P101 NMR - University of Tokyoishimada.f.u-tokyo.ac.jp/public_html/nmr49/program/postersummaryP...Phosphatidylcholine as Studied by Solid State NMR Spectroscopy Naoko Uekama1,

NMR

12 2 2 2

3 2 2 1 4 2

1 2 3 4

Investigation of the interaction mechanism between tea catechins and phospholipid membranes by NMR spectroscopy

Yoshinori Uekusa12 Miya Kamihira-Ishijima2 Osamu Sugimoto2 Ken-ichi Tanji2 Kozo Nakamura3 Takeshi Ishii2 Shigenori Kumazawa2 Koichi Kato1 Akira Naito3 and Tsutomu Nakayama2

1Okazaki Institute for Integrative Bioscience National Institutes of Natural Sciences 2Department of Food and Nutritional Sciences University of Shizuoka 3Department of Bioscience and Biotechnology Shinshu University 4Graduate School of Engineering Yokohama National University Epicatechin gallate (ECg) a galloyl-type green tea polyphenol strongly interacts with phospholipid membranes Our previous NOE experiments revealed an important site of ECgndashphospholipid membranes interaction the B ring and galloyl moiety of ECg locate near the γ position of phospholipid To elucidate the mechanism of this interaction we measured the interatomic distance between the carbonyl carbon of ECg and the phosphorus of phospholipid by 31Pndash13C rotational echo double resonance (REDOR) method in solid-state NMR spectroscopy Based on the results of REDOR and previous solution NMR experiments it was revealed that the galloyl moiety of ECg contributes to stabilization of catechin molecules in the phospholipid membranes through cationndashπ interaction between the galloyl ring and quaternary amine of the phospholipid head-group

galloyl epicatechin gallate (ECg) (Fig 1)

ndashπ

P101

－390－

ECg 1Hndash1H 1Hndash13C NOE ECg Bgalloyl γ

NMR 31Pndash13C rotational echo double resonance (REDOR) ECg

ECg D2O DMPC DHPCJEOL JNM ECA-600 NMR

ECg 13C [13C]-ECg [13C]-ECg multilamellar

vesicle (MLV)

13Cndash31P REDOR REDORxy-4 compensation pulse Chemagnetics

CMX infinity-400 NMR

ECg 599 times 10ndash10 [m2s] 13 ECg

ECg

NMR T1 [13C]-ECg13Cndash31P 13Cndash31P REDOR

53 plusmn 01 Aring Fig 2 REDOR NMR NOE

ECg ECg galloyl

galloyl π ndashπ NOE ECg B galloyl

πndashπ πndashπ ndashπ

ECg

ndashπ

ECg galloyl

－391－

濁捥藁2ョ燦零鐚際傘飼使止識削195039際傘

嚠典ŰŘĺ燦ぁ哉冴euroお琢鄰怡h敕 1腰Ǔ 酊 2腰禽ガ闌眠断 1

1便敕56旄euroお脉 2鰭爍pコ彳旄

Magnetic Alignment of Bicelle Composed of Un- and Saturated

Phosphatidylcholine as Studied by Solid State NMR Spectroscopy

Naoko Uekama1 Satoru Tuzi

2 and ż Katsuyuki Nishimura

1

1Institute for Molecular Science

2University of Hyogo

㻌

We have reported the development of new bicelle composed of un- and saturated lipids

together with phosphatidylinositol 4 5-bisphosphate (PIP2) in which can be magnetically

aligned at room temperature stably In this study we explored the origin of enhancement

factor of magnetic alignment of the developed bicelle above by changing the composition of

lipids

Introduction Conventional bicelle prepared from the hydrated mixture of saturated lipids

possessing short and long acyl-chains at proper composition forms planer lipid bilayer and

can be magnetically aligned under static magnetic field from 30 to 40 degC Triba et al

proposed a bicelle prepared by mixture of saturated lipid 12-dimyristoyl-sn-

glycero-3-phosphocholine (DMPC) and unsaturated lipid 1-palmitoyl-2-oleoyl-sn-glycero-3-

phosphocholine (POPC) for long acyl chain lipids and 12-dihexanoyl-sn-glycero-3-

phosphocholine (DHPC) for short acyl chain lipid respectively in order to achieve magnetic

alignment at temperature lower than that of conventional bicelle1)

In the following we refer

above bicelle to as POPCDMPCDHPC-bicelle However we found out that

POPCDMPCDHPC-bicelle magnetically aligned only at narrow temperature range

Furthermore we also found out that addition of phosphatidylinositol 45-bisphosphate (PIP2)

to the bicelle at proper molar ratio enables significant enhancement of magnetic alignment

Our developed bicelle magnetically aligned over 3 hold larger temperature range than that of

POPCDMPCDHPC-bicelle stably

Experimental POPCDMPCDHPC-bicelle and PIP2POPCDMPCDHPC-bicelle and

SAPCPOPCDMPCDHPC-bicelle were prepared with q value of 30 Orientational

properties of those bicelles were compared based on 31

P-NMR All of NMR experiments were

嚠典 NMR 飼使止識

禽妻彩栽擦作採祭腰肴載細碕傘腰削裁殺晒栽肴錆済

P102

－392－

Fig 1 Molecular structure of lipid of (a)DHPC (b)

DMPC (c) POPC (d) PIP2 and (e) SAPC used in

this study

Fig 2 31P-NMR spectra of (a) PIP2POPCDMPC

DHPC-bicelle (b) POPCDMPCDHPC-bicelle (c)

SAPCPOPCDMPCDHPC-bicelle respectively

carried out using Varian INOVA 400 spectrometer equipped with JEOL 6 mm od narrow

bore MAS probe at static mode

Results and Discussions Figure 1 shows the molecular structure of lipids used in this study

Figure 2 shows the comparison of 31

P-NMR spectra for (a) PIP2POPCDMPC DHPC-bicelle

(b) POPCDMPC DHPC-bicelle and (c) SAPC POPCDMPC DHPC-bicelle respectively

The peaks around -3 and -11 ppm are originated from DHPC and POPCDMPC mixture

respectively The peak around -155 ppm is 演edge of axially symmetric powder pattern of 31

P chemical shift anisotropy from multi lamella vesicles (MLVs) As shown in Figure 2 (a)

PIP2POPCDMPCDHPC -bicelle was magnetically aligned stably from 14 to 20degC In

contrast POPC DMPCDHPC-bicelle was magnetically aligned only at 16 degC At 18 degC 演edge of axially symmetric powder pattern of

31P chemical shift anisotropy from MLVs was

appeared Furthermore magnetic alignment of SAPCPOPCDMPCDHPCndashbicelle was lower

than those of other bicelles Thus we concluded that polar head region of PIP2 may contribute

to the enhancement of magnetic alignment of bicelle

References

(1) Triba MN Devaux PF Warschawski DE Biophys J 2006 91 1357

－393－

B1+ B1

-

Non uniformity correction of human brain image at high field using B1

+ and B1- mapping

Hidehiro Watanabe Nobuhiro Takaya Fumiyuki Mitsumori National Institute for Environmental Studies

A new method of correcting image non-uniformity at high field is proposed Image non-uniformity originates from the spatial distribution of RF transmission and reception fields represented as B1

+ and B1- respectively In our method B1

+ mapping was performed in vivo by a phase method In B1

- mapping images with multiple TEs were acquired with a multi-echo adiabatic spin echo (MASE) sequence which enables homogeneous excitation By T2 fitting of these images an M0

MASE map was obtained in which signal intensity was expressed as the product of B1

