(immunomodulator)

immunosupressive agents immunopotentiating agents / immnuoadjuvants (immunonormalizing agents) (immunosubstituting agents)

innate immune response/adaptive immune responseBT

1. hypersensitivity2. autoimmune diseasessystemic lupus erythematosus1type 1 diabetes mellitus3. immunoproliferative diseasemultiple myeloma

4. immunodeficiency diseaseHIVsolid tumorshematological malignanciesinfectious diseases5. graft rejection6. tumor

1 2 3/

1.immunosuppressive agents2.3.4.24~48h5.

/

1. 2. 3. /4. 5.

TTIL-1IL-2IL-6-GREnGRE-IBNFB

calcineurinTFK506-FKBPTNFATIL-2TIL-2FKBPmTOR

cyclosporinCsATIL-1-transforming growth factor-TGF-cyclophilincalcineurinT(nuclear factor of activated T cellsNFAT)NFAT

( systemic lupus erythematosusSLE)(lupus nephritisLN)(myelodysplastic syndromeMDS)(nephrotic syndromeNS)

B

tacrolimusFK506FK506FKBPNFATTFK506G0ATCD3IL-2FK506Ca2+TBTB

-FK506FK506

mycophenolate mofetilMMF MMFMPAMPAinosine monophosphate dehydrogenaseIMPDHde novo synthesis pathwaysalvage pathwayIMPDHMPAIMPDH4~5TBIMPDHMPA

MMFIgA

MMFMPAMPAGMMFMPAMPA

ATG

ATGTCD2. CD3. CD4. CD8CD11aCD18CD25CD44CD45TBT

Aza10%~15%TATG

-CD3 (Muromonab-CD3)-CD3TCD3TTT

tripterygium glycosidesIL-2

immunopotentiating agents

1 Q102 3 NPT-15392poly ICpoly AU4 5 PHAAConA

1 -2. AIDSataxia-telangiectasia syndrome2 3

(bacillus calmette-guerin vaccine ,BCG) TBNKBCGBCG BCG

levamisoleLMS LMST/TEPHAcAMPTIL-2

LMSLMSLMS

-2 aldesleukin IL-2IL-2IL-2ThTcNKBIL-2IL-1

interferonIFN-NKIFNIFNKaposi

transfer factorTFTFRNAreverse transcriptaseTFDNATFTTFIgG

1 thymosin 1T1 T1TT1TdTIFNIL-2IL-2IFN- HBsAgHBeAgT1CD3CD4HBVIFN-T1

1.2. 3.4.5.-CD3

/

immnuoadjuvants (immunonormalizing agents) (immunosubstituting agents)1.

1.immunosuppressive agents2.3.4.24~48h5.2.

3.

/

4. TIL-1-transforming growth factor-TGF-cyclophilincalcineurinT(nuclear factor of activated T cellsNFAT)NFAT

5.-CD3

-CD3TCD3TT