דר איתן פאר מצגת גלולות

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15-35 ' -

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- FSH .. 15" - . - (30 ") ( ) ."

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, 17 , 2E :- - , , - ligand DNA RNA DNA . , , -- messengers NO, , kinase .- NO ."

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Pathways for Estrogen Carcinogenesis"

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, , , . ' C.O.M.T . , , ' . - tissue estrogen levels . - ."

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2030"

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30 ' 20 , , . - Pearl Index- -100 , ( 1200 ).Archer 1708 (26,554 ) 20 ' E 1143 30:-PI- 20 0.88PI- 30 1.02- Rosenberg M.J- Contraception- 1999:60:321-329Archer D- Am J Obstet Gynecol- 1999;185- 39-44

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30 20- , 6676 (R.R-1.6) - (R.R=1.3). . .Rosenberg M.J- Contraception- 1995;51:283-288Akerlund M Br J Obstet Gynecol- 1993;100:832-838Appel T.B- Contraception -1987;35:523-532Endrikat J- Contraception 1997;55:131-137"

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- 30 20Meade 50 30 ' E 60% VTE 20 'Young , , Meade T.B Br Med J 1980;280:1157-1161Young R.L Am J Obstet Gynecol 1999;181:59-62"

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- , 4 . , Rosenberg M J- Contraception , 1995;52:137-141"

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- , , ' ( AKR1C4) . ( LEU VAL). 68% . . . ."

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GESTODENE ( ). 100%, . . .Wilde MI, Balfour JA, Drugs:1995 Aug:50(2) 364-95"

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, , . , .Endrikat J-Contraception 199;60:269-274Crook D Am J Obstet Gynecol- 1993;69:1183-1189Rosenberg MJ Contraception 1996;53:85-9

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70-80%- . - 50% . . , . .

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HYSTEROSCOPIC VIEW OF ATROPHIC ENDOMETRIAL CAVITYCourtesy of Panay N"

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WHY BREAKTHROUGH BLEEDING?Dilated surface vessels in a Norplant user with bleeding on minimal pressureHickey M et al. Hum Reprod 1998;13(11):31903196"

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- - 20 '"

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8058 . 77 70% - .18% - ( ). , .

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Non Contraceptive Benefits of OCMenorrhgia Irregular mensesEndometrial CADysmenorrheaIron Def. AnemiaAcneHirsutism Ovarian CAFunctional Ov. CystsBenign Breast DisPMSOsteoporosisSalpingitisSherifk K Am J Obstet Gynecol- 1999 ;80- s343-348Thorneycroft I.H- Contraception- 1999;60:255-263"

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***********Hysteroscopic view of endometrial cavity of women taking Norplant (levonorgestrel-releasing contraceptive hormone). ****