{x}f E l

kqrfur E t r

1*/

29.04.20t6 r.ffie YTBEP}KNAIOera FJe

o npoBeAeHHbrx HcrrbrTaHr{flx MeAr,rqr.rHcKofo lBAeJrus (oonytlaTeJlb-peql4pKyJlflTop Bo3Ayxaynbrpa(buorreroBbrfi 6elrrepnquAumft OPyE-3-5-(KPOHT) B HcnorIHeHI4I4 OPYBn-3-5-(KPOHT) (AE3AP-7) c <fulnrpoM Bo3AyrrHbrM yronbHbrM cMeHusIrvr @YC-(KPOHT), Ty9 45 l -029 - 1l | 7 69 43 6 -20() 6 upousnoAc'rBa AO dPOHT-M D, Pocclts

B nponegeHr,r[ u(]nbrraHufi yrac'rBoBirJrn :- Arquonepnoe o6qecrBo (KPOHT-IvI)- OfEHy r{M. aKaA. B.B.IIerpoBcKofo (PHUX), Mocxna- LlcnarcarrerrbHar nat5oparopnr (3K3OHA) Mfy r,rM. M.B. JloMoHocosa B nrlrlepyxoBoAr..rreJrr, KaHA. xLtM. HayK A.A. ZsaHoea

Pyxoeo4uleJrb r.rcrbrr alruit -.qoKr. Me,4. HayK, npoSeccop H.A. TperoaaOrsercrse:nnrrfi uc[oJrnrlTenb - KaHA. MeA. HayK, aHecre3uoJror-peaHaMaroJrof JI.f. llerpocru

OdocnonarHrle ucrrbrranuftflpone4eula€ ccrBp€Meunoft odrqeft aHecr*rlrr c npr{MeHeH}reM r.rHraJrrrluoHubrx

aHecrerLIKoB neHs6e)KHo co[poBoxraercq 3afpr3HeHHeM Bo3AyG onepaqproHHbD(rtBoHapKo:ru.recrofi cMe)cblo, coAepx(iarr{efi ralorenocoAep)Karrlue LrHfiIJItIIpIoHHbIe auecrerl{Kll:ceno$nypau, nro$lypall I4 Ap. llouu.uo aHecrerr.rKoB B Bo3Ayxe oileparluoHHbrx npncyrcrByroropraHlilqec.Kue coeAHHeFILIfl ocHoBHofi u xuclornoft npr{poAbr (Qeuolu, crrripTbr, aMMr{aK, rrapbrKLIcnor u ulero.Ieft I4 Ap ), coAepx(alquecs B.qesr.rn0uqlapyroql,lx 14 MoroilIr4x cpeAcrBix.

I4coreAoeaHut noKa3blBaror, rrro B flpouecce onepupoBaHur B Bo3.{yxe olepaquoHubrxcoAepxl,{rcs 400-1200 ltr/u' e$upa (ltAK* ao 300 ur/u'), ao 200 rr,rr/vr3 u 6olee $roporaHaOAK Ao 20 rtar/rtr') (*Caullul{ 2.1.3.2630-10). llpo(peccuonanrnoft AerrenbHocrr{aHecre3lloJloroB rlpucylqpr raKlre Het5nafolprlr{THbre Sarroprt, KaK Anr{TeJIbHoe nosAeftcteueI{HranuIIIioHHbx, anecrerl{KoB, nor}brrrreHrraJr $nsuuecrar u gMorItroHiIJIbHar Hafpy3Ka,cTpeccoBbl,e cHTyaquLI H /{p.

OAlruu [13 ocHoItHhIX srlronolr4rrecKrrx Sax:ropon, Bbr3brBarorq]rx HapyueHlrr 3AopoBLr,sBnterct KpoHr4qecKoe nos4eficrnue ocrarotrHbrx KoHuenrpaqufi rerytrrrx aHecrerr4KoB BBo3A)4(e ()nepaqrloHHblx. Pesyrlraru gKcnepr,rMeHTaJrbHbx r{ccreAoeaHuft AoKa3hrBarorc[Ioco6Hocrb I{HraJItIIuoHHbrx irHr3c1g114Ksr r HapKorur{ecKr4x 14 cy6uaprornqecKr,Ix

t i 0 0 o 4 i i

€'EAE'FA"[bE{OE AilEE{TqTFY F[r\v{IFIbIX CIPE AEWt3A{-{tAm

({p"{}iCI FOCC[4-[A]

@E&EFAJrblt{oEtrCIcv,qAP{:rBeffiFo-P.5FoA}E{E{"ge"s*x{E{sE vqPE}KXEEt}xE',

..ecli"dili[clmffi r:rrngs'n{E{8"$ec{Eeff PxplevPrff 14

vn#eiiii''lxagni\$4$A 6"8" {1E"sP&BCKol'so,{€rE EE{y d}H!{X nFI" fiHaA' 6"S" Eteqlouffeoi'o>>}

A6P!68{scoB$KHfi REF", 2, tu4cex*4:-Pjlqcwn' rcn-1' {'!€991'

r*eeo*, t*se) :rae*s-ei-%t#f;iffgegn8e-88 E'nlatt I nncs@nrred'ru

0r.1.-I4CX|376iII

IO.B.Beron2016 r.

