Structure and Dynamics of BiomembranesHiroshi Noguchi
Institute for Solid State Physics, University of Tokyo, Kashiwa, Chiba 277-8581, [email protected]
H. Noguchi, EPL 108, 48001 (2014); H. Noguchi, J. Chem. Phys. 143, 243109 (2015);H. Noguchi, Sci. Rep. 6, 20935 (2016).
Tubulation by Banana-shaped ProteinsBAR superfamily protein
Csiderrod= 1 Csiderrod= -1
Tubulation dynamics ischanged by the sign ofside curvature Cside.
0
0.5
1
0 4000 8000
<zcl
2 >1/2 /r r
od
t/τ
(c)Csiderrod =
-1
0
1
0
0.5
1
<Ncl
>/N
rod
(b)Csiderrod = -1
0
1
3
4
-1 0 1
Cro
dr ro
d
Csiderrod
(a)iso
part
net
1/Crod
-1/Cside
curved rod
percolated network istransiently formed.
Dynamics of Red Blood Cells in Flows
Polymer-Grafting Induced Micro-Domain
Octopus-like Micelles
Rolled lamella Induced by Shear Flow
synclonizationof tumbling andtank-treadingrotation
Flow-induced ordered structures
H. Noguchi, Phys. Rev. E 80, 021902 (2009); J. Phys. Soc. Jpn. 79, 024801 (2010);Phys. Rev. E 81, 056319 (2010); Phys. Rev. E 81, 061920 (2010).
capillary flow
shear flow
viscosity ratio
shea
rrat
e
J. Liam McWhirter, H. Noguchi, and G. Gompper, PNAS 106, 6039 (2009);Soft Matter 7, 10967 (2011); New J. Phys. 14, 085026 (2012);.
cryo-TEM image of binarymixture f diblock copolymersJain et al. Macromol. 37, 1511(2004.).Local curvature difference
induces phase separation.
Red molecules formrim and worm arms.
Red worms is directlyconnected to blue disk.
Phase diagram
spon
tane
ous
curv
atur
e
repulsion between different molecules
Octopus-like micelles are formed at very low CMC.Two types of connection structures are found.
Shear flow unstabilizes lamellar structure leading torolled lamella, which scattering pattern agrees withintermediate state into onion phase in experiment.
Polymer grafting can stabilize micro-domains, sincepolymer have larger entropy at domain boundary.
H. Noguchi, Soft Matter 8, 3146 (2012).
low shear rate high shear rate
rolling
Sites binding three or moreneighboring membranes forma large cluster to gain entropyof membrane fluctuation.
H. Noguchi, EPL 102, 68001 (2013).
H. Shiba, H. Noguchi, and G. Gompper, J. Chem. Phys. 139, 014702 (2013).
H. Wu, H. Shiba, and H. Noguchi, Soft Matter 9, 9907 (2013).
Entropy-driven Assembly
Yanagisawa et al, Soft Matter 8, 488 (2012).
mixed state micro-domain
polymerdensity
increasesredu
ctio
nof
inte
ract
ion
oftw
oty
pes
ofpa
rticl
es
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