- and M0(1-e-TRT1) The ratio of this M0MASE map to the B1

+ map showed a similar spatial pattern in different human brains These ratios of M0

MASE to B1+ in 24 subjects were

averaged and then fitted to obtain a universal ratio map of B1-B1

+ ( ) Uniform image intensity was achieved by using both the measured B1

+ and calculated B1- from the map

MRIB1

MRI

B1 B1

B1+ B1

- 1

47 T B1+

B1-

B1+ = |B1

+| B1- = |B1

-|

47 T MRI INOVA Varian USA TEM25 mm B1

+

2SE B1

+

P103

－394－

CPMG multi-echo adiabatic spin echo MASES = M0

MASE exp(-TET2)M0

MASE B1- M0(1-exp(-TRT1))

TR = 4sM0 (1-exp(-TRT1)) 10 M0

MASE B1-

B1+ B1

-

B1-B1

+

Fig 1) B1-B1

+

B1- B1

+

B1-B1

+ n=24

B1+ B1

+ B1-

Fig 2B1

+ B1-

M0

B1+ B1

- MRI

References1 Hoult D I The principle of reciprocity in signal strength calculations ndash a mathematical guide Concepts Magn Reson 2000 12 173-183

Fig 1 Maps of B1+ M0

MASE and M0MASEB1

+ in one subject are shown at the left Profiles along the three lines in each map in 5 subjects are overlaid at the right An M0

MASE map was generated by removing CSF after fitting MASE images with multiple TEs Profiles in each map had similar patterns in different subjects

Fig 2 Non-uniformity correction of MASE images obtained from a single subject using both B1

+ (a) and B1- (b)

maps An M0MASE image (c) was

generated after fitting the MASE images with multiple TEs A more uniform image was obtained after B1

-

correction (d)

c d

a

04

1

b

B1-B1

+

c d

aa

04

1

04

1

04

1

bb

B1-B1

+

－395－

2

Detection of Membranes by MR Imaging with Ultrasonic

Takuya Ogura1

Naotaka Nitta2

and Kazuhiro Homma2

1Photonics Research Institute AIST Tsukuba Japan

2Human Technology Research Institute AIST Tsukuba Japan

In recent MR imaging studies the measurement of MR imaging with sending mechanical

vibrations to objects is called ldquoMR Elastographyrdquo and is watched In this study we have

detected very thin membranes which by MRI sending ultrasonic waves [MHz range] to

samples Phantoms are pure water in the plastics container which thin films as a boundary

plane are attached Measurements are modified diffusion-weighted imaging methods As a

result they can be detected that ultrasonic waves are reflected by the thin films

It is difficult that the thin boundary plane inside homogeneous matters is visualized by MRI

But it is indicated possibility that the boundary plane can be clearly and easily visualized

through imaging propagation of ultrasonic waves

P104

－396－

－397－

1H-NMR

1 1 12 1 1 1

1 2( )

Clinical application of 1H NMR metabolomics-3Marker quantification in bio-fluid

Itiro Ando1 Takuo Hirose1 Kazuhisa Takeuchi 12 Yutaka Imai1 Hiroshi Sato1 Masako Fujiwara11 Graduate School of Pharmaceutical Sciences Tohoku University Sendai Japan

2CKD Center Koujinkai Central Hemodialysis Clinic Sendai Japan

Quantitative analysis of metabolites is important in 1H NMR-based metabolomics of plasmaHuman plasma contains a high density of proteins which heavily adsorb the commonly-usedstandard compound of TSP (sodium 3-(trimethylsilyl) propionate 2 2 3 3-d4) We haveevaluated calcium formate as an alternative standard in 1D single-pulse 1H NMR spectra toquantify plasma metabolites and found excellent linearity with those obtained bybiochemical analysis Formate however is not always available for internal standard inmedical analysis because it presents in plasma endogenously Then we examined theapplicable conditions of TSP as an internal standard such as dilution of plasma andconcentration of TSP

NMR

NMRH NMR

NMRNMR

TSP DSSsodium 22 dimethyl -2-silapentane-5-sulfonate-d6

(Fig1)

glucose creatinine H NMR

P105

－398－

T1() 65 s

1

TSP

(Fig2)TSP DSS

NMR CPMGCPMG

single-pulse D1D

IAndo T Hisose K Takeuchi Y Imai M Fujiwara et al Quantification ofmolecules in 1H-NMR metabolomics with formate as a concentration standard(2010) J Toxicol Sci 35 253-256

Fig 2Correlation between sensitivity of TSP and dilution factor of plasma

TSP sensitivity TSP detected TSP addedTSP detected (integral of TSP peakintegral of formate peak) formate added

Enlargement around 3times dilution of plasma

TSP(2mM)

Fig1 Superposition of spectra at different dilution of plasma with formate as aninternal standard when each concentration of formate and TSP added is constant

Formate(05mM)

110171513

TSP(2mM

Both height and width offormate signals did notchange

The height and the width of TSP signalincreased and decreased respectivelywhen plasma was progressively diluted

Plasma was diluted with saline to 1 10 so on

－399－

Correlation analysis between phytochemicals and insect genetic traits involved in plant-insect-symbiont interactions for field-harvested samples

Hirokazu Sasaki12 Tsutomu Tsuchida3 Yuuri Tsuboi3Eisuke Chikayama12 Jun Kikuchi1245

1Grad Sch NanobioSci Yokohama City Univ 2RIKEN PSC3RIKEN ASI 4Grad Sch Bioagr Sci Nagoya Univ 5RIKEN BMEP

An ecosystem is a living community which depends on each member and its surrounding environment especially in terms of acquiring chemical energy Thus far however chemicals involved in the interactions between plants insects and symbionts are largely unknown In this study we conducted extensive survey of the genetic traits of the pea aphids endosymbiotic bacteria and chemical components of legume plants From the NMR-based metabonomic analyses we identified some phytochemicals which might be involved in the plant adaptation of the pea aphids with specific symbionts Further we will discuss the plant-insect-endosymbiont interactions in eco-system based on the results of 3D-correlation analysis

Fig1 Concept of our correlation analysis plants(x) ndash insects(y) - symbionts (z) for field-harvested samples

Microsatellite analysis (z)


Red clover (R)

White clover (W)

Alfalfa (A)

NMR (x)NMR (x)

1

-1

Insect genetic traits (z)

Phytoche

micals (x)

Symbionts (y)

3D-Correlation3D-Correlation

New environmental science and its application to agricultureNew environmental science and its application to agriculture

(A) (W) (R)

Symbiontsinfection rate (y)


100

0PCRField samplings at

various environments Microsatellite analysis (z)

Mic t llitanalysis (z)

MicrosatelliteMicrosatelliteMicrosatelliteanalysis (z)analysis (z)analysis (z)


Red clover (R)

White clover (W)

Alfalfa (A)

Red clover (R)

White clover (W)

Alfalfa (A)

NMR (x)NMR ( )NMR ( )NMR (x)NMR (x)NMR (x)

1

-1

1

-1


Phytoche

micals (x)

Symbionts (y)

3D-Correlation-3D3D3D3D---CorrelationCorrelationCorrelationC l ti3D-Correlation

New environmental science and its application to agricultureNew environmental science and its lication to ricultureNew environmental science and its application to agricultureNew environmental science and its application to agricultureNew environmental science and its application to agricultureNew environmental science and its application to agriculture

(A) (W) (R)


Symbiontsinfection rate ( )

y biontsSymbiontsSymbiontsinfection rate (y)infection rate (y)infection rate (y)ct


