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Rafsos
Grb2
PTB
Ras
MAPK
Ubiquilin
Mint - 2 Mint - 3Mint - 1
Fe65
AICD
C
PS1 / PS2
Pen-2Aph - 1α1Aph - 1α2Aph - 1β
cleavageactivatesγ - secretase
γ - secretase
α - secretase
β - secretase
ADAM10ADAM17
BACE1
BACE2
- 40- 42- 49
CLAC-P
Protease α2M
Aβ
Aβ Aβ
AβAβ
Aβ
Protease IDE
Protease NEP
Protease PLG
N
APP
NCT
OLIGOMERIZATION DEGRADATIONCLEARANCE / EXPORT
CYTOPLASM
Aβ
P3ApoE
ApoE
SH2
Shc
Aβ
Aβ
Aβ
Aβ Aβ Aβ
Aβ
Aβ
YENPTY
LRP
NOTCH
ErbB4
CD44
P75N
T
R
γ secretase
E-CADHERIN
Alzheimer’s Disease:Amyloid Precursor Protein (APP) processing