

RICARDO BLANCO ALONSO. Estudio abierto de seguimiento a largo plazo de Tofacitinib (CP-690,550), para el tratamiento de la artritis reumatoide. A3921024. PFIZER LIMITED.

MIGUEL ÁNGEL GONZÁLEZ-GAY MANTECÓN. Estudio de fase III, multicéntrico, aleatorizado doble ciego, y controlado con placebo para evaluar la eficacia y la seguridad de certolizumab pegol en sujetos con espondiloartritis axial (EA axial). AS001. UCB CELLTECH.

JOSÉ LUIS PEÑA SAGREDO. Estudio en fase III, multicéntrico, aleatorizado, doble ciego, controlado con placebo y de grupos paralelos para evaluar la eficacia y la seguridad de dos dosis de apremilast (CC-10004) en pacientes con artritis psoriásica activa. CC-10004-PSA-002. CELGENE CORPORATION.

RICARDO BLANCO ALONSO. Ensayo clínico fase Ib/IIa, escalada de dosis, simple ciego, para evaluar la seguridad de la administración intravenosa de células madre mesenquimales alogénicas expandidas derivadas de tejido adiposo (eASCs) a pacientes con artritis reumatoide (AR) refractaria, Vs 2.0 de 18 de noviembre de 2010, Hoja de Información al Paciente y Consentimiento Informado Vs 3.0 de 14 de Diciembre de 2010. Cx611-0101. TIGENIX, S.A.U.

RICARDO BLANCO ALONSO. Estudio aleatorizado, doble ciego, controlado con placebo y con control activo de secukinumab para demostrar la eficacia en 24 semanas y evaluar la seguridad, tolerabilidad y eficacia a largo plazo durante 1 año en pacientes con artritis reumatoide activa que tienen una respuesta inadecuada a anti-TNFα, protocolo en castellano vs. de fecha 29 de abril de 2011, HIP y CI Vs de fecha 3 de mayo de 2011, HIP y CI farmacogenético Vs. de fecha 29 de abril de 2011. CAIN457F2309. NOVARTIS FARMACEUTICA, S.A.

JOSÉ LUIS PEÑA SAGREDO. Estudio en fase 3, aleatorizado, doble ciego, controlado con placebo y multicéntrico sobre la eficacia y la seguridad de cuatro ciclos de tratamiento de 12 semanas (48 semanas) con epratuzumab en pacientes con lupus eritematoso sistémico moderado a intenso (EMBODY 1). SL0009. UCB INC.

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RICARDO BLANCO ALONSO. Estudio de Fase IIB, aleatorizado, multicéntrico, en doble ciego, de búsqueda de dosis y controlado con placebo/principio activo, para evaluar la eficacia y la seguridad de BMS-945429 en inyecciones subcutáneas, con o sin metotrexato, en sujetos con artritis reumatoide de moderada a grave con respuesta inadecuada al metotrexato. IM133-001. BRISTOL-MYERS SQUIBB INTERNATIONAL CORPORATION (BMSIC).

RICARDO BLANCO ALONSO. Estudio prospectivo, Fase IIb/III, multicéntrico, randomizado, doble ciego, controlado, de 3 grupos paralelos y 24 semanas de duración con posible extensión, para comparar la eficacia y seguridad de masitinib, a la dosis de 3 y 4.5 mg/kg/día, con metotrexato, con randomización 1:1:1, para el tratamiento de pacientes con artritis reumatoide activa y con una respuesta inadecuada a 1. metotrexato, a 2. cualquier FAME incluido al menos un fármaco biológico si previamente resultó ineficaz en pacientes tratados con metotrexato o a 3. metotrexato en combinación con cualquier FAME incluidos fármacos biológicos. AB06012. AB SCIENCE.

RICARDO BLANCO ALONSO. Estudio de extensión a largo plazo de los estudios WA22762 y NA25220, multicéntrico, abierto para evaluar la seguridad y eficacia de tocilizumab subcutáneo en pacientes con artritis reumatoide moderada a grave. ML28488. ROCHE FARMA, S. A.

