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超音波教學 Section 2
陳志堯 Director
洪正修主任 趙灌中主任
September 15, 2006
Ultrasonic Characteristics & Differential Diagnosis on
Leiomyoma, Adenomyosis and Adenomyoma
Review of the Literature
What is Leiomyomata?The elephant in the room
Uterine leiomyomas are benign myometrial neoplasms enriched in extracellular matrix.
Uterine leiomyomas are the most
common gynecologic disease of the
corpus uteri and are readily detected
by trans-vaginal sonography.
They are the primary indication for hysterectomy, over
200000 cases annually in US. Science June, 2005
Tumors occur in 77% women and approximately 25% of Caucasians have clinical significant lesions.
In African-American women, clinical disease is more severe more and concordant with prevalence.
Science June, 2005
Risk Factors & Prevalence The prevalence of clinical significant fibroids peaks
in the perimenopausal years and declines after menopause.
Increased Risk: obesity & early menarche, race Decreased Risk: old age of the last child birth. (COX-2, PGE)
Science June, 2005
Genetics of Uterine Leiomyoma
• Approximately 40% display cytogenetic alternations, frequently involving chromosome 12, t(12;14). (HMGA2)
• Hereditary leiomyomatosis and RCC (HLRCC):
Fumarate hydratase gene (FH).
• Tuberous sclerosis complex gene (TSC); BHD.
• CYP19 & CYP17 (black African women).
• Deletions of 7q, 3q and 1p; rearrangements of 6p, 10q and 13q.
Science. June 2005; Obs & Gyn. April 2006
Genetic AlterFH
BHDTSC2
HMG2A
Autocrine: TGF.etc
Estrogen & Progesterone
Tumor Growth ECM
ObesityParityRace
Leiomyomata Leiomyosarcoma?
However, it appears that a subset of myomas with a deletion of a specific portion of chromosome 1 have both a specific cellular morphology and gene transcription profiles akin to those of leiomyosarcomas.
Christacos NC. Genes Chromosomes Cancer 2006;45:304–12.
Location of Leiomyoma
• Sub-serosa
• Intra-mural
• Sub-mucosal
• Cervical
• Broad Ligament
Subserosa
Intramural
Submucosa
Cervical
Broad Ligament
KC Wen. 2005
Misguided Mass Mimics Myoma
The Major impacts of Leiomyomata
Symptoms
Infertility a. Mechanical
b. Alter the biochemical nature of intrauterine fluid
C. Abnormal ultrastructure
Submucous and Outer Myometrium Leiomyomas are Two Distinct Clinical
Entities
Fertility Sterility 2003
Junctional Zone Myometrium
1. Expression levels of E and P receptors are significantly higher in submucous fibroids compared to subsersal leiomyomas.
2. Submucous leiomyomas have significantly less karyotype aberrations than outer myometrial leiomyomas.
3. Using color Doppler sonography, Tsuda identified a leiomyoma artery in 85% submucous leiomyoma, but only in 42% intramural leiomyoma.
4. Growth rate is less in submucous type.
What is Adenomyosis?What is Adednomyoma?
Adenmyosis is a common gynecological disorder that is characterized by the presence of heterotopic endometrial glands and stroma in the myometrium with adjacent smooth muscle hyperplasia.
Bryann Bromley. J Ultrasound Med 19:529–534, 2000
Caroline Reinhold. Human Reprod Update 4:337-349, 1998
Prevalence: 5~70%
This broad range is due to the different criteria used for diagnosis, as well as the diligence with which adenomyosis is pursued on pathologic examination.
Kurman RJ. Pathology of the Female Genital Tract. 2nd Edition. New York, Springer-Verlag, 1984, p 297
• The frequency has been estimated between 20 and 40% of hysterectomy specimens.
Adenomyoma is the Nodular Form of
Adenomyosis
Sonographic Accuracy (84.3%)
General enlargement of uterine size
Global appearance (95%)
Mottled inhomogeneous myometrial texture (Sun-shine pattern) (100%)
Small cystic spaces within myometrium (82%)
Shaggy indistinct endometrial stripe (82%)
Bromley B. J Ultrasound Med. 2000
The Clinical Triads
Uterine enlargement
Dysmenorrhea
Menorrhagia
Small myometrial lucent areas
Shaggy endometrial stripe
ADENOMYOMA
The Final TalkAdenomyoma & Leiomyoma
How to Differentiate?
TVS is an effective, non-invasive, and relatively in-expensive procedure for the pre-operative differential diagnosis of adenomyoma versus leiomyoma.
Fedele L. Am J Obstet Gynecol, 1992
Botsis D. J Clinical Ultrasound, 1998
Huang RT.
Ultrasound OBS&GYN
1995
THANKS!