OTIIET

Korrqe'Tpailir,rfix IIpH AIutTeJIbHOM BO3A.fiCTB'II' AaBaTb TepaTOreHHbIe' gM$pUoTOKclIqeCKHe lt

Apyrue;Qor"ffi 3pe'r.rs coAepxaHr,rs BpeA'brx BeulecrB B Bo3Ayxe oco6e'Ho

ue6naroup[sTHoe cocTorHue nor,4yumofi cpeAbl co3AaeTcfl n pa6o'reft 3OHe aHecTe3I'IOJIOfa

xupypm, lI oflepauuonsoft MeA]Iu]Iucrlofi cecrprt'

OcnoeHoe flofiaA]aHue agecrerlaKon n aruocifepy oflepaquonsofi npoucxoAllT B MOMeIIT

3arrpaBKlr lFrapKo3o-AbrxarenHroft am[apaTypbl, a TaKXe IIp]I IHraJUIqI{OHHOM HapKo3e c

BbrAbrxaeMrru 6onHrbrMtr BO3AyXotvt. Bce oHu oKa3blnaror ne6naroilpllsTHOe (uorpex'ualouee)

Aeftcreue Ha 3AOpoBbe u npo(peccl{oHanbHyIo TpyAocfloco6noctr 3HatIuTe[bHOrO q]ICJIa npauefi'

a'ecre3r.roJroroB, MeAr,ril,rrHcKr{x cecrep, ia6oiarorulrx exeAHeBHo B ollepaq?IoHnrx 6norax'

HebnaronprI4ITHoMY eosAefictsurc [oABeplaeTc ' I{ [epcoHaJl flocileouepaq]IoHgblx orAelenuft

B CB'3I4 C 3afpt3HeH[eM BO3AyXa UHI'aJI'qIOHHbIMI'I aHeCTeTI'IKaMH' BbIAbIxaeMbMlI 6Olblrrruu

rrocJre o6utefi aHecre3lln, a raK6e B CBfi3lr c tacrroJrb3oBaHl,Ie lesun$uuraPYlolllflx I,I MOIOIqIX

cpeAcrB.Ha ceroAnsmHl4:ft AeHb Her poccr'Iftcr<nx HopM IIo AoIIycTI'IMbIM KoHIIeHTpaqlItM B

BO3Ay(e agecTe3lrpylon,llx ra3oB. Ho ne6larolpusTHoe sosAeficrsue Ha nepcoHaJl Heocnopl4Mo

(nenOCpe4CTBeHHbIe: IIOB6IIII9HHaS yTOMnteMOCTb' IOJIOBHaJI 6Ons' cOHJIIIBOCTI B 1repr,IOA

11poBeAeH!1[ aHecTe3l,Ifi, Hapy111egl,Ie 11c1axuqecKgfi u t[usuuecrofi axrusHOCTlI; OTAaneHHbIe:

*porrtaar,ue sa6onesaHllt opraHon xponoo6pallleHl{t I4 III'IIIIeBapeHvIs, Hapy[IeHI4e I'IMMyHHbIX

MexaH[3MOB, UtrrtepruqocKue rrpotBlreHll g U t'p.')'

Yxe unorue roAbr B MI,Ipe BeAyTCS pa6orH no oHI',IXeHI'IIO KOHUeHTpaII[II B BO3AyXe

aHecT*I{pyIoIqI{x fa3oB, HaIIpI'IMep, [p]lTOqHO-BbITtxHbIe BeHT]IJItq]Iu c MexaH]IqecKI4M

uO6yxaenueu v KoH,ryqIIoHupoBaHI'Ie BO3Ayxa' [ofJIoTI'ITeJIbHbIe Qunrrpsr' B KaIIecTBe

a,4cop6enla B KOTOpbrx ucrroJlgyerct aKTgBl{poBannrrfi yroJlb' cfleqllaJlbHrte rpy6ru 4lx

orBeAeHlIrI ra3oBbrx cueceft ug nouerqenufi'

Illupororo [prr]/reHeHr.rs TaKr,re MeToAbI 3aIIILITbI He HaIIIJI]I.

Oco6rre tpa6o"u*ryr flpeAbs]BJurorcr K BeHTilJII{poBaHI4Io rloMerqeHl{fi ouepaquoHHoro

6lora r4 oTAeJrbHbx oneparlr{oHurx. 3AeCb AOJIXHa 6rtrr ycrauoBneHa caMocTofiTeJIbHaJ{

cl,rcreMa rrp[ToqHo-srrrsxHofi BeHTrIJItqurI c MexaHI,IqecKLtM no6yxAeHl4eM' ecJIlI orcyrcrByer

BO3MOxHOcTr lpllMegeHllt KSHAaIIIIoHI,IpOBaHut BO3Ayxa. OAUaTO 3aqaCTyIO TaKI'Ie

Bbrrrxgbre crrcreMbr He c11paBnf,K)lcs c oqucrKofi no:4yxa. 3ra npo6neua oco6eHHo ocrpo

Bcraer nllu neo6xoAlrMocrr.r yAaneHr{t cI,IJIbHo 3arpt3HeHHoro Bo3Ayxa. Kpotvte roro, ecJII'I

cr,rcreMa BeHTLIrsrIupr ne c6alaHcr,rpoBaHa, To Moxer 6uru uapyilreH TeflJlonoft peNNvt

rroMerrleHllr, ocoOeuuo B xonoAHoe BpeMfi roAa.

Olurrprr Ha ocHoBe aKrl{Br,rpoBaHHoro yilLf,, ycraHaBnl.{BaeMble B HapKo3o-

AhrxarenbHyro anlaparypy, 3arpyArlrrcT ero AbIXaHI,Ie (yBenI,I'II,IBaerc.l co[por]IBJIeHtIe

BblAbxaely1oro Bo3Aylia) v 3HaqlareJlbuoe KoJII{lIecrBo BoAsHbIx IIapoB cHl4xalor I'IX

a4cop6rapyrcuylo cnoco6uocrr.Br,lueugno)KeHr{oe Ar,rKTyer ueo6xo4urraocrb npI{MeHeIrI{.[ cileIII{aJIbHbx 3aIII}ITHhrx Mep

I.Jrs otrr,r[IeHr,rs vr flpeAyrrpexAeHus 3afps3HeHus Bo3Ayxa onepall]IoHHbD( 6roros a

nocJreoflepallploHHbrx orAelenr,rfi .

Olflrenrou ncnrrrarurft flBultcfl, <O6lyrareJlb-pequpKylqTop Bo3Ayxaynmpa(furoleronufi tiarrepnqulnrrfi OPyB-3-5-(KPOHT) B I,IcnoJIHeHIdE nepe4nnxHofiOPVBn-3-5-(KPOHT) (AE3AP-7), ourarqennufi (fumrpoM Bo3AyIIrHbIM yronbHblM cMeHHbIMOyC-(KllOHT>>, npora:3BoAcrBa AO (KPOHT-M), Poccus. ,{alee rlo reKcry (peql{pKyJulrop>.

