Immune Deficinecy

8/8/2019 Immune Deficinecy

1/51

Gp8 L`wl Imwdp I+ H`fdkdx W+K+

@FFTKD MDJ@C@KDCP


2/51

Etfbk @fftkimdj`c`dkcp Z`wts


3/51

Bcrt`wdm `fftkd mdj`c`dkcp spkmwifd iw

b

crt`wdm `fftkimdj`c`dkcp spkmwifd %B@MS ) `s b m`sdbsd ij }ed etfbk `fftkd sps}df

cbtsdm gp }ed etfbk `fftkimdj`c`dkcp z`wts %E@Z)+


4/51

]e`s cikm`}`ik qwiowdss`zdnp wdmtcds }ed djjdc}`zdkdss ij

}ed `fftkd sps}df bkm ndbzds `km`z`mtbnsstscdq}`gnd }i

iqqiw}tk`s}`c `kjdc}`iks bkm }tfiws+

E@Z `s}wbksf`}}dm }ewitoe m`wdc} cik}bc} ij b ftcits

fdfgwbkd iw }ed gniims}wdbf `}e b gim`np jnt`m

cik}b`k`ko E@Z. stce bsgniim. sdfdk. zbo`kbn jnt`m.qwdsdf`kbn jnt`m. bkm gwdbs} f`nl+\=V\4V


5/51

]e`s }wbksf`ss`ik cbk `kzinzd bkbn . zbo`kbn iw iwbn

sdu . gniim }wbksjts`ik . cik}bf`kb}dm epqimdwf`ckddmnds . ducebkod gd}ddk fi}edw bkm gbgp

mtw`ko qwdokbkcp . ce`nmg`w}e . gwdbs}jddm`ko iw

i}edw duqistwd }i ikd ij }ed bgizd gim`np jnt`ms+


6/51

B@MS `s ki b qbkmdf`c+ @k 711?. `} bs ds}`fb}dm

}eb} 33+7 f`nn`ik qdiqnd n`zdm `}e }ed m`sdbsdiwnm`md. bkm }eb} B@MS l`nndm bk ds}`fb}dm

7+2 f`nn`ik qdiqnd. `kcntm`ko 331.111 ce`nmwdk+


7/51

B@MS Cb}doiwp


8/51

E@Z qbw}`cnds


9/51

Scedfb}`c ij E@Z

Wdqn`cb}`ik


10/51

Cn`k`cbn Jdb}twds

'_edk spfq}ifs mi mdzdniq. }edp bwd tstbnnps`f`nbw b} j`ws} }i }eisd ij ciffik f`kiw `nnkdssds.stce bs }ed 'jnt'. ducdq} }eb} }edp nbs} nikodw bkmbwd fiwd sdzdwd+

Qdws`s}dk} }`wdmkdss. tkduqnb`kdm jdzdws. wdctww`kok`oe} sdb}s. qwinikodm dknbwodfdk} ij }ednpfqe kimds. bkm d`oe} niss bwd bnn ciffik+


11/51

Cn`k`cbn Jdb}twds

2+ Sdwicikzdwsìk `nnkdss & sddk `k 21$ ij `km`z`mtbns b jd ddls bj}dwduqistwd bkm ci`kc`mds `}e sdwicikzdwsìk+ Qwdsdk}s `}e bk

`kjdc}ìts fikiktcndis`s n`ld `nnkdss+

7+ @kctgb}ìk qdwìm & }e`s `s }ed qdwìm edk }ed qb}`dk} `s cifqnd}dnpbspfq}ifb}`c bkm fbp zbwp jwif b jd fik}es }i b fiwd }ebk 21pdbws+ ]ed fdm`bk `kctgb}ìk qdwìm `s 5&21 pdbws+

3+ B@MS&wdnb}dm cifqndu iw qdws`s}dk} odkdwbn`xdm npfqebmdkiqb}ep+

=+ Jtnn&gnik B@MS+


12/51

Iqqiw}tk`s}`c @kjdc}ìks

Qwi}ixibn qkdtficps}`s cbw`k`` %ki }eitoe} }i gd b jtko`).

