Name : Lie Khie Chen

Birth : Jakarta

Graduates

MD : FMUI 1994

Internist : FMUI 2003

Consultant : FMUI 2006

PhD : FMUI 2014

Occupation

Internal Medicine Department

Tropical Medicine and Infectious Diseases Division

Interest

Sepsis

Antimicrobial Treatment

Antimicrobial Resistance

Fungal Infection

HIV and opportunistic infections

Curriculum Vitae

Workshop PIN PAPDI 2014

Diagnosis dan Penatalaksanaan

Sepsis

Khie Chen

Tropical Medicine and Infectious Disease Division

Internal Medicine Department

Medical Faculty University of Indonesia

SepsisClinical syndrome

Host responseto infection

Systemicprocess

Multi organ system affected

Konsep Disfungsi dan Gagal Organ pada Sepsis

The Major Networks of

the Host Response

Following Microbial

Challenge by PAMPs

(Pathogen Associated

Molecular Patterns) or

Tissue Injury by DAMPs

(Danger Associated

Molecular Patterns)

Definisi Sepsis

SCCM/ESICM/ACCP/ATS/SIS 2001

Infeksi : terdokumentasiataususpek

Parameter umum:Suhu(temperatur rectal/ core>38,3oC)

Hipotermia (temperatur rektal/core90x/ menit atau

>2SD diatasnilai normal menurut umur

Takipnu >30x/ menit

Perubahanstatus mental/kesadaran

Edema ataubalancairan positif (>20ml/kg/24jam)

Hiperglikemia (glukosaplasma>110 mg/dl) tanpadiabetes

Parameter inflamasi: Lekositosis(Lekosit>12.000/ul)

Lekopenia(Lekosit10%

PeningkatanCRP > 2SD nilainormal

PeningkatanPCT > 2SD nilainormal

Parameter hemodinamik:Hipotensiarterial

(tekanansistolik70%

Indekskardiak>3.5 l/menit/m2

Levy MM, Fink MF, Marshall JC, et al. 2001

SCCM/ESICM/ACCP/ATS/SIS international sepsis definition

confrences. Intensive Care Med 2003; 29: 530-8.