100


various environments

P106

－400－

1) Tsuchida et al (2004) Science 333 pp1989 2) Caillaud et al (2004) Molecular Ecology Notes 4 446-448 3) Mochida et al (2009) BMC Genomeics 10 e568 4) Chikayama et al (2008) PLoS ONE 3 e3805 Akiyama et al (2008) In Silico Biol 8

e27 Chikayama et al (2010) Anal Chem 82 pp1653

Fig 2 Correlation analysis between phytochemicals(x) and symbionts(y)

SerratiaRegiellaRickettsiaSpiroplasma

7595 45 1085 2030Eend

osym

biot

icba

cter

ia

1H-NMR chemical shift (ppm)

9014 761 3182 311

-1 106-06

Green (A)Blue (W)Red (R)


7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


－401－

Transverse relaxation rate of the water molecule in gelatin gel doped with ferritin

Nobuhiro Takaya Hidehiro Watanabe Fumiyuki MitsumoriNational Institute for Environmental StudiesTsukuba Ibaraki Japan

We reported that the apparent transverse relaxation rate (R2dagger = 1T2

dagger) of the tissue water in human brain is well explained with a linear combination of relaxations due to ferritin iron ([Fe]) and the macromolecular mass fraction (fM = 1 ndash water fraction) We are attempting to mimic the relaxation using simple model systems In one model system of agarose and ferritin the water relaxation was described as the similar linear combination but the contribution of agarose was almost B0 independent With another model of gelatin and ferritin the relaxation of water due to gelatin showed the B dependence Difference in the above two systems suggested the difference in relaxation mechanisms

0

P107

－402－

BB0

Table1 Coefficients of and obtained with a multiple regression analysis for the observed R2 values in gelatin gels doped with vearious amounts of ferritin at four B0 strengths was from a buffer solution containing no ferritin nor gelatin

F Mitsumori H Watanabe N Takaya Magn Reson Med Vol62 1326-1330 (2009) p374(2009)

Fig1 B0 dependence of coefficient in two model systems of gelatin gel and agarose

Table2 Comparison of values in vivo in gelatin and in agarose gels at 47T

－403－

Investigation of metabolic profiling methods for aquatic organism from Keihin region

Seiji Yoshida1 Yasuhiro Date14 Shigeharu Moriya123 Jun kikuchi1245

1Grad Sch NanoBioSci Yokohama City Univ 2RIKEN BMEP 3RIKEN ASI 4RIKEN PSC 5Grad Sch Bioagr Nagoya Univ

Preservation and deviation of homeostasis can be evaluated by statistical analysis of changes in major metabolite composition this new-field is so called as metabonomics Similar study environmental metabonomics is also introduced in wild-life samples such as fishesRelationship between variations of chemical compositions in fish and environmental changes in their habitat is important for consideration of taste safety and quality in fishery product Therefore we are exploring differences of metabolic profiling in fish from both natural and artificial environment We focused on the yellowfin goby that is a primary consumer in the Keihin region Extraction conditions of muscle and internal organs in fish were successfully determined by 1H-NMR measurements Then we processed the NMR spectra to a data matrix and compared yellowfin goby in natural and artificial environments by PCA

[ ] DNA

1)

NMRPrj

2)

(Fig1) Fig1 Concept of our environmental metabonomics study of fish grown in natural and artificial environments

Metabolic phenotyping

Maltivariate analysis

Finding Biomakers

Environments

Bioaccumulation from various environmental factors

Natural Artifical



Finding Biomakers

Environments


Natural Artifical

P108

－404－

[[ ]

1H-NMR bin

[ ] [ ]

[ ] 1H-NMR PCAFig2 PCA

PCA83 ppm

[ ] 1) Nicholson amp Lindon Nature4551054-1056 (2008)

7 371-378 (2009) 16 81-85 (2010) 2) Viant et al Environ Sci Tech43219-225 (2009)

Artifical environment

Natural environment

ArtificalA enviroonmennnn

Natural environment


Natural environment

Fig2 PCA of internal organ samples of yellowfin goby Natural (left) and artificial (right) environments were classified for both PC2 and PC3 directions

－405－

NMRMagRO

1 1 1 1 1

1 1 1

1

A new tool using ontology engineered data structure MagRO system designedfor analysis and validation of NMR data as well as assistance in deposition tothe public database

Naohiro Kobayashi1 Yoko Harano1 Takahisa Ikegami1 Chojiro Kojima1 Junko Sato1Haruki Nakamura1 Hideo Akutsu1 and Toshimichi Fujiwara1

1Institute for Protein Research Osaka University Suita Japan

Owing to the recent developments of NMR techniques for biomolecules a lot of usefulinformation has been archived in the public database like PDB and BMRB On the otherhand the data structure required for the database has been getting more complicated whichstrongly discourages the NMR scientists to exchange the NMR data each other This isbecause the NMR study tends to provide highly hierarchical information cross-linked betweena number of NMR experiments and parameters In this study we have designed a coreprogram which can manage the complicated data structure using ontology engineeringtechniques called ldquoMagRO (Magnetic Resonace Ontology)rdquo system Using the coreprogram we have developed a GUI based analysis tool with the spectrum viewer Sparky forNMR data analaysis as well as tool for assistance on deposition to NMR database BMRB

NMR

NMR NMRMagRO (Magnetic Resonace Ontology)

GUI

BMRB

GUI NMRMagRO-Core Windows

MacOSX Linux OS C

Ontology Database Data validation

P109

－406－

GUI SparkyGUI MagRO-Core

GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2

Development of computer assisted technique for efficient and robustNMR spectral analysis

Masashi Yokochi1 Yoshihiro Kobashigawa1 Tomohide Saio2 Fuyuhiko Inagaki1

Faculty of Advanced Life Science Hokkaido University2 Graduate School of Life Science Hokkaido University

NMR spectral pattern matching gives strong evidence for reliable NMR signalassignments Human brain is extremely good at the pattern recognition rather thancomputer especially in NMR assignment analyses Well-trained analyst can distinguisha signal from a spectral noise (eg ripple) and detect small signal distortions due tooverlaps However NMR signals are distributed in high dimensional NMR spectrawhich make it difficult to treat an amount of spectral data Spectral pattern recognitionby computer can make this important but redundant task much easier We demonstratehere that the accuracy of NMR assignment prediction is greatly improved by usingspectral intensity as well as peak list information These tools contribute to improve thereliability of NMR data analysis

P110

－408－

A BA B

NMR

Fig 1

NMR

Fig 1 Distribution of correlation coefficients

－409－

Fig 2

Fig 2 Accuracy of prediction of assignment using the spectral correlation

15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)

Fig 3 Assignment candidates presentation tool using the spectral correlation

－411－

Chemical shift-structure correlation with ab initio quantum chemical methods and classical molecular dynamics Eisuke Chikayama12 Yoshiyuki Ogata1 Yusuke Morioka2 Jun Kikuchi123

1RIKEN PSC 2Graduate School of Bionano Yokohama City University 3Graduate School of Bioagri Sci Nagoya University Abstract Recent high performance computing (HPC) technologies enable us ab initiocalculations in quantum chemistry by method such as post Hartree-Fock (post-HF) and density functional theory (DFT) Achieving highly accurate results however needs further optimizations of levels of theory including method and basis set solvent effects molecular ensembles ways of calibrations to experimental values There is only a small number of studies yet in causes and effects between calculated shielding constants and molecular ensembles in numbers of levels of theory We here performed principal components analysis (PCA) for analyzing relation between calculated shielding constants and molecular ensembles The shielding constants were calculated for coordinates of an ethanol molecule in a vacuum by using ab initio quantum calculations with the levels of theory for methods of HF B3LYP(a DFT) and MP2 (a post-HF) and for basis sets of 6-31G(d) and cc-pVTZ Molecular ensembles were calculated by classical molecular dynamics at 29815 K in 10 ns

post-Hartree-Fock(post-HF) (DFT)

