Analysis of Aromatic amines
benzocaine, procaine hydrochlorideparacetamol, lidocaine hydrochlorideadrenaline, dopamine hydrochlorideoxprenolol, carteolol hydrochloride
Contents
(Feature)2. BABAPABA3. 4. 1. Schiff
1. 3. 4. 5. (Feature)2.()+/
--Identification
1.2.Identification
Identification
/ /Identification
a. b.Identification
10NaOH()Identification
UVIdentification
Identification
IR cm-1 cm-1 C=O 1692 C-O 1271, 1170, 1115 N-H 2585 2645 1550 N-H 1280 N-H Identification
Identification
Detection of specific impurities11 2pH5.5-6.5(1
Detection of specific impurities2.3.O-TLC(254nm)
Detection of specific impurities4. 1.0g1220ml1ml30min1.0g50g0.005%
Detection of specific impurities1.2%TLC
Detection of specific impurities (ropivacaine) SR
Detection of specific impurities
Assay (volumetric analysis) ( spectrometry ) ( chrometography ) (sodium nitrite method)(non-aqueous titrimetry)
Assay(sodium nitrite method)NaNO2 + HCl HNO2 + NaClHNO2 + HCl NOCl + H2OHBrNO+ HBrNO+
Assay11030HNO2 [Ar-NN]Cl- + H2O Ar-OH + N2+ HCl2 3NaNO2,42/3HNO25KBr6(-)
Assay(non-aqueous titrimetry)
AssayUV257nm2005
AssayHPLCHPCE
(Phenethylamine)
*
Identification
Adrenaline0.1mol/LNoradrenaline bitartratePhenylephrine hydrochlorideIsoprenaline hydrochloride5%Dopamine hydrochloride1%
Identification
IdentificationUVIR
(mg/ml)nm (nm) (A)0.102720.052800.500.5%0.032800.1mol/L0.25263, 2700.012340.600.1mol/L0.03243, 2960.082740.50251, 257, 263
IdentificationChp 10mg1ml220%1ml1ml
Detection of specific impurities
Detection of specific impurities
Detection of specific impurities
C(mg/ml)(nm) A HCl(92000) 2.0 3100.05 2.0 3100.20 2.0 3100.05 2.0 3100.15 1.5 3470.06
Detection of specific impuritiesHPLCTLC
Assay
Assay()
Assay2
Assay()8ml 0.05mol/L25ml20.1mol/L1ml0.05mol/L18.42mgC18H26N2H2SO4
AssayUV HPLC (GC-MS)
(enalapril maleate)(benazepril hydrochloride)(lisinopril)
(lisinopril)
Identification
Detection of specific impurities
Assay(Ch.P)(BP)-HPLC
Assay