Perquprynxrop upeAHa3Harren 4rrfl o6eerapaxvrBanns. Bo3Ayxa noueqesuftynrrpa(flroJreroBbrM Lr3nytreHr.reM B npr{cyrcrBl4l,I moAefi. 3(f(pelcrunHocrb o6essapaxtrBanvlfl.99,90 , npor.r3BoAI{TeJILHocrb 100 rr,r'.

Oalrrp OyC-(KPOHT), ycraHoBneusufi B pellrpKynflrop, rpeAHa3Haqeu AJrfr

Snnrrpaqulr u oqucrKri Bo3Ap(a or opraHuqecKux coeAI{HeHLIfi ocHoBHofi I4 KI4cJIorHofiuptrpoAbr MeroAoM aA,cop6quu (asp,ogolu, aHecrBlrpyroqpre BelqecrBa, Ae3un$uqupyroullle !I

crepHwr3yrcuue cpeAcTBa tr r.II.). (Du:Ibrp oyc-(KPOHT) I43rOTaBJIlIBaeTCf I,I3

yrneHanonHeHHofo BoJroKHa HOBOIO IIOKOJIeHI',I'. ilornorqatolJlaf, cIIOCO6nocrr STOro MaTepHna

3HatrI4Te.[bHO Bb[rre, treM aKTI4BUpoBaHHTCIO yrnq. on ne BIII'ITrIBaeT BOASHrIe [apbl lI3 BO3Ayxa'

Koropble npI'IBoAtr K culrtxteulato aAcoll6 upyroruefi cnoco6no cua'

I { e . l l t r r o u c l l b l T a H n q q B u n : a c b n p o B e p K a ( o n p e 4 e n e u u e o t | { e r r u n u o c r u )

AorroJrHplTengroft $yuglun pequpKyJlflTopa: oqucrKl{ Bo3Ayursofi cpeAbl oT I{HraJIsUI4oHHbIx

aHecTeTlrKOB 14 ApyrlrK OpfaHl{qecrKl{x coe4nuenrafi ocuosuoft 14 Xraclornoft IIpHpoAbI

(Ae:nu$IlUl4pyloqux rr crepl{nl{3yloxqux cpe4crn) rpu noMoIIII4 $ulrrpon Bo3AyIIIHsIX

yronbHbrx cMeHHbrx o)/c-dPoHT>i, ycranoBJIeHHbIX B peuI4pKyJIflTOp' B yciloBl4flX pa6orst

onepaul4oHnoro 6loxa.

3aAaqu lrcrlblTalruft srcrroqarn:- Oqenxy cop$UIlonuofi cnoco6Hoprl4 Sranrrpon Bo3AyIIIHbIx yroJlbHblx cMeHHbIx OVC -

(KPOF{]') B yMeHb[I3HI,IE o6Uefi 3afpfl3HeHHocTI'I so3Ayxa onepalll4oHHoro oTAeJIeHI'It

opraHI,IqecKI{MI{coeAI'IHeHI4sMuocnosHofiI,IKl'tcJlorHofinpupogrt'- oqesq, copo{uouuofi cnoco6Hcrc:t}I tpranrrpon Bo3AyIIIHbIx yfonbHblx cMeHHbIX oyc-

(KPOHT) B IIofloLu,eHI,IlI LIHIanfl[4oHHoro aHecTeTI{Ka ceno$lypaua u }MeHbueHI4I4

3af pfl 3HeH I.'It I'IM BO3AyX a o[epaIII4OH]r0il'

MeroArara rpoBeAeHl{s ncnrrrauuifr

Haqalo ucnuraluuft 10'11'2015 r ' ' oKoHrraHIae - 01'03'2016r '

oqenra cop6quonHofi crroco6socru $unrrpon oyc-dPoHT) ro o6uefi

3aIp,'{3}IeHHocTI4 Bo3AyXa o[epaII]I0HHo|o oTAeJIeHI{' opraHI,IqecK}1MI,I coeAI,IHeHH.flMLI

ocHosHoft r4 Kr,rcJroTHoft upupoAbl rlpoBeAeHa c noMoIIIbIO Ia3OaHanH3aTOpa (KOJII4OH-18)

(puc.1), 3aB Ns291-Vt, rpo'r3BoArrenb ooo 6rOpO aHiulurl,IqecKoro npn6opocrpoeHHt

(XPOMIET-3KOJIOI-iVIfli, Poccmr (cua,4ere6crno o npoBepKe Ns083364850 or

30.06.2015r). fasoaHarr.r3arop rpeAHa3HaqeH Ant I{3MepeH}It cyMMapHOfi KOHIIeHTpaII}IH

BpeAHbIX BeIIIeCTB B BO3AyXe.

Puc. I fasoananla3arop (KOJII{OH- I B)

[.na nponeAeHnr ucnurasrrfi 6srra srt6paHa oIIepaIIHoHHa{ nnoulaAblo 33,5 u2 c

o6ueo6v:eusofi neurnlxqueft, He) o6opyAonauuar cneqLIanbHbIML{ cpeAcrBaMI'I ot{I4crKI4

Bo3Ayxa 'DfEHy (PHl,lX rlM. aKaA. B.B. llerpoBcKoro) r. Mocrna, A6puxoconcruft nep, 4.2.