10 ns(MD) 100 HFB3LYP(DFT)MP2(post-HF)6-31G(d)cc-pVTZ

1 ns 1 ns2 ns 10 ns MD CACTUS(httpcactusncinihgov) Mol2 (Tripos) acpype (httpcodegooglecompacpype) GROMACS GAFF

MD GROMACS 405 Wolf29815 K Nose-Hoover 10 ps (1 ns2 ns

) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)

C(2)-C(1)-O(4)-H(3) MDGaussian09 HF B3LYP MP2 3 6-31G(d)

cc-pVTZ 2 MP2cc-pVTZ1 1

100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100

MP2cc-pVTZ 5HCO 9 100

(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)

Figure 1 (a) Map of dihedral angles CCOH vs HCCO in an ethanol molecule Plot of 1 ns (open darkdiamond) 2 ns (dark square) and 10 ns (black circle) Each type has 100 points (molecularconformations) (b) PCA score plot of shielding constants of all the atoms in an ethanol molecule inPC1 and PC2 for five types of simulations varying levels of theory and basis sets

－413－

12 2 2 2 2 2 1

1 -BIRD 2

Mandatory chemical shift deposition to PDBBMRB with biological NMR structures

Eiichi Nakatani12 Naohiro Kobayashi2 Yoko Harano2 Takanori Matsuura2 Hideo Akutsu2 Haruki Nakamura2 Toshimichi Fujiwara2

1JST-Institute for Bioinformatics Research and Development 2Institute for Protein Research Osaka University Chemical shifts are basic parameters to elucidate biomolecular structures and interactions PDB (Protein Data Bank) and BMRB (BioMagResBank) will introduce new policy that NMR structure must be deposited with the chemical shifts The new deposition system and procedure have been developed in collaboration with wwPDB (World Wide Protein Data Bank) members of RCSB-PDB PDBj PDBe and BMRB Here we explain the new features of chemical shift mandatory deposition updated data processing systems at the PDBj and other deposition sites NMR

100 PDB Protein Data Bank NMR PDB

BMRB BioMagResBankwwPDB World Wide PDB RCSB PDBj PDBe BMRB

4BMRBPDB

1 ADIT-NMR httpnmraditproteinosaka-uacjpbmrb-adit

2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB

BMRBIUPAC NMR-STAR 31

NMR BMRBNMR-STAR 21 NMR-STAR 31

BMRB httpbmrbproteinosaka-uacjpdepositBMRB

ADIT-NMR

ADIT-NMR PDB BMRBPDB

BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR

Fig 1 New web page for file uploading in ADIT-NMR

Fig 2 Web checker for nomenclature consistency between PDB and Chemical Shifts httpnmraditproteinosaka-uacjpcgi-binbmrb-aditstandalone-shift-coord

－415－

固体高分解能ＮＭＲの感度向上クライオコイルプローブによるアプローチ水野　敬野田　泰斗竹腰清乃理

日本電子株京大院理）

13 1313 13 1313

13 13

13 13 13 13

1313

13 $ 1313amp$ 1313 13 ( 13) 13 ( 1313 amp13 + amp ( 1313( ( 13 13 - + 13 ( 13 13 $ 13130 13amp$ 13 13 13) $ 1313amp$ 1313 131313 13 1 13 2 1313 13) $ 1313 0 13amp$ 13 3 45 1313 13 13) 1313 13 ( 61313 amp 13 amp 13amp 13) amp 13) 13 13(13 5-7 13) 13) 8 13 amp39 13 amp 1313(amp 13 $ 1313 0$ 1 13 13 0 ( (1313 13) 1313 0

ＮＭＲ検出コイルプリアンプなどの信号検出系を極低温（+以下）に冷却し試料を検出系から断熱して室温下に置くことにより検出系の熱雑音低下Ｑ向上によって +～倍程度の -向上を達成するプローブ装置は溶液ＮＭＲにおける「クライオプローブ」として知られる我々はこの手法を固体高分解能ＮＭＲプローブに適用する「クライオコイル0プローブ」を段階的に開発製作した 5lt5=

5gt 1313

クライオコイル0プローブによる固体高分解能の感度向上の例として試作２号機における 0の実験結果を示す磁石は35ワイドボアマグネットプローブは試作２号機で行った測定の共鳴周波数は +28( A 5水溶液基準社製の 7 試料管で試料回転速度は最大 5 8まで出せるがスピン拡散を促進するため今回は 7 8で測定した試料は BAEligAで 52時間本焼した A13 の79標識試料 (

0 の 5次元スペクトルで比較すると検出系を室温時に置いたときを基準にした低温運転時の-

C13gt 感度向上 A 1313 プローブ

みずの　たかしのだ　やすとたけごし　きよのり

P113

－416－

向上率は倍であった 13またクライオコイルスペクトルの応用例として次元交換の結果を示す 13２次元磁化交換スペクトルを通常のプローブでは４日以上かかるところ約時間以内に効率よく測定することができたメインピーク 13とマイナーピーク 13との間に明確なクロスピークを確認することができた今後測定条件を変えたりなどしてデータを収集し拡散様式（運動によるものかスピン拡散によるものか）の違い各マイナーピークの帰属を明らかにし電池の充放電特性のメカニズムを調べる

x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10

本研究は平成年度採択13により財政的に支援された $ amp ( ) +$amp - 13 $ amp (

) +$amp -13

－417－

P114 （発表取消のため欠番）

－418－

－419－

Validation of NMR process parameters in quantitation of organic compounds

Toru MIURA Takeshi SAITO Yoko OHTE Toshihide IHARA National Metrology Institute of Japan AIST

AbstractQuantification using NMR is one of the attractive methods for purity determination of organic compounds We have optimized data acquisition and process parameters and optimized their associated uncertainties for the quantification Last year we proposed a process parameter set for quantification in this presentation quantitative validation of the process parameter set was demonstrated using quantification experiment between two reference materials whose purity was certified

1NMR

1

2

14-BTMSB-d414-bis(trimethylsilyl)benzene-d4

TRM 998 02 (k=2)

TRM 996 05 k=2

acetonitrile-d3 Acros OrganicsNMR

NMR JNM-ECS400Table 1 MNova 611

MESTRELA RESERCH Figure 1

NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl

chlorfenapyr 14BTMSBd4

SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D

ISAnalyte-1Analyte-2Analyte-3Analyte-4

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR

1) T Ihara T Saito and N Sugimoto Synthesiology 2 (2009) 12-22 2) T Miura et al The 48th Annual Meeting of the NMR Society Japan (2009)

Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－

Detection of substances hidden in the body using NQR Yukihide Yamane Yu Nakahara Junichiro Shinohara Hideo Sato-Akaba Hideo Itozaki

Graduate School of Science Engineering Osaka University

A nuclear quadrupole resonance (NQR) detection technique which does not require a static

magnetic field can be applied to remote sensing more simply than a NMR technique We

evaluated the possibility that the NQR technique can detect the substances hidden in the body

with a simple experiment using conductive salt solutions (saline solution) for simulating a

human body The calculation based on the conductivity indicated that skin effect measured in

09 salt solution decreased 20 of RF magnetic fields measured in pure water However

the results of experiments showed the possibility to detect the substances hidden in the body

using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution

Fig2 RF magnetic amplitude by gradiometer field plotted as a function of distance in the conductive salt solutions with different concentration of NaCl

