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- 234 -
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Z[\] 78 -0.98 2.139 -1.4653 -0.5006 2.5 mg 83 -1.81 2.492 -2.3534 -1.2650 5 mg 74 -1.74 2.442 -2.3089 -1.1775 p=0.0257
10 mg 78 -1.90 2.639 -2.4925 -1.3024 p=0.0113
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� j<!"ÌÇ#FSB 5V¹dutZ[\]kS��k�d YM905 2.5 mgW5 mgW10 mgkeý�S Williams er%S"��¢°uMØCø����� 2.5%FWI"#e 10 mg kû�Z[\]kVýd�+5Vø��F�YÀv01��°ut¯uWq�eàáÐ~C�
¤àáÐSÄÅFV1����� j<!"�EeÌÇ#eb-4Y 10 mgW5 mgW2.5 mgeëû£°ut�1W24 Ð_£u�e��� j<!"�EeÌÇ#Y 0 ^C��~FeHÌV!"�Û�£°u��e¬STU�d��gt
� 5 24O6Èi¾�ÉÊÏÐ�yzuÌL��´^"# ��E �� G�H� 95% Ë 95%ÆË Williamsr%
Z[\] 42 -1.25 2.076 -1.9007 -0.6072 2.5 mg 49 -1.11 1.706 -1.5987 -0.6189 5 mg 46 -1.61 1.948 -2.1871 -1.0302
10 mg 46 -1.70 1.823 -2.2369 -1.1543 p=0.1741
- 243 -
2.7.6.18 ������ODS1� 11/50 (3) 24O6Èi¾�ÉÊyzuÌL��´^
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2.5 mg 51 -1.39 2.348 -2.0526 -0.7317 5 mg 47 -1.69 2.194 -2.3321 -1.0438
10 mg 47 -1.79 1.770 -2.3140 -1.2746 p=0.1220
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�� #ÌÇ#FSB 7V¹dutZ[\]kS��k�d YM905 2.5 mgW5 mgW10 mgkeý�SWilliamser%S"��¢°uMØCø����� 2.5%FW10 mgkûZ[\]kVýd�+5Vø��F��Àv01ut¯uWq�eàáÐ~C�¤àáÐSÄÅFV1
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2.5 mg 83 -1.96 3.289 -2.6781 -1.2416 5 mg 74 -2.08 2.894 -2.7516 -1.4105 p=0.1012
10 mg 78 -2.63 3.211 -3.3500 -1.9021 p=0.0077
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� 8 1ÌÈi¾�ÉÊËy^ yzu�ÕO�ÍÎUÀ(��´^"# ��E �� G�H� 95% Ë 95%ÆË Williamsr%Z[\] 78 9.99 26.510 4.0095 15.9636
2.5 mg 81 23.33 34.815 15.6324 31.0287 p=0.0072 5 mg 73 30.90 35.174 22.6914 39.1047 p=0.0001
10 mg 77 42.53 39.148 33.6442 51.4152 p<0.0001
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2.7.6.18 ������ODS1� 13/50
� 10 ����8ÜÝ �� 1(Z[\] 2.5 mg 5 mg 10 mg 4+
pqjTU�E 79 83 75 80 317 qúU 37(46.8%) 42(50.6%) 41(54.7%) 51(63.8%) 171(53.9%)
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2.7.6.18 ������ODS1� 14/50
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2.7.6.18 ������ODS1� 15/50
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2.7.6.18 ������ODS1� 16/50
� 10 ����8ÜÝ �� 4(Z[\] 2.5 mg 5 mg 10 mg 4+
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2.7.6.18 ������ODS1� 17/50
� 11 ¨�&8ÜÝ �� 1(Z[\] 2.5 mg 5 mg 10 mg 4+
pqjTU�E 79 83 75 80 317 qúU 15(19.0%) 21(25.3%) 26(34.7%) 42(52.5%) 104(32.8%)
ãäâ� 2(2.5%) 2(2.4%) 0 0 4(1.3%) L] 1(1.3%) 0 0 0 1(0.3%) Æ[j~OÙ^ 1(1.3%) 2(2.4%) 0 0 3(1.0%) ð[j~OÙ^ 0 1(1.2%) 0 0 1(0.3%) åâ� 2(2.5%) 2(2.4%) 3(4.0%) 4(5.0%) 11(3.5%) Æb`P 0 1(1.2%) 0 0 1(0.3%) �jcM`P 1(1.3%) 0 0 0 1(0.3%) �� 1(1.3%) 1(1.2%) 3(4.0%) 3(3.8%) 8(2.5%) ��R 0 0 0 1(1.3%) 1(0.3%)
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- 250 -
2.7.6.18 ������ODS1� 18/50
� 11 ¨�&8ÜÝ �� 2(Z[\] 2.5 mg 5 mg 10 mg 4+
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