Cauurapuo-f[r.HeHlrqecKat o6pa6ou<a rroMeIrIeHI4t npoBoAllnacb IIocJIe oKoHqaHrlfl

ouepaqrrr,r u aHecTe3r,ru u He M(JrIa BJIIIITb Ha pe3ynbTaTbl r'ICnUrauufi. OlpeAelenue

coAepxalrr{q opraHurrecKr.rx BeulecrB 6suo npoBeAeuo Bo BpeMs 17 onepauufi c o6ruefr

asecregueft ceno(fryp'anoM B ycnonruxx pa6orbl AByx pequpKyntropoB OPyE-3-5-<KPOHT> c

ycraHoBneHHbrM (frannrprra OyC-(K:POHT), pacnonoxeHnblx B onepauuosriofr B Mecrax

6ecnperurrcrBeHHoro ra6opa u nsl6poca Bo3Ayxa (ocuonnar rpyuua). Kourpolrua:l rpynna

BKrrotrara prccneAoBarrue coAepxatFryu opraHl4qecKl4x Belqecrs s roft xe olepaUuoHHofi 6es

pa6oru peqrpKyJrrropoB Bo BpeMs 1,1 ouepaqufi. fasoaHanl43arop pa3Meluilnct B pa6oqefi rone

aHecre3r4oJrora, cecrpbl-aHecre3r,rcrKlr r xllpyproB. Irl:uepenne KoHIreHTpaqrII4 BpeAHbx

BerrIecTB B BO3AyXe ocyl[ecTBJlf,Ilocb B TeqeHfie Bceft oflepaql4l4 B aBTOMaT]IqecKoM pex]IMe',

AaHHbre $rmcuponalnct, B raMfiTI'I I'a3oaganll3aTopa c nocJIeAyIoUI'IM ltx O6pa6OmOft'

Cpaenrarert,Hblft aHaJILI3 coAep)KaHI'It OpraH[tIecK]IX cOeAuHeHI'Ift n rOs'Uyxe B O6eI4x rpynflax

npoBeAe' ,.a 5 sra,,ax: .n,o Haqara r4'r,;firlu,n ceBo6Jrypa'oM, Bo BpeMtt BBoAHoft agecre3lll. Ao

KoxHoro pa3p$a Ha QOHS I4HraJIsqIIlI ceBoSJIypaHa l-2 o6qero o/o sa Bbl'4oxe' B MoMeHT

o6pa6orru orepaqnoHHoro IIoJIt Ae3I4HOlIqupyrcUI{M}I cpeAcrBaMI;I' qepe3 1-3 qaca I'IHIaISqI4I'I

ceno(pnypaHa u B KOHUe onepaqlll4 IIocJIe npeKpalueHl'It IIoAaqu ceBo(bJlypaHa' Anfl aHaJII',I3a

Bbr6paHo rro 9 oflepaqHfi us ocHoBHOfi I'I KOHTpOnruoft rpynll' B KOTOpbIX KOHIIeHTpauI4t

opfaHlrrlec]c'Ix BeIue;TB cocraBJlsna > 1 00 rnr/rt'r3'

oqerrry copoq}toHHofi c[o0o6HocTI,I (punrrpon B IlornoueHl4H uHraJl'uuoHHo|o

arrecTeTIIKiI ceBoQnypaua IIpI4 pa6oTs peUI{pKyJIfTopa I4 6eg nero npoBeAeuo I'IcnbITaTeiIbHofI

ra6oparopneil ne11O:lOtt4n- Mero;oM -

tasoBofi xpoMarorpatfuu c xpoMaro-Macc-

crreKTpoMetpllefr e upo6e Bo3Ayxa I43 OnepauuonHoft B OCHOBHOfi U ronrponlnofi rpyilIe BO

BpeMs noAaql{ ceno(lnypaHa naulleHTy I{ B KoHqe 3-x qacosoft onepauuu'

CtitrprcnIqeCKyl6 o6pa6Orry [aHHbIx npOBoAI'InI4 rrpn IIOMOIU]I IIaKeTa cTaTIlcTHqecKI'tx

rporpaMM Statisticai Package forr Social Science 1SeSSl I 1'0 ArIs Windows' Ans

npeAcTaBn.eHlrr AaHHbrx II oIIeHKI{ AOCTOBepHocTH pa3JIUqUfi ron}ItIecTBeHHOrO [plI3HaKa

ucnoJlb3oltanll cJIeAyIoU[e noKa3aTeJI]I: CpeAHee 3HaIIeHI4e' CTaHAapTHas oil[6Ka cpeAHeil'

crag.[aprproe orKJroHeg]re, Kp]ITepuft CtttoAt"tu. Pesymratrt uc1rbITaHI'Ifl ctII'ITaJII'Icb

AocroBeprlblMll ilPu P<0,05.

Pery.nrrarnr ucnuranuftB Ta6nrue 1 llpuloxenue 1 npeACrauleHbl (parruvecrlle AaHHbIe KoHIIeHTpaIIEI{

opraHlrqe(]Kr4x BerrIecT.B B BO3AyXe oflepaul4onnofi ofirosHoft I{ KOHTpOnrUofi rpynn Ha Bcex

3Ta[ax I,IocJIeAoBaHus' kIs Hee cneAyer' tITo coAepxaHl'Ie opraHl'IrrecK]Ix BeIrIecrB B Bo3Ayxe

o[epaU[OHuOfi AO HaqaJIa LIHransUIIu aHecTeTpIKa 6rtlo MI'IHHMaJIbHbIM LI IIO rpymlaM He

orn""-""s. Ha srarre BBoAHoro HilpKo3a r,r r.rnran-rrqu[ ceBo(bnypaHa B€JIHII]IHa 3arpt3HeHut

BO3.{yXa ilocToBepHo ),BeJrr'rqltnur" , o6eux fpynflax' no 6rrla n 3,5 pa3a HI'IXe n OCnOSHOft

rpyilre nil lpoue pa6or.u perlr4pKyJrrr:fopoB B cpaBI{eHI{I'I C KOHTpOllnoft rpynuoft (p < 0,05)'

d; BpeMifl o6pa6orru orepaquorrrnoro no* 4eru$raqupyloql'IMl'I cpeAcrBaMI'I (roxuufi

aHTr{cerrrr{r ,{esllcenllrl OII, BKnrlorrarouluit utxuttEulr{etHr6eHsI'IJIaMMoHI,It xnopl'IA 0,130 ,

u3onpoillrJlosrfr crutpT 70oA, (fytmquonalruue 4o6anxu, Kpaclarenb) co4epxaHue

opraHl4qecKEx BeIqecTB B Bo3AyXe pe3KO BO3paCT4nO B O6euX rpy[uax I4CIIbITaHH' AO

o4unaronofi BeiILIqnrtbL OAnaxo t66"*""uto.tu ot{uuleHl'Is Bo3Ayxa onepaquouuofi B

ycnoBr{sx pa6oru perlrpKynsropoB 6rura AocroBepHo BrIIIIe. ?Is Ta6ruqst 2 kr Ta6nuqrr 3

flpunoxeuus,2 o'rcnuAHo, rrTo Anq yMeHbrrreHEtr KOHIIeHTpaqulI BpeAHbIx BeIIIeCTB B BO3AyXe

orr.puq"o"uofi na 50o/o s ycnoBr{flx pa6orrr peq}IpKyntropoB rpe6onalocr n 1,7 pa3a MeHbIne