Fig3 Decay of NQR intensity from HMT (200g) in the conductive salt solutions with different concentration of NaCl

16 Sm 15 005 mHMT 200g NQR

Martin B Kraichman The resistivity of aqueous solutions of sodium chloride Defense documentation center for scientific and technical information AD437890 1964

3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT

3308 MHzFig1 Experimental setup of the NQR measurement for HMT (200 g) in the conductive medium

to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa

Development of an NQR NMR double resonance spectrometer to search

for NQR frequencies

Hideo Sato-Akaba Bryn Baritompa Junichiro Shinohara Hideo Itozaki


We are developing a small NQR NMR double resonance spectrometer to search for NQR

frequencies and to detect NQR signals from small samples of several grams The polarization

transfer from proton to 14

N nuclei was done by a level crossing technique for enhancing the

NQR signal intensity A sample was shuttled between a high field (828 mT) and a low field

(several mT) for polarization of protons level crossing and free induction decay of 4N nuclei

using an air compressor and solenoid valves A single-shot NQR signal from diethylamine

hydrochloride was observed

NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR

Figure 2 NQR NQR500g 1008MHz

1000 NQR

NMR 14N NQR

[1] J Seliger and V Žagar NATO Science for Peace and Security Series B Physics and Biophysics 139-158 (2009)

[2] J Luznik et al J Appl Phys 102 084903 (2007)

Fig 1 Schematic diagram of a homemade NQR NMR double resonance system The resonator coils for NMR and NQR which were set at the middle of the magnets were not shown

Fig 2 Single-shot polarization transfer 14N NQR spectrum from diethylamine hydrochloride (2 g)

－425－

Our activities on construction of reliable SDBS-NMR data Mami Nabeshima Toshiki Yamaji Shinichi Kinugasa and Takeshi Saito

National Metrology Institute of Japan (NMIJ) AIST

We have been constructing a reliable NMR database of SDBS (Spectral Database for Organic Compounds SDBS-NMR) open freely through AISTrsquos web site SDBS-NMR compiles high quality solution state 1H and 13C NMR spectra which are acquired and evaluated by ourselves Chemical structures for these spectra with their chemical shift assignments are also provided We will discuss one of our activities to ensure the reliability of SDBS-NMR with (S)-1-(tert-butoxycarbonyl)-3-pyrrolidinol (SDBS No 51972) as an example 13C NMR spectrum of this compound observed at 30degC showed two sets of resonances from pyrrolidine-ring carbons which are cisoide and transoide to the carbonyl group the resonances became one set when the spectrum was obtained at 70degC This suggested these resonances were originated from two structures due to the restricted rotation around the carbamate C-N bond

SDBS WebSDBSWeb MS IR HNMR 13CNMR Raman ESR

SDBS-NMR HNMR 13CNMRweb

NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－

- DEPT gHMQC gHMBC- IR MS--

Fig 1 SDBS 51972 (S51972)(S)-1-(tert-butoxycarbonyl)-3-pyrrolidinol

13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR

1) 47 NMR P4202) GCLevy GLNelson J Am Chem Soc 94 4897 (1972)

N

O

O OH

Fig 1 Structure of the compound S51972

Fig2 13C NMR spectra of the compound S51972 and its expansion in DMSO-d6

solution

Fig3 13C NMR spectra of the compound S51972 obtained at 1) 30 2) 50 and 3) 70 respectively

－427－

Automatic scanning for NQR frequencies Junichiro ShinoharaYu Nakahara Hideo Sato-Akaba and Hideo Itozaki


Nuclear quadrupole resonance (NQR) spectroscopy has potential applications in the detection of illegal substances such as narcotics which frequently include 14N (I=1) To apply NQR to narcotic detection the NQR frequency of each compound must be known We introduce an automatic scanning system for finding NQR frequencies using the pulse method

(NQR)

NQR

NQR

NQR

NQR

NQR

NQR

Fig1 Setup of an automatic NQR frequency scanning system

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit

Electromagnetic shield

Sample Pick up coil

Oscilloscope

Instrumentationcontrol

Tuning control signal

Voltage signal of the pick up coil

Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)

(a)Equivalent circuit (b)Calculated RF field intensity at 1036MHz

(c) Matching and tuning algorithm Fig3 Matching and tuning mechanism (a) Equivalent circuit of resonator (b) RF field intensity for a fixed frequency calculated as a function of C1 and C2 The maximum intensity is possible to obtain by selecting C1 and C2 (c) Matching and tuning algorithm to search maximum RF field intensity by adjusting C1 and C2 automatically

Fig2 Mechanical adjustment of the capacitors for impedance matching and frequency tuning

C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]

RF field intensity [au]

400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF

Fig4 RF field intensities generated by the RF coil The intensity was plotted as a function of RF frequency with and without automatic matching and tuning

NQR

NQR Apollo TecmagNTNMR NTNMR Visual Basic

NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]

AutomaticmatchingC1C2 fixed

－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

1032kHz 1034kHz 1036kHz 1038kHz 1040kHz

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR

Fig5 Demonstration of automatic scanning to search NQR frequency of sodium nitrite using a step of 2kHz A peak was found at 1036kHz

NQRNQR

NQR

[1] RA Marino SM Klainer Multiple spin echoes in pure quadrupole resonance J Chem Phys 67 (1977) 3388ndash3389

－431－

ECg 1Hndash1H 1Hndash13C NOE ECg Bgalloyl γ

NMR 31Pndash13C rotational echo double resonance (REDOR) ECg

ECg D2O DMPC DHPCJEOL JNM ECA-600 NMR

ECg 13C [13C]-ECg [13C]-ECg multilamellar

vesicle (MLV)

13Cndash31P REDOR REDORxy-4 compensation pulse Chemagnetics

CMX infinity-400 NMR

ECg 599 times 10ndash10 [m2s] 13 ECg

ECg

NMR T1 [13C]-ECg13Cndash31P 13Cndash31P REDOR

53 plusmn 01 Aring Fig 2 REDOR NMR NOE

ECg ECg galloyl

galloyl π ndashπ NOE ECg B galloyl

πndashπ πndashπ ndashπ

ECg

ndashπ

ECg galloyl

－391－








1



㻌





lipids






















P102

－392－



this study



















References


－393－

B1+ B1

-


+ and B1- mapping













MRIB1

MRI

B1 B1

B1+ B1

- 1

47 T B1+

B1-

B1+ = |B1

+| B1- = |B1

-|


+

2SE B1

+

P103

－394－


MASE exp(-TET2)M0


TR = 4sM0 (1-exp(-TRT1)) 10 M0

MASE B1-

B1+ B1

-

B1-B1

+

Fig 1) B1-B1

+

B1- B1

+

B1-B1

+ n=24

B1+ B1

+ B1-

Fig 2B1

+ B1-

M0

B1+ B1

- MRI



MASE and M0MASEB1




+ (a) and B1- (b)



-

correction (d)

c d

a

04

1

b

B1-B1

+

c d

aa

04

1

04

1

04

1

bb

B1-B1

+

－395－

2


Takuya Ogura1

Naotaka Nitta2

and Kazuhiro Homma2












P104

－396－

－397－

1H-NMR

1 1 12 1 1 1

1 2( )





NMR

NMRH NMR

NMRNMR


(Fig1)


P105

－398－

T1() 65 s

1

TSP

(Fig2)TSP DSS

NMR CPMGCPMG

single-pulse D1D





TSP(2mM)


Formate(05mM)

110171513

TSP(2mM




－399－








Red clover (R)

White clover (W)

