, (Cl.H), N.D , RH(AHG).. Email:yaniv@ranherbs.com

, . ("") (). , "" . , .

: . . . , . , .

: . . , . , , , . , .

. (), , . , , , , . , (), , .

, . , , . , - 50% p53 " ". , , . , , .

. - . , (). , , , , :

. . . . . . - .

: : . , , . .

():

, , () , . 1577 , .

1915-1918 , . - " 1" " 2", , . , , - ( ). , .

, -20 . () ( , ) . -50 , .

, ; "" .

. : , . , (). (P53) . , .

, , .

. . .

. , -23,000 . -120,000 . , . -60% . . . , .

, :

T ()

( )

()

( ) ' '

: () () () ()

. , () () (). , , .

, . () . , . , ( , ) (, , ). , . .

, () , . , .

. . (). , , .

: - . , . ( ), .

: . . ,

( ). , (Arsphenamine) -20 .

: (Nitrogen Mustard). , , . .

, 1940 . - , , , . . , , , .

: , ( , , ). , .

. - . . . . , .

: , , . (, , , ), . , , , . , .

: , , , . , , , . . , .

. . , , , .

: . - , , ( T CD8) . .

. (Tumor specific antigen) , , . - HER-2 .

( -. (Fv) , . ( ) .)

-: - , - . VEGF - Vascular Endothelial Growth Factor. .

- -70, , . 1996 - . 2004 () - VGEF.

, . - .

- . :- ( ).- - .- - . - -:

- :

Antioxidant . (ROS) .

-:Camellia sinensisSchizandra chinensis/Wu wei ziGanoderma lucidumCurcuma longa

Antitumour . . . .

:Larrea mexicanaPhytolacca decandraThuja occidentalisScutellaria barbata

Anti-inflammatory - . : ; ; ; . ; COX - LOX; ; ; .

- , , . .

() Alterative . , -. : , .

, , . .

- AlterativesTabebuia impetiginosaArctium lappa

Lymphatic . . (-) .

:Galium aparineIris versicolor

()1. : . , , .

2. - : , , -/ " .

3. /: . "", , (,), , .

1. - : , , , :

Astragalus membranaseus (1995) 115 ( ). . ' - 15 , , ' - 5 . 82.76% ' 47.37% '. .1

(2005) ( ) . 72 , . sFas, sFasL, TNF-? - IL-6 - .

( , ). , . , , , , .4

(2006) - (). 34 : - 12 (" 940 ) 12 ; - 30 (2472 ) . .5

Andrographis paniculatae (2007) Andrographolide . T , IL-2 -IFN- T .7,8

(2007) , Neoandrographolide, -. : NO - TNF-alfa " .9 iNOS -COX-2 , p38 10MAPK.

Withania somnifera 1980 -58 8-12 60 . . . .1

3 101 50-59 . , . (ESR). 71 .2

1985 . 100 mg\kg 8 . .3

1987 (Cyclophosphamide) .4

: 1967, 1970, 1976 .Withaferin A Carcinoma Human nasopharyngeal. - ascites Carcinoma cell Erlich.8-12

(2004) , ( ).5

.

Rhodiola rosea - 40 . , -. , . , , , , , .1

Eleutherococcus senticosus .(5) - 1987 Natural killer cells - T-helper cells .(6)

:Panax Ginseng,Atractylodes.

2. - :

Tabebuia impeteginosa - -60 . , .

Lapachol - , -, . Lapachol DNA , DNA . , .1

cell line HCT-116 - () -, , -. - NF-kappaB NF-kappaB-DNA . , - NF-kappaB.2

- Lapachol - , - . 1970 - - Chase Pfizer & Co. inc, Lapachol , "" , "-" .

" Lapachol , . , , 4.Lapachol

Arctium lappa (4 ), (0.5 "/ ). , , P-450, NADPH, , . .5

. 30 SOD ( ), . -MDA -Lipofuscin ( ) . , " ".6

, ( ), Arctigenin, , .7

: , ( ). (apoptosis). - Matairesinol, Arctigenin, Didehydroarctigenin , Arctigenin .8

, Arctigenin . . , (). .9

/ :

Larrea mexicana -, -, -, -, (), , \ , , (), , , , .

. , . (Lignans). (2006) ,Larrea divaricata 0.040.1 mg/l (Helicobacter pylori) clarithromycin - metronidazole.1

(2006) (Methanolic) L. divaricata - . - . - .2

(2005) Larrea tridentate . .4

(2007) NDGA E6 (VPH) . E6 p53 ( ) . E6 p53 .7

Phytolacca spp.

-, -, -, -, \ , , , (), , , .

Anemarrhena asphodeloides (2007) , , Sarsasapogenin. .

* ( ), . .

Scutellaria barbata-Ban zi lian

:-, ,-( ),.

: , ( ,),.

3.- /:

Ganoderma lucidum , . " (1999) Mao, T. el al : , , - .

(1999) Wang, S.Y. et al ' T." (2003) Gao, Y. et al , 1800 " 3 12 . (IL-2) Natural killer.1

(2004) 720 " 10 .4

Curcuma longa-Turmeric

-, , \ , (), (), , , \, , \ , , \ , , , .