RICARDO BLANCO ALONSO. Estudio de fase III, multicéntrico, aleatorizado, doble ciego, controlado con placebo de secukinumab subcutáneo en jeringas precargadas para demostrar la eficacia a las 16 semanas y evaluar la eficacia, seguridad y tolerabilidad a largo plazo, hasta 5 años, en pacientes con Espondilitis Anquilosante activa. CAIN457F2310. NOVARTIS FARMACEUTICA, S.A.

RICARDO BLANCO ALONSO. Estudio de fase 3, aleatorizado, doble ciego, controlado con placebo y un comparador activo, para evaluar la eficacia y seguridad de baricitinib en pacientes con artritis reumatoide con actividad moderada-severa y respuesta insuficiente al tratamiento con metotrexato. I4V-MC-JADV. LILLY, S.A.

Mª ENRIQUETA PEIRÓ CALLIZO. Estudio multicéntrico, doble ciego, aleatorizado, con grupos paralelos y controlado con fármaco activo para determinar la eficacia y seguridad de la prednisona de liberación modificada (Lodotra®) comparado con prednisona de liberación inmediata (prednisona IR) en sujetos con polimialgia reumática (PMR). LOD3501. MUNDIPHARMA RESEARCH LIMITED A.

RICARDO BLANCO ALONSO. Estudio fase 3, multicentrico para evaluar la seguridad y eficacia de Baricitinib en pacientes con artritis reumatoide. I4V-MC-JADY. LILLY, S.A.

RICARDO BLANCO ALONSO. Estudio multicéntrico, aleatorizado, en doble ciego, controlado con placebo y de grupos paralelos, de CNTO 136 (sirukumab), un anticuerpo monoclonal humano anti-IL-6, administrado subcutáneamente, en sujetos con artritis reumatoide activa a pesar del tratamiento con anti-TNFα. CNTO136ARA3003. JANSSEN-CILAG, S.A.

RICARDO BLANCO ALONSO. Estudio de fase III, aleatorizado, controlado con placebo, para evaluar la eficacia y la seguridad de abatacept en inyección subcutánea en adultos con artritis psoriásica activa. IM101-332. BRISTOL-MYERS SQUIBB INTERNATIONAL CORPORATION (BMSIC).

RICARDO BLANCO ALONSO. Estudio de fase II, aleatorizado, doble ciego, controlado con placebo, de búsqueda de la dosis, sobre la eficacia y seguridad de tofacitinib en pacientes con espondilitis anquilosante (EA) activa. A3921119. PFIZER, INC.

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RICARDO BLANCO ALONSO. Estudio Estudio multicéntrico, de grupos paralelos, de seguridad y eficacia a largo plazo de CNTO 136 (sirukumab) en artritis reumatoide en sujetos que han completado el tratamiento en los estudios CNTO136ARA3002 (SIRROUND-D) y CNTO136ARA3003 (SIRROUND-T). CNTO136ARA3004. JANSSEN-CILAG INTERNATIONAL, NV.

RICARDO BLANCO ALONSO. Estudio multicéntrico, aleatorio, a doble ciego y comparativo con fármaco activo y con placebo de 24 semanas de duración, seguido de una evaluación a largo plazo de la eficacia y la seguridad de Ixekizumab (LY2439821) en pacientes con artritis psoriásica activa que nunca han recibido un fármaco antirreumático biológico modificador de la enfermedad. I1F-MC-RHAP (Reiteración). ELI LILLY & COMPANY.

RICARDO BLANCO ALONSO. Estudio de fase III, aleatorizado, doble ciego, controlado con placebo, para evaluar la eficacia y la seguridad de 2 dosis de tofacitinib (CP- 690.550) o adalimumab en pacientes con artritis psoriásica activa. A3921091. PFIZER, INC.

RICARDO BLANCO ALONSO. Estudio de fase III, aleatorizado, doble ciego, controlado con placebo, para evaluar la eficacia y la seguridad de 2 dosis de tofacitinib (CP- 690.550) en pacientes con artritis psoriásica activa y una respuesta inadecuada al tratamiento con al menos un inhibidor del TNF. A3921125. PFIZER, INC.