Alfalfa (A)

NMR (x)NMR (x)

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)



100






Red clover (R)

White clover (W)

Alfalfa (A)

Red clover (R)

White clover (W)

Alfalfa (A)


1

-1

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)





100



P106

－400－





7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06



7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


－401－





0

P107

－402－

BB0





－403－





[ ] DNA

1)

NMRPrj

2)




Finding Biomakers

Environments


Natural Artifical



Finding Biomakers

Environments


Natural Artifical

P108

－404－

[[ ]

1H-NMR bin

[ ] [ ]


PCA83 ppm




Natural environment


Natural environment


Natural environment


－405－

NMRMagRO

1 1 1 1 1

1 1 1

1





NMR


GUI

BMRB


MacOSX Linux OS C


P109

－406－


GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－








1



㻌





lipids






















P102

－392－



this study



















References


－393－

B1+ B1

-


+ and B1- mapping













MRIB1

MRI

B1 B1

B1+ B1

- 1

47 T B1+

B1-

B1+ = |B1

+| B1- = |B1

-|


+

2SE B1

+

P103

－394－


MASE exp(-TET2)M0


TR = 4sM0 (1-exp(-TRT1)) 10 M0

MASE B1-

B1+ B1

-

B1-B1

+

Fig 1) B1-B1

+

B1- B1

+

B1-B1

+ n=24

B1+ B1

+ B1-

Fig 2B1

+ B1-

M0

B1+ B1

- MRI



MASE and M0MASEB1




+ (a) and B1- (b)



-

correction (d)

c d

a

04

1

b

B1-B1

+

c d

aa

04

1

04

1

04

1

bb

B1-B1

+

－395－

2


Takuya Ogura1

Naotaka Nitta2

and Kazuhiro Homma2












P104

－396－

－397－

1H-NMR

1 1 12 1 1 1

1 2( )





NMR

NMRH NMR

NMRNMR


(Fig1)


P105

－398－

T1() 65 s

1

TSP

(Fig2)TSP DSS

NMR CPMGCPMG

single-pulse D1D





TSP(2mM)


Formate(05mM)

110171513

TSP(2mM




－399－








Red clover (R)

White clover (W)

Alfalfa (A)

NMR (x)NMR (x)

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)



100






Red clover (R)

White clover (W)

Alfalfa (A)

Red clover (R)

White clover (W)

Alfalfa (A)


1

-1

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)





100



P106

－400－





7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06



7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


－401－





0

P107

－402－

BB0





－403－





[ ] DNA

1)

NMRPrj

2)




Finding Biomakers

Environments


Natural Artifical



Finding Biomakers

Environments


Natural Artifical

P108

－404－

[[ ]

1H-NMR bin

[ ] [ ]


PCA83 ppm




Natural environment


Natural environment


Natural environment


－405－

NMRMagRO

1 1 1 1 1

1 1 1

1





NMR


GUI

BMRB


MacOSX Linux OS C


P109

－406－


GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－



this study



















References


－393－

B1+ B1

-


+ and B1- mapping













MRIB1

MRI

B1 B1

B1+ B1

- 1

47 T B1+

B1-

B1+ = |B1

+| B1- = |B1

-|


+

2SE B1

+

P103

－394－


MASE exp(-TET2)M0


TR = 4sM0 (1-exp(-TRT1)) 10 M0

MASE B1-

B1+ B1

-

B1-B1

+

Fig 1) B1-B1

+

B1- B1

+

B1-B1

+ n=24

B1+ B1

+ B1-

Fig 2B1

+ B1-

M0

B1+ B1

- MRI



MASE and M0MASEB1




+ (a) and B1- (b)



-

correction (d)

c d

a

04

1

b

B1-B1

+

c d

aa

04

1

04

1

04

1

bb

B1-B1

+

－395－

2


Takuya Ogura1

Naotaka Nitta2

and Kazuhiro Homma2












P104

－396－

－397－

1H-NMR

1 1 12 1 1 1

1 2( )





NMR

NMRH NMR

NMRNMR


(Fig1)


P105

－398－

T1() 65 s

1

TSP

(Fig2)TSP DSS

NMR CPMGCPMG

single-pulse D1D





TSP(2mM)


Formate(05mM)

110171513

TSP(2mM




－399－








Red clover (R)

White clover (W)

Alfalfa (A)

NMR (x)NMR (x)

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)



100






Red clover (R)

White clover (W)

Alfalfa (A)

Red clover (R)

White clover (W)

Alfalfa (A)


1

-1

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)





100



P106

－400－





7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06



7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


－401－





0

P107

－402－

BB0





－403－





[ ] DNA

1)

NMRPrj

2)




Finding Biomakers

Environments


Natural Artifical



Finding Biomakers

Environments


Natural Artifical

P108

－404－

[[ ]

1H-NMR bin

[ ] [ ]


PCA83 ppm




Natural environment


Natural environment


Natural environment


－405－

NMRMagRO

1 1 1 1 1

1 1 1

1





NMR


GUI

BMRB


MacOSX Linux OS C


P109

－406－


GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

B1+ B1

-


+ and B1- mapping













MRIB1

MRI

B1 B1

B1+ B1

- 1

47 T B1+

B1-

B1+ = |B1

+| B1- = |B1

-|


+

2SE B1

+

P103

－394－


MASE exp(-TET2)M0


TR = 4sM0 (1-exp(-TRT1)) 10 M0

MASE B1-

B1+ B1

-

B1-B1

+

Fig 1) B1-B1

+

B1- B1

+

B1-B1

+ n=24

B1+ B1

+ B1-

Fig 2B1

+ B1-

M0

B1+ B1

- MRI



MASE and M0MASEB1




+ (a) and B1- (b)



-

correction (d)

c d

a

04

1

b

B1-B1

+

c d

aa

04

1

04

1

04

1

bb

B1-B1

+

－395－

2


Takuya Ogura1

Naotaka Nitta2

and Kazuhiro Homma2












P104

－396－

－397－

1H-NMR

1 1 12 1 1 1

1 2( )





NMR

NMRH NMR

NMRNMR


(Fig1)


P105

－398－

T1() 65 s

1

TSP

(Fig2)TSP DSS

NMR CPMGCPMG

single-pulse D1D





TSP(2mM)


Formate(05mM)

110171513

TSP(2mM




－399－








Red clover (R)

White clover (W)

Alfalfa (A)

NMR (x)NMR (x)

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)



100






Red clover (R)

White clover (W)

Alfalfa (A)

Red clover (R)

White clover (W)

Alfalfa (A)


1

-1

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)





100



P106

－400－





7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06



7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


－401－





0

P107

－402－

BB0





－403－





[ ] DNA

1)

NMRPrj

2)




Finding Biomakers

Environments


Natural Artifical



Finding Biomakers

Environments


Natural Artifical

P108

－404－

[[ ]

1H-NMR bin

[ ] [ ]


PCA83 ppm




Natural environment


Natural environment


Natural environment


－405－

NMRMagRO

1 1 1 1 1

1 1 1

1





NMR


GUI

BMRB


MacOSX Linux OS C


P109

－406－


GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－


MASE exp(-TET2)M0


TR = 4sM0 (1-exp(-TRT1)) 10 M0

MASE B1-

B1+ B1

-

B1-B1

+

Fig 1) B1-B1

+

B1- B1

+

B1-B1

+ n=24

B1+ B1

+ B1-

Fig 2B1

+ B1-

M0

B1+ B1

- MRI



MASE and M0MASEB1




+ (a) and B1- (b)



