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8/17/2019 Patologi Mata
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PATOLOGI MATA
Fairuz, dr, SpPA
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Anatomi dan Histologi
Kelopak mata (eyelids)
- Cutaneous dan conjunctial
- epitel gepeng !erlapis dan epitel konjuntia yang le!i"
tipis
- kelenjar se!asea (#eis n $ei!om), kelenjar apokrin
($oll) an kelenjar ekrin %ola mata
- ocular glo!e, dan kelenjar air mata
- Konjungtia, kornea, sklera, intraocular
tissue & iris, ciliar !ody, c"oroid, retina, lensa cairanitreous
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KELOPAK MATA (EYELID)
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Chalazion
Se!aceous glands o' eyelid, eit"er
mei!omian glands (deep type) or #eis
glands (super'icial type)
A non-speci'ic response to o!struction o't"ese se!aceous glands Causes
include in'ection and tumor
ipogranulomatous in'lammation *it"lipid drop-out spaces
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Chalazion
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KELENJAR AIR MATA
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+AC.CS/0/0S
Canaculitis
+apat dise!a!kan karena proses in'eksi di
jaringan sekitar seperti konjungtia, "idung Purulen e1udate
Kronis & pene!alan dinding sal acrimal
+AC.0/H0AS0S Karena proses in'lamatory
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+AC.A+230/0S
All ages
acrimal gland
C"ronic in'lammatory cells in'iltration
$ay "ae 'ollicles $ay !e
granulomatous Sometimes may !e
di''icult to distinguis" 'rom lymp"oma
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$0K40C#5S disease
C"ronic dacryoadenitis disertai
pem!esaran kelenjar parotis dan
kelenjar liur lain %enign lymp"oepit"elial lesion
%ila disertai dengan kegagalan sekresi
kelnjar lacrimal dan conjunctial sertakeratokonjungtiitis sicca Sjogren5
syndrome
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Konjungtiva
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Pingueula
+egeneratie process in su!epit"elial
connectie tissue o' !ul!ar conjunctia
Pro!a!ly related to sun e1posure
Focal, yello*is"-gray, raised mass 2lastotic degeneration o' collagen in
su!stantia propria Possi!ly 'oreign !ody giant
cell response (actinic granuloma) Calci'ication
may occur in older lesions C"eck 'or dysplasiaor s6uamous carcinoma in oerlying
epit"elium ule out elasto'i!roma
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Pingueula
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Pte!"giu#
21tend into t"e cornea
$icroscopically usually some actinic
elastosis , aria!le amount o' acute and
c"ronic in'lammation and congestion o'!lood essels
$ore important lesion t"an t"e
pinguecula
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/4$.
Papilloma
S6uamous cell carcinoma
$elanoma maligna
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Ke!atoonu$
Second or t"ird most common indication 'or
keratoplasty
4sually presents during adolescence
Centers o' corneas
2arly, t"inning and asymmetric ectasia o' corneal
stroma .'ten surrounded !y !ro*n ring o' iron deposit
(Fleisc"er7s ring) ater, posterior stromal striae and
possi!ly endot"elial rupture *it" stromal edema and
clouding 2arliest lig"t microscopic c"anges are discontinuities
o' %o*man7s layer, 'illed *it" eit"er epit"elial cells or
'i!ro!lasts 3e1t, stromal t"inning !ecomes o!ious
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Ke!atoonu$
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RETINO%LA&TOMA
$ost common intraocular neoplasm o'
c"ildren
4sually presents !et*een 89 mont"s
and : years Can !e !ilateral
A!out 8;< 'amilial (t"ese "ae
disproportionate s"are o' multi'ocalcases) Autosomal dominant
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S"eets o' neoplastic small round cells *it"
"yperc"romatic nuclei, scant cytoplasm
and many mitoses 4sually e1tensie areas
o' isc"emic necrosis and calci'ication *it"nuclear de!ris, sparing periascular
regions osettes "elp'ul to strengt"en
diagnosis !ut not al*ays seen osettes
occur as t*o types, Flexner-Winterstein*it" small lumen and Homer-Wright
(neuro!lastomatous) *it" central neuropil
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$alignant Poor prognostic 'eatures
include poor di''erentiation ('e*
rosettes), multi'ocality, large size, optic
nere and c"oroidal inasion anditreous seeding
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Retino'la$to#a
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Retinoblastoma