BpeMeHLI., tIeM B KortTponbHofi rpynne, a oqHIIIeHI'Ie Bo3AyXa B onepaUuoHltoft sa 90%6

"u.tyrr-,o n 2,5 para 6rrcrpee l:,47,1t4,7 rvruu. npoTlIB 115,0 + 4J,2 MI{H', p < 0'05)'

Cogepxa.nue opraHuqecKr{x Berrleqm B Bo3Ayxe qepe3 2-3 ..lmLca onepaIII4I'I H aHecre3HI'I TaKXe

xapaKTepru3oBirJrocL urensruefi KoHrleuTpaqnir ux B ycnoBl'Isx pa6orbl peuupKyffropon. B

lliunoxgnuu 3 npe,qcraBJreHa rlla(puuecxar 3aBI,IclIMocrb sua'reurfi max ronqenrpaqprfi

opraHr,rqecKr.,rx BerII€)crB nocJle AonoirHLITeJIbHoro 3afps3HeHHs .qesuHabl'Iq}1pytolllllMll

cpeAcrBa1,ru n npo6ax Bo3Ayxa onepauuonsofi u llx Ir3MeHeHlIfl rlo BpeMeHI'I.

B ronqe 2-4 e,acosoii oneplnqr,rn rr aHecre3vrvt fi rIpeKpaIrIeHuI,I [oAarru ceno(lnypaua e

Arxarelsnrrfi KoHT)/p coAepxcar{ue opraH}IqecK}IX BeulecrB s ocHoeHoft rpynne c

peqEpKy,IItTopilMI{ 6rrno [orITIl n 2 paza HlI111e, IIeM B KoHTpoJIbHoft (p< 0'05).

P*ynpagr gcntrranraft 11o orIeHKe cop6quonnofi ctroco6uocru tfnnrrpon ro

r,rgraJrfirlaoHHoMy anrecrerlrKy ceno(llypauy (Cenopauy) upe4crauleHbl B IIporoKoJIax

r.rcrrhrrarer6nofi na6o1)aropr.,ru <3KIO3OH,{> (IIpuroxeHI,Ie 4 llpororoJlbl tIctIbITaHIafi). Aualns

rloJlyqeggbrx AaHHbrx [oKa3aJr, qro KouqeHTpaqufl cenoipnypana B Bo3Ayxe oflepauuonnoft n

MoMeHT 3anpaBKI,I ceBoo[ypalla BxcflapuTeJlb !I IIoAaqu ero 6oJIbHOMy' a TaKXe qepe3 2'5-3'5

traca oreparllIl[ r,r anecrlgru cenosnypanoM 6b[ra cooTBeTCTBeHHO B 2,5 paza ra 5,5 pasa H]IXe

npu pa6ore pequpKynflropoB c t[unrtparr'ru. - 3na AaHHbIe CBI',IAereJIbcTByIoT O BbICOKOfi

cuoco6nocTl{ Bo3AyIIHbIx yronbtur* .r*at"rrx $unrrpOs,OyC-(KPOHT)' II3TOTOBJIeHHrIX II3

yrne'arroJlrreHHono BoJroKHa HoBo1o ,ro*on"tt", aacop6upoBarb I4HTaJIflII[oHHbIfi aHecrerl'IK

teeoS.tryparil LI3 Bo3Ayxa orrepaquonnofi '

3axnroqenuellpone4ennble I'Ic;rlblTarrrlfl rIoKa3aJIrI :

llpone4enueouepaqufinyclonl,ttxl'IHTaJIflIII'IoHHofiaHecTe3I{I4IaJIoreHocoAepXaIqI'IM

aHecrerlrKoM cenoipll'panou 14 ApyruMI'I opraHI4qecKI'IMIl Tty:y"

coeAlIHeHusMlI

corrpoBox;laeTcr 3HaqtrTeJrbHbIM 3afps3HeHI'IeM BO3AyXa oflepaquosgoft c o6uteo6MenHof

BeHTr.rJrtql4iefi. O6pa6oTlKa oflepaq"or,toro [oJIs Ae3I4HSr'rUupyIoUI'IM]I pacTBopaMI'I Ip]IBOA]IT K

IonoJrglrTenbHoMy Bo3pacTaHI{Io OpraHI4qecKI'Ix BSIIIeCTB B BO3AyIIIHOfi CpeAe 6eS

lICrIOJIb3OB,aHlIs cfleqfiailbHbrx cpeAcrB 3aIqI'ITbI'

flpnuenenue o6nyuateirt-peqflpKynflropa Bo3Ayxa ynltpa<puoJleroBofo

oarrepuqlrAHoro oPylB-3-5-dPoIIT>), ocHaIIIeHHofo $Iurrpou Bo3AyrIHbIM yroJIbHbIM

cMerrHbrM OyC-<KpOHTD, no3Borrr{no yMeHbIIrI,ITb coAepxaHl4e opraH[IqecKl'Ix BeIIIecrB B

Bo3Ap(e o[epaUl4oHnOii, mmotlilt I{HraJltqr'ronnrrfi aHecTeT}IK ceno(pnypaH e 1'5-3'5 pa3a Ha

ocHoBHbrx orallax ouepaulll{ 14 aHecre3III4' CnequtfrauHocrb <prlnrrpa ryYTf11l1?.^:,

rroilrorqeH;r4r,r ceBooJrypaHa noATBepxAeHa cIIeqIIaJIbHbIM I'ICCJIeAOBaHI',IeM I4C[bITaTeJIbHOI',I

naooparolluu xr,rM[Ko-irHaJrr4TtrrrecKllx I4cCJIeAOBaHI4fi (3KO3OHA)' flpu pesroM BO3paCTaHI4H

coAepxagr,rs opraflLrqegKl,Ix coeAI4HeIIuil B Bo3Ayxe orepaqllounofi (Ao 10 pas)' o6ycloueHuoM

rrpr,rMeHeHr.reM Ae3lIHOllqllpyoqru( cpeAcTB, oquulegl4e Bo3Ayxa orrepalluoHHofi oT

