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Analysis of Aromatic amines. 第八章 芳香胺类 药物的分析. 药物分析教研室. 对氨基苯甲酸酯类. benzocaine, procaine hydrochloride. 芳胺类. 芳香胺. 酰胺类. paracetamol, lidocaine hydrochloride. 苯乙胺类. 芳烃胺类. adrenaline, dopamine hydrochloride. 苯丙胺类. oxprenolol, carteolol hydrochloride. 1. 3. 2. 芳胺类. 苯乙胺类. 苯丙胺类. - PowerPoint PPT Presentation
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Analysis of Aromatic amines
benzocaine, procaine hydrochlorideparacetamol, lidocaine hydrochlorideadrenaline, dopamine hydrochlorideoxprenolol, carteolol hydrochloride
Contents
(Feature)2. BABAPABA3. 4. 1. Schiff
1. 3. 4. 5. (Feature)2.()+/
--Identification
1.2.Identification
Identification
/ /Identification
a. b.Identification
10NaOH()Identification
UVIdentification
Identification
IR cm-1 cm-1 C=O 1692 C-O 1271, 1170, 1115 N-H 2585 2645 1550 N-H 1280 N-H Identification
Identification
Detection of specific impurities11 2pH5.5-6.5(1
Detection of specific impurities2.3.O-TLC(254nm)
Detection of specific impurities4. 1.0g1220ml1ml30min1.0g50g0.005%
Detection of specific impurities1.2%TLC
Detection of specific impurities (ropivacaine) SR
Detection of specific impurities
Assay (volumetric analysis) ( spectrometry ) ( chrometography ) (sodium nitrite method)(non-aqueous titrimetry)
Assay(sodium nitrite method)NaNO2 + HCl HNO2 + NaClHNO2 + HCl NOCl + H2OHBrNO+ HBrNO+
Assay11030HNO2 [Ar-NN]Cl- + H2O Ar-OH + N2+ HCl2 3NaNO2,42/3HNO25KBr6(-)
Assay(non-aqueous titrimetry)
AssayUV257nm2005
AssayHPLCHPCE
(Phenethylamine)
*
Identification
Adrenaline0.1mol/LNoradrenaline bitartratePhenylephrine hydrochlorideIsoprenaline hydrochloride5%Dopamine hydrochloride1%
Identification
IdentificationUVIR
(mg/ml)nm (nm) (A)0.102720.052800.500.5%0.032800.1mol/L0.25263, 2700.012340.600.1mol/L0.03243, 2960.082740.50251, 257, 263
IdentificationChp 10mg1ml220%1ml1ml
Detection of specific impurities
Detection of specific impurities
Detection of specific impurities
C(mg/ml)(nm) A HCl(92000) 2.0 3100.05 2.0 3100.20 2.0 3100.05 2.0 3100.15 1.5 3470.06
Detection of specific impuritiesHPLCTLC
Assay
Assay()
Assay2
Assay()8ml 0.05mol/L25ml20.1mol/L1ml0.05mol/L18.42mgC18H26N2H2SO4
AssayUV HPLC (GC-MS)
(enalapril maleate)(benazepril hydrochloride)(lisinopril)
(lisinopril)
Identification
Detection of specific impurities
Assay(Ch.P)(BP)-HPLC
Assay