Estefanía Jaramillo Jaramillo

Universidad Pontificia Bolivariana

Molecular Biology

INTRODUCTION Each notice has a very

important contribution for the medicine and biology, because give us big answers about a lot of cells process. This answers can give us information about the cure for diseases that affect our society.

MEIER GORLIN SYNDROME

ORC1 PROTEIN

REPLICATION CENTROSOMEREGULATION

MEIER GORLIN SYNDROME

Meier Gorlin syndrome is caused

by a mutated protein, called

ORC1, this protein is involved in DNA

replication and centrosome regulation

MEIER GORLINCAUSED BY

ORC1 PROTEIN

AFFECTS DNA REPLICATION

AND CENTROSOME REGULATION

THE PATIENTS ARE THE SHORTEST AND HAD THE

SMALLEST BRAIN SIZE

Only 53 cases of Meier-Gorlin syndrome have been reported, this syndrome is caused by ORC1 protein, that is the largest of six proteins called the origin recognition complex.

The patients are shorts and they have a small brain size

PERSONAL OPINION

THIS KING OF STUDIES GIVE US A BIG INFORMATION ABOUT CELLS

MECHANISMS THAT AFFECT THE NORMAL OPERATIONS. THESE INFORMATION CAN BE USE IN

TRATAMIENT OF DISEASES LIKE MEIER GORLIN SYNDROME BECAUSE THEY KNOW THE SPECIFIC PROTEIN THAT

CAUSES THIS PATHOLOGY.

COMPUTER MODEL

Mycoplasma genitalium

FUNDAMENTAL BIOLOGICAL PROCESSES

MODEL OF AN ORGANISM The world's first

complete computer model of an organism has been created, this organism is the smallest bacterium, only 525 genes

Mycoplasma genitalium

This organism is the smallest bacterium, only with 525 genes.

Appears in human urogenital and respiratory tracts. The model

allows researchers to learn more about importants cells processes like mitosis and DNA replication.

Mycoplasma genitalium

UROGENITAL

THE MODEL EXPLAIN

PROCESSES THAT

WOULD BE DIFFICULT

TO PERFORM IN AN ACTUAL ORGANISM

RESPIRATORY

PERSONAL OPINION

EVERY TIME WE ARE ADVANCING AND FINDING ANSWERS A LOT OF

QUESTIONS, THIS MODEL ALLOWS TO KNOW MORE ABOUT CELLS

INTERACTIONS AND FUNDAMENTAL PROCESSES. THIS MODEL IS A VERY

IMPORTANT STEP FOR FIND THE CURE FOR A LOT OF DISEASES.

MEDICAL UTILITY

If we know the type of mutatation that causes Meier Gorlin syndrome, we can avoid and prevent that the affect protein appears in the genome or maybe find a solution to some symptoms of Meier Gorlin syndrome.

MEIER GORLIN

ORC1 PROTEIN

THE SHOREST , SMALLEST

BRAIN SIZE

AVOID MORE PEOPLE WITH MEIER GORLIN

A BIG ADVANCE FOR

MEDICINE

MEDICAL UTILITY

Every time molecular biology and medicine are more related, many pathologies has its explain from molecular biology. The model allow to know about importants cells processes

MOLECULAR BIOLOGY MEDICINE

EVERY TIME THEY ARE MORE RELATED TO EXPLAIN AND FIND CURE FOR MANY PATHOLOGIES

BIBLIOGRAPHY 

MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB. Fac. de Medicina, 2006. 208 p.

 Science Daily, Protein Involved in DNA Replication, Centrosome Regulation Linked to Dwarfism, Small Brain Size, July 31, 2012.

Science Daily, Researchers Produce First Complete Computer Model of an Organism, July 21, 2012.