Autoimmune Liver Diseases
*WANG, GQ
AIHPBCPSCAIC (Overlap Syndromes)
*WANG, GQ
AILD
*WANG, GQ
AIHPBCPSC60%HLADR3DR4dsDNA
*WANG, GQ
*WANG, GQ
*WANG, GQ
Autoimmune Hepatitis (AIH)- (4:1)Czaja AJ & Freese DK.
Diagnosis and treatment of AIH. Hepatology 2002; 36:479-497
*WANG, GQ
AIHMcFarlane IG. Pathogenesis of autoimmune hepatitis. Biomed
& Pharmacother. 1999; 53:255
*WANG, GQ
Potential mechanisms of immune-mediated damage in AIH
*WANG, GQ
AIH
*WANG, GQ
AIH-Interface hepatitis
*WANG, GQ
AIH-Plasma cell infiltration
*WANG, GQ
AIH N IH/PN BN LH RLC CN PPI (%) (%) (%) (%) (%) (%)
I 21 100 57.1 95.2 71.4 33.3 95.2
II 5 100 80.0 100 100 80.0 20.0
IH/PN/ RLC LH PPI CN 2002162730
*WANG, GQ
AIHSLE
*WANG, GQ
AIH N ALT AST Glo ANA LKM1 (F/M) (U/L) (U/L) (%) SMA (%)
I 21 19/2 40.5 287.2 206.1 42.6 95.2 0 18.6 II 5 5/0 12.5 389.6
319.8 26.1 0 100 19.1
IIIIII 2002162730
*WANG, GQ
AIHANASMA ILKM-1 /SLA/LP pANCA ASGPR ILC-1
*WANG, GQ
ANAANAAIH6713SMA54AIHANA 1:320 (1:40~1:16384)74ANA
1:40ANARNADNAHepG2ANAPBCPSC
*WANG, GQ
SMA
SMAAIH8733ANA54SMA1:160(1:40~1:5120)80AIH1:40SMAF-tubulindesminvimentin
*WANG, GQ
(LKM1)LKM1ANASMAAIH
LKM1LKM1P-450CYP 2D6P450 2D650Kda
*WANG, GQ
/SLA/LP/SLA/LPAIH50KdatRNP(Ser)Sec) SLA/LPAIHAIH
*WANG, GQ
pANCA pANCAAIH90pANCAAIHpANCAAIHAIH
*WANG, GQ
ILC1ILC1AIHLC140AIH2032LC1LKM1LC1HCVAIH
*WANG, GQ
(-actin)AIHSMAAIHHLA DR3SMASMAAIH
*WANG, GQ
ASGPRASGPRANASMALKM1ASGPR
*WANG, GQ
AIH
ALTIgG1.5 ANASMALKM1180, 120AMA
*WANG, GQ
AIH1- AECMV EBV
