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Events,. Events,. %. Authors. OR (95% CI). RR (95% CI). Treatment. Cases. Control. Weight. Aggerholm et al., 2008. 1.05 (0.17, 6.65). 1.05 (0.17, 6.65). 1/8. 1/8. 103/868. 1.37. Braga et al., 2012. 0.50 (0.09, 2.92). 0.50 (0.09, 2.92). 1/5. 1/5. 50/125. 1.49. - PowerPoint PPT Presentation
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Overall (I-squared = 2.0%, p = 0.426)
Hammiche et al., 2012
Duits et al., 2009
Authors
Ramlau-Hansen et al., 2009
Jensen et al., 2004
Shayeb et al., 2011
Aggerholm et al., 2008
Koloszar et al., 2005 & Fejes et al., 2005 & Fejes et al., 2006
Li et al., 2009
Lévy et al., unpublished
Keltz et al., 2010 & Relwani et al., 2011
Vujkovic et al., 2009 & Hammiche et al., 2011
Eskandar et al., 2012
Braga et al., 2012
1.15 (0.93, 1.43)
0.57 (0.10, 3.31)
0.81 (0.13, 4.85)
RR (95% CI)
1.40 (0.52, 3.76)
0.94 (0.69, 1.30)
0.35 (0.05, 2.34)
1.05 (0.17, 6.65)
1.64 (1.01, 2.66)
0.82 (0.37, 1.82)
1.96 (0.87, 4.42)
1.70 (0.71, 4.06)
0.34 (0.03, 4.30)
1.49 (0.70, 3.18)
0.50 (0.09, 2.92)
65/288
1/5
1/6
Treatment
3/10
23/55
1/17
1/8
13/30
6/92
2/3
1/1
0/2
12/54
Events,
1/5
1363/5687
54/153
137/662
Control
40/187
533/1204
136/802
103/868
42/159
79/991
111/326
18/41
50/102
10/67
Events,
50/125
100.00
1.49
1.44
Weight
4.75
40.61
1.28
1.37
18.81
7.12
6.91
6.07
0.72
7.93
%
1.49
1.15 (0.93, 1.43)
0.57 (0.10, 3.31)
0.81 (0.13, 4.85)
OR (95% CI)
1.40 (0.52, 3.76)
0.94 (0.69, 1.30)
0.35 (0.05, 2.34)
1.05 (0.17, 6.65)
1.64 (1.01, 2.66)
0.82 (0.37, 1.82)
1.96 (0.87, 4.42)
1.70 (0.71, 4.06)
0.34 (0.03, 4.30)
1.49 (0.70, 3.18)
0.50 (0.09, 2.92)
65/288
1/5
1/6
Cases
3/10
23/55
1/17
1/8
13/30
6/92
2/3
1/1
0/2
12/54
1/5
Lower prevalence in underweight Higher prevalence in underweight
1.0269 1 37.2
Overall (I-squared = 41.6%, p = 0.024)
Lévy et al., unpublished
La Vignera et al., 2012
Tunc et al., 2011
Vujkovic et al., 2009 & Hammiche et al., 2011
Koloszar et al., 2005 & Fejes et al., 2005 & Fejes et al., 2006
Eskandar et al., 2012
Lotti et al., 2011
Ramlau-Hansen et al., 2009
Chavarro et al., 2009
Shayeb et al., 2011
Keltz et al., 2010 & Relwani et al., 2011
Hammiche et al., 2012
Authors
Jensen et al., 2004
Duits et al., 2009
Eskenazi et al., 2003
Braga et al., 2012
Magnusdottir et al., 2005
Zorn et al., 2007 & Zorn et al., 2012
Li et al., 2009
Aggerholm et al., 2008
Martini et al., 2010
1.11 (1.01, 1.21)
1.15 (0.93, 1.42)
3.00 (1.65, 5.46)
2.46 (0.79, 7.66)
0.66 (0.47, 0.93)
