Summary ofNew Products Introduced:
September 14-24, 2013
For more detailed product info visit: https://www.caymanchem.com/NewProducts
14645 BACE1 (human recombinant)
Source: recombinant C-terminal hexahistidine-tagged protein
expressed in Sf-21 cells · Mr: 48.4 kDa
Initiates the first step in the production of the β-amyloid peptide
(Aβ) in the brain.
Inhibition of BACE activity could potentially block the entire
cascade of Alzheimer’s disease pathogenesis.
source: http://www.cipsm.de/en/publications/researchAreaF/2008/Regulatory_RNA_goes_awry_in_Alzheimer___s_disease/index.html?style=1
11913 (S)-Mephenytoin
An anticonvulsant and substrate of the cytochrome P450 (CYP)
isoform CYP2C19, also known as mephenytoin 4-hydroxylase
CYP2C19 metabolizes a variety of therapeutic agents, including
omeprazole, proguanil, diazepam, propranolol, citalopram,
imipramine, and certain barbiturates.
Genetic defects in CYP2C19 result in poor metabolism of these
compounds; (S)-mephenytoin is used to screen for such
mutations by assaying its metabolites in urine.
(S)-mephenytoin
14865 α-Truxillic Acid
Can be formed by the dimerization of two molecules of
α-trans-cinnamic acid
Related to incarvillateine, a natural antinociceptive compound
Significantly blocks inflammatory pain while having little effect on neurogenic pain
The related compound SB-FI-26 (Item No. 14191) binds FABP5; FABP5 acts as a transporter of the endocannabinoid
anandamide
α-truxillic acid
SB-FI-26(Item No. 14191)
UHRF1 domains
UHRF1 (ubiquitin-like with PHD and ring finger domains 1) is a nuclear
protein binds chromatin and participates in the maintenance of DNA
methylation
14777UHRF1 PHD domain (human recombinant) Exclusive Source: Recombinant N-terminal GST-tagged protein expressed in E. coli · Mr: 35.5 kDa
14778UHRF1 tudor-like region (human recombinant; GST-tagged)Source: Recombinant N-terminal GST-tagged protein expressed in E. coli · Mr: 45.6 kDa
14779UHRF1 tudor-like region (human recombinant; His-tagged)Source: recombinant protein expressed in E. coli · Mr: 31.9 kDa
PHD domains and tudor domains are involved in protein binding; these
domains may facilitate UHRF1 interactions with histones in
nucleosomes.
tudor-like regionHis-tagged
PHD domain
14939 Rabeprazole (sodium salt)
A selective and irreversible inhibitor of the gastric H+/K+ ATPase pump (IC50 = 72 nM)
Trade name AdipHex®, sold to treat GERD (gastric esophageal
reflux disease)
Metabolized by the cytochrome P450 (CYP) isomers CYP2C19 and CYP3A4: high and low metabolizers exist
Also has in vitro antibacterial activity against H. pylori
(IC50 = 0.29 μM) rabeprazole
source: http://effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-reports/?pageaction=
displayproduct&productid=756
14803 Cyanidin chloride
A natural antioxidant
An anthocyanidin found in a variety of fruits (grapes, blueberries,
cherries, cranberries, raspberries, more) and vegetables (red
cabbage, red onion); reddish-purple color; most abundant in
plant seeds and skin
In addition to antioxidant activity, has vasoprotective effects and
can interfere with inflammation, carcinogenesis, obesity, and
diabetes
cyanidin chloride
14985 Clenbuterol (hydrochloride)
A sympathomimetic β2-adrenoceptor agonist that has been used as a
bronchodilator (20 μg/dose in humans) in the treatment of
pulmonary diseases such as asthma
At higher doses, clenbuterol acts as an anabolic steroid, favoring
skeletal muscle protein synthesis at the expense of fat
deposition. It has been used by athletes to enhance
performance, by dieters to encourage weight loss, and by
livestock farmers to produce animals with leaner meat.
Banned by the FDA and the International Olympic Committee and
prohibited for use in food-producing animals in the US, Europe,
and China
clenbuterol
14938 Finasteride
An analog of testosterone that competitively blocks its metabolism to
dihydrotestosterone (DHT) by the type II 5α-reductase (IC50 = 4.2 nM)
with 100-fold less affinity for the type I enzyme
Used in the treatment of benign prostatic hyperplasia, decreasing human
prostatic dihydrotestosterone levels by 70-90% and reducing prostate
size; marketed as Proscar
Used to block androgenic alopecia (male pattern baldness); marketed as Finpecia/ Propecia
finasteride
source: http://www.hrbr.ie/finasteride-hair-loss-treatment/
An inhibitor of SREBP (sterol response element-binding protein) activation
Prevents SCAP-mediated escort of either SREBP-1 or SREBP-2 to
the Golgi (IC50 = 5.6 µM), blocking constitutive SREBP-mediated
gene expression in the human prostate cancer cell line DU145
Prevents insulin-induced adipogenesis in 3T3-L1 cells
Inhibits high glucose-induced upregulation
of TGF-β in primary rat mesangial cells
alters lipid metabolism in vivo, reducing
hepatic fat accumulation in ob/ob mice
Source: http://upload.wikimedia.org/wikipedia/commons/2/2d/SREBP_pathway.png
13562 Fatostatin
fatostatin
New Forensic Products
14360 JWH 081 N-(4-hydroxypentyl) metabolite-d5
An internal standard for GC- or LC-mass spectrometry
14546 5-fluoro PB-22 N-(2-fluoropentyl) isomerAn isomer having the fluorine atom at the 2 position, rather than at the
terminal 5 position, of the alkyl group
14892 AM2201 8-quinolinyl carboxamideAn analog of AM2201 where 8-quinolinol replaces the naphthalene group
New Forensic Products
90014364-Methylethcathinone metabolite (hydrochloride) ((±)-Pseudoephedrine stereochemistry)
A cathinone sold as “legal high” replacements for controlled stimulants such as methamphetamine and ecstasy
Features conversion of the β-keto group to β-hydroxy and the
S,S orientation of pseudoephedrine
4-MEC
Metabolite“pseudoephedrine stereochemistry”
Metabolite“ephedrine stereochemistry”
New Forensic Products
14078 R-MMC (hydrochloride)
New on websites
Named to suggest similarity to popular 4-MMC
Structurally similar to bk-MDEA (ethylone)
R-MMC
bk-MDEA, ethylone, MDECItem No. 9001123
4-methylmethcathinone4-MMC, MCAT, mephedrone
Item No. 10801