2

3

4

5

6

15%-45%

7

8

1 30%-70%

2

5%15%10% 10%10% 1070(gg)

2 10%20%10%25% (PVP)

1

1

8%-10%5%-20%

2(CMS-Na)

300: 4%8%5%

3

(CCNaL-HPC

4 CO2

5

80

6

3

2 3

=0.31%

PEGPEG 4000 PEG 6000 C

1

210%

2 1%:0.153%

1% 2%5%

1

2

80-100

1 23

1

11+

12 : :

12

135060 80-100

13

14 1%-3% 3%-5% 20-3020%-40% 5020%

2

3

123

11 23

11 12-20

12

13

212)

2

1

1

=

1

= *

22)

=

+

31234

1

2 161927335575

4

5

1/3

1 2

1

2 5-20g

1

2

3

4

5 1/3

6

7

8

9(

10

1 2

1 1 2 3

2 1 2 360min60min15min60min

2 4 5 6

: :

1+:

2

3

4

5 BG

65%-75%

1 10153035 515 15%20% 10%CAP 30-50 35

265g/g 100 1518

2 35-50 1-4

365%-75% 40 1015

4 815

5 80-100 10020%80

12PEG345

HPMCHPCHECCMC-NaPVP PEG

CAPHPMCP

.

.

SZ-

PL-2000

TBJ

PVC

80-1003%-5%10% 5%0.3% 100

2021

g (mg) 0.1 40 60 0.1-0.29 20 40 0.3-0.49 10 50 0.5 10 100