Certamen de BioqumicaUNIVERSIDAD AUTNOMA DEL ESTADO DE MXICOFacultad de MedicinaBeatriz Mota VegaTOXICIDAD DE LOS SALICILATOS

Farmacologa Humana Jess Florez, Elsevier Espaa; 2004Relacin entre la concentracin srica de salicilato y sus efectos teraputicos y txicosConcentracin(mg / dL)EfectoTeraputicoToxico

Estimulacindel Centro RespiratoriopCO2 ALCALOSIS RESPIRATORIAPerdida de HCO3Por la orinaAcelerado metabolismo de glucosaa piruvato con el desacople en laFosforilacin oxidativaDisminucin en lafuncin renalACIDOSIS METABLICAHiperventilacinEFECTOS RESPIRATORIOS Y METABLICOS

Efecto de los Salicilatos en la Produccin Intramitocondrial de ATPSal- SalicilatosTE- Transporte de electronesATP- Adenosin TrifosfatoAspirin and Related Drugs K.D Raisford, 2004

ComplejoIComplejoIIComplejoIIIComplejoIVATP Sintetasa

Efecto de los Salicilatos en el Metabolismo de la GlucosaAspirin and Related Drugs K.D Raisford, 2004

RESULTADOSSobre algunos procesos anablicos Sobre la glucemia y el equilibrio acido- base

Hiponatremia

Monograma de Donepara la intoxicacinpor salicilatos

BIBLIOGRAFIAKennedy, J, Davis, J. Arch Biochem Biophys. Effects of salicylate and other benzoates on oxidative enzymes of the tricarboxylic acid cycle in rat tissue homogenates. Kaplan, EH, 1954; 51:47

Christel Norman, Katharine A. Howell, A. Harvey Millar, James M. Whelan, and David A. Day.The American Society for Plant Biologists Salicylic Acid Is an Uncoupler and Inhibitor of Mitochondrial Electron Transport; 2004 January; 134(1): PMC316328

Miyahara, JT, Karler, R. Effect of salicylate on oxidative phosphorylation and respiration of mitochondrial fragment. Biochem J 1965; 97:194.

Thurston, JH, Pollock, PG, Warren, SK, Jones, EM. Reduced brain glucose with normal plasma glucose in salicylate poisoning. J Clin Invest 1970; 49:2139

T. Y. Chan. The risk of severe salicylate poisoning following the ingestion of topical medicaments or aspirin.Department of Clinical Pharmacology, The Chinese University of Hong Kong, Shatin, New Territories. February 1999

B. J. Chapman and A. T. Proudfoot. Adult Salicylate Poisoning: Deaths and Outcome in Patients with High Plasma Salicylate Concentrations Regional Poisoning Treatment Centre, Royal Infirmary Edinburgh Accepted for publication 28 November 1988.

Karen Sapienza, William Bannister and Rena Balzan Mitochondrial involvement in aspirin-induced apoptosis in yeast.Microbiology 154 (2008), 2740-2747; DOI10.1099/mic.0.2008/017228-0

Toxicologa Clnica Ramon Bataller Sifre, Jos V Balaquer Martinez Editorial Universitat de Valncia 2004

Farmacologa HumanaJesus Flores, Juan Antonio Armijo, Africa Mediavilla 2004

Aspirin and Related Drugs K.D Raisford; Editorial CRC Press,2004

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goodman y gilman toxicologia casos orientados