Biochemistry Aipg

8/13/2019 Biochemistry Aipg

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BIOCHEMISTRY(AIPG)

2013

no questions

2012

1. What is the most sensitive indicator of cellular

energy?

A. ATP

B. ADP

C. Phosphocreatine

D.

AMP

2011

1. Which of the following is not present in basal lamina

A. Rhodopsin

B. Entactin

C. Laminin

D. Integrin

Ref: James 3/e p. 294

2. Shingomyelinse deficiency is seen in

A. Niemann pick disease

B. Garber disease

C. Tay sach’s disease

D. Krabbe’s disease

Ref: Satyanarayan 3/E, 307

3. Decreased BMR is seen in

A. Obesity

B. Hyperthyroidism

C. Feeding

D. Exercise

Ref: Ganong 22/e p. 462

4. Somatomedin mediate

A. Chondritin sulfate deposition

B. LipolysisC. Gluconeogenesis

D. Decreased rate of glucose uptake by cells

Ref: Ganong 22/e p. 382

5. Gout is disorder of

A. Purine metabolism

B. Pyrimidine metabolism

C. Ketone metabolism

D. Protein metabolism

Ref: Harrison 17/e p. 2444

2010

32. Most LIPOGENIC carbohydrate

A. Fructose

B. Glucose

C. Ribose

D.

Sucrose

Ref: Harper 22/e p 193

33. Denaturation of DNA

A. Fragmentation of DNA molecules

B. Reversible separation of DNA

C. Irreversible separation of DNA

D. Coagulation of DNA

Ref: Aynes 2/e p. 427

34. Cereals are deficient in

A. Vitamin C

B. Vitamin B – Complex

C. Iron

D. Calcium

Ref: Lippincott 2/e 15

35. ATP are store house of?

A. Energy

B. Phosphate

C. Protein

D. Glucose

Harper 22/e 337

36. During phagocytes respiratory burst involves

activation of

A. Oxidases

B. Hydrolase

C. Peroxidase

D. All

37. FSH, LH, TSH acts through

A. Cyclic AMP



B. Cyclic GMP

C. Both

D. None

Harper 22/e 427

38. The Highest percentages of polyunsaturated fatty

acids are present in?

A. Ground nut oil

B. Palm oil

C. Margarine

D. Soyabean oil

Park 19/e 481

39. ___ is not a transcription factors

A. Insulin

B. Estrogen

C.