1.11 (0.78, 1.59)
1.06 (0.52, 2.15)
1.06 (0.85, 1.33)
0.91 (0.48, 1.75)
1.20 (0.61, 2.36)
1.10 (0.89, 1.35)
0.99 (0.65, 1.51)
1.24 (0.96, 1.61)
RR (95% CI)
1.16 (1.01, 1.33)
1.09 (0.88, 1.34)
2.39 (0.89, 6.43)
0.65 (0.44, 0.96)
0.81 (0.30, 2.22)
1.14 (0.71, 1.84)
1.36 (0.90, 2.08)
1.18 (0.91, 1.53)
1.10 (0.95, 1.28)
1285/4649
109/279
30/50
13/37
33/102
45/153
19/120
45/71
9/46
25/233
164/883
38/87
97/221
Treatment
123/240
132/587
10/41
26/100
6/32
Events,
25/79
26/239
92/657
218/392
1623/6416
111/326
10/50
3/21
50/102
42/159
10/67
78/131
40/187
11/123
136/802
18/41
54/153
Control
533/1204
137/662
5/49
50/125
6/26
Events,
23/83
79/991
103/868
124/246
100.00
8.22
2.06
0.64
4.83
4.58
1.55
7.72
1.80
1.67
8.37
3.64
6.69
Weight
10.81
8.19
0.83
3.99
0.80
%
3.01
3.64
6.67
10.30
1.11 (1.01, 1.21)
1.15 (0.93, 1.42)
3.00 (1.65, 5.46)
2.46 (0.79, 7.66)
0.66 (0.47, 0.93)
1.11 (0.78, 1.59)
1.06 (0.52, 2.15)
1.06 (0.85, 1.33)
0.91 (0.48, 1.75)
1.20 (0.61, 2.36)
1.10 (0.89, 1.35)
0.99 (0.65, 1.51)
1.24 (0.96, 1.61)
OR (95% CI)
1.16 (1.01, 1.33)
1.09 (0.88, 1.34)
2.39 (0.89, 6.43)
0.65 (0.44, 0.96)
0.81 (0.30, 2.22)
1.14 (0.71, 1.84)
1.36 (0.90, 2.08)
1.18 (0.91, 1.53)
1.10 (0.95, 1.28)
1285/4649
109/279
30/50
13/37
33/102
45/153
19/120
45/71
9/46
25/233
164/883
38/87
97/221
Cases
123/240
132/587
10/41
26/100
6/32
25/79
26/239
92/657
218/392
Lower prevalence in overweight Higher prevalence in overweight
1.131 1 7.66
Overall (I-squared = 70.6%, p = 0.000)
Braga et al., 2012
Shayeb et al., 2011
Aggerholm et al., 2008
Vujkovic et al., 2009 & Hammiche et al., 2011
Martini et al., 2010
Chavarro et al., 2009
Zorn et al., 2007 & Zorn et al., 2012
Koloszar et al., 2005 & Fejes et al., 2005 & Fejes et al., 2006
Duits et al., 2009
Jensen et al., 2004
Li et al., 2009
Eskandar et al., 2012
Keltz et al., 2010 & Relwani et al., 2011
Tunc et al., 2011
Magnusdottir et al., 2005
La Vignera et al., 2012
Authors
Lotti et al., 2011
Lévy et al., unpublished
Ramlau-Hansen et al., 2009
Hammiche et al., 2012
Eskenazi et al., 2003
1.28 (1.06, 1.55)
0.50 (0.14, 1.76)
1.22 (0.92, 1.63)
0.62 (0.33, 1.16)
0.97 (0.58, 1.62)
1.11 (0.92, 1.35)
1.26 (0.59, 2.71)
2.14 (1.34, 3.41)
1.67 (1.19, 2.35)
2.24 (1.77, 2.83)
1.15 (0.88, 1.49)
1.57 (0.42, 5.83)
1.06 (0.53, 2.12)
1.05 (0.67, 1.65)
2.13 (0.63, 7.19)
3.94 (1.91, 8.14)
2.50 (1.32, 4.72)
RR (95% CI)
0.50 (0.25, 1.00)
0.88 (0.62, 1.23)
0.88 (0.30, 2.52)
1.29 (0.92, 1.81)
1.40 (0.19, 10.30)
476/1480
2/10
51/246
10/135
9/19
82/146
