Razvitak i plastičnost kortikalnih putova

8/14/2019 Razvitak i plastičnost kortikalnih putova

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Razvitak i plastičnost

kortikalnih putovaSekundarna prevencija u pedijatriji

Slavonski brod, 27. veljače 2010.

Akademik Ivica Kostović



Plan

• Razvitak puteva

• Razvitak funkcija

•

Perivenrtikularna leukomalacija istrukturna plastičnost



NEUROGENETIC EVENTS IN THE HUMAN CORTEX I.: LAMINARAND TEMPORAL PARAMETERS (WHERE AND WHEN

NEUROGENETIC EVENTS OCCUR ?)

1. Proliferation

2. Migration

3. Cell differentiation

4. Synaptogenesis

5. Axonal outgrowth

6. Cell death



Rakic (1995): Radial unit hypothesisand sequential ingrowth of afferents



eurogene c even s andevelopmental windows




http://slidepdf.com/reader/full/razvitak-i-plasticnost-kortikalnih-putova 7/38White matter – adult human brain – Weigert staining







Bilaminar distribution of dendrites –10,5w

Nissl Golgi

Early bilaminar circuitry -





Accumulation Below the CP and Targetselection 22-23 PCW



Accumulation of thalamocorticals



in vivo MR Fibronectin AchE

22w 22w 23w

Accumulation of thalamocorticals



Ingrowth and AddressSelection - 24-32 PCW

Synaptogenesis in the CP –

28PCW



AchE reactivity in the prefrontal CP

28 PCW



Vanhatalo et al inClin Neurophys (113) 2002

Neural activity:Brain waves



Fitzgerald M (2005):

The development of nociceptive circuits.

Slater R (2006):Cortical pain responses in human

infants.



Axonal strata andcrossroads –

guidancemolecules





Crossroad significance –pathways, tangential

& radial migration

Judaš et al, AJNR

2 G



Born at 27, MRI at 44 GW Born at 27, MRI at 44 GW



Crossroad signal



Lesion in the crossroads

l l i f h d



Focal PVL – lesion of the PVL crossroads



MRI – structural trias after perinatal lesion



CP after massive destruction of WM

Ult d l li d i t i l l i



Ultrasound – localized periventricular lesion- PVH



Perinatal reorganization of selectively



Kostović et al (2002):Disappearance of the SP

(Nissl – MRI – PAS-AB)and development of the corona radiata

Perinatal reorganization of selectivelyvulnerable zones



Patterns of structuralplasticity of fiber

pathways:

1. Detouring

Structural plasticit



TI/ Fiberracking

Courtesy of dr. M. StaDept. Of Radiology, University of Tubin

Structural plasticity



matosensory afferent projections

24 weeks GA time

S1

S1

subplate

I. Kostovic, yesterdayrtesy of dr. M. Staudtt. Of Radiology, University of Tubingen

Corticostriatal system



Structuralrearrangement of cortico-striatalconnections

Goldman-Rakic PS, Science1978

Corticostriatal system



CE

P

28w.g.

Maturation of thecorticostriatal

pathway

• Corticostriatal axons

“wait” for a long time before

entering (about 20 weeks)!

• Developmental time window!



Corticostriatalmaturation



Reorganization of striatalmoduls

• Caudate and rostral putamen

without modular organization

• Possible reorganization of the

nigrostriatal projection system

in the caudal putamen

C

Th

AChE



C

P

CI

Reorganization of striatal modulsrevealed by MAP-2

MAP-2 (microtubule-associated protein2):

• expressed in neurons

•synaptic plasticity

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Razvitak i plastičnost kortikalnih putova