-

correction (d)

c d

a

04

1

b

B1-B1

+

c d

aa

04

1

04

1

04

1

bb

B1-B1

+

－395－

2


Takuya Ogura1

Naotaka Nitta2

and Kazuhiro Homma2












P104

－396－

－397－

1H-NMR

1 1 12 1 1 1

1 2( )





NMR

NMRH NMR

NMRNMR


(Fig1)


P105

－398－

T1() 65 s

1

TSP

(Fig2)TSP DSS

NMR CPMGCPMG

single-pulse D1D





TSP(2mM)


Formate(05mM)

110171513

TSP(2mM




－399－








Red clover (R)

White clover (W)

Alfalfa (A)

NMR (x)NMR (x)

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)



100






Red clover (R)

White clover (W)

Alfalfa (A)

Red clover (R)

White clover (W)

Alfalfa (A)


1

-1

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)





100



P106

－400－





7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06



7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


－401－





0

P107

－402－

BB0





－403－





[ ] DNA

1)

NMRPrj

2)




Finding Biomakers

Environments


Natural Artifical



Finding Biomakers

Environments


Natural Artifical

P108

－404－

[[ ]

1H-NMR bin

[ ] [ ]


PCA83 ppm




Natural environment


Natural environment


Natural environment


－405－

NMRMagRO

1 1 1 1 1

1 1 1

1





NMR


GUI

BMRB


MacOSX Linux OS C


P109

－406－


GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

2


Takuya Ogura1

Naotaka Nitta2

and Kazuhiro Homma2












P104

－396－

－397－

1H-NMR

1 1 12 1 1 1

1 2( )





NMR

NMRH NMR

NMRNMR


(Fig1)


P105

－398－

T1() 65 s

1

TSP

(Fig2)TSP DSS

NMR CPMGCPMG

single-pulse D1D





TSP(2mM)


Formate(05mM)

110171513

TSP(2mM




－399－








Red clover (R)

White clover (W)

Alfalfa (A)

NMR (x)NMR (x)

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)



100






Red clover (R)

White clover (W)

Alfalfa (A)

Red clover (R)

White clover (W)

Alfalfa (A)


1

-1

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)





100



P106

－400－





7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06



7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


－401－





0

P107

－402－

BB0





－403－





[ ] DNA

1)

NMRPrj

2)




Finding Biomakers

Environments


Natural Artifical



Finding Biomakers

Environments


Natural Artifical

P108

－404－

[[ ]

1H-NMR bin

[ ] [ ]


PCA83 ppm




Natural environment


Natural environment


Natural environment


－405－

NMRMagRO

1 1 1 1 1

1 1 1

1





NMR


GUI

BMRB


MacOSX Linux OS C


P109

－406－


GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

－397－

1H-NMR

1 1 12 1 1 1

1 2( )





NMR

NMRH NMR

NMRNMR


(Fig1)


P105

－398－

T1() 65 s

1

TSP

(Fig2)TSP DSS

NMR CPMGCPMG

single-pulse D1D





TSP(2mM)


Formate(05mM)

110171513

TSP(2mM




－399－








Red clover (R)

White clover (W)

Alfalfa (A)

NMR (x)NMR (x)

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)



100






Red clover (R)

White clover (W)

Alfalfa (A)

Red clover (R)

White clover (W)

Alfalfa (A)


1

-1

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)





100



P106

－400－





7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06



7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


－401－





0

P107

－402－

BB0





－403－





[ ] DNA

1)

NMRPrj

2)




Finding Biomakers

Environments


Natural Artifical



Finding Biomakers

Environments


Natural Artifical

P108

－404－

[[ ]

1H-NMR bin

[ ] [ ]


PCA83 ppm




Natural environment


Natural environment


Natural environment


－405－

NMRMagRO

1 1 1 1 1

1 1 1

1





NMR


GUI

BMRB


MacOSX Linux OS C


P109

－406－


GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

1H-NMR

1 1 12 1 1 1

1 2( )





NMR

NMRH NMR

NMRNMR


(Fig1)


P105

－398－

T1() 65 s

1

TSP

(Fig2)TSP DSS

NMR CPMGCPMG

single-pulse D1D





TSP(2mM)


Formate(05mM)

110171513

TSP(2mM




－399－








Red clover (R)

White clover (W)

Alfalfa (A)

NMR (x)NMR (x)

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)



100






Red clover (R)

White clover (W)

Alfalfa (A)

Red clover (R)

White clover (W)

Alfalfa (A)


1

-1

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)





100



P106

－400－





7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06



7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


－401－





0

P107

－402－

BB0





－403－





[ ] DNA

1)

NMRPrj

2)




Finding Biomakers

Environments


Natural Artifical



Finding Biomakers

Environments


Natural Artifical

P108

－404－

[[ ]

1H-NMR bin

[ ] [ ]


PCA83 ppm




Natural environment


Natural environment


Natural environment


－405－

NMRMagRO

1 1 1 1 1

1 1 1

1





NMR


GUI

BMRB


MacOSX Linux OS C


P109

－406－


GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

T1() 65 s

1

TSP

(Fig2)TSP DSS

NMR CPMGCPMG

single-pulse D1D





TSP(2mM)


Formate(05mM)

110171513

TSP(2mM




－399－








Red clover (R)

White clover (W)

Alfalfa (A)

NMR (x)NMR (x)

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)



100






Red clover (R)

White clover (W)

Alfalfa (A)

Red clover (R)

White clover (W)

Alfalfa (A)


1

-1

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)





100



P106

－400－





7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06



7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


－401－





0

P107

－402－

BB0





－403－





[ ] DNA

1)

NMRPrj

2)




Finding Biomakers

Environments


Natural Artifical



Finding Biomakers

Environments


Natural Artifical

P108

－404－

[[ ]

1H-NMR bin

[ ] [ ]


PCA83 ppm




Natural environment


Natural environment


Natural environment


－405－

NMRMagRO

1 1 1 1 1

1 1 1

1





NMR


GUI

BMRB


MacOSX Linux OS C


P109

－406－


GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－








Red clover (R)

White clover (W)

Alfalfa (A)

NMR (x)NMR (x)

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)



100






Red clover (R)

White clover (W)

Alfalfa (A)

Red clover (R)

White clover (W)

Alfalfa (A)


1

-1

1

-1


Phytoche

micals (x)

Symbionts (y)



(A) (W) (R)





100



P106

－400－





7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06



7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


－401－





0

P107

－402－

BB0





－403－





[ ] DNA

1)

NMRPrj

2)




Finding Biomakers

Environments


Natural Artifical



Finding Biomakers

Environments


Natural Artifical

P108

－404－

[[ ]

1H-NMR bin

[ ] [ ]


PCA83 ppm




Natural environment


Natural environment


Natural environment


－405－

NMRMagRO

1 1 1 1 1

1 1 1

1





NMR


GUI

BMRB


MacOSX Linux OS C


P109

－406－


GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－





7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06



7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


7595 45 1085 2030Eend

osym

biot

icba

cter

ia


9014 761 3182 311

-1 106-06


－401－





0

P107

－402－

BB0





－403－





[ ] DNA

1)

NMRPrj

2)




Finding Biomakers

Environments


Natural Artifical



Finding Biomakers

Environments


Natural Artifical

P108

－404－

[[ ]

1H-NMR bin

[ ] [ ]


PCA83 ppm




Natural environment


Natural environment


Natural environment


－405－

NMRMagRO

1 1 1 1 1

1 1 1

1





NMR


GUI

BMRB


MacOSX Linux OS C


P109

－406－


GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－





0

P107

－402－

BB0





－403－





[ ] DNA

1)

NMRPrj

2)




