Upload
felix-norris
View
221
Download
3
Embed Size (px)
Citation preview
Neuropsychological Functions Neuropsychological Functions of the prefrontal cortexof the prefrontal cortex
김홍근대구대학교 재활심리학과
OverviewOverview
Prefrontal executive functionPrefrontal executive functionRegional prefrontal syndromesRegional prefrontal syndromesNeuropsychological assessment Neuropsychological assessment
of prefrontal syndromesof prefrontal syndromes
The prefrontal lobe as “the seat of the The prefrontal lobe as “the seat of the highest human mentality”highest human mentality”
Phylogenetic perspectivePhylogenetic perspectiveOntogenetic perspectiveOntogenetic perspectiveAnatomical perspectiveAnatomical perspectiveNeuropsychological perspectiveNeuropsychological perspective
Phylogenetic perspective: Phylogenetic perspective: Species differences in prefrontal cortexSpecies differences in prefrontal cortex
Ontogenetic perspective:Ontogenetic perspective:Late maturation of prefrontal cortexLate maturation of prefrontal cortex
3333
33
22
22
2211
11
11
( 출처 : 연세의대 신경해부학 / 조직학 website)
Anatomical perspective: Anatomical perspective: Extensive prefrontal lobe connectionsExtensive prefrontal lobe connections
( 출처 : 연세의대 신경해부학 / 조직학 website)
Neuropsychological perspective:Neuropsychological perspective:Phineas Gage Phineas Gage (accident in 1848)(accident in 1848)
( 출처 : 연세의대 신경해부학 / 조직학 website)
Prefrontal function: Prefrontal function: Early descriptionsEarly descriptions
Personality (Harlow, 1868)Personality (Harlow, 1868)Abstract attitude (Goldstein, 1927)Abstract attitude (Goldstein, 1927)Mental set (Jacobsen, 1935)Mental set (Jacobsen, 1935)Self-regulation (Luria, 1962)Self-regulation (Luria, 1962)Concept formation (Milner, 1964)Concept formation (Milner, 1964)
Prefrontal function: Prefrontal function: Recent descriptionsRecent descriptions
Supervisory mental processSupervisory mental processCognitive flexibilityCognitive flexibilityMeta-cognitionMeta-cognitionGoal-directed behaviorGoal-directed behaviorExecutive functionExecutive function
An example of an executiveAn example of an executive
A model of prefrontal executive functionA model of prefrontal executive function
Memory
Attention
Language Spatial PrExecutive
Function
The regional prefrontal syndromesThe regional prefrontal syndromes(Cummings, 1985)(Cummings, 1985)
Dorsolateral Orbitofrontal
Mesial frontal
Core hypothesesCore hypotheses
Anatomical
area
Function Syndrometype
DorsolateralDorsolateral CognitionCognition DisorganizedDisorganized
OrbitofrontalOrbitofrontal EmotionEmotion Disinhibited Disinhibited
Mesial frontalMesial frontal MotivationMotivation Apathetic Apathetic
Dorsolateral syndromeDorsolateral syndrome(Disorganized type)(Disorganized type)
Poor judgmentPoor judgmentConcrete thinkingConcrete thinkingLack of insightLack of insightPoor planningPoor planningcognitive cognitive
inflexibilityinflexibility
Orbitofrontal syndromeOrbitofrontal syndrome (Disinhibited type)(Disinhibited type)
Social misbehaviorSocial misbehaviorPoor impulse controlPoor impulse controlEmotional labilityEmotional labilityHypersexualityHypersexualityStimulus-driven Stimulus-driven
behaviorbehavior
Mesial frontal syndromeMesial frontal syndrome (Apathetic type)(Apathetic type)
Poor initiativePoor initiativeDiminished verbal Diminished verbal
output & motor output & motor behaviorbehavior
Akinetic mutismAkinetic mutismUrinary incontinenceUrinary incontinence