}iuiqnbsfis`s. cwp}isqiw`mis`s

Jtkobn cbkm`m`bs`s. cwp}iciccis`s

e`s}iqnbsfis`s. cicc`mìmifpcis`s

Gbc}dw`bn Fpcigbc}dw`tf bz`tf cifqndu. F]G

b}pq`cbn fpcigbc}dw`bn m`sdbsd

sbnfikdnnb sdq}`cbdf`bftn}`qnd iw wdctwwdk} qpiodk`c gbc}dw bn kjdc}ìk

Z`wbn CFZ. ESZ. ZXZ. HCZ


13/51

Iqqiw}tk`s}`c ]tfitws

]ed fis} jwdrtdk} iqqiw}tk`s}`c }tfitw. Lbqis`/s sbwcifb.

`s igsdwzdm `k 71$ ij qb}`dk}s `}e B@MS+

LS `s igsdwzdm fis}np `k eifisdutbns bkm `}s wdnb}`zd

`kc`mdkcd `s mdcn`k`ko+ @} `s ki bssic`b}dm `}e b etfbk

edwqds z`wts 5 %EEZ&5)+

Fbn`okbk} npfqeifbs bwd bnsi jwdrtdk}np sddk `k B@MS

qb}`dk}s+


14/51

Lbqis`s Sbwcifb


15/51

I}edw Fbk`jds}b}ìks

@} `s ki wdciok`sdm }eb} E@Z&`kjdc}dm qb}`dk}s fbp

mdzdniq b ktfgdw ij fbk`jds}b}ìks }eb} bwd ki}duqnb`kdm gp iqqiw}tk`s}`c `kjdc}ìks iw }tfitws+

]ed fis} jwdrtdk} kdtwinio`cbn m`siwmdw `s B@MS

dkcdqebniqb}ep e`ce `s sddk `k }i }e`wms ij cbsds+

I}edw fbk`jds}b}ìks `kcntmd cebwbc}dw`s}`c sl`k dwtq}ìks

bkm qdws`s}dk} m`bwweidb+


16/51

Dq`mdf`iniop

2+ Sdutbn }wbksf`ss`ik & fbnd eifisdutbns bkm ciks}`}t}d}ed nbwods} w`sl owitq `k K+ Bfdw`cb bkm _ds}dwk Dtwiqd+

@k mdzdniq`ko citk}w`ds

7+ Gniim)gniim qwimtc}s & @Z mwto bgtsdws wdqwdsdk} }edsdcikm nbwods} B@MS qb}`dk} owitqs `k }ed TS bkm Dtwiqd+


17/51

Dq`mdfìniop

3+ Zdw}`cbn }wbksf`ssìk & }ed }wbksf`ssìk wb}d jwif fi}edw }i}ed kdgiwk zbw`ds jwif bwitkm 24$ `k _ds}dwk Dtwiqd }itq }i 41$ `k Bjw`cb+ Zdw}`cbn }wbksf`ssìk fbp icctw

}wbksqnbcdk}bnnp wit}d. qdw`kb}bnnp mtw`ko }ed g`w}e qwicdss. iwqis}kb}bnnp }ewitoe gwdbs} f`nl+

@k 7113. bk ds}`fb}dm =+5 f nnìk qdiqnd %wbkod8 =+7:+3f`nnìk) gdcbfd kdnp `kjdc}dm `}e E@Z+ ]e`s `s fiwd }ebk `kbkp ikd pdbw gdjiwd+ ]imbp. sifd 3?+5 f`nnìk qdiqnd %wbkod83=+:=7+3 f`nnìk) bwd n`z`ko `}e E@Z. e`ce l`nndm 7+0 f`nnìk%wbkod8 7+:3+3 f`nnìk) `k 7113. bkm izdw 71 f`nnìk s`kcd }edj`ws} cbsds ij B@MS dwd `mdk}`j`dm `k 2052+


18/51


19/51

Onigbn E@Z)B@MS ds}`fb}ds

dkm ij 711?


20/51

E@Z ebs l`nndm fiwd

}ebk 74 f`nn`ik

qdiqnd bkm `}e 7f`nn`ik qdiqnd

mp`ko `k 711:

bnikd+


21/51

Onigbn ]wdkms


22/51

Dzdwpmbp. izdw

?111 qdiqndgdcifd `kjdc}dm

E@Z bwitkm }ed

iwnm


23/51

Wdo`ikbn s}b}`s}`cs jiw E@Z * B@MS. dkm ij 711?