RICARDO BLANCO ALONSO. Estudio multicéntrico, aleatorizado, doble ciego fase III de Secukinumab, controlado con placebo para demostrar la eficacia a las 16 semanas y evaluar la seguridad, tolerabilidad y eficacia a largo plazo en un periodo de 3 años en sujetos con espondilitis anquilosante activa. CAIN457F2314. NOVARTIS FARMACEUTICA, S.A.

RICARDO BLANCO ALONSO. Estudio multicéntrico, aleatorizado, doble ciego, controlado con placebo, de fase III de secukinumab subcutáneo en autoinyectores, para demostrar la eficacia a las 24 semanas y para evaluar la seguridad, tolerabilidad y eficacia a largo plazo hasta 3 años en pacientes con Artritis Psoriásica activa. CAIN457F2318. NOVARTIS FARMACEUTICA, S.A.

RICARDO BLANCO ALONSO. Estudio abierto, de extensión, a largo plazo, con Tofacitinib (CP-690,550) para el tratamiento de la artritis psoriásica. A3921092. PFIZER, INC.

RICARDO BLANCO ALONSO. Estudio de fase IIIB/IV aleatorizado, de criterios de valoración de la seguridad, de 2 dosis de Tofacitinib en comparación con un inhibidor del factor de necrosis tumoral (TNF) en pacientes con artritis reumatoide. A3921133. PFIZER, INC.

CRISTINA MARTÍNEZ DUBOIS. Estudio de fase 2a para evaluar la seguridad, la eficacia y los efectos farmacodinámicos de ABT 981 en pacientes con osteoartritis de rodilla. M13-741. ABBVIE INC.

RICARDO BLANCO ALONSO. Estudio multicéntrico, aleatorizado, con doble enmascaramiento, controlado con placebo, de 24 semanas de duración, seguido de una evaluación a largo plazo de la eficacia y la seguridad de ixekizumab (LY2439821) en pacientes con artritis psoriásica activa que han recibido un fármaco antirreumático modificador de la enfermedad biológico. I1F-MC-RHBE. ELI LILLY & COMPANY.


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RICARDO BLANCO ALONSO. Estudio de fase IIb, multicéntrico, aleatorizado, doble ciego, de ALX-0061 administrado subcutáneamente como monoterapia, en sujetos con artritis reumatoide de moderada a severa con intolerancia al metotrexato o para los que el tratamiento continuado con metotrexato es inadecuado. ALX0061-C202. ABLYNX NV.

RICARDO BLANCO ALONSO. Estudio de fase III, multicéntrico, aleatorizado, doble ciego, controlado con placebo de secukinumab (150 mg) por vía subcutánea con o sin una dosis de carga por vía subcutánea para evaluar la eficacia, la seguridad y la tolerabilidad durante un máximo de 2 años en pacientes con espondilitis anquilosante activa. CAIN457F2320. NOVARTIS FARMACEUTICA, S.A.

RICARDO BLANCO ALONSO. Estudio de extensión, de Fase II, multicéntrico, abierto para evaluar la eficacia y seguridad a largo plazo de ALX-0061 subcutáneo en sujetos con artritis reumatoide de moderada a severa que hayan completado uno de los estudios anteriores de Fase IIb con ALX-006. ALX0061-C203. ABLYNX NV.

ENSAYOS POSTAUTORIZACIÓN Y OTROS

JOSÉ HÉCTOR FERNÁNDEZ LLACA. Estudio sobre la obesidad y los factores de riesgo cardiovasculares en pacientes con psoriasis en tratamiento sistémico. MSD-PSO-2011-01. MERCK SHARP & DHOME ESPAÑA.

Mª ENRIQUETA PEIRÓ CALLIZO. Evaluación del riesgo cardiovascular, y de sus determinantes, en pacientes con artritis reumatoide, espondilitis anquilosante y artritis psoriásica. CARMA. FUNDACIÓN ESPAÑOLA DE REUMATOLOGÍA F.E.R.