Neuropsychological assessment of Neuropsychological assessment of prefrontal syndromes: Overviewprefrontal syndromes: Overview
WAIS: Poor sensitivityWAIS: Poor sensitivityMMPI: Poor response validityMMPI: Poor response validitySpecialized tests are neededSpecialized tests are neededEXIT (EXecutive Intelligence Test)EXIT (EXecutive Intelligence Test)
(Kim, 2001)(Kim, 2001)
EXIT (EXecutive Intelligence Test) EXIT (EXecutive Intelligence Test)
NormNorm 16~19, 20~24, 25~34, 16~19, 20~24, 25~34, 35~44, 45~54, 55~64 yrs35~44, 45~54, 55~64 yrs
Adm timeAdm time 25 minutes25 minutesScoreScore EIQ (Executive IQ)EIQ (Executive IQ)SubtestsSubtestsStroop testStroop test
Verbal fluency Verbal fluency Design fluencyDesign fluencyRey AVLTRey AVLT
Stroop testStroop test
파랑 노랑 빨강 검정
빨강 검정 파랑 노랑
노랑 빨강 파랑 검정
Verbal fluencyVerbal fluency
사람 사모사랑하는 감정
사랑하니까 사랑사랑 사주 팔자
사과 나무 사과사춘기
사람 사주사랑이 불타는 나무
Design fluencyDesign fluency
Rey AVLTRey AVLT
RecallRecall
내가 불러 줬던 내가 불러 줬던 단어들을 단어들을 기억해서 기억해서 말하시오말하시오
RecognitionRecognition
내가 불러 줬던 내가 불러 줬던 단어들을 다음 단어들을 다음 에서 고르시오에서 고르시오
Core features of EXIT as Core features of EXIT as a psychometric instrumenta psychometric instrument
Multi-task approachMulti-task approachUnstructured testingUnstructured testingUse of control testsUse of control testsQualitative scoringQualitative scoringNormative M=100, SD=15Normative M=100, SD=15
The rationale for prefrontal pathology The rationale for prefrontal pathology in schizophreniain schizophrenia
Disorganized thinking, speech, Disorganized thinking, speech, & behavior& behavior
Disordered dopamine systemsDisordered dopamine systemsPrefrontal metabolic deficitPrefrontal metabolic deficit
A validity study of EXITA validity study of EXIT
SampleSample Schizophrenic pts: n=45Schizophrenic pts: n=45
Normal controls: n=27Normal controls: n=27MeasureMeasure WAIS: VIQ, PIQ, FIQ WAIS: VIQ, PIQ, FIQ
EXIT: EIQEXIT: EIQHypothesisHypothesis Largest group-difference Largest group-difference
in EIQin EIQ
Schizophrenic pts vs Normal controlsSchizophrenic pts vs Normal controls
70
80
90
100
110
VIQ PIQ FIQ EIQ
NormalsSchizos
Case 1: Frontal head injuryCase 1: Frontal head injury
10399 101
56
50
60
70
80
90
100
110
VIQ PIQ FIQ EIQ
Male, 29 yrsMale, 29 yrsPolicemanPolicemanCar accident Car accident
6 months ago6 months agoPersonality Personality
deterioration deteriorationDisorganized Disorganized behavior behavior
Case 2: Parkinson’s diseaseCase 2: Parkinson’s disease
99 100 100
73
60
70
80
90
100
110
VIQ PIQ FIQ EIQ
Female, 63 yrsFemale, 63 yrsHousewifeHousewifeParkinson-like Parkinson-like
symptom onset: symptom onset: 3.5 yrs ago3.5 yrs ago
Progressive Progressive deteriorationdeterioration
Case 3: Korsakoff’s diseaseCase 3: Korsakoff’s disease
91
8387
49
40
50
60
70
80
90
100
VIQ PIQ FIQ EIQ
Female, 39 yrsFemale, 39 yrsHousewifeHousewifeHeavy alcohol Heavy alcohol
ingestion ingestion during last 4 yrsduring last 4 yrs
Physical weaknessPhysical weaknessMental confusionMental confusion
Case 4: Carbon monoxide poisoningCase 4: Carbon monoxide poisoning
94 92 93
49
40
50
60
70
80
90
100
VIQ PIQ FIQ EIQ
Male, 36 yrsMale, 36 yrsUnemployedUnemployedHeart attack Heart attack
6 months ago6 months agoRestlessnessRestlessness
Stimulus-driven Stimulus-driven behavior behavior
SummarySummary
Prefrontal lobe as the central Prefrontal lobe as the central executiveexecutive
3 types of regional prefrontal 3 types of regional prefrontal syndromessyndromes
EXIT (EXecutive Intelligence Test)EXIT (EXecutive Intelligence Test)