24/51

Ds}`fb}dm bgit}

33 f`nn`ik qdiqnd

}eb} d lki ijbwd ctwwdk}np

n`z`ko `}e E@Z+


25/51

E@Z Qb}eiodkds`s

]ed qwijitkm `fftkistqqwdssìk sddk `k B@MS `s

mtd }i }ed mdqnd}ìk ij ]= ednqdw npfqeicp}ds+

@k }ed `ffdm`b}d qdwìm jinni`ko duqistwd. E@Z

`s qwdsdk} b} b eòe ndzdn `k }ed gniim %bs md}dc}dm

gp E@Z Bk}òdk bkm E@Z&WKB bssbps)+


26/51

E@Z Qb}eiodkds`s

@} }edk sd}}nds mik }i b cdw}b`k ni ndzdn %sd}&qi`k})mtw`ko }ed `kctgb}ìk qdwìm+ Mtw`ko }ed `kctgb}ìkqdwìm. }edwd `s b fbss`zd }twkizdw ij CM= cdnns.edwdgp CM= cdnns l`nndm gp E@Z bwd wdqnbcdm djj`c`dk}np+

Dzdk}tbnnp. }ed `fftkd sps}df stcctfgs bkm B@MSmdzdniq edk l`nndm CM= cdnns cbk ki nikodw gd

wdqnbcdm %`}kdssdm gp eòe E@Z&WKB. E@Z&bk}òdk. bkmni CM= citk}s)+


27/51

E@Z ebnj&n`zds

Bc}`zb}dm cdnns }eb} gdcifd `kjdc}dm `}e E@Z qwimtcd

z`wts `ffdm`b}dnp bkm m`d `}e`k ikd }i }i mbps+

Qwimtc}`ik ij z`wts gp seiw}&n`zdm. bc}`zb}dm cdnns bccitk}s

jiw }ed zbs} fbhiw`}p ij z`wts qwdsdk} `k }ed qnbsfb+

]ed }`fd wdrt`wdm }i cifqnd}d b s`kond E@Z n`jd&cpcnd `s

bqqwiu`fb}dnp 2+4 mbps+


28/51

E@Z ebnj&n`zds

Wds}`ko cdnns }eb} gdcifd `kjdc}dm qwimtcd z`wts iknp bj}dw`fftkd s}`ftnb}ìk< }edsd cdnns ebzd b ebnj&n`jd ij b} ndbs}

4&: fik}es+ Sifd cdnns bwd `kjdc}dm `}e mdjdc}`zd z`wts }eb} cbkki}

cifqnd}d }ed z`wts n`jd&cpcnd+ Stce cdnns bwd zdwp niko n`zdm.bkm ebzd bk ds}`fb}dm ebnj&n`jd ij bqqwiu`fb}dnp }ewdd }isù fik}es+

Stce niko&n`zdm cdnn qiqtnb}ìks qwdsdk} b fbhiw cebnndkodjiw bk}`&wd}wiz`wbn }edwbqp+


29/51


30/51

Nbgiwb}iwp M`bokis`s

Sdwiniop `s }ed tstbn fd}eim jiw m`bokis`ko

E@Z `kjdc}`ik+ Sdwinio`cbn }ds}s cbk gdm`z`mdm `k}i scwddk`ko bkm cikj`wfb}iwp

bssbps+ Scwddk`ko bssbps seitnm gd bs

sdks`}`zd edwdbs cikj`wfb}iwp bssbps

seitnm gd bs sqdc`j`c bs qiss`gnd+


31/51


Scwddk`ko bssbps & DN@SB `s }ed fis} jwdrtdk}nptsdm scwddk`ko bssbp+ ]ed sdks`}`z`}p bkmsqdc`j`c`}p ij }ed qwdsdk}np bzb`nbgndciffdwc`bn sps}dfs ki bqqwibceds 211$gt} jbnsd qis`}`zd bkm kdob}`zd wdbc}`iks icctw+

Sifd bssbps ebzd qwigndfs `k md}dc}`ko E@Z&2stg}pqd I+


32/51


Cikj`wfb}iwp bssbps & _ds}dwk gni} `s wdobwmdm bs}ed oinm s}bkmbwm jiw sdwinio`cbn m`bokis`s+

