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Emergent & urgent Hypertension
Reference: Harrison 2012, Chapter 247
به نام خدا
Presented by Dr Sadatinejad, Seyyed Mohsen,student of Medicine from Iran,Kashan 29/6/2015
Definitions:
• Hypertension:• Stage I: 140-159/90-99• Stage II: >160/100
• Hypertensive Urgency:• Systolic BP >180 or Diastolic BP >120 in the absence of
end-organ damage
• Hypertensive Emergencies:• SBP >180 or DBP>120 in the presence of end-organ
damage
Hypertensive Emergencies:
Hypertensive encephalopathyMalignanthypertension StrokeMyocardial infarction/unstable anginaAcute left ventricular failureAortic dissectionAdrenergic crisisPostoperative hypertensionPreeclampsia/eclampsia of pregnancy
Malignant hypertension
Acute ↑ of BP (hypertensive crisis) in a patient with underlying hypertension
or sudden onset of HTN in a previously normotensive individual
with irreversible organ damageSBP >180 or DBP >120
Damage : diffuse necrotizing vasculitis arteriolar thrombi fibrin deposition in arteriolar walls (kidney, brain, retina, and other organs)
Malignant hypertension
Damage : diffuse necrotizing vasculitis arteriolar thrombi fibrin deposition in arteriolar walls (kidney, brain, retina, and
…) Fibrinoid Necrosis progressive retinopathy (arteriolar spasm, hemorrhages,
exudates, and papilledema) renal function with proteinuria microangiopathic hemolytic anemia encephalopathy
Hx: use of MAO inhibitors , OCP,cocaine, amphetamines ,…
Normal
Autoregulation in brain
s
↓ ↓ of BP, under the lower limit of autoregulation = cerebral ischemia (also Renal and Coronary blood flows )
initial Goal
↓ MAP : 25% of HTN (160/100–110 mmHg)in minutes to 2 hIV nitroprusside, labetalol,nicardipine
preeclampsia
5–7% of pregnant women after 20 weeks of gestation
new onset of hypertension (BP>140/90 mmHg) + proteinuria (>300 mg/24 h) (organ damage)
Eclampsia = onset of seizures (convulsions) in a woman with pre-eclampsia
Severe preeclampsia
BP >160/110 mmHgproteinuria >5 g/24 hCNS dysfunction (headaches, blurred vision,
seizures, coma)
Renal dysfunction (oliguria or creatinine > 1.5 mg/dL)
pulmonary edemahepatocellular injury (ALT > 2-fold the upper limits of
normal)
hematologic dysfunction (platelet count < 100,000/L or DIC)
placental dysfunction (oligohydramnios or severe IUGR)
HELLP syndrome (hemolysis, elevated liver enzymes, low platelets)
treatment
Mild preeclampsia Bed restSevere preeclampsia delivery +
labetalol(IV) Nifedipine hydralazine ACEI (-)Magnesium sulfate