JOSÉ HÉCTOR FERNÁNDEZ LLACA. Registro epidemiológico observacional para evaluar el perfil clínico de los pacientes con psoriasis moderada a grave en España. Estudio ARIZONA. JAN-PSO-2010-01. JANSSEN-CILAG, S.A.

JOSÉ HÉCTOR FERNÁNDEZ LLACA. Efecto de la inmunogenicidad de las terapias anti-TNF sobre la respuesta terapéutica obtenida en los pacientes con psoriasis en placas moderada a grave. Estudio PREDIR. PFI-ETA-2012-01. PFIZER, S.L.U.

JOSÉ HÉCTOR FERNÁNDEZ LLACA. Estudio observacional para evaluar las recaídas en pacientes con psoriasis moderada - grave tratados con fármacos biológicos de acuerdo a la práctica clínica, en España. Estudio BioPRES. NOV-PSO-2013-01. NOVARTIS FARMACEUTICA, S.A.

RICARDO BLANCO ALONSO. Registro observacional prospectivo a 5 años para evaluar los acontecimientos adversos de interés y la eficacia en adultos con lupus eritematoso sistémico activo, con autoanticuerpos positivos, tratados con o sin BENLYSTA (belimumab). HGS1006-C1124. GLAXOSMITHKLINE RESEARCH & DEVELOPMENT LIMITED.

TESIS DOCTORALES

Alfonso Fernando Corrales Martínez. EVALUACIÓN DEL RIESGO CARDIOVASCULAR EN PACIENTES CON ARTRITIS REUMATOIDE. Director/es: Javier Llorca Díaz, José Antonio Parra Blanco, Miguel Ángel González-Gay Mantecón. UNIVERSIDAD DE CANTABRIA.

Trinitario Pina Murcia. MODIFICACIÓN DE MARCADORES DE RIESGO CARDIOVASCULAR EN PSORIASIS TRAS TERAPIA ANTI-TNF. Director/es: Javier Llorca Díaz, Miguel Ángel González-Gay Mantecón. UNIVERSIDAD DE CANTABRIA.

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Javier Loricera García. CARACTERIZACIÓN CLÍNICA DE LAS VASCULITIS CUTÁNEAS. Director/es: Miguel Ángel González-Gay Mantecón, María Del Carmen González Vela, Ricardo Blanco Alonso. UNIVERSIDAD DE CANTABRIA.

Vanesa Calvo Del Río. CARACTERIZACIÓN CLÍNICA DE LA PÚRPURA DE SCHOENLEIN-HENOCH. Director/es: Miguel Ángel González-Gay Mantecón, María Del Carmen González Vela, Ricardo Blanco Alonso. UNIVERSIDAD DE CANTABRIA.

Natalia Palmou Fontana. EFECTO DE LOS FARMACOS INHIBIDORES DEL FACTOR DE NECROSIS TUMORAL ALFA SOBRE LA CALIDAD DE VIDA EN PACIENTES CON ESPONDILITIS ANQUILOSANTE Y ARTRITIS PSORIASICA. Director/es: Joaquin Jordan Bueso, Julian Eloy Solis Garcia Del Pozo. UNIVERSIDAD DE CASTILLA-LA MANCHA.

Sara Diaz Angulo. ESTUDIO DE LA PREVALENCIA DE DISFUNCIÓN Y AUTOINMUNIAD TIROIDEA EN PACIENTES CON URTICARIA CRÓNICA, VITÍLIGO Y ALOPECIA AREATA EN LA COMUNIDAD AUTÓNOMA DE CANTABRIA. Director/es: Marcos Antonio González López, Marcos López Hoyos. UNIVERSIDAD DE CANTABRIA.

Documents

PUBLICACIONES INVESTIGACION REUMATOLOGIA · J Eur Acad Dermatol Venereol. 2015 Feb 4. doi: 10.1111/jdv.13005. ... Taboada VM, Ortiz AM, Tornero J, Marsal S, Moreno-Muelas JV. 2014