Eidzdw. `}s sdks`}`z`}p `s nidw }ebk scwddk`koD@Bs+ N`kd `fftkibssbps `kciwqiwb}d zbwìts E@Zbk}òdks ik k`}wicdnntnisd s}w`qs+ ]ed`k}dwqwd}b}ìk ij wdstn}s `s s`f`nbw }i _ds}dwk gni}

`} `s fiwd sdks`}`zd bkm sqdc`j`c+


33/51

DN@SB jiw E@Z bk}`gimp

F`cwiqnb}d DN@SB jiw E@Z bk}`gimp8 cinitwdm dnns`km`cb}d wdbc}`z`}p


34/51

_ds}dwk gni} jiw E@Z bk}`gimp

]edwd bwd m`jjdwdk} cw`}dw`b jiw }ed`k}dwqwd}b}`ik ij E@Z _ds}dwk gni}wdstn}s d+o+ CMC. _EI. Bfdw`cbk Wdm

Cwiss+

]ed fis} `fqiw}bk} bk}`gim`ds bwd}eisd bob`ks} }ed dkzdniqdonpciqwi}d`ks oq271. oq2:1. bkmoq=2

q7= bk}`gimp `ststbnnp qwdsdk} gt}fbp gd bgsdk} `k }ed nb}dw s}bods ijE@Z `kjdc}`ik


35/51

I}edw m`bokis}`c bssbps

@} kiwfbnnp }blds =&: ddls gdjiwd E@Z&bk}`gimp bqqdbws

jinni`ko duqistwd+ B m`bokis`s ij E@Z `kjdc}ìk fbmd gd fbmd dbwn`dw gp }ed

md}dc}ìk ij E@Z bk}òdk. qwi&MKB. bkm WKB+

Eidzdw. }edwd bwd zdwp jd c`wctfs}bkcds edk }e`s `shts}`j`dm d+o+ m`bokis`s ij E@Z `kjdc}ìk `k gbg`ds giwk }iE@Z&`kjdc}dm fi}edws+


36/51

Qwiokis}`c }ds}s

Ikcd b m`bokis`s ij E@Z `kjdc}ìk ebm gddk fbmd. `} `s`fqiw}bk} }i fik`}iw }ed qb}`dk} b} wdotnbwnp jiw sòks ijm`sdbsd qwiowdssìk bkm wdsqiksd }i bk}`z`wbn cedfi}edwbqp+


37/51

Qwiokis}`c }ds}s

E@Z z`wbn nibm & E@Z z`wbn nibm `k sdwtf fbp gd fdbstwdm gpbssbps e`ce md}dc} E@Z&WKB d+o+ W]&QCW. KBSGB. iw gMKB+E@Z z`wbn nibm ebs ki gddk ds}bgn`sedm bs ebz`ko oiim

qwiokis}`c zbntd. bkm `k fik`}iw`ko wdsqiksd }i bk}`z`wbncedfi}edwbqp+

E@Z Bk}òdk }ds}s & }edp dwd `mdnp tsdm bs qwiokis}`cbssbps+ @} bs siik bqqbwdk} }eb} md}dc}ìk ij E@Z q7=bk}òdk bs ki} bs oiim bs sdw`bn CM= citk}s+ ]ed tsd ij E@Zq7= bk}òdk bssbps jiw qwiokis`s ebs ki gddk stqdwsdmdmgp E@Z&WKB bssbps+


38/51

Cn`k`cbn Fbk`jds}b}ìks

Jb}òtd

Jdzdw bkm kòe} sdb}s _}+ Niss

Odkdwbn`xdm npfqebmdkiqb}ep

SIG

Kik&qwimtc}`zd citoe


39/51

Cn`k`cbn Fbk`jds}b}ìks

Sl`k ndsìks. mwp sl`k. bkm qbnniw

Obs}wi`k}ds}`kbn tqsd} bkm cewik`c m`bwwedb

Dmdfb

Z`stbn `fqb`wfdk}

Qb`kjtn iwbn ndsìks

Dbsp gwt`s`ko bkm `kcwdbsd w`sl jiw gnddm`ko Hi`k} qb`ks


40/51

@K]DWZDK]@IKS JIW CN@DK]S _@]EE@Z)B@MS BKM I]EDW

@FFTKIMDJ@C@DKC@DS


41/51

Mwto ]edwbqp

Sifd fdm`cb}ìks ebzd mdfiks}wb}dm bk}`wd}wiz`wbndjjdc}s< eidzdw. bk}`wd}wiz`wbn }edwbqp iknp `ke`g`}s z`wbn

wdqn`cb}ìk bkm mids ki} l`nn }ed z`wts+ Ktcndis`md bkbnio wdzdwsd }wbkscw`q}bsd `ke`g`}iws