Finding Biomakers

Environments


Natural Artifical



Finding Biomakers

Environments


Natural Artifical

P108

－404－

[[ ]

1H-NMR bin

[ ] [ ]


PCA83 ppm




Natural environment


Natural environment


Natural environment


－405－

NMRMagRO

1 1 1 1 1

1 1 1

1





NMR


GUI

BMRB


MacOSX Linux OS C


P109

－406－


GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

BB0





－403－





[ ] DNA

1)

NMRPrj

2)




Finding Biomakers

Environments


Natural Artifical



Finding Biomakers

Environments


Natural Artifical

P108

－404－

[[ ]

1H-NMR bin

[ ] [ ]


PCA83 ppm




Natural environment


Natural environment


Natural environment


－405－

NMRMagRO

1 1 1 1 1

1 1 1

1





NMR


GUI

BMRB


MacOSX Linux OS C


P109

－406－


GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－





[ ] DNA

1)

NMRPrj

2)




Finding Biomakers

Environments


Natural Artifical



Finding Biomakers

Environments


Natural Artifical

P108

－404－

[[ ]

1H-NMR bin

[ ] [ ]


PCA83 ppm




Natural environment


Natural environment


Natural environment


－405－

NMRMagRO

1 1 1 1 1

1 1 1

1





NMR


GUI

BMRB


MacOSX Linux OS C


P109

－406－


GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

[[ ]

1H-NMR bin

[ ] [ ]


PCA83 ppm




Natural environment


Natural environment


Natural environment


－405－

NMRMagRO

1 1 1 1 1

1 1 1

1





NMR


GUI

BMRB


MacOSX Linux OS C


P109

－406－


GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

NMRMagRO

1 1 1 1 1

1 1 1

1





NMR


GUI

BMRB


MacOSX Linux OS C


P109

－406－


GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－


GUI Python-TkInter

GUI

GUI

BMRB NMR

PDBj-BMRB

MagRO-core

GUI

Spectrum

GUI

data analysis

BMRB

data exchange

MagRO

－407－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

1 1 2 1

1

2





P110

－408－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

A BA B

NMR

Fig 1

NMR


－409－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

Fig 2


15N edited NOESY

PC

300

－410－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

NMR Olivia

(Fig 3)


－411－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－







) 100 ps (10 ns) 100

P111

－412－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

2 2 () H(Mol2 8)-C(2)-C(1)-O(4)



100 10 ns MD5 500 R

2111 prcomp

1 ns 1 ns 2 ns MD2 10 ns 2

( -60 60 180 ) (Fig 1a)10 ns MD 100


(PC1) 405 (Fig 1b)PC1

PC2

(a) (b)


－413－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

12 2 2 2 2 2 1

1 -BIRD 2






4BMRBPDB


2 NMR-STAR 31 3

4 PDB BMRB PDB BMRB

BMRB

P112

－414－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

ADIT-NMR

PDB

BMRB

PDB BMRB




ADIT-NMR


BMRBNMR

PDBj

wwPDBPDBj ADIT-NMR



－415－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－



13 1313 13 1313

13 13

13 13 13 13

1313



5gt 1313





P113

－416－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－


x10

10 5 0 -5 -10 -15

10 0 -10

10

0

-10

40 20 0 -20 -40

(c)

13 13 13 13 $amp ( ) + ( $- ( $- $0AElig (100 12 3 4 (12 (52 $0AElig (0 12 3 6 17 7 1 888 6( 00 ( ) 4 1 10


) +$amp -13

－417－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－


－418－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

－419－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－




1NMR

1

2


TRM 998 02 (k=2)

TRM 996 05 k=2




NMR

P115

－420－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

Table 1ONOFF

Figure 2

n=12

( 02 Hz)

N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


N

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

DN

O

Br

F

F

F

N

CH3

Cl


SiCH3

CH3

CH3

SiCH3

CH3

CH3D

D

D

D


NMR qNMR


Certfied value

996 05

(k=2)

Pur

ity(

)

Certfied value

996 05

(k=2)

Pur

ity(

)

－421－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－










using NQR

NQR NMRNMR

NQR

NQRNQR

HMT16

Sm

HMT 200 gNQR

09 30 15 001 005 m

NQR FID NQR RF

P116

－422－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

Fig2 3308 MHz

Fig3 HMT NQRNQR 005

m 25 90o

NQR 004 m005 m NQR 20

NQR

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

RF

mag

netic

am

plitu

dby

gra

diom

eter

[a

u]

Water

09 salt solution

30 salt solution

15 salt solution

00

02

04

06

08

10

12

0 001 002 003 004 005 006

Distance [m]

NQ

R in

tens

ity [a

u]

Water

09 salt solution

30 salt solution

15 salt solution



16 Sm 15 005 mHMT 200g NQR


3308MHz RF 320 W400 micros 50 ms 1000

NQR

09 16 Sm 30 47 Sm 15 16 Sm HMT


to oscillator

Sample

Gradiometer

to oscilloscope

Prove

Water tank

－423－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

Bryn Baritompa


for NQR frequencies











NQR

NQR

NQR

NQR

NQR

NQR

NQR NMR

NQR

[1 2]

NQR NQR NMR

NQR NMR NQR

Bryn Baritompa

P117

－424－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

~ ~

NQR

NMR 14N NQR(T1 )

NQR (~ 2 g)5

01s

NQRNQR


1000 NQR

NMR 14N NQR





－425－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－






NMR NMR

SDBSWebNMR

SDBS-NMR NMR

SDBS-NMRSDBSWeb

1)

NMRSN

P118

－426－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－



13CNMR C-N

2) N 5

(Fig 2)

Fig 3 30 50 7013CNMR 30

70

C-NWeb

30 702D

NMR C-N

SDBS-NMR NMR


N

O

O OH



solution


－427－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－




(NQR)

NQR

NQR

NQR

NQR

NQR

NQR


PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

PC

NQRconsole

Matchingcircuit

Poweramplifier

4circuit


Sample Pick up coil

Oscilloscope




Pre- amplifier

Cross diode

Crossdiode

P119

－428－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

NQR

2

Fig3(a)

C1 C2 Fig3(b)C1 C2

Fig3(c)




C1

C2L

R

I

Variable capacitor

Stepping motor

Coupler

C2

C1C1

1

23

4

5 6 7

8

9

1010

11111212

1313

1414 1515 1616

1717

1818C1

C2 C2

C1 C1

C2

1919

20202121

2222

2323

2727

2626

25252424

3 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

3003 10 10

4 10 10

5 10 10

6 10 10 1 10 102 10 10

3 10 10

0

10

20

30

40

100 200300

0

20

40

C2 [pF]


400

600

500C1 [pF]

Frequency1036MHz

300

－429－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

12MHzC1 C2

Fig4 12MHz RF

RF


NQR


NQR NQR

NTNMRNQR

NQR

000

001

002

003

004

005

10 11 12 13 14

Frequency [MHz]

RF

fiel

d In

tens

ity [a

u]


－430－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


-20 -10 0 10 20

0

500

1000

1500

2000

2500

3000

NQ

R s

ign

al [a

u]

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz

-20 -10 0 10 20

kHz


NQR NQR

115mm 120mm 22500g

298K 488W SLSE [1]

500 950kHz 2kHz 1036kHz

NQR Fig5 NQR


NQRNQR

NQR


－431－

Documents

P101 NMR - University of Tokyoishimada.f.u-tokyo.ac.jp/public_html/nmr49/program/postersummaryP...Phosphatidylcholine as Studied by Solid State NMR Spectroscopy Naoko Uekama1,