細胞生物学

第8回

奈良教育大学　理科教育講座 生物学教室　細胞生物学研究室

石田正樹

細胞周期

M

= mitosis!

DNA = DNA synthesis!

S

G0 DNA �

=

G2

Gap 2!

Gap 1!

G1�

G1� S G2

����

���� ������

�����M G1�

+

Start checkpoint!����������

G2/M checkpoint!DNA��������!����������

��/�� checkpoint!����������������

/CDK

M

G

S

G2

(Cdk)

Cycline dependent protein kinase

M

G0

S

G1/S

S

M

Cycline

Cell cycle engine

/CDK

Cdk

CDK

P ATP P ATP

G1/S

CKI

G0

CKI

P Start checking point

P

P

P P

ubiquitin =

(CKI) CDK Inhibitor protein

P P

DNA

X-ray

DNA

p53

Mdm

p53

Mdm2 p53

p53

Mdm

p53 P

p53

p53 P

DNA p21

p21mRNA

P21 CKI)

P

P

P21 CKI

DNA

CKI

G /S /Cdk

S

: EGF etc.

mRNA

mRNA

S /Cdk

CKI

DNAp53

p53

mRNA

P Rb

P P P P

E2F

E2F E2F

S

Rb mRNA

P

DNADNA

Cdc6 Cdc Cell division cycle gene

Cdc6

P

Cdc6

G1

ORC

P

P S G2/M

P

P

DNA

P

G

APC

APC securin

separase APC

Cohesin complex

Cdc20

APC

Anaphase-promoting

complex

M /Cdk

M Cdk M

M

CAK

Cdk Cdk activate kinase

Wee1 Wee1

Cdk

Cdc25

Cdc25 Cdc25

P

P

P

M-Cdk

P

P

Wee1

G M

M-Cdk Cdk M-Cdk

CAKWee1

Cdc25

M

GS

G2

M

S

S

mRNA P Rb

P P P P

E2F

E2F E2F

DNA

Cdc6

P P

P

DNA

X-ray DNA

Mdmp53

Mdm

p21 p53 P

P21 CKI)

APC Cdc20

APC

Cdc25 Cdc25 P

CAK CAK

Wee1 Wee1