13/115
16/27
46/104
63/136
29/57
2/16
21/133
25/54
7/23
10/11
20/40
Treatment
6/20
29/97
3/16
31/68
1/7
Events,
1623/6416
50/125
136/802
103/868
50/102
124/246
11/123
23/83
42/159
137/662
533/1204
79/991
10/67
18/41
3/21
6/26
10/50
Control
78/131
111/326
40/187
54/153
5/49
Events,
100.00
1.81
7.17
4.47
5.28
7.91
3.61
5.65
6.76
7.60
7.38
1.69
4.01
5.80
1.90
3.81
4.39
Weight
4.07
6.74
2.35
6.77
0.82
%
1.28 (1.06, 1.55)
0.50 (0.14, 1.76)
1.22 (0.92, 1.63)
0.62 (0.33, 1.16)
0.97 (0.58, 1.62)
1.11 (0.92, 1.35)
1.26 (0.59, 2.71)
2.14 (1.34, 3.41)
1.67 (1.19, 2.35)
2.24 (1.77, 2.83)
1.15 (0.88, 1.49)
1.57 (0.42, 5.83)
1.06 (0.53, 2.12)
1.05 (0.67, 1.65)
2.13 (0.63, 7.19)
3.94 (1.91, 8.14)
2.50 (1.32, 4.72)
OR (95% CI)
0.50 (0.25, 1.00)
0.88 (0.62, 1.23)
0.88 (0.30, 2.52)
1.29 (0.92, 1.81)
1.40 (0.19, 10.30)
476/1480
2/10
51/246
10/135
9/19
82/146
13/115
16/27
46/104
63/136
29/57
2/16
21/133
25/54
7/23
10/11
20/40
Cases
6/20
29/97
3/16
31/68
1/7
Lower prevalence in obese Higher prevalence in obese
1.0971 1 10.3
Overall (I-squared = 42.7%, p = 0.046)
Lévy et al., unpublished
Eskandar et al., 2012
Authors
Hammiche et al., 2012
Braga et al., 2012
Koloszar et al., 2005 & Fejes et al., 2005 & Fejes et al., 2006
Magnusdottir et al., 2005
Martini et al., 2010
Duits et al., 2009
Jensen et al., 2004
La Vignera et al., 2012
Shayeb et al., 2011
Keltz et al., 2010 & Relwani et al., 2011
Aggerholm et al., 2008
Chavarro et al., 2009
2.04 (1.59, 2.62)
1.47 (0.82, 2.64)
4.79 (2.67, 8.57)
RR (95% CI)
1.42 (0.35, 5.76)
1.75 (1.11, 2.77)
2.38 (1.62, 3.52)
0.52 (0.04, 7.56)
1.88 (1.56, 2.28)
0.48 (0.07, 3.12)
1.13 (0.28, 4.52)
3.00 (1.42, 6.35)
1.97 (1.00, 3.85)
1.14 (0.27, 4.75)
2.10 (0.19, 23.31)
2.80 (0.90, 8.66)
148/244
6/12
90/126
Treatment
1/2
7/10
17/27
0/3
9/9
1/10
1/2
6/10
6/18
1/2
Events,
0/1
3/12
1345/4852
111/326
10/67
Control
54/153
50/125
42/159
6/26
124/246
137/662
533/1204
10/50
136/802
18/41
Events,
103/868
11/123
100.00
10.12
10.18
Weight
2.79
12.88
14.69
0.84
20.18
1.66
2.84
7.45
8.62
2.70
%
1.03
4.02
2.04 (1.59, 2.62)
1.47 (0.82, 2.64)
4.79 (2.67, 8.57)
OR (95% CI)
1.42 (0.35, 5.76)
1.75 (1.11, 2.77)
2.38 (1.62, 3.52)
0.52 (0.04, 7.56)
1.88 (1.56, 2.28)
0.48 (0.07, 3.12)
1.13 (0.28, 4.52)
3.00 (1.42, 6.35)
1.97 (1.00, 3.85)
1.14 (0.27, 4.75)
2.10 (0.19, 23.31)
2.80 (0.90, 8.66)
148/244
6/12
90/126
Cases
1/2
7/10
17/27
0/3
9/9
1/10
1/2
6/10
6/18
1/2
0/1
3/12
Lower prevalence in morbid obese Higher prevalence in morbid obese
1.0357 1 28
.