: (OA), (IBD), ( ).

. , (Curcumin). , 97% . , - . , Lipoxygenase 5 - Cyclooxygenase.

, .2 (RA) 120 " .3 20 " -18 , 45 . (Lipid peroxide) .4

- . , : ; - ( ) ; (PKC), .5

, 6; - - , .7

Schisandra chinensis-Wu wei zi

, -, -, , , \ , .

-1996, AFLATOXIN B1 . E . .1

SCISANDRIN B (CC14) CARBON TERACHLORIDE. -SCISANDRIN B . . .2

(THA) TACRINE - SCISANDRIN B . TACRINE , .3

Camellia sinensis-Green tea . , , , , , . 6 , -1.5 .

. , . . , , . ". , . -16 , -17 . , .

. , , - . , . .

( ). : - : benzoic acid, carvacrol, chlorogenic acid, gallic acid, cinnamic acid, salicylic acid, thymol - (3.4-27%): epicatechin, epigallocatechin, epicatechin 3 gallate, epigallocatechin 3 gallate, catechin, gallocatechin, theogallin, trigalloyl glucose, epiafzelichin, tannic acid, thearubigin, theaflavin

: quercetin, quercitrin, kaempferol, apigenin, hyperoside, rutin, vitexin, astragalin, luteolin : procyanidin-B -2, prodelphinidin-A-2-3'-o-gallate : - : linalool, nerol, neral, citronellol, geraniol, gernial, citral, myrcene, ocimene - : , farnesol, 4-terpineolbeta-sesquiphellandrene - : , , - : -, , , ,

: (9-27%), (6.5%), (0.5%) : - caffeine (1-5%), theophylline, theobromine, theanine : : : C, B1, B2, B3, B5, ( (E, K : , , , , , , , , , , .

-, \ , , , , , , , . : ( ), ( ). : , , (), ().

-2003 \ . (1-6 ). , DNA . , .1

. () 18,244 45-64, 12 . 190 -42 . 772 -.2

2001 .3,4 , .5

13,916 40-69 86.7% . , - HDL .6 .7 .8

1. :PLM4DE Astragalus 150 mgDE Andrographis 100 mgDE Lonicera 50 mgDE Zingiber 50 mg: 0-3 , 3 2-5 Caps X 3-4

ONC2DE Ganoderma 100 mgDE Grifola (maitake) 100 mgDE Cordyceps 100 mgDE Glycyrrhiza(DGL) 20 mgDE Zingiber 30 mg: 1-3 , 3 ONC3DE Ganoderma lucidum 350 mg: 1-3 , 1-3

YU PING FENG SANHuang Qi - Astragalus membranaceus Fang Feng - Ledebouriella seseloides Bai Zhu - Atractylodes macrocephala

MUSHRUMS " "

Ganoderma-25%Cordyceps-15%Poriacoccus(Fu ling)-30%Polyporus(Zhu ling)-25%Zingiber-5%5-10cc *2

GAN RAN(SFF)

Ban lan genJin yin huaDa qing yeChuan xin lianBo heChai huSheng jiang

( ):

BU ZHONG YI QI TANG+BA ZHEN TANG

( ) Althaea r.1 X 3

Laxy syrup

FH10Pulv.Elettaria 150 mgDE Zingiber 100 mgDE Glycyrrhiza (DGL) 100 mg: 0-5 ,

2. :

- 1Cytotoximix Tinc. Larrea/Iris - 25%Tinc. Tabebuia - 30%Tinc.Scutellaria barbata-30%Tinc. Zingiber- 5%Ext.Glycyrrhiza-10%5-10cc X 4-5

2

-/ : ONC4FE scutellaria barbata 90%FE zingiber officinale 10% " 1:1 . : 5-10 " , .

2.ONC5FE Anemarrhena rhizome 80%FE Zingiber officinale 10%FE Atractylodes rhizome 10% " 1:1 . : 5-10 " , .

. . , , . () ().

:1. / .2. , .3. .

, ( ), , ' ( ) -.

: Galium-

, ' :PLM4ONC2/ONC3YU PING FENG SAN

' , ( ) 1:2 1:1

3. : ONC2DE Ganoderma 100 mgDE Grifola (maitake) 100 mgDE Cordyceps 100 mgDE Glycyrrhiza(DGL) 20 mgDE Zingiber 30 mg: 1-3 , 3

ONC3DE Ganoderma lucidum 350 mg

: 1-3 , 1-3

MUSHRUMS " "

Ganoderma-25%Cordyceps-15%Poriacoccus(Fu ling)-30%Polyporus(Zhu ling)-25%Zingiber-5%5-10cc *2

MTB7Comp.Curcuma longa mix (1:1): 5-10 ", 1-3 MTB8 ( )Comp. Curcuma longa caps (95%) - 1000 mg: 1-3 , . ONC1DE Camellia Sinensis(95%) 350 mg: 1-3 , 3

Comp.Curcuma longa(1:1) Liq-Ext.Curcuma longa(1:1)-95% Liq-Ext.Piper nigrum(1:1)-5%

5-10cc*2

:

1 .