New Cayman Chemical Products - Sept 24th, 2013

  • View

  • Download

Embed Size (px)


Slides with new product info for the last week...


  • 1. Summary of New Products Introduced: September 14-24, 2013 For more detailed product info visit:

2. 14645 BACE1 (human recombinant) Source: recombinant C-terminal hexahistidine-tagged protein expressed in Sf-21 cells Mr: 48.4 kDa Initiates the first step in the production of the -amyloid peptide (A) in the brain. Inhibition of BACE activity could potentially block the entire cascade of Alzheimers disease pathogenesis. source: Regulatory_RNA_goes_awry_in_Alzheimer___s_disease/index.html?style=1 3. 11913 (S)-Mephenytoin An anticonvulsant and substrate of the cytochrome P450 (CYP) isoform CYP2C19, also known as mephenytoin 4-hydroxylase CYP2C19 metabolizes a variety of therapeutic agents, including omeprazole, proguanil, diazepam, propranolol, citalopram, imipramine, and certain barbiturates. Genetic defects in CYP2C19 result in poor metabolism of these compounds; (S)-mephenytoin is used to screen for such mutations by assaying its metabolites in urine. (S)-mephenytoin 4. 14865 -Truxillic Acid Can be formed by the dimerization of two molecules of -trans-cinnamic acid Related to incarvillateine, a natural antinociceptive compound Significantly blocks inflammatory pain while having little effect on neurogenic pain The related compound SB-FI-26 (Item No. 14191) binds FABP5; FABP5 acts as a transporter of the endocannabinoid anandamide -truxillic acid SB-FI-26 (Item No. 14191) 5. UHRF1 domains UHRF1 (ubiquitin-like with PHD and ring finger domains 1) is a nuclear protein binds chromatin and participates in the maintenance of DNA methylation 14777 UHRF1 PHD domain (human recombinant) Exclusive Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 35.5 kDa 14778 UHRF1 tudor-like region (human recombinant; GST-tagged) Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 45.6 kDa 14779 UHRF1 tudor-like region (human recombinant; His-tagged) Source: recombinant protein expressed in E. coli Mr: 31.9 kDa PHD domains and tudor domains are involved in protein binding; these domains may facilitate UHRF1 interactions with histones in nucleosomes. tudor-like region His-tagged PHD domain 6. 14939 Rabeprazole (sodium salt) A selective and irreversible inhibitor of the gastric H+/K+ ATPase pump (IC50 = 72 nM) Trade name AdipHex, sold to treat GERD (gastric esophageal reflux disease) Metabolized by the cytochrome P450 (CYP) isomers CYP2C19 and CYP3A4: high and low metabolizers exist Also has in vitro antibacterial activity against H. pylori (IC50 = 0.29 M) rabeprazole source: search-for-guides-reviews-and-reports/?pageaction= displayproduct&productid=756 7. 14803 Cyanidin chloride A natural antioxidant An anthocyanidin found in a variety of fruits (grapes, blueberries, cherries, cranberries, raspberries, more) and vegetables (red cabbage, red onion); reddish-purple color; most abundant in plant seeds and skin In addition to antioxidant activity, has vasoprotective effects and can interfere with inflammation, carcinogenesis, obesity, and diabetes cyanidin chloride 8. 14985 Clenbuterol (hydrochloride) A sympathomimetic 2-adrenoceptor agonist that has been used as a bronchodilator (20 g/dose in humans) in the treatment of pulmonary diseases such as asthma At higher doses, clenbuterol acts as an anabolic steroid, favoring skeletal muscle protein synthesis at the expense of fat deposition. It has been used by athletes to enhance performance, by dieters to encourage weight loss, and by livestock farmers to produce animals with leaner meat. Banned by the FDA and the International Olympic Committee and prohibited for use in food-producing animals in the US, Europe, and China clenbuterol 9. 14938 Finasteride An analog of testosterone that competitively blocks its metabolism to dihydrotestosterone (DHT) by the type II 5-reductase (IC50 = 4.2 nM) with 100-fold less affinity for the type I enzyme Used in the treatment of benign prostatic hyperplasia, decreasing human prostatic dihydrotestosterone levels by 70-90% and reducing prostate size; marketed as Proscar Used to block androgenic alopecia (male pattern baldness); marketed as Finpecia/ Propecia finasteride source: 10. An inhibitor of SREBP (sterol response element-binding protein) activation Prevents SCAP-mediated escort of either SREBP-1 or SREBP-2 to the Golgi (IC50 = 5.6 M), blocking constitutive SREBP-mediated gene expression in the human prostate cancer cell line DU145 Prevents insulin-induced adipogenesis in 3T3-L1 cells Inhibits high glucose-induced upregulation of TGF- in primary rat mesangial cells alters lipid metabolism in vivo, reducing hepatic fat accumulation in ob/ob mice Source: 13562 Fatostatin fatostatin 11. New Forensic Products 14360 JWH 081 N-(4-hydroxypentyl) metabolite-d5 An internal standard for GC- or LC-mass spectrometry 14546 5-fluoro PB-22 N-(2-fluoropentyl) isomer An isomer having the fluorine atom at the 2 position, rather than at the terminal 5 position, of the alkyl group 14892 AM2201 8-quinolinyl carboxamide An analog of AM2201 where 8-quinolinol replaces the naphthalene group 12. New Forensic Products 9001436 4-Methylethcathinone metabolite (hydrochloride) (()-Pseudoephedrine stereochemistry) A cathinone sold as legal high replacements for controlled stimulants such as methamphetamine and ecstasy Features conversion of the -keto group to -hydroxy and the S,S orientation of pseudoephedrine 4-MEC Metabolite pseudoephedrine stereochemistry Metabolite ephedrine stereochemistry 13. New Forensic Products 14078 R-MMC (hydrochloride) New on websites Named to suggest similarity to popular 4-MMC Structurally similar to bk-MDEA (ethylone) R-MMC bk-MDEA, ethylone, MDEC Item No. 9001123 4-methylmethcathinone 4-MMC, MCAT, mephedrone Item No. 10801