XHMr,IqecKI,Ix ToKcI,IqeOKI,IX BeIIIaa",u "U

g0 % HacTyIIaeT n 2'5 para 6uctpee' rIeM rtpll

crIoHTaHH OM Oq[ilIeHl{lr.oAnospervreHHo c ocHoBHofi oynxqueft peqfipKyJltropa - o6e$apaxllBaH[e BO3Ap(a Or

Mr4KpOOpraHr,r3MoB rrprcl{cxoAl,IT efo (lranlrpaqua u oqucTKa IIpu IIoMoIIII4 yCTaHOBJIeHHbIX

yroJlbHblll "ot4y-"irx

tfnnrtpon OYC-<KPOHT)) I43 yIneHaIIoJIHeHHofo BoJIoKHa HoBoro

rIoKoJIeHpH or ToKcrrrrHbrx opfaHr,IqecKI,IX coeArlHenuft ocnoeHoft IE xucnorHofi rlp[poAbl'

llpurrleneulre peq[pK)/JItTOpa He oKzt3blBaeT BO3AeficTB]Is Ha naql4eHTa I'I MeAI4IIuHcKHfi

rrepcoHaJl.lluyrennrre pe3ynbrarbr lt-ro3BoJrrlor peKoMeHAoBarb I'Ic[oJIb3oBaHI{e o6ly'rarenr-

peqllpKyJulropa Bo3tryxa ynrrper(fuoJleroBoro 6amepuquAHofo OPyE-3-s<(KPOHTD'

ocHaIIIeHiHoro Su.ilrrpolr BS3TAyIIIH6IM yroJIbHbIM cMeHHbIM OyC-(KPOHTD'

rrpotr3BoltcrBa AO (:KPOHT-MD, POCclls Am npeAyrrpexAeHl'Ifl Lr OtII{UIeHI'Ifl BO3Ayxa

olepaUr4oHHbrx B TeqeHr{e sceil oneparluu or roKcl{qecKux opraHl'IqecKux coeAI'IHeHI'Ifi,

BKJIrorIaKrr[ux r.rHftrnJrq]roHHbre arrecTeTIrKI'I kr Apyfl4e opraHHrrecKl1e fleTyql4e BeIrIecTBa

ocnosuoii lI KLIcJIorHo.ft npupogrt.flpr.ruenerue pequpKyn-flTopa c AorroJrHl{renrnofi $ynrquefi oq}IcrKrI Bo3Ayxa rBJlserct

e66er<runHbrM, rrpoclbrM r4 HeAoporr,rM perIIeHI,IeM AJII co3Aauut 6e3oracHofi no:4ytnuoft

cpeAbr )\nfl MeAr.rqugcKoro uepoonaila orrepalluoHubrx 6roxos u uocneonepallnoHHbD{

or.ueleHltft.

PyrconopprreJrb ncrrbrrauufr :

.{oxr. MeA. HayK, npotpeccop

Ornerclnenurrfi ucl:oJrlrrlTeJrb :

Kana. MeA. HayK, aHecTe3l{oJlor-peaHlaMaroJlor

H.A. Tperona

H. JI.f. IlerpoclH

flpuuoxenrae I

Tafinnqa 1. oa*mecKue KorrqerrTpary*r opraril.*€cr${x coe4ur1erilfi e Bo3.uyxe oflepaqfloHgoft

HA BCeX 3Tarlil( UCCJI9,UOBaI{}IS

A * ouepauuu c peqrpKyrsropaMu (ocuonnar rpyrlna),B - onepauuu 6es peqr.rpKyrsropon (routponrnax rpynua);* -p <0,01 n cpaBHeHrrl{ crpyuuofi 6e:pewrprynxropoB.

IlpexpauennerIoAaql[

cenoilnygana,ur/u'

2qaca uocJleIIHraflcquu

ceao$ryp$rou,rtrr/ut

O6pa6otraoEepaTIHOIIHOTO

rIoJxg,on./#

HaqartoI,IIIFAJI'UU}1

ceeo([nypanou,nrr/frl'

[o na'ra:rar4Hrailsqrru[

ceno$nypanou,Mr/M-

Ta6nuqa 2. 3ga'{errur SllxruuecK}Ix Konlrenrpa{ufi

onrpuu"o"tuoft 14 BP'llrlegu otr-I4ilIegl4g ero

geruuQuUuPYroqurr'u'r'p tAt'"*u (> 1 00 rt'rr/rt'r3)

flPunoNenue 2

oprauuqecKllx Belqecrn n npo6ax sogAyxa

noana AOTIOJIHIITeJIbHOI0 3arpf,3Helrl'Ifl

er#Ar"rr t ptr"lxynttop"Mu (ocuonnar rpynna)'

B - oneiauuu 6ee pelrrrpnyn"iopon (rourponrnar rpynna);* - p < Qr,01 n cpaBHelrru c rpynnoii 6er peuupryntropoB'

Ta6 luqa3 .Cpannuren r r ra l cKopocTboquu leH l , I suo= ly } l ^ : -1 . "3 .3u "oHHbIx I IocJ IeMaKCUMITJIbHOTo 3arptI3HeHIAt ero opraHHqecKItMU BeIIIecTBaMI{ (> IUU Mr/M ,,

Konuqecrso onePaqrafi, N

Ep.-"6 y-.trureHus KouqeHTpaqufi oprauuuecKrlxn^"'^^rD D n,.,^6arr Ro3llvxa ollepaqlloHurx, (rnrun)

Kot-nooIIepa-

qufi

1

Koniqesrpauur (n) opraHl'Iqecx:nx

rreulecrB B BolAYXe, (ur/vt-)

(,qata uccnelonauur)ono./^

Vuenblllenfie Ha )U'lo

M, + 6,, U4g_--

J M(irl-b[rvnrlw rre

M1t 61, MIIH

A BA148

( 10 .1 1 .15 r . )

A B

46 1,201 9 20

50 752

242( l 6 . l l . l 5 r . )

1 5

4012 60a t37

r i l8 .11 .15 r . )1 7 4 ' '

( l l . l 2 . l5 r . )

42 i .431 3 6(14.12.1s ra.) :

1 8 t 64

1 5 6(26 .11 .15 r . )

50 8 0 ,5

170(30 .11 .15 r . )

8 1 5

5 5 19,06

1 5 6(01 .12 .15 r . )

27 60

48 r20;7

1 5 6(08.12.15 r.)

