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Biochemistry & medicine

introduction

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1 、 definition

Science concerned with

chemical basis of life

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Science concerned with

the chemical constituents

of living cells and with the

reaction and process that

they undergo

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2 、 The aim of biochemistry

Describe and explain in

molecular term

All chemical process of

living cell

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（ 1 ） major objective of

biochemistry

Complete understanding at the molecular level of all the chemical processes associated with

living cells

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determine

isolation

analyze

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(2) Further objective

Attempt to understand

how life began

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An appreciation of the biochemistry of less complex form of life is often direct relevance to human biochemistry

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3.knowledge of biochemistry is essential to all life science

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immunology

physiology

pharmacology

pathology

microbiology

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4 、 reciprocal relationship

between biochemistry &

medicine has stimulated

mutual advance

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* Biochemistry studies have

illuminated many aspects of

health & disease

* the study of various aspects of

health & disease has opened up

new areas of biochemistry

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biochemistry

Nucleic

acidprotein lipid Carbohydrates

Genetic

diseaseSickle cell anemia

medicine

arteriosclerosis Diabetes mellitus

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5. Normal biochemical

processes are the basis

of health

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Definition of health

“Complete physical,mental &

social well-being and not merely

the absence of disease and infirmity”

------WHO

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The situation in which all of the many

thousands of intra & extra cellular

reactions that occur in the body are

proceeding at the rates commensurate

with its maximal survival in the

physiological state

A strictly biochemistry viewpoint about health:

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6. Biochemical research has

impact on nutrition and

preventive medicine

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7. all disease has a

biochemical basis

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(1)physical agent:

mechanical trauma,

extremes of temperature,

sudden changes in atmospheric

pressure,

radiation,

electric shock

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(2)chemical agents:

drugs,

certain toxic compounds,

therapeutic drugs

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(3)biologic agents:

Viruses,

Bacteria,

Fungi,

Higher forms of parasites

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(4) oxygen lack

loss of blood supply,

depletion of the oxygen-carrying capacity

of the blood,

poisoning of the oxidative enzyme

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(5) genetic disorders:

Congenital , molecular

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(6) immunology reaction

Anaphylaxis,

Autoimmune disease

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(7) nutritional imbalances

Deficiencies,excesses

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(8) Endocrine imbalances

hormonal deficiencies,excesses

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8. Biochemical studies

contribute to

diagnosis, prognosis

& treatment

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Disease causes

scurvy deficiencies of vitamin

rickets C,D respectively

Arteriosclerosis genetic,dietary

environment factors

Phenylketonuria mainly mutation in

the gene coding

phenylalanine hydroxylase

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Disease causesCystic fibrosis mutation in the gene

coding the CFTR

proteinCholera exotoxin of

vibrio cholera

Diabetes type I genetic and environment factors resulting in

deficiency of insulin

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9.many biochemical studies

illuminate disease

mechanisms & disease

inspire biochemical

research

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Use example(1) to reveal the fundamental demonstration

causes &mechanisms of the genetic

of diseases defects in CF(2) to suggest rational use of a diet low in

treatment of diseases phenylalanine

for the treatment of s

phenylketonuria(3) to assist in the diagnosis use of the plasma

of specific disease enzyme CK-MB in

the diagnosis of

myocardial infarction

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Use example

(4) To act as screening use of measurement of

tests for the early blood tyrosine or

diagnosis of certain diseases TSH in the

neonatal diagnosis

of congenital

hypothyroidism

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Use example

(5)To assist in monitoring use of the plasma enzyme

the progress of certain ALT in monitoring the

disease progress of infectious

hepatitis

(6) To assist in assessing the use of measurement of

response of diseases to therapy blood CEA in certain

patients who have

been treated for cancer

of the colon