8/11/2019 oxcarbazepine.doc
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Trial design Results
Multicenter, randomized, 28-week,
double-blind, placebo-controlled, dose-
ranging (600, 1200, and 2400 mg/da!, 4-
arm, parallel-group trial ("arcs et al
2000!#
$%carbazepine ad&uncti'e terap was
)ound to be a sa)e and e))ecti'e terap in
patients wit uncontrolled partial seizures#
*))ecti'eness increased wit dose#
Multicenter, double-blind, randomized,
parallel-group trial to assess te
antiepileptic e))icac o) o%carbazepine as
monoterap in a re)ractor epileps
patient population ("edoun et al 2000!#
$%carbazepine was )ound to be sa)e and
e))ecti'e in te treatment o) patients wit
partial epileps pre'iousl recei'ing
treatment wit oter antiepileptic drugs#
Multicenter, randomized, placebo-
controlled trial o) o%carbazepine as
ad&uncti'e terap in cildren wit
inade+uatel controlled partial seizureson 1 or 2 concomitant
antiepileptic drugs
(lauser et al 2000!#
$%carbazepine ad&uncti'e terap was
)ound to be sa)e, e))ecti'e, and well
tolerated in cildren wit partial seizures#
Multicenter, double-blind, randomized,
placebo-controlled, 2-arm parallel group,
monoterap design (cacter et al
1...!#
$%carbazepine monoterap was e))ecti'e
and sa)e#
ouble-blind, controlled clinical trial o)
o%carbazepine 'ersus pentoin as
monoterap in cildren and adolescents
wit epileps (uerreiro et al 1..!#
$%carbazepine sowed e))icac and sa)et
as )irst-line treatment and ad signi)icant
ad'antages o'er pentoin in terms o)
tolerabilit#
ouble-blind, randomized, parallel-group
comparison wit pentoin in adult
patients wit epileps ("ill et al 1..!#
ese trials support te e))icac and sa)et
o) o%carbazepine as )irst-line treatment# n
addition, te results sow tat
o%carbazepine as signi)icant ad'antages
o'er pentoin in terms o) tolerabilit#
ouble-blind, randomized, parallel-group
comparison wit sodium 'alproate inadult patients wit epileps
(3riste et al
1..!#
*))icac and tolerabilit o) o%carbazepine
was e+ui'alent to tat o) 'alproic acid#
ouble-blind, randomized, parallel-
group, monoterap trial compared
o%carbazepine at 2400 mg/da wit
o%carbazepine at 00 mg/da in patients
wit uncontrolled partial-onset seizures
(acdeo et al 2001!#
$%carbazepine monoterap at 2400
mg/da is well tolerated and e))icacious in
patients wit uncontrolled partial onset
seizures#
5rospecti'e, open-label, multicenterstud to e'aluate te e))icac
and
$%carbazepine as monoterap ma be a)a'orable treatment option )or
patients wit