X`miztm`kd %BX]) bs }ed j`ws} bk}`&z`wbn bodk} seik }i ebzd gdkdj`c`bn djjdc} bob`ks} E@Z `kjdc}ìk+Eidzdw. bj}dw qwinikodm tsd. BX]&wds`s}bk} s}wb`ks wbq`mnp bqqdbws e`ce n`f`}s }ed djjdc} ij BX]+

%Cik}`ktdm)


42/51

Mwto ]edwbqp %Cik}`ktdm)

Kik&ktcndi}`md bkbnio wdzdwsd }wbkscw`q}bsd

`ke`g`}iws Qwi}dbsd `ke`g`}iws

Jts`ik `ke`g`}iws

@fftkd dkebkcdfdk}


43/51


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45/51


46/51

Ktws`ko Fbkbodfdk}

Bssdssfdk}

E`s}iwp

Qeps`cbn bssdssfdk} bkm cn`k`cbn fbk`jds}b}ìks

@kjdc}ìks8 iqqiw}tk`s}`c. qwi}ixibn. jtkobn. gbc}dw`bn. z`wbn

Fbnòkbkc`ds8 Lbqis`s sbwcifb. fbnòkbk} npfqeifbs

Dkmicw`kd cifqn`cb}ìks

Kdtwinio`c m`siwmdws d+o+ B@MS mdn`w`tf cifqndu


47/51

Ktws`ko Fbkbodfdk}

Bnni cn`dk} }i duqwdss jddn`kos ij jdbw bkm bku`d}p

@k B@MS icctws. qnbcd cn`dk} `k wdzdwsd `sinb}ìk ]wdb} spfq}ifb}`cbnnp

Qwdzdk} }ed icctwwdkcd ij qwdhtm`cd

Igsdwzd jiw sòks ij `kjdc}ìk

Fb`k}b`k sl`k `k}dow`}p


48/51

Ktws`ko Fbkbodfdk}

Qwifi}d kiwfbn gidn fizdfdk}

]dbce dkdwop ciksdwzb}`ik }dcek`rtds B`m `k sinz`ko fdk}bn s}b}ts qwigndfs

Ednq fb`k}b`k kt}w`}`ikbn s}b}ts

Qwifi}d iq}`fbn b`wbp cndbwbkcd


49/51

Edbn}e Qwifi}`ik bkm @nnkdss Qwdzdk}`ik 'fbld cbwdjtn cei`cds bgit} sdutbn bc}`z`}p.

cifftk`cb}d bssdw}`zdnp `}e pitw sdutbn qbw}kdw

bkm kdoi}`b}d jiw sbjdw sdutbn qwbc}`cds. wdfizd bnciein bkm mwtos jwif sdutbn bc}`z`}p.' bkm

'tsd nb}du cikmifs jiw `k}dwcitwsd'%BCEB. 7112)+


50/51

Edbn}e Qwifi}ìk bkm @nnkdss Qwdzdk}ìk

Dmtcb}ìk `s }ed gds} eiqd jiw qwdzdk}ìk+

E@Z `s }wbksf`}}dm fis} ij}dk `k }ewdd bps8 Sdutbn

Qbwdk}dwbn

Qdw`kb}bn


51/51

]wbksf`ssìk bkm Edbn}e Cbwd _iwldws

Kddmnd s}`cl iw sebwqs `khtw`ds bwd }ed qw`fbwp fdbksij E@Z `kjdc}ìk jiw edbn}e cbwd iwldws+

_iwldws cbk bnsi gd `kjdc}dm }ewitoe duqistwd ij kik&`k}bc} sl`k bkm ftcits fdfgwbkds }i gniim bkm gimpjnt`ms+

]ed gds} qwdzdk}ìk jiw edbn}e cbwd qwiz`mdws `s }ed

ciks`s}dk} tsd ij s}bkmbwm qwdcbt}ìks jiw bnn cn`dk}s bswdciffdkmdm gp }ed CMC+

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Immune Deficinecy