.
Overall (I-squared = 55.1%, p = 0.001)
Martini et al., 2010
Subtotal (I-squared = 55.8%, p = 0.004)
Lévy et al., unpublished
Authors
Aggerholm et al., 2008
Subtotal (I-squared = 58.9%, p = 0.033)
La Vignera et al., 2012
Zorn et al., 2007 & Zorn et al., 2012
Infertile population
Vujkovic et al., 2009 & Hammiche et al., 2011
Eskandar et al., 2012
Chavarro et al., 2009
Tunc et al., 2011
General population
Jensen et al., 2004
Li et al., 2009
Koloszar et al., 2005 & Fejes et al., 2005 & Fejes et al., 2006
Keltz et al., 2010 & Relwani et al., 2011
Shayeb et al., 2011
Magnusdottir et al., 2005
Eskenazi et al., 2003
Ramlau-Hansen et al., 2009
Braga et al., 2012
Lotti et al., 2011
Duits et al., 2009
Hammiche et al., 2012
1.17 (1.06, 1.29)
1.12 (0.97, 1.29)
1.13 (1.01, 1.27)
1.09 (0.89, 1.33)
RR (95% CI)
1.08 (0.84, 1.40)
1.30 (1.03, 1.65)
2.80 (1.57, 5.01)
1.40 (0.92, 2.13)
0.71 (0.52, 0.97)
2.30 (1.28, 4.14)
1.27 (0.68, 2.40)
2.33 (0.77, 7.06)
1.16 (1.02, 1.31)
1.38 (0.92, 2.07)
1.44 (1.07, 1.94)
1.02 (0.69, 1.51)
1.14 (0.94, 1.38)
1.51 (0.67, 3.37)
2.25 (0.84, 5.98)
0.90 (0.51, 1.61)
0.73 (0.51, 1.04)
0.94 (0.75, 1.19)
1.29 (1.07, 1.56)
1.26 (0.98, 1.61)
1909/6373
309/547
1547/4816
144/388
Treatment
102/793
362/1557
56/100
41/106
42/121
130/379
41/360
20/60
153/299
28/255
108/284
64/143
221/1147
16/46
11/48
12/62
35/120
51/91
196/733
129/291
Events,
1623/6416
124/246
853/3067
111/326
Control
103/868
770/3349
10/50
23/83
50/102
10/67
11/123
3/21
533/1204
79/991
42/159
18/41
136/802
6/26
5/49
40/187
50/125
78/131
137/662
54/153
Events,
100.00
8.89
74.93
7.61
Weight
6.34
25.07
2.32
3.69
5.23
2.27
2.02
0.76
9.26
3.85
5.51
4.08
7.73
1.34
0.95
2.34
4.63
6.90
7.79
6.47
%
1.17 (1.06, 1.29)
1.12 (0.97, 1.29)
1.13 (1.01, 1.27)
1.09 (0.89, 1.33)
OR (95% CI)
1.08 (0.84, 1.40)
1.30 (1.03, 1.65)
2.80 (1.57, 5.01)
1.40 (0.92, 2.13)
0.71 (0.52, 0.97)
2.30 (1.28, 4.14)
1.27 (0.68, 2.40)
2.33 (0.77, 7.06)
1.16 (1.02, 1.31)
1.38 (0.92, 2.07)
1.44 (1.07, 1.94)
1.02 (0.69, 1.51)
1.14 (0.94, 1.38)
1.51 (0.67, 3.37)
2.25 (0.84, 5.98)
0.90 (0.51, 1.61)
0.73 (0.51, 1.04)
0.94 (0.75, 1.19)
1.29 (1.07, 1.56)
1.26 (0.98, 1.61)
1909/6373
309/547
1547/4816
144/388
Cases
102/793
362/1557
56/100
41/106
42/121
130/379
41/360
20/60
153/299
28/255
108/284
64/143
221/1147
16/46
11/48
12/62
35/120
51/91
196/733
129/291
Lower prevalence in abnormal weight Higher prevalence in in abnormal weight 1.142 1 7.06