1 5

: ,148,..8

130(24.02.16 r.)

127(28.01.16 r.) ;

45

469

1 1 8(26.02.16 r.) r* lifu 'r i 1 9

47,1 + 4,7* 115,0+ 47,2M n + 6 n 757t35,5 19,7 * 10,8*

* - p. 0,01 e cpaBHeHuI,I c rpynnoft 6es peuupxyJltropoB

flpranoxeuue 3

180

160

3na.regus max Korr[egtpauraft oprauuqecKl{x BeI[ecrB rIocJIe AorloJIIrI'ITeJIbHqro 3al*pf,3rreu]It

4e:uE(bUqnpylou+[ME CpeAeTBaI\d]I u npo6ax Bo3AyXa ollepaullollHOfi n ux H3MeIteHI;Ifl IIO

BpeMeHrr

Ks*qra*$rlsasJ$

at

*cFfsslpKysF{F*ls*

r,*. $e$p*iryr{JF$taps8

lo 40 50 8S too 120

* -p < 0,01 s cpaBltenru c rpynnoft 6es peunpryJlflropoB'

Bfcrq, rm.

140

aI

flpuloxeuue 4:uacr 1

*' E$ PATGFisx itltMt{ RC - t,t'l AJlt',l T H {E CX r'tx sl ccne ilnea H n t'1

1{Cn}!1:ATfJtL't{AE Jt} ' ! #

git}l: dlE*:;-,?Ht16! ffiffiffi {i$. ii-uii**l'sssr{}ssii*{ry'il''$

ai;nbil&TEfi1bHAg fiA&$'PATffF$fl <smfist*ht'Qx

nporoKo- ?lpJ_Hl:*ffi r."r_-.t_T;*Lln'? 2015 r

.?arss**s{{ff rid},xfffc}ff&M'*

,\"mtc Jrulayis,ia: I{J{00, '}f,f':xrrfc ttf da{s'

ffi T-H,'HllTlJ;*mmffi 1iftil:::ilh"**,ffi iifi #.$ffi :ffi;-*.'I*f '."-:;1*?;:lJo-iiil-ir:as$&"t0r4], Jq'*.,rrdels,i,|r:.1;*o,;*, ..qa-';fpi}#/-v".' i,* mpsulxt tttf*r'

,.JddffifffiT#*ffi##r#1#r',1$t"bsff#;ffi- /iilnrii;ir+i^ a i,.un,*** xr,'a,{ffo'c*u"',

{tp*ffifd,r4e - -** .-*$rirnar{*{ i* ; c J$,J.f,}#'ff. ryg--f#"trJsry" ... -H p:un tlptlsr;s*r{}Ifi I{c

&{*r:rr c$Sn'.$*} ttp*fi: r}w4;v*rqlmr*e* ,*ii*n irrffidilf 'il*l*n* &s" J}e;rry**r*.a*arl rlarr' *

tf*;x: *mru.ffiru:fr5#r1"'S* I ,1,' ,*,,*r'd,'sso;u q{yft,,n*r,"er6 uafr 'ror*p'wrup*c nixrdpru,*

i.5,, *o" r*"Jruw orrrloP*J'V**t*::gru trx$'rlpx: #Mpp rtptxfi wpa***ww.Ww $tllx{m'ld}tf{t"urlrsd{'$iJ3't}r/#$'tfs4Fs'{;' *ffffimm#;*ru###xffiif{-ffI;::*:.

:'- r***qh$vff$s}*', s r:Ydd'ir'r*

.3- *rry*:r ,J, i ,***r,# :ls,*.'o -qn*ir"4{itfAi$t{r 513rjs*** orq**ro-u1g,\a?'x6,rF-rrr;51ntf#$g$i:1*; il {1?}#f lN$ef?{*l:'!t

{ce**g'rls.rxrirtr'ttl " .;*:ql:i;;I ffi::*'''i't "on"ni*''r-$ro

ors.}'sffr - Ji? xesi}" t{

'h.[dt trg *r*:r*n&d *t6rrmTsl4!{i1; dd€rmw}*lyxs{s"1'*li$6}{m{ 8* *1ffi'psTg'r*s, t{}*rufds,,{f{ Hod oapedr'rerr

Srxr*pf,rfl, rr*&*frt*ys*&g *!rierirfi&,?,i*.e$*r# rqtqf,n * *#iffiji*iffiu d*ttlt*-u':-to't-gl or" l*-CIJ lg$le

$ t f t * n w T X X * r *F * n Y t ? b r 6 ? b . @

{Xsfie*argFr'i${es. uetfipr.}rx*fi

IlEs,*qe|*lr*:M e

. ! ' * , . 1 ; . . l } : . r y i l r l { ' t l t r l t i H s ; 1

lii:lll:lla* 3 *.t{}LtA. "

r l i . r g t . r l i r , l r t l j l t { . ' ; , : r : ; -

. t e { . ' : P a l t r r x

i,*i ,rsat -tste, -" - "

I "ei'l;-5-Jttt "'f . r r , * - l i * Y r l r r t g l * , * , r ' t l '

1 f i " - l J d l t ? t '

- ; { l ' 4 f l l l i

nurr,Oo lr t f i iH'{ tn-r jF3-tdlr l

o*rior'.u : ur"uf{Tli-1-"

181#S

tllkrsgsrs*nuranrml

l'X e X.!*lC*Xpx*arr**rx**"sn*rrp*51*1FrF*nirig4t !i l't*l}t&rl&"fm*e{"liiff.

