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Steve Holmes, PhD Director, Therapeutic Targets Kymab Limited. I am in the Biotechnology industry. Each gene Can be translated Into a specific protein. DNA. Proteins are large and complex and carry out the body’s functions. A code Organised into genes >30,000 in each of us. - PowerPoint PPT Presentation
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Steve Holmes, PhDDirector, Therapeutic Targets
Kymab Limited
2
I am in the Biotechnology industry
DNA
A codeOrganised into genes>30,000 in each of us
Each geneCan be translated
Into a specificprotein
Proteins are large and complex
and carry out the body’sfunctions
Most biological medicinesare PROTEINS
IgG Monoclonal AntibodyMW ca. 160,000
Biologics. Some of the Molecules
-InterferonMW ca. 18,500
Biologics : Some of the Molecules used in Medicine
Aspirin MW 180
InsulinMW ca. 6,000
Pharmaceutical Product Sales
2000 2008 20140
10
20
30
40
50
60
70
Total Sales $Billion
• By 2014 Biologics are expected to account for 75% ($50Bn) of the revenues from the top 10 best selling drugs
• Five of the Top 10 are predicted to be monoclonal antibodies
2000 2008 20140
100
200
300
400
500
600
Biologic DrugsConventional Drugs
Top 10 - Sales $Billion
Mechanism of Action of Monoclonal Antibodies
Monoclonal Antibody
Effector function
Unique bindingfunction
Clinical use of Monoclonal AntibodiesRheumatoid Arthritis – Disease Reversal
Clinically Approved anti-TNFMonoclonal Antibodies for RA
RemicadeHumira
A day in the life of Steve Holmes
►Research ideas for monoclonal antibody therapy for Amyotrophic lateral sclerosisIP, literature and competition searchesReview list of experts in field
►Prepare for meeting with Contract Manufacturing Organisation
►Attend antibody research group meeting►Attend management meeting►Telecon with Wellcome Trust►Prepare project plan for new monoclonal
Kymab: Therapeutic monoclonal antibody company
Life cycle: idea to clinic
Ideas Research Development Late clinical trials ApprovalEarly clinical
trials
~8 years
What is my job in the cycle?• Ideas
• Research
• Development
What skills are required to do my job?• Immunology, biochemistry, molecular biology
• Antibody generation, antibody engineering, cell line development and manufacturing
• Disease biology expertise
• Clinical trials
• IP, Fund raising, Bus. Dev.
• Years of experience
• Track record
Kymab: Therapeutic monoclonal antibody company
Life cycle: idea to clinic
Ideas Research Development Late clinical trials ApprovalEarly clinical
trials
~8 years
How did I gain the skills?What skills are required to do my job?• Immunology, biochemistry, molecular biology
• Track record
• Years of experience
• Clinical trials
• IP, Fund raising, Bus. Dev.
• Disease biology expertise
• Antibody generation, engineering, cell line development and manufacturing
Post-Doc (3 years)Assistant Professor (4 years)On job training
Kymab: Therapeutic monoclonal antibody company
Life cycle: idea to clinic
Ideas Research Development Late clinical trials ApprovalEarly clinical
trials
~8 years
How did I gain the skills?What skills are required to do my job?• Immunology, biochemistry, molecular biology
• Track record
• Years of experience
• Clinical trials
• IP, Fund raising, Bus. Dev.
• Disease biology expertise
• Antibody generation, engineering, cell line development and manufacturing
AcademiaBiotech. and Pharma. industry
Kymab: Therapeutic monoclonal antibody company
Life cycle: idea to clinic
Ideas Research Development Late clinical trials ApprovalEarly clinical
trials
~8 years
How did I gain the skills?What skills are required to do my job?• Immunology, biochemistry, molecular biology
• Track record
• Years of experience
• Clinical trials
• IP, Fund raising, Bus. Dev.
• Disease biology expertise
• Antibody generation, engineering, cell line development and manufacturing
AcademiaBiotech. and Pharma. industry
30+ Patents 60+ Publications
Kymab: Therapeutic monoclonal antibody company
Life cycle: idea to clinic
Ideas Research Development Late clinical trials ApprovalEarly clinical
trials
~8 years
How did I gain the skills?What skills are required to do my job?• Immunology, biochemistry, molecular biology
• Track record
• Years of experience
• Clinical trials
• IP, Fund raising, Bus. Dev.
• Disease biology expertise
• Antibody generation, engineering, cell line development and manufacturing
Pharma and Biotech industry
Kymab: Therapeutic monoclonal antibody company
Life cycle: idea to clinic
Ideas Research Development Late clinical trials ApprovalEarly clinical
trials
~8 years
How did I gain the skills?What skills are required to do my job?• Immunology, biochemistry, molecular biology
• Track record
• Years of experience
• Clinical trials
• IP, Fund raising, Bus. Dev.
• Disease biology expertise
• Antibody generation, engineering, cell line development and manufacturing
Biotech industry30+ Patents, 60+ publications
Kymab: Therapeutic monoclonal antibody company
Life cycle: idea to clinic
Ideas Research Development Late clinical trials ApprovalEarly clinical
trials
~8 years
How did I gain the skills?What skills are required to do my job?• Immunology, biochemistry, molecular biology
• Track record
• Years of experience
• Clinical trials
• IP, Fund raising, Bus. Dev.
• Disease biology expertise
• Antibody generation, engineering, cell line development and manufacturing
30+ yearsMonoclonal antibodies in clinical trialsDomantis – sold to GSK for £230M
Bosatria4 mAbs
Biotechnology Industry
Salary, Career path and career progression/promotion opportunities
BSc 0 – 4 years experience ~£18K - £35KPhD 0 – 4 years experience ~£20K - £50K
Career Path Science Career Career Opportunities
Research Associate Marketing/Sales
Scientist Patent attorney
Senior Scientist Business Dev./CBO
Director CEO
CSO Consultant
Found own company