Vitamin DD. Glucocoticoid

40. Ist clinical sign of vitamin A deficiency is

A. Night blindness

B. Bitot’s spots

C. Xerostomia

D. Conjunctival dryness

Davidson 19/e 318

41. The reducing equivalent for fatty acid synthesis is

derived from

A. Glycolysis

B. Kreb’s cycle

C. Urea cycle

D. Pentose phosphate pathway

Harper 22/e 202

42. Compared to cow’s milk, mother’s milk has

abundance of

A. Lactose

B. Fat

C. Protein

D. All

Park 19/e 500

2009

43. Steroid hormone receptors have attachment site for allEXCEPT

A. Steroid hormone

B. Transcription repressors

C. Hormone responsive element

D. Transcription activators

Ref: Harper 26/e, p. 458

44. Insulin causes lipogenesis by all EXCEPT?

A. Increasing acetyl CoA carboxylase activity

B. Increase the transport of glucose into the cell

C. Inhibit pyruvate dehydrogenase

D. Decrease intracellular cAMP level

45. True about G – protein coupled receptors is

A. G protein bind to hormones on the cell surface

B. All the three subunits alpha, beta & Gamma should

bind to each other for G protein to act

C. G proteins acts as inhibitory and excitatory

because of difference in alpha sub unit

D. G protein bound to GTP in resting stage


46. Thiamine deficiency causes decreased energy

production because

A. It is required for the process of transamination

B. It is co – factor in exudative reduction

C. It is co - enzyme for transketolase in pentose

phosphate pathway

D. It is co – enzyme for pyruvate dehydrogenase


47. All are true about glutathione EXCEPT

A. It is a tripeptide

B. It converts Hb to met Hb

C. It conjugates xenobiotics

D. It scavenges free radicals and superoxide ions


48. In molecular cloning Blue – White screening is used

for

A. To screen for recombinant vectors

B. To detect gene mutation

C. To identify desired chromosomal DNA insert in

plasmid vectors

D. To detect host DNA in Situ

2008

49. Amino acid which is used in transportation ofammonia and helps in urea synthesis is

A. Arginine

B. Glutamate

C. Aspirtate



D. Glycin

Ref: Lippincott’s 2/e, p. 286, 240-241

50. Which of the following enzyme is stable at acidic pH?

A. Pepsin

B. Trypsin

C. Chemotrypsim

D. Carboxypeptidase

Ref: Harper27 / e p. 485

51. Type of collage found in hyaline cartilage is

A. Type I

B. Type II

C. Type III

D. Type IV

Ref: Harper 27/E p. 561, 546

52. Protein purification and separation can be done by all

EXCEPT

A. Centrifugation

B. Electrophoresis

C. Densitometry

D. Chromatography

Ref: Harper 27/E p. 21-24

53. All of the following processes are involved in the

detection of mRNA expression EXCEPT

A. Northern blot

B. RT – PCR

C. Microarray

D. RNA sequencing


54. All of the following are the components of basement

membrane EXCEPT

A. Rhodopsin

B. Laminin

C. Entactin

D. Dystroglycan


55. Which of the following is the most active form of

calcium in the circulation?

A. Ionized calciumB. Complexed with phosphate

C. Complexed with oxalates

D. Bound to albumin

Ref: Guyton 8/e p. 870-81

56. A small Ca2+ binding protein that modifies the activity

of many enzymes and other proteins in response of

changes of Ca2+ concentration is known as

A. Cycline

B. Calmodulin

C. Collagen

D. Kinesin

Ref: Harper 27/E p. 482

57. Which of the following has low glycemic index?

A. Whole wheat bread

B. Brown rice

C. Ice cream

D. Potato


58. Keton bodies are utilized by all EXCEPT

A. RBC

B. Brain

C. Heart

D. Muscles


59. Which of the following is a good sources of saturated

fatty acids

A. Palm oil

B. Sunflower oil

C. Ground nut oil

D. Olive oil

Ref: lippincott’s 2/e, p 314

60. All are good sources of n – e poly – unsaturated fatty

acids EXCEPT

A. Groundnut oil

B. Mustard oil

C. Corn oil

D. Fish oil


61. Which of the following maskes hydrophobic to

hydrophilic?

A. Methylation

B. Acetylation

C. Glucuronidation

D. Hydroxylation




62. The conversion of ethanol to aldehyde is mediated by

A. Alcohol dehydrogenase

B. Aldehyde dehydrogenase

C. Xenthine oxidase

D. Catalase

Ref: Harper 27/E p. 225, 95,96

63. Which of the following participates in transamination

reaction?

A. Thiamine pyrophosphate

B. Pyridoxal phosphate

C. Cyanocobalamine

D. Niacin


64.

Regarding pentose phosphate pathway all of thefollowing are true EXCEPT

A. Occurs in the cytosol

B. No ATP is produced in the cycle

C. It is active in adipose tissue, liver, and gonads

D. The oxidative phase generates NADPH and the

nonoxidative phase generates pyruvate

Ref: Harper 27/E p. 177, 180

65. All of the following are precursor of adrenaline

EXCEPT

A. Noradrenalin

B. Phenylalanine

C. Isoprenaline

D. Dopamine

Ref: Harper 27/E p. 276, 455

66. Intrinsic factor

A. Is a polysaccharide

B. Is a glycoprotein

C. Helps in foliate absorption

D. Helps in blood coagulation

Ref: Harper 27/E p 499-500

67. Which of the following is true about vitamin K ?

A. Vitamin K1 is synthesized in intestine by microbial

flora

B. Vitamin K2 exists in plants

C. Vitamin K is fat soluble and require bile for itsabsorption

D. Vitamin K absorbs because it is water soluble

Ref: Harper 27/E p 495

2007

68. The most abundant protein present in body is

A. Globulin

B. Albumin

C. Collagen

D. Hemoglobin


69. All of the following types of collagen EXCEPT one are

present in cartilage

A. 2

B. 4

C. 6

D. 9


70. All of the following are sarcolemmal proteins EXCEPT

A. Syntrophin

B. Dystrophin

C. Dystrobrevin

D. Dysmorphin


71. High content of cholesterol is present in

A. Coconut oil

B. Egg yolk

C. Hydrogenated fat

D. Ghee (unsaturated)


72. Fatty acids help in synthesis of all EXCEPT

A. Glucose

B. Cholesterol

C. Ketone bodies

D. Fat


73. Increase in pyruvate and lactate is seen in which of the

following deficiency?