"$*l l*1

13.?,2&

' Y r - ' ! l : i l B 1 { ' : i r ' ' : : } i :i . . - . . " - . ' ' :

* ,6* eg i ; ; sq f * i t t " * i i 5 ' i i t tHp*6 * r

r ' j , , i l ! i :* : ; r i l r l . i : .** ; :3i i ' !11'Nl4

* * x g : : : : ; : * x 4 1 ' : ! 1 d f i { 1 M T s 1 1 i 9 i 1 h t t * f l

_.:'.1t f , t ' - !

l - { t - . ' d f { 4 . , ' - ! 4 B a x o g A - A . t t " x . ey KOe oAHren b y l !$ *1** .^ - . - * * * r * *_-

{Jrpannua 1 tt:i I

#ryflpuloxeuue 4 truc;r 2

H*nillfAgen:b&&a&F,e*s.&t*r'ts*&}ljl*{g,**ftt}F'Jgp1tffi,qEr1flfi:r'{{:q$s;!*8e!4.14&

Z7'fK'rr,m;;, i !r*:1{' r. {tltss** Jlt*tria*sxt st:Psjffi e$,.ra i; { :**. fi "rsrril:l;rt*xsd$mxtln$

P e I y n b ra r b r , u c l1u i - Ia N u iHaflEergo * nFtr{r"r *$talr*

f,f6rm*ar*r*]t,{*$" $.&ilitpst{trda}

s9,48

l-X * Xt{f,'XFldtr$]'*l&ts-{,ttfl{Ypet*6*fp4{fi${ri6a$ ri h4s&itlli!Trs*tll&J. S*i t 5l

afine,riATEJt bHAn fi AFfi peTopltn *eFl{FSSI{l&rr

' .| .?p f iT0K0f !e4CnbtTAHHf th{g$*&g*gr&s.13 ' *s1sr "

l l f ;*1o[r" r ':$r:pu'r4a tsa'\"l lrodi irf 0t lPltlr ;

ilaxe'i.ilrf(: A0 stt P$IIT-llt "

&apffi Snnanwma: tirt4&,s{sc#d*s}isx $$.jlflcrtth *. ,{**i{'lc*f, }*tr fl&qpffi$trsd|:#&& *' $' rei'n' I

{:6regr ncntrr*m&: np*6*r aprd-l,x*t ,Nor{amett'l,}* *nr.$!l* jpff{i*rffs&Jf yx

!T'**ii;;;

";;;; ;;;n

" n - rti*"i"*on'e 4*" 0*1* r}o *r)-r wHf,"o'f rdl''Ttnn{'t} c'rl'

.lAd6-U.+-t lmg4k*:)lltii, .lftnfir${f(xf *,runn" ""

d " oS':t1'uo*u"&-Isqlryfr:f'?'lfftrrp 6{'ldy'($

_g:rry*rfr*rraroerrtr oilrrropriqrnloarri nlryrryruxlcpr*rr ,"14) irffPt?fI1'.trx, ra cn*fr{l*r '!'fp$d

-*eds&currr-nd*, ,rlr*noful#'';;;."";?i'A4l"'fiCC#" {ff'8AFAII7 A '}1''?ddtrsr "rtt'"ttn&ft'n/''i

y{'lFt$trdr,.!ir. n<t illt.tl.}f}l1-

no*** { I rrur€Jlcu $$ ncn uiri:: tlt { c J{' J-'i'-l0l 5'

,b{snrn xasupr *on*, iiil#i*,lil"A sist-rpi&.'&,,*{, ,il#rns*nri{qis fi.s" .rr**ryr*xen*aa e *r#qa:{i{,;

ffih tf$S:#:1f,.1flf#5'iit''e*rrp?anurna# n*r*r,wrr,'s.ttna* *ana{nmopns * }*ip]onr}u

{cscms6.Kn **:m t nS o Pul'ru;;;;rre,p. f#u**** dgry$ipl$r?"rao*i c'**r*ft*dhtrdtttrr-'{t{'a @raqpm***r *s'$rfJr*ltr*t'sa

-li#jte#rxr*,ts *ldsNtt{*|i1*Ir S }t'"'t,t?OHtr"'J-.*irnr{gsnr 3flrspffqoffifr}****rr6 *rur*gvrnlpe^} /fi'"('IftdT rr,;Ynw f***x$tqqyreu'*}** $ r'u{litq,

d.glN,r:tr.r rtl,l,,eirtt'-l fe)"rurrr*xr'r$crxt' ur'rfx4ru - ;ri;]iiii;,.-,-,i,..r.bx'd /?.qndrf.rr?s-ry*i, filrdl,",t,ryn{Ad.rJ

J-'vr:;'u r "1. :i'rw,I irr,re"-l* .{clltrlltrtt{r idqitutt'iir t?o

ftif ie{F*,it F{'r*c}.irl ,, *rJ*i*rry#are o,'i**s**c},'I;t{Prt}dr+*a*rw* *,ra&*,r'itl - "$} "r*snj'

ttt$ .Mrt.urrldrrqft.'ir/c, fAdt.fi','r&4 r.tt ."tt!,.L\Tfi.fi$l'tttprtsr.recr:r,rrr onpedu..l*xrr

$ffx.*l::ffi :Jiffi T$;ffi ffiwffi;ffi :,4!ir*ir"*r,:h / #" {,i. / e$}*,

Iin*ol**rertxe' :. t lss!";1h*&*is *?a,arim:*d

f l : : I i r J 1 " f , N ! t f r k .

. . t j ! . . - : 4 [ ! t { : . : ! { t - : ! . t 1 : ;

: : i : ' ' a t - . | t i . i ) a . :

i:e ijmp*41-? ir &,tl s*"-.t if tr sJ1& l{*

r€ rr;:K*? *k6i:.b t*ti l i i l?l ltt&"

l r i l : t , G S l ' r L 5 - t ; i - : t i l ' ! Y

**$ p* 3 .pBt t81 i \14 ; * , t : *u t t ' : * r * * ! * ; !

i .a " t { ' }sq$renb l , '1f i -dd*:*t&-"- l r lnanse A A u r 'u

-'{d

{rg*ol*ta ,l l**