A. Thiamine

B. Pyridoxine

C. Niacin

D. Vitamin C


74. Exrahepatic cholestasis is associated with



A. Increased bilirubin in urine

B. Increased urobilirubin in urine

C. Increased bilirubin and increased urobilirubbin in

serum

D. Increased bilirubin in serum

Ref: Harper 27/E p 290-292

75. Dark color urine and clay stool is seen in

A. Obstructive jaundice

B. Hemolytic jaundice

C. Hepatocellular jaundice

D. Severe dehydration


76. Which of the following is correct method for

estimation of true serum creatinine?

A. Jaffe reaction

B.

Kinetic jaffe reactionC. Enzyme immunoassay

D. Plasma gel filtration

77. For glucose estimation in blood the mode of transport

from a primary health care center to laboratory is done

by addition of

A. Potassium oxalate + NaF

B. Potassium oxalate + citrate

C. EDTA

D. Sodium citrate


78. In all of the following RNA participates directly

EXCEPT

A. Post translational modification

B. Post transcriptional modification

C. DNA replication

D. Splicing


79. All of the following procedure can be used to detect

the chromosomal mutation EXCEPT

A. Single stranded length polymorphism

B. Agarose – gel – electrophoresis

C. Protein gradient electrophoresis

D. Pulse – field – gel – electrophoresis


2006

80. Vitamin B12 acts a coenzymes to which one of the

following enzymes?Isocitrate dehydrogenase

A. Isocitrate dehydrogenase

B. Homocysteine methyl transferase

C. Glycogen synthase

D. G-6-P dehydrogenase

Ref: Chetterjea Shindre, 6/E, P. 181

81. The ligand – receptor complex dissociates in the

endosome because;

A. Of its large size

B. The vesicle looses its clathrin coat

C. Of the acidic pH of the vesicle

D. Of the basic pH of the vesicle

Ref: Chetterjea Shindre, 6/E, P. 19

82. The human plasma lipoprotein containing the highest

percentage of triacylglycerol by weight is

A. VLDL

B. Chylomicrons

C.

HdlD. Ldl

Ref: Lippioncott, 3/E, P. 225, 230

83. The sigma (s) subunit of prokaryotic RNA polymerase

A. Binds the antibiotic rifampicin

B. Is inhibited by a=amanitin

C. Specifically recognizes the promoter site

D. Is part of the core enzyme

84. An affected male infant born to normal parent could

be an example of all of the following except;

A. mRNA

B. tRNA

C. rRNA

D. snRNA

Ref: Harper, 26/E, P. 356

85. proteins are linear polymers of amino acids, they fold

into compact structures. Sometimes these folded

structure associate to form homo-or hetero-dimers.

Which one of the following refers to this associated

from?

A. Denatured state

B. Molecular aggregation

C. Precipitation

D. Quaternary structures


86. The structural proteins are involed in maintaining the

shape of cell or in the formation of matrices in the

body. The shape of these point is

A. GlobularB. Fibrous

C. Stretch of beads

D. Planar




87. Iron is present in all of the following except;

A. Myoglobin

B. Cytochrome

C. Catalase

D. Pyruvate kinase

Ref: Harper’s, 25/E, P. 360

88. During phagocytosis, the metabolic process called

respiratory burst involves the activation of;

A. Oxidase

B. Hydrolase

C. Peroxidase

D. Dehydrogenase

Ref: Robbins, 7/E, P. 60

2005

89.

The cell component that is genetically continuousfrom one cell generation to the next is

A. Nuclear membrane

B. Golgi complex

C. Central Bodies

D. Chromatin

90. Golgi bodies are responsible for:

A. Synthesis of plypeptides

B. Formation of glycoproteins only

C. Modification and sorting of glycoproteins

D. Lipid and steroid synthesis

Ref: Garland’s Publishing Company, 1/E, P. 355 – 361

91. Enzymes that move a molecular group from one

molecule to another are known as:

A. Ligases

B. Oxidoreductases

C. Transerases

D. Dipeptidases

Ref: Mathews, 3/E, P. 392

92. The amino acid residue having an imino side chain is:

A. Lysine

B. Histidine

C. Tyrosine

D. Proline

Ref: Harper’s, 25/E, P. 29

93. Vitamin A

A. Is water soluble

B. Deficiency causes impaired vision

C. Maintains normal plasma of clotting factorsD. Is required for formation of clotting factors

Ref: Biochemistry by Devlin , 5/E, P. 1140, 1141

94. Differential expression of same gene depending on

parent of origin is referred to as:

A. Genomic imprinting

B. Mosaicism

C. Anticipation

D. Non penetrance

Ref: Robbins, 7/E, P. 186

95. Fluoride used in collection of blood samples for

glucose elimation, inhibits the enzyme

A. Glucokinase

B. Hexokinase

C. Enolose

D. Glucose – 6 – phosphtase


2004

96. Shine – Dalgarno sequence in bacterial mRNA is near:

A. ANUG codon

B. UAA codon

C. AUG codon

D. UGA codon

Ref: Lippincott’s Biochemistry, 2/E, P. 395

97. A segment of Eukaryotic gene that is not represented

in the mature mRNA is known as:

A. Intron

B. Exon

C. Plasmid

D. TATA Box


98. An enzyme that makes a double stranded DNA copy

form a single stranded RNA template molecule is

known as:

A. DNA polymerase

B. RNA polymerase

C. Reverse transcriptase

D. Phosphokinase


99. The transmemebrane region of protein is likely to

have:

A. A stretch of hydrophilic amino acids

B. A stretch of hydrophobic amino acids

C. A disulphide loop

D. Alternating hydrophilic and hydrophobic amino

acidsRef: Harper, 26/E, P. 450

100. Which of the following group of proteins assist in the

folding of other proteins:



A. Proteases

B. Proteosomes

C. Templates

D. Chaperones


101. Which of the following is membrane bound enzyme

that catalyses the formation of cyclic AMP from ATP:

A. Tyrosine kinase

B. Polymerase

C. ATP synthase

D. Adenylate cyclase

Ref: Ganong, 19/E, P. 41

102. To which of the following family of chemical

mediators of inflammation, the lipoxins belong:

A. Kinin system

B. Cytokines

C. Chemokines

D.

Arachidonic acid metabolites

103. The most abundant glycoproteins present in the

basement membrane is

A. Laminim

B. Fibronectin

C. Collagen type 4

D. Heparin sulphate

Ref: Tencates 5/e p. 366, 368

104. A person on fat free carbohydrate rich diet continues

to grow obese, which of the following lipoproteins is

likely to be elevated in his blood?

A. Chylomicrons

B. VLDL

C. LDL

D. HDL


105. Which of the following elements is known to

influence the body’s ability to handle oxidative stress:

A. Calcium

B. Iron

C. Potassium

D. Selenium

Harrison 15/e 469

106. The most common condition of inherited blindness

due to mitochondrial chromosomal anomaly is:

A. Retinopathy of prematurity

B. Lebers hereditary optic neuropathyC. Retinitis pigmentosa

D. Retinal detachment

Harrison 15/e 1711, 405

2003

107. Enzymes concerned with the citric acid cycle are found

in the:

A. Nucleus

B. Ribosomes

C. Mitochondria

D. Non particulate cytoplasm

Ref: Harper 25/e p. 230

108. Which cell organelle contains DNA

A. Mitochondrion

B. Golgi body

C. Endoplasmic reticulum

D.

Centriole

Ref: Harper 26/e p.322, 323

109. The code world of which proteins is also an initiation

code for proteins:

A. Leucine

B. Isoleucine

C. Methionine

D. Lysine

Ref: Lehninger 2/e p. 898

110. The main enzyme responsible for activation of

Xenobiotics is:

A. Cytochrome P – 450

B. Glutathione S- transferase

C. NADPH cytochrome P – 450

D. Glucuronyl transferase

Ref: Harper 25/e 780

2002

111. In oxidative phosphorylation, the ATP production and

respiratory chain are linked by:

A. Chemical methods

B. Physical methods

C. Chemiosmotic methods

D. Confirmational changes

Ref: Lippincott 2/e p 70

112. Substrate level phosphorylation is seen in the

conversion of:

A. Acetoaccatate to alpha ketoglutarate

B. Succinyl CoA to succinate



C. Fumarate to malate

D. Succinate to funarate

Ref: Harper 25/e 192, 185

2001

113. The nitrogen of the body is supplied by:

A. Triacyl glycerol

B. Proteins

C. Glucose

D. Lipids

114. Collagen is rich in:

A. Glutamate and glycine

B. Alanine and glycine

C. Proline and glycine

D.

Glutamate and proline

Ref: Harper 25/e 696, 697

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Biochemistry Aipg